Case Reports in Ophthalmological Medicine最新文献

{"title":"Unmasking Orbital Myopathy: When Enlarged Extraocular Muscles Indicate More Than Thyroid Eye Disease: Report of Two Cases.","authors":"Daisuke Shinohara, Muhammad Abumanhal, Yasuhiro Takahashi","doi":"10.1155/crop/7712244","DOIUrl":"10.1155/crop/7712244","url":null,"abstract":"<p><strong>Introduction: </strong>Orbital myopathy is a condition involving the extraocular muscles, and establishment of a differential diagnosis is crucial to determine its etiology. However, the broad spectrum of the etiologies and the overlap in their clinical and radiological findings often make the diagnosis challenging. We report two cases of orbital myopathy that clinically mimicked thyroid eye disease (TED).</p><p><strong>Case presentation: </strong>Both patients underwent unsuccessful medical ± surgical treatments, based on the presumed diagnosis of TED at other institutions. One patient presented with enlargement of multiple extraocular muscles, causing proptosis and extraocular motility restriction, whereas the other showed inferior rectus muscle enlargement and subsequent severe restrictive hypotropia. Incisional biopsy was performed at our institution in both cases: Lacrimal gland biopsy confirmed a histopathological diagnosis of immunoglobulin G4-related ophthalmic disease in one patient, whereas extraocular muscle biopsy revealed metastasis from breast carcinoma in the other.</p><p><strong>Discussion: </strong>These cases underscore the importance of comprehensive diagnostic approach, including consideration of alternative etiologies and tissue biopsy, to ensure accurate diagnosis of orbital myopathy.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"7712244"},"PeriodicalIF":0.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papilledema With Facial and Vestibulocochlear Nerve Involvement in Idiopathic Intracranial Hypertension: An Unusual Case.","authors":"Rosángela López-Mena, Carolina Rojas-Cruz, Fernando Ruiz-Magaña, Eduardo I Arteaga-Chan","doi":"10.1155/crop/5103077","DOIUrl":"10.1155/crop/5103077","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic intracranial hypertension (IIH) is defined by elevated intracranial pressure in the absence of an intracranial mass or cerebrospinal fluid abnormality and is commonly associated with papilledema. Although cranial nerve involvement may occur, simultaneous facial and vestibulocochlear nerve dysfunction is rare and may lead to diagnostic confusion.</p><p><strong>Case presentation: </strong>A 42-year-old obese woman with metabolic comorbidities developed acute right-sided peripheral facial palsy preceded by facial pain and accompanied by severe headache, pulsatile tinnitus, and blurred vision. A 5-day course of oral prednisolone for presumed Bell's palsy yielded no improvement. Ophthalmologic referral on Day 7 revealed bilateral Frisén Grade I papilledema with normal automated perimetry and absence of visual field defects. Neurological examination confirmed House-Brackmann Grade III facial palsy, and audiometry demonstrated bilateral high-frequency sensorineural hearing loss (right worse than left). After systematic exclusion of cerebellopontine angle lesions, demyelinating disorders, infectious neuritis, and venous sinus thrombosis, brain MRI showed a Grade IV sellar arachnoidocele and a neurovascular contact of the right facial nerve (Chavda Grade I). Lumbar puncture on Day 12 documented an opening pressure of 36 cm H₂O with normal cerebrospinal fluid, confirming IIH. Acetazolamide was started on Day 13 together with a structured weight-management program. At the 2-month follow-up, audiometry demonstrated complete recovery. By 3 months, papilledema persisted (Frisén Grade I), best corrected visual acuity improved to 20/100 in both eyes, visual fields remained without enlargement of the physiological blind spot, and facial nerve function returned to House-Brackmann Grade I. However, at the 6-month follow-up, a new localized inferior scotoma was detected on Humphrey perimetry, representing a progression from previously normal visual fields, whereas spectral-domain OCT demonstrated bilateral optic atrophy with ganglion cell-inner plexiform layer thinning, indicating irreversible axonal damage despite persistent papilledema.</p><p><strong>Conclusion: </strong>This case broadens the phenotypic spectrum of IIH, showing that facial and vestibulocochlear neuropathies are reversible with pressure reduction. Yet, progressive visual field loss may ensue despite stable papilledema, revealing the optic disc as an unreliable proxy for neuronal integrity. Only spectral-domain OCT-by quantifying inner retinal layer loss-can expose silent axonal degeneration and must therefore become the cornerstone of long-term monitoring, independent of clinical appearance.