CARTILAGE最新文献

{"title":"Proteomics Analysis Reveals Serum Biomarkers Reflecting Joint Pain and Physical Limitations in Knee Osteoarthritis Before and After Joint Replacement Surgery.","authors":"Anne-Mari Mustonen, Janne Tampio, Kristiina M Huttunen, Petro Julkunen, Laura Säisänen, Lauri Karttunen, Jusa Reijonen, Amir Esrafilian, Tiina Kuningas, Atul Kumar, Heikki Kröger, Petteri Nieminen","doi":"10.1177/19476035261455413","DOIUrl":"10.1177/19476035261455413","url":null,"abstract":"<p><p>ObjectiveOsteoarthritis (OA) is an age-related musculoskeletal disorder lacking effective disease-modifying therapies and early diagnostic biomarkers. This study aimed to identify serum proteins that could indicate the occurrence of knee OA (KOA) and correlate with patients' pain and functional impairment.Design/MethodsFasting serum samples were collected from controls (n = 8) and patients with end-stage KOA at baseline (n = 8) and 12 months after total knee arthroplasty (n = 8). Proteomics analysis was conducted with liquid chromatography-mass spectrometry, followed by univariate and multivariate statistics and pathway analyses by MetaboAnalyst and STRING. Partial correlations were calculated with R, adjusted for sex, age, and body mass index, using a linear regression model.Results151 proteins were upregulated and 5 proteins downregulated in baseline KOA compared to control. These proteins were linked to the complement system, immune response, coagulation, inflammatory response, calcium homeostasis, and extracellular matrix remodeling. Of these, complement factor I showed strong biomarker potential. Several proteins emerged as statistically significant predictors of cartilage loss, pain sensitivity, physical function, and corticospinal excitability. Systemic alterations persisted 12 months after surgery.ConclusionSerum proteins may serve as biomarkers of KOA, reflecting disease-related immune, inflammatory, and tissue-remodeling processes that persist after joint replacement.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261455413"},"PeriodicalIF":2.6,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Responses of Estrogen Receptor α and β in Chondrocytes Under Excessive Mechanical Stress.","authors":"Saki Takesue, Naoto Hirose, Makoto Yanoshita, Sayuri Nishiyama, Eri Tsuboi, Naoki Kubo, Daiki Kita, Yuki Asakawa, Kotaro Tanimoto","doi":"10.1177/19476035261423781","DOIUrl":"10.1177/19476035261423781","url":null,"abstract":"<p><p>IntroductionOsteoarthritis (OA) is more common in women, suggesting a link to estrogen. Estrogen supports cartilage homeostasis and metabolism via two receptors: ERα and ERβ. Mechanical stress is the primary cause of OA and affects cellular functions, including receptor activity. The link between excessive mechanical stress and ERs in cartilage is poorly understood. This study examined ER expression changes in chondrocytes under mechanical stress and the role of estrogen in cartilage degradation and ER regulation.MethodsATDC5 chondrocytes were treated with 17β-estradiol (E2; 1.0 × 10⁻⁷M) and subjected to cyclic tensile strain using the Flexcell Tension Plus FX-2000. Total RNA and proteins were extracted, and IL-1β and MMP-13 expression were analyzed using RT-PCR and western blotting. RT-PCR was used to examine the expression of ERα and ERβ.ResultsThe CTS group had significantly downregulated ERα expression at all time points and upregulated ERβ expression after 3 and 6 hours compared with controls. In the E2+CTS group, IL-1β and MMP-13 expression were suppressed after 3 and 6 hours, coinciding with significant upregulation of ERβ compared with the CTS group.ConclusionsEstrogen exerts a chondroprotective effect under excessive mechanical stress, suggesting that ERβ mediates this effect.