CARTILAGE最新文献

{"title":"Ankle Alignment Changes After High Tibial Osteotomy due to Valgus-Shaped Distal Tibia.","authors":"Sem Dorst, Roel J H Custers, Nienke van Egmond, Ralph J B Sakkers, Harrie Weinans, Eva A Bax","doi":"10.1177/19476035261465607","DOIUrl":"10.1177/19476035261465607","url":null,"abstract":"<p><p>PurposeMedial open-wedge high tibial osteotomy (MOW-HTO) is effective for correcting varus knee deformity but may unintentionally affect ankle joint alignment. This study investigated radiographic factors associated with postoperative ankle alignment changes following valgus-producing MOW-HTO.MethodsA retrospective analysis was conducted on a prospective cohort of 50 knees in 49 patients (mean age 46.3 ± 8.2 years). Patients were included if they underwent MOW-HTO between 2016 and 2024, were enrolled in the hospital knee registry, and had both pre-and postoperative whole-leg radiographs available. These weight-bearing long-leg radiographs were used to assess tibial bone deformity and ankle joint alignment. Postoperative ankle alignment was classified as deviating closer to neutral or further from neutral. Correlation analyses and within- and between-group comparisons were performed, with significance set at p < 0.05.ResultsAfter MOW-HTO in varus-shaped knees, all alignment parameters shifted toward valgus. Tibial deformity predominantly originated from the distal tibia, with a medial center of rotation of angulation (CORA), reflecting an overall valgus-shaped tibia. Distal tibial valgus showed a strong correlation with talar orientation relative to the ground (ρ = 0.81, p < 0.001). Patients deviating further from neutral had nearly 5° more distal tibial valgus than those deviating closer to neutral (p < 0.001), and more frequently showed an overall valgus-shaped tibia (p < 0.01). Additionally, larger correction angles were moderately associated with greater valgus shift of the ankle (ρ = -0.44, p < 0.001).ConclusionMOW-HTO results in a valgus shift of the talar orientation, particularly in patients with preoperative distal tibial valgus, an overall valgus-shaped tibia, and larger correction angles. Thorough preoperative assessment of tibial morphology is essential to better anticipate postoperative ankle alignment changes.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261465607"},"PeriodicalIF":2.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avascularity, Cartilaginous Matrix Composition, and Glycolytic Metabolism in Articular Cartilage and the Inner Meniscus: A Mechanobiological Trade-off With Testable Predictions.","authors":"Rafael Iñigo Pavlovich","doi":"10.1177/19476035261478272","DOIUrl":"10.1177/19476035261478272","url":null,"abstract":"<p><p>BackgroundArticular cartilage and the inner (white) zone of the knee meniscus are characterized by minimal vascularity, a dense extracellular matrix (ECM), and cellular metabolism adapted to diffusion-limited oxygen and nutrient delivery. These features support long-term load-bearing function but limit intrinsic healing.^1-3HypothesisRather than framing avascularity as an \"evolutionary optimization,\" we propose a mechanobiological trade-off in which anti-angiogenic maintenance of avascularity helps preserve matrix continuity and load support, while constraining vascular-dependent repair.^1,4Evidence/ConceptAnti-angiogenic regulation is plausible in the inner meniscus, where chondromodulin-I (ChM-I) is enriched and functionally inhibits endothelial cell proliferation.4 Metabolic compatibility provides a complementary biological rationale: hypoxia-responsive signaling (including HIF-1alpha) supports chondrocyte survival and matrix homeostasis in avascular cartilage, and classic biochemical observations in cartilage are consistent with limited oxidative capacity and strong dependence on glucose availability.^8,10 Mechanically, the clinically relevant question is whether vascular \"space\" formation within an otherwise continuous, hydrated ECM measurably alters stiffness- and fluid-pressurization-dependent load support.^5-7 We treat finite-element analysis (FEA) only as an illustrative sensitivity concept: channel-like discontinuities within a composite are expected to increase local shear/strain concentration and reduce apparent compressive stiffness, depending on geometry and constitutive assumptions.