Case Reports in Ophthalmological Medicine最新文献

{"title":"Central Serous Chorioretinopathy Deteriorated With Everolimus Administration in Advanced Renal Cell Carcinoma: A Case Report.","authors":"Mahdi Nemati, Mohammadreza Niyousha, Banafshe Kharazi, Narges Hassanpoor","doi":"10.1155/crop/1200325","DOIUrl":"10.1155/crop/1200325","url":null,"abstract":"<p><strong>Background: </strong>Everolimus, an antineoplastic drug, is associated with various systemic adverse effects. This case report is aimed at presenting a novel ophthalmological complication, drug-associated central serous chorioretinopathy (CSCR), following everolimus administration.</p><p><strong>Methods: </strong>A 54-year-old male with metastatic renal cell carcinoma presented with blurred vision and metamorphopsia. Comprehensive ophthalmologic examination, including multimodal imaging with optical coherence tomography (OCT), fluorescein angiography (FA), and fundus autofluorescence (FAF), was performed. A thorough review of his medical history and recent medication changes was conducted to identify potential associating factors.</p><p><strong>Results: </strong>Multimodal imaging confirmed bilateral CSCR with subretinal fluid and pachychoroid features. The only recent change in his medication regimen was the initiation of everolimus (10 mg daily) 1 month prior to symptom onset. All other known risk factors for CSCR, such as corticosteroid use, were absent. Upon discontinuation of everolimus, the patient's symptoms and visual acuity improved. Follow-up OCT imaging demonstrated complete resolution of the subretinal fluid.</p><p><strong>Conclusion: </strong>Everolimus can potentially be a risk factor for subclinical CSCR deterioration in prone population. Ophthalmologists and oncologists should be aware of this rare but significant adverse effect.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"1200325"},"PeriodicalIF":0.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Cutaneous Myxoma of the Eyelid: A Case Report.","authors":"Mariana I Fonseca, Christian Nieves-Rios, Jorge Billoch, Joseph Campbell","doi":"10.1155/crop/9241454","DOIUrl":"10.1155/crop/9241454","url":null,"abstract":"<p><p>Cutaneous myxomas are rare, benign mesenchymal tumors of the dermis. They may occur in isolation or as part of genetic syndromes and can affect the head and neck regions, yet eyelid involvement is rare. We report a case of a 24-year-old male with a 10-year history of a recurrent right upper eyelid lesion, previously excised five times. Clinical examination revealed a pearly, nodular lesion, and histological findings of dermal fibroplasia and dilated vessels, initially misdiagnosed as a hemangioma. Subsequent recurrence and excisional biopsy showed hypocellular myxoid stroma with embedded spindled cells, confirming the diagnosis of cutaneous myxoma. Systemic evaluation excluded syndromic associations such as cardiac myxoma. The patient remained recurrence-free at 3 months postoperatively. Early-onset disease, multiple recurrences, and unusual location emphasize the need for careful clinicopathologic correlation and long-term follow-up. Recognition of this rare entity is critical for appropriate management, exclusion of systemic associations, and reduction of recurrence risk. This case highlights that recurrent eyelid lesions, even when previously diagnosed as benign vascular lesions, should prompt reconsideration of rare myxoid tumors.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"9241454"},"PeriodicalIF":0.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Rhegmatogenous Retinal Detachment in Straatsma Syndrome: A Case Report.","authors":"Isabela Nunes de Sousa Bandeira Lima, Alline Gonçalves Dos Reis Melo, Wener Passarinho Cella","doi":"10.1155/crop/6341643","DOIUrl":"10.1155/crop/6341643","url":null,"abstract":"<p><strong>Introduction: </strong>Straatsma syndrome is a rare congenital condition classically defined by the triad of persistent myelinated retinal nerve fibers, ipsilateral axial myopia, and amblyopia. Although generally regarded as a stable developmental anomaly, growing evidence suggests that eyes with Straatsma syndrome may harbor clinically relevant abnormalities of the vitreoretinal interface, predisposing them to late-onset retinal detachment. Most reported cases describe macular hole-associated retinal detachment driven by focal, abnormally strong vitreoretinal adhesion overlying myelinated fibers at the macula. Peripheral rhegmatogenous mechanisms, however, remain poorly characterized.