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261423781"},"PeriodicalIF":2.6,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contralateral Knee Alignment Parameters Have Limited Influence on Coronal Alignment Progression Compared With Ipsilateral Parameters in Patients With Knee Osteoarthritis.","authors":"Kee Soo Kang, Byung Sun Choi, Hyuk-Soo Han, Chong Bum Chang, Kwangho Chung, Du Hyun Ro","doi":"10.1177/19476035261450111","DOIUrl":"10.1177/19476035261450111","url":null,"abstract":"<p><p>ObjectiveTo compare alignment parameters in bilateral lower extremities and evaluate the effect of contralateral limb on hip-knee-ankle angle (HKAA) longitudinally.MethodsNative bilateral lower extremities of 3,045 Korean patients with long-leg radiographs were followed for progression of knee osteoarthritis. Concordance rates of Functional Knee Phenotypes (FKPs) and Coronal Plane Alignment of the Knee (CPAK), the proportion of patients with identical bilateral subtypes, were assessed. Varus, neutral, and valgus alignments were defined as baseline HKAA ≤177°, 177°< HKAA <183°, and HKAA ≥183°, respectively. Multivariable linear regressions for follow-up HKAA were conducted.ResultsConcordance rates for FKPs and CPAK were 41.6% (95% confidence interval: 39.9-43.4%) and 53.5% (51.7-55.2%), respectively, at baseline and 35.5% (33.8-37.2%) and 55.4% (53.7-57.2%) at a mean 4.0-year follow-up. Contralateral parameters, Kellgren-Lawrence grade (<i>P</i> = 0.005) in bilateral varus group, medial proximal tibial angle (MPTA) (<i>P</i> = 0.046) in ipsilateral varus-contralateral neutral group, MPTA, and mechanical lateral distal femoral angle in bilateral neutral (<i>P</i> < 0.001; <i>P</i> = 0.012, respectively) and valgus (<i>P</i> = 0.003; <i>P</i> = 0.004) groups, were associated with follow-up HKAA. However, their standardized β values were smaller than ipsilateral values.ConclusionConcordance rates of FKPs and CPAK between bilateral limbs were 41.6% and 53.5% at baseline, respectively. Contralateral parameters have limited influence on coronal alignment progression compared with ipsilateral parameters.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261450111"},"PeriodicalIF":2.6,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subchondral Knee Injections: A Comprehensive Systematic Review of Current Clinical Outcomes, Safety, and Arthroplasty Delay.","authors":"Yazan Abu Salem, Carlotta Franceschi, Pietro Conte, Giuseppe Anzillotti, Daniele D'Arrigo, Berardo Di Matteo, Elizaveta Kon","doi":"10.1177/19476035261420389","DOIUrl":"10.1177/19476035261420389","url":null,"abstract":"<p><p>IntroductionOsteoarthritis is considered a whole-joint disease involving subchondral bone. Intraosseous therapies such as calcium phosphate (CaP), platelet-rich plasma (PRP), and mesenchymal stem cells (MSCs) offer joint-preserving options for knee osteoarthritis (OA).PurposeTo critically appraise and update the clinical evidence on intraosseous injections for knee osteoarthritis, focusing on safety, functional outcomes, need for retreatment, and conversion rates to total knee arthroplasty (TKA).MethodsA systematic review of PubMed, Embase, and Cochrane was conducted following PRISMA guidelines and PROSPERO registration (CRD420251104989). Clinical studies reporting outcomes of intraosseous injections with CaP, PRP, or MSCs for knee osteoarthritis with ≥5 patients and ≥6 months of follow-up were included. Methodological quality was assessed using the modified Coleman Methodology Score and Cochrane Risk of Bias 2.0 tool.ResultsTwenty-four studies involving 1,109 patients (mean age, 55 years; mean follow-up, 38 months) met inclusion criteria: 10 on CaP, 6 on PRP, and 8 on MSCs. Five were randomized controlled trials (RCTs). Most studies reported significant improvements in pain and function. CaP injection outcomes were variable, with TKA conversion rates ranging from 1.3% to 45%. PRP and MSCs studies showed favorable safety profiles and lower conversion rates. Long-term MSCs data indicated sustained relief and delayed TKA over up to 15 years. However, overall study quality was modest, with only one RCT rated as low risk of bias.ConclusionIntraosseous injections may improve symptoms and delay arthroplasty in selected patients with knee OA, with MSCs showing the most favorable long-term results. PRP appears to be a safe option whereas CaP outcomes are more variable. Standardized protocols and high-quality RCTs with long-term follow-up are needed to optimize patient selection and treatment efficacy.