Journal of pharmacy & bioallied sciences最新文献

{"title":"Comparative Evaluation of Subgingivally Delivered Gengigel and Nanobio Fusion Gel as an Adjunct to Scaling and Root Planing in the Management of Chronic Periodontitis: A Randomized Controlled Clinical Trial.","authors":"Tabinda Khan, Swati Agarwal, Ellora Madan, Abhinav Abhinav, Pransi Gupta, Arham Siddiqui","doi":"10.4103/jpbs.jpbs_39_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_39_26","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate and compare the clinical effectiveness of subgingivally delivered Gengigel and nanobio fusion (NBF) gel as adjuncts to scaling and root planing (SRP) in patients with chronic periodontitis.</p><p><strong>Materials and methods: </strong>This randomized controlled clinical trial included patients aged 18-65 years diagnosed with chronic periodontitis and presenting with periodontal pockets measuring ≥5 mm and ≤10 mm. Ninety-nine periodontal sites were randomly allocated into three groups: Group A (SRP alone), Group B (SRP with subgingival Gengigel), and Group C (SRP with subgingival NBF gel). Clinical parameters including plaque index, modified sulcular bleeding index, probing pocket depth (PPD), and clinical attachment level were recorded at baseline, 15 days, and 3 months. Statistical analysis was performed to assess intra- and intergroup differences.</p><p><strong>Results: </strong>All three groups demonstrated statistically significant improvement in clinical parameters from baseline to 3 months (<i>P</i> < 0.01). Intergroup analysis showed that both adjunctive therapy groups exhibited superior outcomes compared to SRP alone. Group B demonstrated greater and sustained reduction in gingival bleeding and PPD at 3 months, whereas Group C showed early clinical improvements.</p><p><strong>Conclusion: </strong>Subgingival delivery of Gengigel and NBF gel as adjuncts to SRP resulted in significant clinical benefits in chronic periodontitis management. Gengigel demonstrated a slight advantage in long-term reduction of inflammation and pocket depth.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"242-244"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pharmacovigilance Reporting Patterns and Adverse Drug Reactions in a Tertiary Care Teaching Hospital.","authors":"Dipika Baria, Ishita Nishad Gogdani, Akash Dubey, Naresh Parmar","doi":"10.4103/jpbs.jpbs_120_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_120_26","url":null,"abstract":"<p><strong>Background: </strong>Pharmacovigilance is crucial in the safety of drugs and it is here that adverse drug reactions (ADRs) are observed, especially in a tertiary care environment where polypharmacy is prevalent. This paper set out to assess the patterns of pharmacovigilance reporting and examine the nature of ADRs in a tertiary care teaching hospital.</p><p><strong>Methods and materials: </strong>The study was prospective observational and was carried out after 12 months involving 250 patients with suspected ADRs. The sources of data included the spontaneous reporting forms, patient records, and laboratory results. The World Health Organization (WHO) causality assessment scale was used to determine ADRs. Descriptive statistics were presented in the form of mean ± standard deviation and percentages, and Chi-square and <i>t</i>-tests were used in the inferential statistics.</p><p><strong>Results: </strong>The average age of the patients was 47.8 (18.5) years, and the patients were mostly male (58%). The largest percentage of ADRs reported was in the medicine department (42%), then surgery (22) and pediatrics (16). The most commonly involved classes of drugs were antibiotics (36%) and antiepileptics (18%). Type A reactions were found in 64 percent of the cases, whereas Type B reactions were found in 36 percent. WHO causality assessment indicated that 52% of ADRs were possible, 34% probable, and 14% certain. ADRs were serious in 28% of the patients. Underreporting was observed and only 68 percent of ADRs were reported in writing. The incidence of ADRs was significantly greater in patients who were on polypharmacy (five or more drugs) than in those on fewer drugs (<i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>The article identifies some gaps in pharmacovigilance reporting and presents the necessity to involve better awareness, training, and regular reporting systems to improve drug safety in clinical practice.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"191-193"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Evaluation of Cut 380A Intrauterine Device Versus Depot Medroxyprogesterone Acetate For Long-Acting Reversible Contraception.","authors":"Manisha Meena, Rupali Dewan","doi":"10.4103/jpbs.jpbs_1633_25","DOIUrl":"10.4103/jpbs.jpbs_1633_25","url":null,"abstract":"<p><strong>Background: </strong>India's family-planning program increasingly emphasizes long-acting reversible contraceptives (LARCs) to curb unintended pregnancy. Copper T 380A (CuT 380A) intrauterine device (IUCD) and injectable depot medroxyprogesterone acetate (DMPA) are the two program-supported LARCs, yet granular comparative Indian data remain scarce.