</p><p><strong>Case presentation: </strong>We report a 64-year-old man with longstanding unilateral Straatsma syndrome who presented with sudden, severe visual loss. Fundus examination and ultrasonography revealed a macula-involving rhegmatogenous retinal detachment originating from a superonasal peripheral retinal tear, without evidence of macular hole formation. Intraoperatively, pars plana vitrectomy disclosed unusually firm vitreoretinal adhesion at the site of the peripheral break, despite the absence of visible myelinated nerve fibers in that region. The patient underwent combined phacoemulsification, pars plana vitrectomy, scleral buckling, and silicone oil tamponade, achieving complete retinal reattachment. Postoperatively, chronic cystoid macular edema developed and was successfully treated with silicone oil removal and intravitreal dexamethasone implantation. Final best corrected visual acuity improved to 20/60, consistent with the pre-existing amblyopia.</p><p><strong>Conclusion: </strong>This case documents a peripheral, tear-related rhegmatogenous retinal detachment in Straatsma syndrome, a mechanism distinct from the macular hole-driven pathway most commonly reported. Although the coexisting high axial myopia constitutes a well-established independent risk factor for peripheral retinal breaks, the intraoperative observation of unusually firm vitreoretinal adhesion at a site devoid of visible myelinated fibers raises the hypothesis that Straatsma syndrome may involve a diffuse abnormality of the vitreoretinal interface extending beyond areas of clinically apparent myelination. As a single observational case, these findings are hypothesis-generating and cannot establish causality; nevertheless, they underscore the importance of meticulous peripheral retinal examination and long-term surveillance in affected patients, particularly in the presence of high axial myopia.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"6341643"},"PeriodicalIF":0.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migratory Preseptal Cellulitis Secondary to Rhinosinusitis Complicated by Left Frontal Subdural Empyema in a Child: A Case Report.","authors":"Frank Sandi, Jacinta Feksi, Henry Humba, Suzana R Lukoo","doi":"10.1155/crop/5117052","DOIUrl":"https://doi.org/10.1155/crop/5117052","url":null,"abstract":"<p><p>Preseptal cellulitis is a common pediatric infection involving the eyelids and surrounding periocular tissues. It is typically benign and rarely progresses to intracranial complications, unlike orbital cellulitis. However, when secondary to rhinosinusitis, the infection may behave unpredictably and extend beyond expected anatomical boundaries. We report a rare case of migratory preseptal cellulitis in a 12-year-old boy, initially presenting with unilateral eyelid swelling, erythema, and fever. Despite prompt initiation of empirical intravenous antibiotics, the condition failed to improve and instead demonstrated an unusual migratory pattern, spreading superiorly to the forehead and crossing the midline to involve the contralateral eye. This atypical progression raised concern for deeper infection and prompted advanced imaging. Computed tomography and magnetic resonance imaging revealed maxillary sinusitis with intracranial extension, resulting in a left frontal subdural empyema. The patient underwent multiple surgical interventions, including incision and drainage of the eyelid, craniotomy for empyema evacuation, and functional endoscopic sinus surgery to address the underlying sinonasal source. Broad-spectrum intravenous antibiotics were continued, as there was no growth after 5 days of incubation. Following combined surgical and medical management, the patient made a full recovery within 20 days, with complete resolution of neurological and ocular symptoms. This favorable outcome underscores the importance of early recognition and aggressive treatment of intracranial complications arising from seemingly localized infections. This case highlights that intracranial extension can occur even in preseptal cellulitis, particularly when symptoms worsen or fail to respond to standard therapy. Migratory eyelid swelling should heighten clinical suspicion for atypical or progressive disease. Prompt imaging, identification of the primary infectious source, and timely multidisciplinary intervention are essential to prevent life-threatening complications.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5117052"},"PeriodicalIF":0.