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5103077"},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Unique Case of Psychogenic Binocular Diplopia.","authors":"Bryce Patrick Johnson","doi":"10.1155/crop/8555901","DOIUrl":"10.1155/crop/8555901","url":null,"abstract":"<p><p>Diplopia is a common chief complaint in the ophthalmology clinic, and it is important to differentiate diplopia requiring urgent work-up versus benign forms of diplopia that can be managed conservatively. This case demonstrates a 39-year-old male who reported the ability to move each eye independently resulting in chronic binocular diplopia. He reported having an extensive work-up done by an outside ophthalmologist that returned unremarkable. His glasses on presentation had a mild myopic correction in both eyes (OU), 1.50 prism diopters (PD) base up (BU) in the right eye (OD), and 0.50 PD BU in the left eye (OS), which helped intermittently-but not completely-resolve his diplopia. On presentation, his visual acuity (VA) was 20/20 OU with correction. He had a normal sensorimotor exam, including being orthotropic in primary gaze, having full motility OU, having normal saccades OU, and having no nystagmus OU. The patient voluntarily moved his eyes in a rhythmic sequence of convergence ➔ left gaze ➔ convergence ➔ right gaze ➔ convergence ➔ repeat. This sequence can initially appear to exhibit independent movement of each eye when done rapidly, but close examination can expose it as simple voluntary ductions and vergences that fall within the domain of normal ocular motility. With proper education, reassurance, and follow-up, the patient's subjective visual disturbances improved. Prompt recognition of this motility sequence can result in favorable visual improvements and avoidance of unnecessary work-up.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8555901"},"PeriodicalIF":0.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Progression of Horseshoe Retinal Tear-Associated Rhegmatogenous Retinal Detachment Without Clinically Evident Complete Posterior Vitreous Detachment: A Case Report.","authors":"Donghyun Lee","doi":"10.1155/crop/4671416","DOIUrl":"10.1155/crop/4671416","url":null,"abstract":"<p><p>Posterior vitreous detachment (PVD) is considered a key event in the pathogenesis of rhegmatogenous retinal detachment (RRD), and horseshoe retinal tears are generally associated with vitreoretinal traction during PVD evolution. We report the longitudinal progression of horseshoe retinal tear-associated RRD without clinically evident complete PVD. A 64-year-old nonmyopic man presented to a general ophthalmology clinic with floaters and preserved visual acuity. Retrospective review of baseline ultrawidefield (UWF) imaging demonstrated a horseshoe retinal tear with localized macula-on temporal RRD extending to within approximately 2.5 disc diameters of the fovea, which had not been recognized initially. Posterior-pole optical coherence tomography (OCT) showed posterior hyaloid attachment at the macula and optic nerve head, without clinically evident complete PVD. However, posterior-pole OCT could not exclude localized peripheral vitreous separation or focal vitreoretinal adhesion adjacent to the tear. Approximately 6 months later, the patient presented with acute visual deterioration, and the detachment had progressed to a bullous macula-off RRD arising from the same tear. PVD was induced during pars plana vitrectomy. This case documents longitudinal progression of localized horseshoe retinal tear-associated RRD without clinically evident complete PVD. Although the underlying mechanism remains inferential, the clinical course is compatible with focal peripheral traction occurring before complete PVD becomes clinically evident. In symptomatic patients, preserved central visual acuity, unremarkable posterior-pole findings, and absence of clinically evident complete PVD should not lower concern for peripheral vitreoretinal traction, retinal breaks, or RRD. Meticulous peripheral retinal examination and intentional review of the temporal retina on UWF imaging remain essential.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"4671416"},"PeriodicalIF":0.