Exploring Trends and Gaps in Osteoarthritis Biomarker Research (1999-2024): A Citation Analysis of Top 50 Cited Articles.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2024-10-18 DOI:10.1177/19476035241288660

Wenjin Hu, Jiyong Yang, Li Liu, Dongchao Li, Yun Zhao, Aiguo Wang

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引用次数: 0

Abstract

Purpose: This study aimed to comprehensively analyze the landscape of osteoarthritis (OA) biomarker research through the citation analysis of top-cited articles, identifying trends and gaps in this field.

Methods: The Web of Science Core Collection was utilized to retrieve the top 50 cited articles on OA biomarkers. Data extraction included publication characteristics, citation metrics, and biomarker categorization. Statistical analyses were conducted to discern correlations and assess significance.

Results: The top 50 cited articles spanned the years 1999 to 2020, and collectively cited 4849 articles, accumulating a total of 6177 citations, resulting in an average of 123.5 citations per document. Citations per article varied between 78 and 359, with a citation density ranging from 3.9 to 23.93. Analysis of the top 50 cited articles revealed comparable impact between recent and older publications. Predominant trends included cartilage-related and blood-based biomarkers, while inflammation-related, radiomics, and multi-omics emerged as potential future research directions. In BIPEDS classification, gaps were identified in biomarkers evaluating intervention efficacy and safety.

Conclusion: Despite significant advancements, there is no universally acknowledged biomarker for OA. Addressing gaps in biomarker exploration is crucial for enhancing OA management strategies. This study provides insights into prevailing trends and future research directions in OA biomarkers, guiding future investigations and therapeutic development.

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探索骨关节炎生物标志物研究的趋势和差距（1999-2024 年）：前 50 篇文章的引用分析》。

目的：本研究旨在通过对高被引文章的引文分析，全面分析骨关节炎（OA）生物标志物研究的现状，找出该领域的趋势和差距：方法：利用科学网核心数据库检索OA生物标记物方面被引用次数最多的50篇文章。数据提取包括出版物特征、引用指标和生物标志物分类。统计分析用于辨别相关性和评估显著性：被引用次数最多的 50 篇文章的时间跨度为 1999 年至 2020 年，共引用了 4849 篇文章，累计引用次数为 6177 次，平均每篇文章被引用 123.5 次。每篇文章的引用次数从 78 次到 359 次不等，引用密度从 3.9 次到 23.93 次不等。对被引用次数最多的 50 篇文章进行分析后发现，近期发表的文章和较早发表的文章的影响力相当。主要趋势包括软骨相关生物标记物和基于血液的生物标记物，而炎症相关生物标记物、放射组学和多组学则成为未来潜在的研究方向。在BIPEDS分类中，评估干预效果和安全性的生物标志物方面存在差距：结论：尽管取得了重大进展，但目前还没有公认的 OA 生物标志物。缩小生物标志物探索方面的差距对于加强 OA 管理策略至关重要。本研究深入探讨了 OA 生物标志物的当前趋势和未来研究方向，为未来的研究和治疗开发提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.