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Paracentral Acute Middle Maculopathy in a Healthy Pregnant Woman: A Case Report.","authors":"K Broniarek, K Michalska-Małecka","doi":"10.1155/crop/1925710","DOIUrl":"https://doi.org/10.1155/crop/1925710","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to report a case of idiopathic paracentral acute middle maculopathy (PAMM) in a healthy woman during the first trimester of an uncomplicated pregnancy.</p><p><strong>Observations: </strong>A 28-year-old woman at 14 weeks gestation presented with sudden onset of a paracentral scotoma in her right eye. Although her best-corrected visual acuity remained 20/20 OU, dilated fundus examination, optical coherence tomography (OCT), and OCT angiography (OCTA) revealed paracentral acute middle maculopathy. A comprehensive systemic workup returned normal results, suggesting no underlying general condition. Over 1 year of follow-up, resolution of fundus and OCT findings, a gradual increase in deep-plexus vessel density in the affected area on OCTA was observed, and improvement in the patient's visual field was noted.</p><p><strong>Conclusions and importance: </strong>Despite its low incidence, PAMM should be included in the differential diagnosis of acute visual disturbances in pregnant women-even when no other risk factors are present. OCTA can be a valuable modality for both diagnosis and monitoring of PAMM.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"1925710"},"PeriodicalIF":0.4,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in a Case of Bilateral Idiopathic Corneal Ascher Rings Associated With Anterior Segment Changes.","authors":"Anca Delia Pantalon","doi":"10.1155/crop/8164915","DOIUrl":"https://doi.org/10.1155/crop/8164915","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study is to report an extremely rare case of corneal annular opacities, incidentally found in a patient referred for age related cataract surgery. Additional anterior segment particularities were detected in this patient.</p><p><strong>Methods: </strong>Clinical and imaging methods were employed for a rigorous ophthalmological examination; a full systemic check-up has been included in the investigation panel, as well.</p><p><strong>Results: </strong>Examinations revealed in a 69-year-old patient bilateral and symmetrical corneal ring opacities, within the full stromal thickness, with gray-whitish appearance and ellipsoid shape; diameters were 4-6 mm, clear central/peripheral cornea; no other corneal structural changes were identified via anterior segment optical coherence tomography (AS-OCT). Specular microscopy parameters, including pachymetry, were unremarkable. Such corneal changes could not be classified as sequelae of infectious keratitis, corneal dystrophies, or degenerations. Systemic pathologies have been also excluded; existent high blood pressure (HBP) and hypercholesterolemia could not be linked to such corneal findings in our patient. By exclusion, the corneal opacities were classified as Ascher rings. Cataract surgery was uneventful, with excellent recovery. IOL power calculation reflected the axial anysometropia (21.5D in OD, respectively, 15D in OS-Clareon SY60WF, Alcon), as well as asymmetric gonioscopy findings.</p><p><strong>Conclusion: </strong>Cataract surgery performed in the presence of Ascher corneal rings alone, does not pose additional risks during phacoemulsification or postoperative intervals. However, association with anterior segment changes (narrow anterior chamber angle, axial anysometropia) might raise additional surgical concerns, though unrelated to the rare corneal findings. These associations have not been reported in any previous cases from literature.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8164915"},"PeriodicalIF":0.4,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratoscleritis and Choroidal Exudative Detachment in the Setting of Ocular Pyoderma Gangrenosum.","authors":"Jeffrey Bodeen, Lulwa El Zein, Justin J Yamanuha, Wassef Chanbour","doi":"10.1155/crop/2166994","DOIUrl":"https://doi.org/10.1155/crop/2166994","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to report a rare case of ocular pyoderma gangrenosum (PG) presenting as keratoscleritis with choroidal effusion following cataract surgery and to highlight its clinical recognition and management.</p><p><strong>Methods: </strong>A 79-year-old man developed a corneal ulcer 2 days after uncomplicated phacoemulsification with intraocular lens implantation. Initial management with topical vancomycin and ceftazidime failed. Comprehensive systemic workup including TPMT, HLA-B51, ANCA, ANA, rheumatoid factor, viral serologies, and syphilis testing was performed. Cultures for bacteria, fungi, and <i>Acanthamoeba</i> were negative. The history of PG confirmed by prior skin biopsy was elicited. Corticosteroid therapy was initiated.