</p><p><strong>Methods: </strong>We undertook a prospective longitudinal study (November 2016-March 2018) at Safdarjung Hospital, New Delhi. Women choosing CuT 380A or DMPA were enrolled consecutively and stratified by timing of initiation-postpartum, postabortion, or interval. Baseline demographics, adverse events, continuation, discontinuation, expulsion, and pregnancy were recorded at 1, 3, 6, 9, and 12 months. Comparative statistics employed χ² or <i>t</i>-tests; <i>P</i> < 0.05 was significant.</p><p><strong>Results: </strong>A total of 162 women were analysed (81 per group), with a mean age of approximately 28 years. Baseline characteristics were comparable between groups. At 12 months, continuation was significantly higher with CuT 380A (74.0%) than DMPA (39.5%) (<i>P</i> < 0.001). Correspondingly, cumulative discontinuation was lower in the CuT 380A group (25.9%) compared with the DMPA group (53.0%). Expulsions occurred only in the CuT 380A group (7.4%). Bleeding disturbances were the most common adverse effect in both groups (CuT 380A 17.2%, DMPA 23.4%). Amenorrhoea increased progressively among DMPA users, reaching 29.6% at 12 months. Other adverse events were uncommon. Four pregnancies (4.9%) occurred in the CuT 380A group (two with the device in situ and two following partial expulsion), while no pregnancies were reported in the DMPA group. Overall satisfaction was significantly higher with CuT 380A (76.5% vs 46.9%, p < 0.001).</p><p><strong>Conclusion: </strong>Both LARCs were safe and highly effective; however, CuT 380A demonstrated superior 12-month continuation and satisfaction, whereas DMPA exhibited a higher drop-out largely driven by bleeding changes and desire for pregnancy. High-quality counselling on anticipated bleeding patterns could further optimize DMPA continuation.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"115-118"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Antimicrobial Activity of LL-37 Peptide Against Periapical Pathogens: A Cross-Sectional Study.","authors":"Kolasani Balaram, Rahul Tiwari, Heena Dixit Tiwari, PrudviRaj Parimi, Kanwarpreet Singh, Varun Vohra, M C Prashant","doi":"10.4103/jpbs.jpbs_958_25","DOIUrl":"10.4103/jpbs.jpbs_958_25","url":null,"abstract":"<p><strong>Background: </strong>Reinfection in the root canal and periradicular area due to the emergence of antibiotic resistance and/or multidrug-resistant strains of mixed colonization of multispecies periapical endodontic is the main reason for endodontic treatment failures. This has imposed a serious public health concern, contributing to decreased clinical efficiency and poor treatment outcomes. To combat these issues, \"antimicrobial peptides are considered as potential alternatives and a promising agent\" in endodontics.</p><p><strong>Objective: </strong>To evaluate and compare the antimicrobial efficiency of LL-37 peptide against periapical endodontic pathogens (<i>Streptococcus mutans, Lactobacillus salivarius, and Actinomyces naeslundii</i>).</p><p><strong>Methodology: </strong>A multispecies biofilm of <i>S. mutans, L. salivarius,</i> and <i>Actinomyces naeslundii</i> was created on 100 hydroxyapatite disks samples (<i>n</i> = 100). Sixty samples (<i>n</i> = 60) were allocated for the peptide group and 20 samples each (<i>n</i> = 20) for the control group treated with disinfecting solution (sodium hypochlorite and normal saline). The minimum inhibitory concentration (MIC) and colony-forming units (CFUs) were assessed.</p><p><strong>Results: </strong>LL-37 peptides showed statistically significant correlation w.r.t CFUs and antimicrobial activity (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>LL-37 peptides were highly effective against periapical endodontic pathogens and hence could be used as a potential therapeutic agent in the future for endodontics.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"137-140"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vitamin D3 Supplements in the Success of Dental Implants: A Comparative Evaluation.","authors":"Nooka Surya Ramalakshmi, Gade Phani Krishna, D Samyuktha, Deepthi Batthula, Jyothirmai Nagisetty, Jahnavi Valiveti","doi":"10.4103/jpbs.jpbs_649_25","DOIUrl":"10.4103/jpbs.jpbs_649_25","url":null,"abstract":"<p><strong>Background: </strong>Dental implants are a reliable treatment for tooth replacement, with success dependent on osseointegration, implant stability, and bone density. Vitamin D3 plays a critical role in bone metabolism, influencing calcium absorption and bone mineralization. However, the effect of vitamin D3 supplementation on implant outcomes remains controversial.