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maculopathy Linked to Light Chain Monoclonal Gammopathy: A Case Report.","authors":"Christina Mitsi, Doukas Dardabounis, Lydia Inglezou, Konstantinos Liapis, Georgios Labiris, Tryfon Rotsos","doi":"10.1155/crop/2299385","DOIUrl":"10.1155/crop/2299385","url":null,"abstract":"<p><p>Monoclonal gammopathies can produce a spectrum of ocular manifestations, most commonly paraproteinemic keratopathy, but retinal involvement, though rare, may be vision-threatening. We report a case of paraproteinemic maculopathy in a 49-year-old female with a history of hypertension and albuminuria, who presented with blurred vision and renal impairment. Examination revealed subretinal yellow infiltrates in the posterior pole with hyperautofluorescence on fundus autofluorescence and subretinal fluid with hyperreflective deposits above the retinal pigment epithelium on optical coherence tomography. Laboratory workup identified an excess of free kappa light chains in serum. A diagnosis of light chain deposition disease (LCDD) was made on the basis of a renal biopsy, and systemic therapy was initiated. At 5 months posttreatment, best-corrected visual acuity improved to 20/20 OU, with resolution of subretinal fluid, although sub-RPE deposits persisted. This case illustrates that monoclonal free light chains can induce maculopathy through RPE and choroidal depositions, mimicking other macular diseases. Early recognition and systemic treatment targeting the underlying plasma cell disorder are essential for visual recovery. Ophthalmologists should maintain a high index of suspicion for paraproteinemic maculopathy in patients with atypical serous macular detachments, particularly when the findings are bilateral or associated with subtle systemic signs, emphasizing the need for a multidisciplinary approach.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"2299385"},"PeriodicalIF":0.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Insights Into Retinitis Pigmentosa: A De Novo <i>RPGR</i> Mutation in an Iranian-Azeri Family.","authors":"Narges Ghezelbash, Mortaza Bonyadi, Mohammad Hossein Jabbarpour Bonyadi","doi":"10.1155/crop/7640514","DOIUrl":"10.1155/crop/7640514","url":null,"abstract":"<p><p>Retinitis pigmentosa (RP) is a genetically heterogeneous disease characterized by progressive vision loss and blindness, primarily due to the degeneration of cone photoreceptor cells. The classic symptoms include a decline in visual acuity and retinal atrophy. In this study, whole-exome sequencing (WES) was performed on a 40-year-old man from a nonconsanguineous Iranian-Azeri Turkish family, who was diagnosed with vision loss and blindness at age 40. DNA was extracted from the proband, his healthy brother, sister, and mother to conduct segregation analysis. WES analysis revealed a hemizygous mutation in a single nucleotide (NC_000023.11)(NM_001034853.2) c.194G>T, located in exon 3 of the <i>RPGR</i> gene. In silico analysis suggested that this mutation likely activates a new cryptic donor site. Segregation analysis confirmed that the variant was absent in the mother and healthy siblings, indicating that it is a de novo mutation. We also screened a cohort of 430 healthy individuals from the same ethnic group, finding no occurrence of the variant. The presence of this de novo mutation, its absence among controls from the same ethnic background, and bioinformatics analysis collectively suggest the pathogenicity of the identified variant.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"7640514"},"PeriodicalIF":0.8,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Schwannoma in the Anterior Orbit: Case Report and Literature Review.","authors":"Bassam Alobaid, Rahaf Alok","doi":"10.1155/crop/1274110","DOIUrl":"10.1155/crop/1274110","url":null,"abstract":"<p><strong>Introduction: </strong>Orbital schwannoma is a rare tumor that can occur in any orbital compartment, posing a diagnostic challenge for clinicians.</p><p><strong>Case presentation: </strong>We report a 35-year-old male who presented with a visible schwannoma in the inferomedial orbital angle. Our patient was treated with en bloc transconjunctival surgical resection without complications.</p><p><strong>Discussion: </strong>Only 35 cases of anterior orbital schwannomas have been reported in the literature. The majority of these masses were superior or superomedial. The nerve of origin was able to be identified in 42.9% of cases only, and the schwannoma arose from the frontal nerve or its branches in about half of these cases. Surgery was the standard of care, although in a few cases small masses were just observed. None of the reported cases has neurofibromatosis. This case highlights the importance of considering schwannoma in the differential diagnosis of anterior orbital masses in any of its anatomical compartments.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"1274110"},"PeriodicalIF":0.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Aflibercept to Treat Choroidal Neovascularization Secondary to Choroidal Osteoma in a 7-Year-Old Child: A Multimodal Imaging Case Report.","authors":"Abdullah Altalhi, Anas Alqurashi, Mohammed Albassam, Abdulmalik Alyahya","doi":"10.1155/crop/5548292","DOIUrl":"10.1155/crop/5548292","url":null,"abstract":"<p><strong>Purpose: </strong>This study is aimed at reporting a case of choroidal osteoma in a young boy complicated by choroidal neovascularization (CNV) and describing its clinical course over 9 months following intravitreal aflibercept injections.