</p><p><strong>Results: </strong>The patient's corneal ulcer, keratoscleritis, and choroidal effusions resolved within 2 weeks of treatment with high-dose topical and oral corticosteroids. Visual acuity improved from hand motion to 20/30, and intraocular pressure normalized. No infectious etiology was identified, and rapid response to steroids excluded active herpetic keratitis.</p><p><strong>Conclusion: </strong>Ocular PG can manifest as postoperative keratoscleritis with choroidal effusions. Negative cultures and poor response to antimicrobials should prompt consideration of immune-mediated keratitis. Early recognition and timely corticosteroid therapy can preserve vision. Preoperative risk assessment and perioperative steroid prophylaxis may prevent postoperative inflammatory complications in patients with known PG.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"2166994"},"PeriodicalIF":0.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Dichoptic Therapy for Amblyopia in a Child Unable to Tolerate Occlusion Therapy due to Autism Spectrum Disorder.","authors":"Shuji Nakatsuka, Yo Iwata, Hirotaka Ito, Yuta Nakano, Kumiko Mokuno, Tomoya Handa","doi":"10.1155/crop/9634126","DOIUrl":"https://doi.org/10.1155/crop/9634126","url":null,"abstract":"<p><p>Children with autism spectrum disorder (ASD) often face challenges with occlusion therapy using eye patches owing to the sensory sensitivity, rigid behaviors, and communication difficulties associated with ASD. In this study, we report the case of a child with ASD who had significant difficulty with eye patch therapy for anisometropic amblyopia and was treated with visual acuity training using Occlu-pad, a dichoptic therapy device. This treatment led to marked improvement in visual acuity and high compliance. After 3 months of home-based therapy for 30 min per day, the best corrected visual acuity in the right eye improved from logarithm of minimum angle of resolution of 0.5 to 0.0, with an average compliance rate of 92%. This case highlights the importance of flexible treatment approaches tailored to individual patient characteristics in managing amblyopia in children with ASD and also demonstrates the potential utility of dichoptic therapy using Occlu-pad.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"9634126"},"PeriodicalIF":0.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A True Double Optic Disc.","authors":"Mesut Tekerek, Nur Demir","doi":"10.1155/crop/6157555","DOIUrl":"https://doi.org/10.1155/crop/6157555","url":null,"abstract":"<p><p>A true double optic disc with two separate vasculatures is an extremely rare condition. The division of the optic nerve into two distinct fascicles is presumed to occur during early stages of embryonic development. Two separate optic discs or one optic disc with two retinal vasculatures are variants of a true double optic disc. This case report highlights a rare form of a true double optic disc with two retinal vasculatures in the same optic disc cup with multimodal imaging.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"6157555"},"PeriodicalIF":0.4,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Retinal Detachment Following Ozurdex Implant in a Nonvitrectomized Eye.","authors":"Abdullah Alkhamees, Khaled Alsabah","doi":"10.1155/crop/6671556","DOIUrl":"10.1155/crop/6671556","url":null,"abstract":"<p><p>Intravitreal injection (IVI) of antivascular endothelial growth factors and dexamethasone implants are among the most performed procedures in ophthalmology, as they are used to treat various retinal diseases. Although considered safe, some rare but sight-threatening complications can occur, like endophthalmitis and retinal detachment. Here, we report a case of a 53-year-old male with a history of lymphoma (treated with chemotherapy in 2016 and currently on Cellcept and low-dose oral prednisolone), diabetes mellitus (DM), hypertension (HTN), and hyperlipidemia, who presented shortly after intravitreal Ozurdex injection in the left eye with retinal detachment (RD). Ozurdex is a valuable option for treatment of chronic diabetic macular edema (DME). This case highlights the need for a high index of suspicion for retinal detachment in pseudophakic patients with compromised retina, even after seemingly routine Ozurdex injection.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"6671556"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}