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261420389"},"PeriodicalIF":2.6,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial Fluid Proteomic Biomarkers in Knee Osteoarthritis: A Systematic Review and Gene Ontology Analysis.","authors":"Elvira Immacolata Parrotta, Giorgia Lucia Benedetto, Giovanni Cuda, Raffaele Covello, Umile Giuseppe Longo, Arianna Carnevale, Olimpio Galasso, Giorgio Gasparini, Michele Mercurio","doi":"10.1177/19476035261446251","DOIUrl":"10.1177/19476035261446251","url":null,"abstract":"<p><p>BackgroundOsteoarthritis (OA) of the knee is a degenerative disorder characterized by cartilage degradation, synovial inflammation, and structural remodeling. Synovial fluid (SF) biomarkers may improve diagnosis, staging, and patient stratification.MethodsFollowing PRISMA guidelines, a systematic search of PubMed and Scopus (2015-2025) was conducted. Human studies analyzing SF with proteomic techniques (LC-MS/MS, SWATH-MS, ELISA) were included. Extracted data were classified by OA stage, sample type, proteomic platform, and identified biomarkers. Functional enrichment was performed with ShinyGO, and protein-protein interaction (PPI) analysis with STRING (v12.0).ResultsSeven studies met the inclusion criteria. Reported biomarkers included Cathepsin G (CTSG), angiotensinogen (AGT), periostin (POSTN), haptoglobin (HP), complement components, and matrix-related proteins such as ADAMTS4 and LYVE-1, which are involved in extracellular matrix remodeling, inflammation, and joint tissue homeostasis. Functional annotation revealed enrichment in glycosaminoglycan binding, complement cascades, and redox pathways. PPI analysis identified central nodes including COL1A1, ACAN, COMP, and POSTN, together with matrix-degrading enzymes such as MMP1, MMP3, and MMP13, highlighting tightly connected extracellular matrix remodeling processes in OA.ConclusionThis review highlights reproducible SF biomarkers with diagnostic and prognostic potential in knee OA. Integrated proteomic and network analysis reinforces the multifactorial nature of OA and suggests key molecular targets. Translationally, a consistent biomarker signature could support early detection, more precise staging, and personalized management, enabling biomarker-guided diagnostics, targeted therapies, and the integration of precision medicine into OA care.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261446251"},"PeriodicalIF":2.6,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial Biomarker Modulation and Clinical Response to Umbilical Cord-Derived MSC Treatment in Knee Osteoarthritis: A Case Series Study.","authors":"Urban Švajger, Matic Kolar, Borut Pompe, Andrej Kobold, Matej Drobnič","doi":"10.1177/19476035261435793","DOIUrl":"10.1177/19476035261435793","url":null,"abstract":"<p><p>ObjectiveUmbilical cord-derived mesenchymal stromal cells (UC-MSCs) are a promising treatment for knee osteoarthritis (KOA). This study aimed to (1) characterize early synovial fluid biomarker changes after intra-articular UC-MSCs therapy in advanced KOA and (2) explore their relationship with short-term clinical outcomes.MethodsIn this prospective, single-arm case series, 15 patients with advanced KOA (Kellgren-Lawrence III-IV) scheduled for total knee arthroplasty received a single intra-articular injection of 20 × 10⁶ allogeneic UC-MSCs. Synovial fluid was aspirated at baseline and approximately 6 weeks post-injection. A panel of 29 soluble biomarkers related to inflammation, matrix remodeling, immune signaling, angiogenesis, and metabolism was quantified using multiplex immunoassays. Clinical status was evaluated with Patient-Reported Outcome Measures (PROMs) before and at a mean of 48 ± 18 days after the injection. Paired differences were analyzed using the Wilcoxon signed-rank tests.ResultsSignificant post-treatment differences were observed in biomarkers associated with extracellular matrix turnover (Matrix Metalloproteinase [MMP]-1, MMP-3, MMP-7, Cartilage Oligomeric Matrix Protein [COMP]), vascular remodeling (Vascular Endothelial Growth Factor [VEGF], Vascular Cell Adhesion Molecule [VCAM]-1), immune modulation (interleukin [IL]-8), and metabolic or structural regulation (Leptin, dickkopf [Dkk]-1). Most PROMs demonstrated significant improvements. These findings describe molecular changes in synovial fluid observed after intra-articular UC-MSC administration.ConclusionsIn this prospective single-arm cohort, intra-articular UC-MSC administration was feasible and well tolerated, and we observed pre-post changes in synovial fluid biomarkers and patient-reported outcomes. These findings do not establish causality and warrant confirmation in controlled studies. The study was registered at Clinicaltrials.gov: Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteoarthritis, NCT06078059, https://clinicaltrials.gov/study/NCT06078059?intr=NCT06078059.