^5-7ConclusionThis framework yields testable predictions for explants and engineered constructs and may guide regenerative strategies that improve transport without mechanically compromising load-bearing architecture.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261478272"},"PeriodicalIF":2.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Allogeneic Integrin α10β1-Selected Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A First-In-Human Phase I/IIa Dose Escalation Study.","authors":"Lucienne A Vonk, Camilla Wennersten, Kristina Uvebrant, Kavitha Siva, Liselotte Theorell, Marc Russo, Stephen Hall, Evy Lundgren-Åkerlund","doi":"10.1177/19476035261475741","DOIUrl":"10.1177/19476035261475741","url":null,"abstract":"<p><p>PurposeSafety and efficacy of allogeneic integrin α10β1-selected MSCs (integrin α10-MSCs) have been shown in two post-traumatic osteoarthritis (OA) equine models. The aim of this study is to evaluate safety, tolerability and preliminary efficacy of allogeneic integrin α10-MSCs in human symptomatic knee OA.MethodsIn a first-in-human prospective multicentre phase I/IIa dose escalation study, 24 patients (41-75 years, Kellgren-Lawrence grade II-III knee OA) were treated with a single intra-articular injection of 4, 8 or 16 million integrin α10-MSCs. Safety and tolerability were assessed by adverse events, electrocardiography, vital signs, and physical and laboratory examinations. Clinical outcome was measured by visual analogue scale (VAS) for pain and Knee injury and Osteoarthritis Outcome Score (KOOS). Structural outcomes were assessed by X-ray and MRI. The total follow-up period was 24 months for the highest dose and 18 months for the lower doses.ResultsThe most frequently reported study drug-related adverse events were injection site pain, joint swelling and injection site movement impairment. All doses showed sustained improvements in pain and function, whereas the 16 million dose cohort showed earlier effects. The 16 million dose cohort also showed a reduction in bone marrow lesions, signs of an improved cartilage quality by T2* relaxation time, and a stable medial minimum joint space width.ConclusionsThis study demonstrated safety and efficacy of intra-articular injection of integrin α10-MSCs for the treatment of mild to moderate knee OA. At a dose of 16 million integrin α10-MSCs, a potentially quick and long-lasting therapeutic effect, supportive of disease-modification, was evident.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261475741"},"PeriodicalIF":2.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Reparative and Immunomodulatory Signatures of Extracellular Vesicles From Human Cartilage-Derived Chondroprogenitors, Chondrocytes, and Bone Marrow Mesenchymal Stem Cells in a Rat Osteoarthritis Model.","authors":"Elizabeth Vinod, Ganesh Parasuraman, Abel Livingston, Daniel Jonathan Roy, Jeya Lisha J, Mariya Sneha Rani J, Deepak Vinod Francis, Noel Naveen Johnson, Anjali Goyal, Grace Rebekah, Solomon Sathishkumar, Alfred Job Daniel, Boopalan Ramasamy","doi":"10.1177/19476035261475567","DOIUrl":"https://doi.org/10.1177/19476035261475567","url":null,"abstract":"<p><p>BackgroundExtracellular vesicles (EVs) mediate many of the reparative effects of cell-based therapies for osteoarthritis; however, the influence of EV source on cartilage repair and systemic immune responses remains unclear. Cartilage-resident chondroprogenitors represent lineage-biased cell populations with enhanced chondrogenic stability when compared with BM-MSCs and chondrocytes.MethodsEVs were isolated from human BM-MSCs, chondrocytes, fibronectin adhesion assay-derived chondroprogenitors (FAA-CPs), and migratory chondroprogenitors (MCPs) obtained from non-diseased donors. EVs were characterised for size, surface markers, and protein content. Osteoarthritis was induced in Wistar rats using the monosodium iodoacetate model. EVs (40 µg) were administered intra-articularly once weekly for six weeks. Each treatment group included 12 joints, with sham and OA controls. Cartilage repair was assessed by routine histological evaluation, collagen immunohistochemistry and modified Mankin scoring. Systemic immune responses were evaluated using splenic IL-6 and TNF-α expression.ResultsAll