{"title":"<i>In vitro</i> Comparison of Shear Bond Strength of Various Cements for Zirconia Crowns.","authors":"Sabari Murugesan","doi":"10.4103/jpbs.jpbs_462_25","DOIUrl":"10.4103/jpbs.jpbs_462_25","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this <i>in vitro</i> study was to compare the shear bond strengths of various cements for zirconia crowns and assess the influence of different luting agents on the bond strength.</p><p><strong>Materials and methods: </strong>Thirty extracted maxillary premolars were mounted in acrylic molds, with the occlusal enamel removed to expose the dentin. Thirty zirconia blocks (2 mm × 3 mm × 5 mm) were milled from Sagemax zirconia, sintered at 1500°C, and sandblasted. The specimens were divided into three groups (<i>n</i> = 10): Group I (RelyX Universal Cement), Group II (G-Cem LinkForce), and Group III (Panavia SA Cement Plus). After cementation, specimens underwent 2000 thermal cycles (5°C to 55°C) and were tested for shear bond strength using a universal testing machine. The maximum load was recorded, and failure modes were examined under a stereomicroscope. Statistical analysis was performed using Kruskal-Wallis ANOVA and the Mann-Whitney U-test (<i>P</i> < 0.05).</p><p><strong>Results: </strong>No significant difference (<i>P</i> = 0.630) in bond strength was found between the groups. The mean bond strengths were group I (11.8 MPa), group II (11.5 MPa), and group III (12.4 MPa).</p><p><strong>Conclusion: </strong>All three cement types provided reliable bond strength for zirconia crowns, with Panavia SA Cement Plus slightly outperforming the others. However, the differences in bond strength were not clinically significant. This study suggests that all three luting agents are viable options for cementing zirconia crowns.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S510-S512"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashvin K Mangat, Sumitra Segahran, Tan Siew Wei, Geetha Nalairndran, Anna Rani Kanagarajah, Phrabhakaran Nambiar
{"title":"A Clinical Study to Assess the Quality of Dental Intraoral Periapical Radiological Reports.","authors":"Ashvin K Mangat, Sumitra Segahran, Tan Siew Wei, Geetha Nalairndran, Anna Rani Kanagarajah, Phrabhakaran Nambiar","doi":"10.4103/jpbs.jpbs_1589_24","DOIUrl":"10.4103/jpbs.jpbs_1589_24","url":null,"abstract":"<p><strong>Statement of the problem: </strong>The implementation of a quality management system in healthcare is critical for improving clinical performance. In dentistry, assessing the quality of intraoral periapical (IOPA) radiological reporting is vital for ensuring accurate diagnosis and treatment planning.</p><p><strong>Aim of the study: </strong>This study aimed to evaluate the quality of IOPA radiological reports produced by dental students over the past 5 years in a faculty of dentistry in Malaysia, focusing on completeness and identifying areas for improvement.</p><p><strong>Materials and methodology: </strong>A retrospective clinical study was conducted to assess the IOPA reports using predefined radiological criteria. These reports were evaluated for essential factors such as patient information, type of radiograph, justification for the radiograph, and specific findings like resorption, supernumerary teeth, and proximity of roots to anatomical structures.</p><p><strong>Results: </strong>The audit found that 100% of the reports correctly included details like patient age, radiograph type, and evidence of justification. However, deficiencies were noted in other areas, with a 65% retake rate and complete omission of the ICDAS radiological scoring system (0%).</p><p><strong>Conclusion: </strong>Despite high accuracy in certain areas, the findings revealed several shortcomings. Further training is required for both undergraduate and postgraduate students, along with yearly audits using a larger sample size to ensure adherence to recommended criteria.