</p><p><strong>Materials and methods: </strong>A total of 20 patients with vitamin D deficiency (10-30 ng/mL) were divided into two groups:Group A (<i>n</i> = 10): Received vitamin D3 supplementation (60,000 IU/week for 8 weeks, followed by 60,000 IU/month for 16 weeks).Group B (<i>n</i> = 10): Did not receive supplementation.All patients underwent standard implant placement. Crestal bone level and bone density were assessed using CBCT, and implant stability was measured using resonance frequency analysis (RFA) at baseline, 3 months, and 6 months postimplant placement. Data were analyzed using ANOVA (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Implant stability improved significantly in Group A compared with Group B at 3 and 6 months (<i>P</i> < 0.05). Crestal bone loss was higher in Group B, but the difference was not statistically significant (<i>P</i> = 0.07). Bone density remained comparable between both groups at all time points (<i>P</i> = 1.00).</p><p><strong>Conclusion: </strong>Vitamin D3 supplementation significantly enhances implant stability, suggesting a role in improving early-stage osseointegration. However, its effect on crestal bone level and bone density remains inconclusive. Preoperative vitamin D3 screening and supplementation in deficient individuals may optimize implant outcomes. Further large-scale studies are needed to establish definitive guidelines.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"125-127"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Arthrocentesis versus Platelet-Rich Plasma Injections in TMJ Disorders: A Clinical Study.","authors":"Amit Rao, Mrinal M Gawali, Sahana B Holla, D Shanmugapriyan, K M Paijas, Sajni Rai","doi":"10.4103/jpbs.jpbs_737_25","DOIUrl":"10.4103/jpbs.jpbs_737_25","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint (TMJ) disorders affect a significant proportion of the population, leading to pain, joint dysfunction, and reduced quality of life. Arthrocentesis and platelet-rich plasma (PRP) injections are two widely used conservative treatments. This study aims to compare the effectiveness of arthrocentesis and PRP in improving pain relief, mouth opening, and functional outcomes in TMJ disorder patients.</p><p><strong>Methods: </strong>A total of 60 patients diagnosed with TMJ disorders were enrolled and divided into two groups (<i>n</i> = 30 each). Group A underwent arthrocentesis, while Group B received PRP injections. Outcomes were measured based on pain reduction (VAS score), maximum mouth opening (maximum mouth opening [MMO] in mm), and functional improvement using the Jaw Function Limitation Scale. Measurements were recorded at baseline, 1 month, and 3 months post-treatment. Statistical analysis was conducted using paired <i>t</i>-tests and analysis of variance (ANOVA).</p><p><strong>Results: </strong>Both treatment groups showed significant improvement. The PRP group demonstrated superior long-term pain relief (VAS: 7.2 to 2.1) compared to arthrocentesis (VAS: 7.4 to 3.5) at 3 months. MMO improved in both groups, with PRP showing a greater increase (35.5 mm to 43.8 mm) than arthrocentesis (34.9 mm to 41.2 mm). Functional limitation scores also improved more significantly in the PRP group.</p><p><strong>Conclusion: </strong>PRP injections provided better long-term outcomes in terms of pain relief and functional improvement compared to arthrocentesis, suggesting its potential as a more effective conservative treatment for TMJ disorders.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"122-124"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Different Local Anesthetics for Pain Management in Surgical Removal of Palatally Placed Impacted Maxillary Canines: A Comparative Study.","authors":"Ali Fahed Alqahtani, Tanveer Ahmed, Dharani Chowdary Kilari, Nirman Das, Aayush Malhotra, Mohammad Zahir Kota, Rahul Tiwari, M C Prashant","doi":"10.4103/jpbs.jpbs_597_25","DOIUrl":"10.4103/jpbs.jpbs_597_25","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of different local anesthetics in managing pain during the surgical removal of palatally placed impacted maxillary canines.</p><p><strong>Materials and methods: </strong>A randomized controlled study was conducted on 90 patients requiring surgical removal of palatally impacted maxillary canines. Patients were divided into three groups, each receiving a different local anesthetic: 2% lidocaine with epinephrine (Group A), 4% articaine with epinephrine (Group B), and 0.5% bupivacaine with epinephrine (Group C). Pain levels were assessed intraoperatively and postoperatively using the Visual Analog Scale (VAS).</p><p><strong>Results: </strong>Articaine demonstrated superior intraoperative pain control compared to lidocaine and bupivacaine (VAS score: 1.5 ± 0.6 vs. 3.2 ± 0.8 and 2.8 ± 0.7, respectively, <i>P</i> < 0.05). Postoperative pain relief was significantly prolonged in the bupivacaine group (VAS score at 6 hours: 2.1 ± 0.9 vs. 4.5 ± 1.0 for lidocaine and 3.8 ± 0.9 for articaine, <i>P</i> < 0.05). No severe adverse effects were reported in any group.</p><p><strong>Conclusion: </strong>Articaine provides superior intraoperative pain control, while bupivacaine offers longer-lasting postoperative analgesia. The choice of anesthetic should depend on the clinical requirements of intraoperative versus postoperative pain management.