EV-treated groups demonstrated improved cartilage morphology compared with controls. EVs derived from cartilage-resident cells consistently promoted superior cartilage repair compared with BM-MSC-derived EVs, with improved proteoglycan retention, collagen type II deposition, and lower modified Mankin scores. FAA-CP and MCP EVs showed comparable reparative profiles and modestly outperformed chondrocyte-derived EVs. BM-MSC EVs exhibited the lowest splenic IL-6 and TNF-α expression, indicating stronger immunomodulatory effects, while cartilage-resident EVs showed immune profiles similar to chondrocytes.ConclusionEV source significantly influences cartilage repair and immunological behaviour in early osteoarthritis. Cartilage-resident cell EVs demonstrate enhanced repair, whereas BM-MSC EVs retain stronger immunomodulatory capacity. These findings support rational EV source selection for cartilage regeneration strategies.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261475567"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Compression on Extracellular Matrix Synthesis by Chondrocytes and Chondrosarcoma Cells.","authors":"Carlo Alberto Paggi, Isa Porsul, Séverine Le Gac, Marcel Karperien","doi":"10.1177/19476035261460455","DOIUrl":"10.1177/19476035261460455","url":null,"abstract":"<p><p>ObjectiveMechanical loading is critical for chondrocyte function and cartilage matrix production, yet its effects on clustered chondrocytes in end-stage osteoarthritis and on chondrosarcoma cells remain poorly understood. This study investigated how cyclic compression influences chondrocytes and chondrosarcoma cells cultured either as single cells or as micromasses.MethodsAn organ-on-chip platform was used to apply cyclic compression to chondrocytes and chondrosarcoma cells embedded in agarose as single cells or micromasses mimicking chondrocyte clusters. Deformation during loading was assessed, and after four days of stimulation, gene and protein expression of cartilage markers and extracellular matrix components were analyzed.ResultsChondrocyte micromasses deformed less than single cells and showed behavior resembling chondrosarcoma cells and their micromasses. All four culture models exhibited distinct mechanobiological responses after four days of compression. Mechanical loading promoted collagen I reorganization in micromasses and increased <b>ACAN</b> and <b>COL2A1</b> expression, with enhanced matrix deposition aligned with the loading direction in one chondrocyte donor and one chondrosarcoma cell line. Semi-quantitative imaging suggested trends toward ECM deposition along the loading axis in some micromass conditions.ConclusionIn this agarose-based organ-on-chip proof-of-concept model, cellular organization was associated with distinct responses to cyclic compression. These findings should be interpreted as model-specific observations from one OA donor and one chondrosarcoma cell line, and require validation in additional donors, cell lines, matrices, and loading conditions before broader conclusions can be drawn.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261460455"},"PeriodicalIF":2.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Age Affect Progression to Total Knee Arthroplasty After Cartilage Surgery: A UK Biobank Cohort Study.","authors":"Nicola J Kuiper, Charlotte H Hulme, Martyn Snow, Martin Frisher, Karina T Wright, Jan Herman Kuiper","doi":"10.1177/19476035261450100","DOIUrl":"10.1177/19476035261450100","url":null,"abstract":"<p><p>ObjectiveEvaluate the association of sex and age at surgery with time to total knee arthroplasty (TKA) following knee cartilage surgery in UK Biobank (UKB) participants.DesignParticipants with a history of knee cartilage surgery were classified into four surgical subgroups: cartilage repair, debridement, microfracture, and unicompartmental knee arthroplasty. Time from index surgery to primary TKA in each group was analysed using the Kaplan-Meier method and the sexes compared using log-rank tests. Cox proportional hazards regression evaluated associations between age at surgery, sex, and surgery type with risk of progression to TKA.ResultsThe study included 1,967 males and 1,741 females. Log‑rank testing demonstrated significant sex‑based differences in time to TKA