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261435793"},"PeriodicalIF":2.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Objective Scoring of Osteoarthritis Severity in Mouse Medial Tibial Cartilage Using Deep Learning.","authors":"Ka Hyon Park, Young-Gwon Kim, Gyuseok Lee, Su-Jin Kim, Yoonkyung Won, Yun Hyun Huh, Tae-Jong Kim, Jang-Soo Chun, Ho-Jun Song, Je-Hwang Ryu","doi":"10.1177/19476035261435798","DOIUrl":"10.1177/19476035261435798","url":null,"abstract":"<p><p>ObjectiveThis study developed and optimized a deep learning model to automate OARSI-based histologic scoring of mouse medial tibial cartilage.DesignSafranin-O-stained cartilage images were obtained from mice with OA induced by medial meniscus instability. A total of 2,788 images from 1,000 knees of 520 mice were included for model development and evaluation. Each data set was evaluated using deep learning models with multiple selection criteria for the reference standard. For preprocessing, horizontal cartilage alignment was learned using a VGG16-based regression model, and the tibial cartilage region was detected using YOLO-v7. These learned weights were applied to generate a rotation- and crop-adjusted cartilage data set, which was used to evaluate three CNNs.ResultsInitial classification of 544 mice cartilage images showed low accuracy, leading to an expansion of the data set to 2,788 images. An algorithm was applied to align the images horizontally and crop only the joint region, thereby reducing misclassification of noncartilaginous regions. This approach significantly improved the accuracy of cartilage degradation scoring. Among the deep learning models evaluated, VGG16 showed the best performance, achieving an MAE of 0.33. The model also recorded a precision of 0.680 (95% CI: 0.668-0.693), recall of 0.645 (95% CI: 0.627-0.664), F1-score of 0.653 (95% CI: 0.636-0.671), and accuracy of 0.648 (95% CI: 0.631-0.665).ConclusionIn this study, the VGG16 model showed high concordance with expert assessments, suggesting the feasibility of automating OA grading from histological images in large-scale animal studies.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261435798"},"PeriodicalIF":2.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Curcumin Treatment on Healing in a Rat Distal Femoral Osteochondral Defect Model.","authors":"Emin Can Balcı, Ender Alagöz, Abdurrahman Acar, Muhammed Uslu, Ozancan Biçer, Alperen Öztürk, Enes Başer, Busra Yaprak Bayrak","doi":"10.1177/19476035261436184","DOIUrl":"10.1177/19476035261436184","url":null,"abstract":"<p><p>BackgroundArticular cartilage injuries often heal with fibrocartilage rather than native hyaline cartilage, resulting in inferior biomechanical properties and increased osteoarthritis risk. Curcumin has anti-inflammatory and antioxidant properties that may support cartilage repair; however, clinical use is limited by poor bioavailability. Micellar formulations enhance systemic absorption.PurposeTo evaluate the effects of orally administered micellar curcumin on structural and molecular markers of osteochondral repair in a rat distal femoral defect model.MethodsThirty-two female Wistar rats were randomly allocated to 4 groups (<i>n</i> = 8 per group). Standardized 2-mm osteochondral defects were created in the distal femur. Animals received 250 mg/kg/day micellar curcumin or distilled water for 30 or 90 days. Macroscopic repair was assessed using the International Cartilage Repair Society (ICRS) scoring system. Histological evaluation followed ICRS guidelines and was performed in a blinded manner by 2 independent observers (intraclass correlation coefficient ICC = 0.89). Immunohistochemical analyses included SRY-box transcription factor 9 (SOX9), collagen type I (COL I), collagen type II (COL II), aggrecan, and matrix metalloproteinase-13 (MMP-13).ResultsCurcumin-treated groups demonstrated significantly higher macroscopic and histological scores than controls, particularly at 90 days. Increased expression of hyaline cartilage markers (SOX9, collagen II, aggrecan) and reduced collagen I expression were observed in treated groups. MMP-13 expression did not differ significantly between groups.ConclusionOral micellar curcumin enhanced structural and molecular parameters of osteochondral repair in this preclinical model. Further translational and clinical studies are required before therapeutic application.