Acellular Particulated Costal Allocartilage Improves Cartilage Regeneration in High Tibial Osteotomy: Data From a Randomized Controlled Trial.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2024-10-27 DOI:10.1177/19476035241292321

Kwangho Chung, Min Jung, Ki-Mo Jang, Sanghoon Park, Jaehong Kim, Sung-Hwan Kim

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引用次数: 0

Abstract

Objective: This study aimed to compare short-term arthroscopic and clinical outcomes between microfractures with (treatment group) and without (control group) acellular particulated costal allocartilage in patients undergoing concurrent high tibial osteotomy (HTO).

Design: This retrospective cohort study enrolled 19 and 21 patients in the treatment and control groups, respectively, and reviewed them at a minimum 2-year follow-up after HTO. Cartilage regeneration status was evaluated according to the International Cartilage Repair Society-Cartilage Repair Assessment (ICRS-CRA) grading and Koshino's macroscopic staging systems during medial locked plate removal. Patient-reported measures, including the visual analog scale pain score, Knee Injury and Osteoarthritis Outcome Score, and International Knee Documentation Committee score, assessed clinical outcomes.

Results: The total points of the ICRS-CRA grading system were significantly higher in the treatment group than in the control group (7.7 ± 3.8 vs 4.2 ± 3.0, respectively; P = 0.007). Likewise, the cartilage status according to Koshino's macroscopic staging system was better in the treatment group (P = 0.022). Patient-reported functional outcomes significantly improved postoperatively but were equivalent between the study groups at the final follow-up.

Conclusions: Microfractures augmented with acellular particulated costal allocartilage resulted in better repair quality than microfractures alone at a minimum 2-year follow-up after HTO, but functional outcomes improved similarly for both treatment approaches.

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细胞颗粒化肋软骨能改善高胫骨截骨术中的软骨再生：来自随机对照试验的数据。

研究目的本研究旨在比较同时接受高胫骨截骨术（HTO）的微骨折患者中使用（治疗组）和不使用（对照组）无细胞颗粒肋骨分配软骨的短期关节镜和临床结果：这项回顾性队列研究分别在治疗组和对照组中纳入了 19 名和 21 名患者，并在 HTO 术后进行了至少 2 年的随访。根据国际软骨修复学会-软骨修复评估（ICRS-CRA）分级和Koshino的宏观分期系统，在内侧锁定钢板移除过程中评估软骨再生状态。患者报告的指标包括视觉模拟量表疼痛评分、膝关节损伤和骨关节炎结果评分以及国际膝关节文献委员会评分，用于评估临床结果：结果：治疗组的ICRS-CRA分级系统总分明显高于对照组（分别为7.7 ± 3.8 vs 4.2 ± 3.0；P = 0.007）。同样，根据 Koshino 的宏观分期系统，治疗组的软骨状况更好（P = 0.022）。患者报告的功能结果在术后明显改善，但在最终随访时，研究组之间的结果相当：结论：在 HTO 术后至少 2 年的随访中，用无细胞颗粒肋骨分配软骨增强微骨折的修复质量优于单纯微骨折，但两种治疗方法的功能改善情况相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.