following debridement (<i>P</i> = 0.002) and microfracture (<i>P</i> = 0.003), with shorter TKA‑free survival observed in females. Cox regression showed that female sex was associated with a higher hazard of progression to TKA compared with male sex (hazard ratio [HR] = 1.19, <i>P</i> = 0.021). Increasing age at surgery was associated with increased risk (HR = 1.05 per year, <i>P</i> < 0.0001).ConclusionFemale sex and older age at surgery were associated with a higher risk of progression to TKA following cartilage surgery. Sex‑specific differences in time to TKA were most evident after debridement and microfracture. These findings describe associations observed within the constraints of available UKB data.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261450100"},"PeriodicalIF":2.6,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Cytotoxicity and Inflammatory Response of Local Anaesthetics and Corticosteroids in Canine Fibroblast-Like Synoviocytes.","authors":"Catarina Sousa, Ana Lima, Adriana Belas, Sónia Campos","doi":"10.1177/19476035261459650","DOIUrl":"10.1177/19476035261459650","url":null,"abstract":"<p><p>ObjectiveThis study investigated the dose-dependent cytotoxicity and immunomodulatory effects of intra-articular local anaesthetics (lidocaine, mepivacaine, levobupivacaine) and corticosteroids (dexamethasone, methylprednisolone, methylprednisolone acetate) on canine fibroblast-like synoviocytes (FLS) <i>in vitro</i>. We evaluated cell viability and the expression of IL-6 and MMP-9.MethodsCanine FLS were exposed to increasing concentrations of intra-articular agents. Cell viability was determined via MTT assays. Immunomodulatory effects were assessed via ELISA for IL-6 and gelatin zymography for MMP-9 activity after TNF-α stimulation with IC₅₀ concentrations.ResultsAll agents exhibited dose-dependent cytotoxicity. Dexamethasone was most cytotoxic (IC₅₀ ≈ 3.4×10^-4 mg/mL) but selectively inhibited TNF-α-induced MMP-9 activity without affecting IL-6 or inducing cytotoxicity at its IC₅₀. Mepivacaine significantly inhibited MMP-9 activity by 40% at 1 mg/mL and uniquely induced IL-6 in unstimulated cells. Lidocaine, methylprednisolone, and methylprednisolone acetate suppressed TNF-α-induced IL-6 expression.ConclusionsCommonly used intra-articular agents induce dose-dependent cytotoxic effects on canine FLS at clinically relevant concentrations. This study provides the first evidence of species-specific responses for mepivacaine, levobupivacaine, and dexamethasone in canine FLS, highlighting mediator-specific and concentration-dependent effects crucial for optimizing intra-articular therapies in veterinary and translational medicine.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261459650"},"PeriodicalIF":2.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal LINC01106 From PRP-Treated ADSCs Alleviates Chondrocyte Inflammatory Injury by Sponging miR-34a-5p to Upregulate SIRT1 Expression.","authors":"Xuan Zhang, Wentao Liu, Jinke Ren, Yangyi Yu, Zhongshi Xu","doi":"10.1177/19476035261445874","DOIUrl":"10.1177/19476035261445874","url":null,"abstract":"<p><p>ObjectiveOsteoarthritis (OA) is characterized by progressive cartilage degeneration driven by inflammation-induced chondrocyte injury, while effective disease-modifying therapies are still lacking. Exosome-based cell-free approaches are emerging as promising alternatives, but their key molecular mediators remain incompletely defined.DesignAdipose-derived stem cells (ADSCs) were pretreated with platelet-rich plasma (PRP) to enhance exosomal function. Isolated exosomes were characterized, and LINC01106 expression was modulated by overexpression or knockdown. Interleukin (IL)-1β-stimulated chondrocytes were used to assess apoptosis, inflammatory cytokine secretion, oxidative stress, and extracellular matrix degradation. The LINC01106/miR-34a-5p/SIRT1 axis was examined using luciferase reporter assays, quantitative real-time polymerase chain reaction (PCR), Western blotting, and immunofluorescence.ResultsPRP pretreatment markedly increased LINC01106 enrichment in ADSC-derived exosomes. LINC01106-rich exosomes significantly reduced chondrocyte apoptosis, suppressed tumor necrosis factor-α (TNF-α) and IL-6 secretion, alleviated oxidative stress, and attenuated