</p><p><strong>Observation: </strong>A 7-year-old boy presented with a 2-month history of decreased vision in his left eye. Clinical examination and multimodal imaging revealed a central choroidal osteoma complicated by an active CNV with associated subretinal hemorrhage and fluid. The patient was treated with intravitreal aflibercept under general anesthesia. Follow-up visits demonstrated early anatomical improvement, with resolution of subretinal hemorrhage and fluid. However, recurrent CNV activity and fluctuating visual acuity were observed.</p><p><strong>Conclusion: </strong>Although choroidal osteoma is more commonly reported in adult females, it should also be considered in young boys. Early treatment with aflibercept was associated with short-term anatomical and transient functional improvements in the management of CNV secondary to choroidal osteoma. However, visual acuity fluctuated during follow-up visits, necessitating recurrent CNV injections. Therefore, regular follow-up is essential due to the risk of recurrence and to preserve long-term visual acuity. Given the rarity of this condition, further studies with larger sample sizes and extended follow-up periods are required to evaluate the effectiveness of anti-vascular endothelial growth factor therapy and establish evidence-based management guidelines.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5548292"},"PeriodicalIF":0.8,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Papillary Traction due to Persistent Hyaloid Vessel Remnants in Aymé-Gripp Syndrome.","authors":"Carolina Carvalho Soares Valentim, Mohamed M Khodeiry, Maja Kostic","doi":"10.1155/crop/2557037","DOIUrl":"10.1155/crop/2557037","url":null,"abstract":"<p><strong>Introduction: </strong>Although papillary traction often arises from anomalous vitreous detachment, it can be related to traction from persistent remnants of the fetal hyaloid vasculature.</p><p><strong>Case presentation: </strong>A 17-year-old girl with Aymé-Gripp syndrome was incidentally found to have bilateral optic nerve elevation in the setting of bilateral persistent hyaloid vessel remnants causing papillary traction. Brain imaging was unremarkable.</p><p><strong>Conclusion: </strong>This case highlights the rare occurrence of bilateral papillary traction in a young patient with a genetic syndrome and underscores the importance of considering papillary traction in the differential diagnosis of optic nerve elevation.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"2557037"},"PeriodicalIF":0.8,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Eye Reveals Disseminated Tuberculosis: A Pediatric Case of Endophthalmitis With Severe CNS Involvement.","authors":"Nicola De Santi, Laura Curci, Eduardo Bianchi, Barbara Iaccheri, Carlo Pallotto, Daniele Rosignoli, Tito Fiore, Giuseppe Vittorio Luigi De Socio, Carlo Cagini","doi":"10.1155/crop/8141797","DOIUrl":"10.1155/crop/8141797","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to report a case of tuberculosis involving central nervous system (CNS) discovered thanks to tubercular endophathlmitis.</p><p><strong>Methods: </strong>This is a case report.</p><p><strong>Observation: </strong>A 14-year-old male presented with acute visual loss, ocular pain, and redness of the right eye following a recent stay in India. The clinical history was notable for prolonged fever, night sweats, and headache. Ophthalmological examination revealed severe intraocular inflammation consistent with panuveitis and endophthalmitis. Neuroimaging demonstrated a large ring-enhancing lesion in the right hemisphere with significant mass effect. Initial microbiological investigations, including vitreous sampling, were negative. A positive interferon-gamma release assay and radiological findings raised suspicion for disseminated tuberculosis, and <i>Mycobacterium tuberculosis</i> DNA was subsequently detected in vitreous samples after repeating a second vitrectomy. Antitubercular therapy was started and definitive diagnosis was made with biopsy of the brain lesion, which demonstrated positive cultures for drug-sensitive <i>M. tuberculosis</i>. The clinical course was complicated by retinal detachment, paradoxical enlargement of the cerebral tuberculoma, and postoperative neurological deficits requiring surgical intervention and rehabilitation.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic complexity of ocular and CNS tuberculosis and emphasizes the need for a high index of suspicion, repeated targeted sampling, and multidisciplinary management to achieve timely diagnosis and appropriate treatment.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8141797"},"PeriodicalIF":0.8,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}