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"128-130"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Efficacy of Platelet-Rich Plasma Augmentation in Follicular Unit Extraction in Hair Density Improvement: A Prospective Study.","authors":"Mohit Saxena, D Jaya Chaithanya, Piyush Sharma, Arnabi Chattopadhyay, Shraddha Jugade, Rummaan A Sheikh","doi":"10.4103/jpbs.jpbs_555_25","DOIUrl":"10.4103/jpbs.jpbs_555_25","url":null,"abstract":"<p><strong>Background: </strong>Follicular unit extraction (FUE) is a popular technique for treating androgenetic alopecia, but variable outcomes in hair density post-surgery persist. \"Platelet-rich plasma (PRP)\" has been proposed as an adjunct therapy to improve outcomes.</p><p><strong>Objective: </strong>This research aims to assess the efficacy of PRP augmentation in improving hair density in patients undergoing FUE.</p><p><strong>Methods: </strong>A prospective research was conducted on 50 participants with androgenetic alopecia. Participants were divided into two groups: FUE with PRP (Group A) and FUE alone (Group B). Hair density was measured at baseline, 3 months, and 6 months post-procedure.</p><p><strong>Results: </strong>At 6 months, Group A demonstrated a 25% greater improvement in hair density compared to Group B (<i>P</i> < 0.05). The PRP group also reported higher patient satisfaction scores.</p><p><strong>Conclusion: </strong>PRP augmentation significantly enhances hair density outcomes post-FUE and offers a promising adjunct for androgenetic alopecia management.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"99-101"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakthrough in Antimicrobial Hydrogels for Dental Tissue Engineering: Regenerative Periodontics, Endodontics, and Pedodontics.","authors":"Rinku Saini Jagnade, Gatha Mohanty, Rinkee Mohanty, Ashtha Arya, Priyatam Karade, Akshyata Panda, Rakhi Issrani","doi":"10.4103/jpbs.jpbs_1591_25","DOIUrl":"10.4103/jpbs.jpbs_1591_25","url":null,"abstract":"<p><strong>Introduction: </strong>With their ability to control infections and promote regeneration, antimicrobial hydrogels are showing great promise as biomaterials for dental tissue engineering.</p><p><strong>Aim: </strong>In this study, hydrogels containing antibiotics, silver nanoparticles, or antimicrobial peptides were synthesized, characterized, and their physicochemical characteristics, antimicrobial efficacy, and biocompatibility were assessed.</p><p><strong>Materials and methods: </strong>With a sustained release of antimicrobial agents, the formulations demonstrated favorable swelling, degradation, and mechanical stability.</p><p><strong>Results: </strong>When compared to blank controls, all modified hydrogels significantly decreased the growth and biofilm formation of <i>Streptococcus mutans</i>, <i>Enterococcus faecalis</i>, and <i>Porphyromonas gingivalis</i> bacteria (<i>P</i> < 0.05). While peptide-modified hydrogels showed better support for stem cell viability, proliferation, and odontogenic differentiation, hydrogels loaded with silver nanoparticles showed the strongest inhibition of biofilm. Effective bacterial reduction and good handling in root canal models were confirmed by <i>ex vivo</i> testing.</p><p><strong>Conclusion: </strong>All of these results point to the possibility of using antimicrobial hydrogels in regenerative periodontics, endodontics, and pedodontics to close the gap between tissue regeneration and infection control.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"147-149"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Role of Xylitol in Enhancing Dental Pulp Stem Cell Differentiation: A Clinical Study.","authors":"Ahmed A Albariqi, U Lavanya Neelima, Sheetal Mujoo, Ravleen Khalsa, Mudita Chaturvedi, Lipsa Bhuyan, Akriti Mahajan","doi":"10.4103/jpbs.jpbs_562_25","DOIUrl":"10.4103/jpbs.jpbs_562_25","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the impact of xylitol on the differentiation of dental pulp stem cells (DPSCs) in clinical settings, focusing on its potential as a bioactive agent to enhance regenerative outcomes.</p><p><strong>Methods: </strong>A controlled clinical study involving 40 patients assessed DPSCs isolated from extracted third molars. Patients were divided into two groups: xylitol-treated (Group A) and control (Group B). Differentiation was evaluated over 14 days using alkaline phosphatase (ALP) activity assays, immunohistochemistry, and mineralization analysis.</p><p><strong>Results: </strong>Xylitol treatment significantly enhanced odontogenic differentiation, evidenced by increased ALP activity (Group A: 78.6 ± 5.4 U/mg; Group B: 56.3 ± 4.7 U/mg, <i>P</i> < 0.05) and higher expression of odontogenic markers. Mineralization was markedly superior in the xylitol group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Xylitol promotes DPSC differentiation, making it a promising adjunct for dental regenerative therapies. Further research into its molecular mechanisms is warranted.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"134-136"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}