matrix metalloproteinase (MMP)-mediated matrix degradation under IL-1β stimulation. Mechanistically, LINC01106 acted as a competing endogenous RNA that sequestered miR-34a-5p, thereby restoring SIRT1 expression. Rescue experiments demonstrated that miR-34a-5p overexpression or SIRT1 silencing abolished these protective effects. In addition, LINC01106-enriched exosomes inhibited nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathway activation in a SIRT1-dependent manner.ConclusionPRP-stimulated ADSC-derived exosomes confer potent chondroprotective effects through the LINC01106/miR-34a-5p/SIRT1 pathway, highlighting a promising cell-free therapeutic strategy for OA.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261445874"},"PeriodicalIF":2.6,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13272194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.","authors":"Giorgia Mazzini, Margo Tuerlings, Vicki van der Stap, Ilja Boone, Rachid Mahdad, Yolande F M Ramos, Ingrid Meulenbelt","doi":"10.1177/19476035261458719","DOIUrl":"10.1177/19476035261458719","url":null,"abstract":"<p><p>BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during <i>in vitro</i> expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on ECM production by hiPSC-derived chondroprogenitors (hiCPCs), their derived chondrocytes (hiCHOs), and primary articular chondrocytes (hACs) from lesioned or preserved areas remains unclear.MethodsWe here compared cartilage ECM formation by hiCPCs/hiCHO's and hACs, with or without FN selection, over extended passaging using 3D organoids. Histology and quantitative image analysis were performed to assess tissue quality across passages.ResultsChondrogenicity in hiCPCs transiently improved early-stage ECM production upon FN-based selection, but accelerated loss of chondrogenicity was seen in later passages. This was evidenced by diminished matrix staining and structural degradation from passage 4 onward. In contrast, hACs from both preserved and lesioned cartilage maintained stable matrix-forming ability across passages, independent of FN-based selection.ConclusionFN-based selection does not preserve long-term chondrogenicity in hiCHOs and may even impair it during extended culture. In contrast, primary cell sources, regardless of cartilage integrity, demonstrate greater and robust chondrogenic capacity without requiring progenitor enrichment. These findings highlight the intrinsic ability of hACs and question the utility of FN-based selection in cartilage tissue engineering.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261458719"},"PeriodicalIF":2.6,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to Work after Surgical Treatment of Osteochondral Defects of the Talus: A Systematic Review and Meta-Analysis.","authors":"Kaj S Emanuel, Sophia van Beelen, Jari Dahmen, Julian J Hollander, Sjoerd A S Stufkens, Paul P F M Kuijer, Gino M M J Kerkhoffs","doi":"10.1177/19476035261457600","DOIUrl":"10.1177/19476035261457600","url":null,"abstract":"<p><p>IntroductionReturn to work (RTW) is a key goal for patients treated for osteochondral lesions of the talus (OLT).AimThe primary objective of this review is to determine the RTW after surgical treatment of an OLT.MethodsAfter preregistration, MEDLINE (PubMed), Embase and Cochrane Library were screened by two authors. RTW time and rate were extracted, and pooled if sufficient data was available. Two authors assessed methodological quality using the MINORS criteria.ResultsA total of 18 studies were included for which 399 patients reported RTW rate and/or time. The overall methodological quality of the studies was poor. The RTW time ranged from 2 to 11 weeks post-operatively and varied across surgical techniques. The overall RTW rate was 93%, with arthroscopic procedures averaging 96%, and open procedures averaging 91% RTW.ConclusionAfter surgical treatment of OLTs, 93% of patients returned to work. Time to RTW ranged from 2 to 11 weeks, although reporting was heterogeneous and methodological quality was generally low. Future studies should include RTW as a core outcome and report work-related restrictions more consistently.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261457600"},"PeriodicalIF":2.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}