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261436184"},"PeriodicalIF":2.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Intra-Articular Hydrogel in Knee Osteoarthritis: A Systematic Review.","authors":"Ashton Kai Shun Tan, Vijay Vengkat Samynathan C, Muhammad Sulaiman Dh, Au Wei Yung, Don Thong Siang Koh, Junwei Soong, Kong Hwee Lee, Hamid Rahmatullah Bin Abd Razak","doi":"10.1177/19476035261439778","DOIUrl":"10.1177/19476035261439778","url":null,"abstract":"<p><p>BackgroundKnee osteoarthritis (KOA) is a prevalent cause of disability. Current intra-articular injections (hyaluronic acid [HA] and corticosteroids) fall short in maintaining long-term effects and repeated usage may result in deleterious effects on the knee. The development of hydrogels offers a potentially safe and longer-lasting alternative.PurposeTo assess current literature and analyse the clinical outcomes of intra-articular hydrogel in patients with KOA.MethodsA systematic search on 4 databases was performed in accordance with the Preferred Reporting Items for Systematic reviews and Meta‑Analyses. Quantitative findings were complemented by narrative synthesis. Study quality was assessed using the Cochrane Risk of Bias (RoB) 2.0 tool and Methodological Index for Non-Randomized Studies guidelines.ResultsTwelve studies comprising 1,413 patients were included. Most reported improvements in clinical outcomes above the minimal clinically important difference. Average follow-up was 11 months. Quality assessment revealed high risk of bias for randomized controlled trials (RCTs) (<i>n</i> = 4) and low to moderate risk of bias non-randomized studies (<i>n</i> = 8).ConclusionIntra-articular hydrogel injections for KOA represent an area of ongoing investigation. Current literature is heterogeneous and limited by methodological shortcomings. Adequately powered RCTs with standardized outcome reporting are needed to clarify their role in routine clinical practice.Level of evidence:Level II.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261439778"},"PeriodicalIF":2.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial Changes in Graft Diameter Following Anterior Cruciate Ligament Reconstruction Using Allograft.","authors":"Jun-Sang You, Sung-Sahn Lee, Dae-Hee Lee","doi":"10.1177/19476035261441851","DOIUrl":"10.1177/19476035261441851","url":null,"abstract":"<p><p>BackgroundTo evaluate the serial changes in graft diameter during the 2 years following anterior cruciate ligament (ACL) reconstruction using serial magnetic resonance imaging (MRI).MethodsThis study involved 38 patients (38 knees) who underwent arthroscopic ACL reconstruction and had MRI immediately after surgery, at 1 year, and at 2 years. Graft diameter was measured at the distal, middle, and proximal levels of the intra-articular length, selecting the sagittal MRI slice that optimally showed the graft at each level. Correlation analysis was performed to identify the relationship between the difference of each graft diameter and demographic data and postoperative assessment results.Results<i>Post hoc</i> analysis over time showed substantial thickening from the immediate postoperative to the 1-year scan (distal, +3.098 mm; middle, +3.284 mm; proximal, +3.074 mm; all <i>P</i> < 0.001), a modest but significant reduction from 1 to 2 years (distal, -0.749 mm; middle, -0.699 mm; proximal, -0.574 mm; all <i>P</i> < 0.001), and persistent enlargement at 2 years compared with those at baseline (distal, +2.348 mm; middle, +2.586 mm; proximal, +2.499 mm; all <i>P</i> < 0.001). Regarding the correlation analyses, the graft diameter measurements at the proximal, middle, and distal sites across the 3 different time points were not significantly correlated with the postoperative results.ConclusionThe graft diameter demonstrated a unimodal peak at 1 year postoperatively, followed by a gradual decrease until 2 years; however, it remained thicker at 2 years than immediately after surgery. These changes were not correlated with postoperative patients' reported outcomes and stability.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261441851"},"PeriodicalIF":2.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}