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S531-S534"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Narrative Review on Oral Squamous Cell Carcinoma.","authors":"Shrikanth Muralidharan, Monali Nikalje, Tulsi Subramaniam, Judy Annie Koshy, Ajit V Koshy, Deepak Bangera","doi":"10.4103/jpbs.jpbs_593_25","DOIUrl":"10.4103/jpbs.jpbs_593_25","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, accounting for nearly 90% of all oral cancers. It remains a significant global health concern due to the high morbidity and mortality, often diagnosed at advanced stages despite advancements in diagnostic tools such as biopsy, imaging, and molecular markers. OSCC is driven by genetic and molecular alterations, including <i>TP53</i> mutations, EGFR overexpression, and dysregulated signaling pathways that promote tumor progression. While treatment primarily includes surgery, radiotherapy, and chemotherapy, emerging approaches such as targeted therapy and immunotherapy are showing promise. However, challenges such as recurrence, metastasis, and treatment resistance persist. Improving early detection strategies, identifying novel biomarkers, and incorporating precision medicine approaches are crucial for enhancing survival outcomes and quality of life in OSCC patients.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S204-S206"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deepika Wadhera, Priyanka Naryal, Tripti Mishra, Jaskirat Singh, Irbinder K Bali
{"title":"Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital.","authors":"Deepika Wadhera, Priyanka Naryal, Tripti Mishra, Jaskirat Singh, Irbinder K Bali","doi":"10.4103/jpbs.jpbs_631_25","DOIUrl":"10.4103/jpbs.jpbs_631_25","url":null,"abstract":"<p><strong>Introduction: </strong>Pancytopenia is a common hematological problem characterized by anemia, leucopenia, and thrombocytopenia. It can be a serious and life-threatening illness.</p><p><strong>Aim: </strong>The objective of this study is to study the clinical presentation and hematological profile in pancytopenia patients.</p><p><strong>Material and methods: </strong>The prospective study was done on 50 pancytopenia patients in a tertiary care hospital and the hematological profile was studied. All the cases with hemoglobin [Hb] less than 13 gm/dL in male and female <12 g/dL, total leukocyte count [TLC] less than 4000/cumm, and platelet count less than 150,000/cumm were included in the study.</p><p><strong>Result: </strong>It was observed that the majority of the cases had hypercellular marrow [40%], 34% normocellular, and 26% hypocellular marrow. Males [52%] were affected more as compared to females [48%]. Megaloblastic erythroid hyperplasia was found to be the commonest cause for pancytopenia [40%], followed by normoblastic erythroid hyperplasia [5.71%], non-Hodgkin lymphoma [11.42%], acute leukemia [2.85%], MDS [2.85%], malaria [2.85%], hypersplenism 2.85%], lymphoid malignancy [2.85%], focal gelatinous [2.85%], AML [2.85%], megakaryocytic thrombocytopenia [2.85%], and plasma cell myeloma [2.85%].</p><p><strong>Conclusion: </strong>It was concluded that the detailed hematological investigations, a thorough clinical examination with hematological studies and bone marrow study is important for understanding the disease process and diagnosing the causes of pancytopenia.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S353-S356"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation of Vitamin D in Different Stages of Hypertension as Per JNC 8 Criteria.","authors":"Neha Vig, Kapila Gaikwad, Yar Mohammad Ansari","doi":"10.4103/jpbs.jpbs_1553_24","DOIUrl":"10.4103/jpbs.jpbs_1553_24","url":null,"abstract":"<p><strong>Background: </strong>Recent research over the past few decades has highlighted a link between vitamin D levels and cardiovascular risk factors, particularly blood pressure. The current investigation sought to assess whether serum vitamin D levels are related to blood pressure within Indian population.</p><p><strong>Methods: </strong>This observational cross-sectional study included 600 participants (300 cases with hypertension and 300 controls). Inclusion criteria were patients aged 20-70 years with hypertension, while individuals with secondary hypertension, chronic kidney disease, or chronic liver disease were excluded. Blood pressure was measured using a mercury sphygmomanometer. Vitamin D levels were analyzed using automated analyzers.</p><p><strong>Results: </strong>A weak but statistically significant negative association between serum vitamin D levels and blood pressure was found.</p><p><strong>Conclusion: </strong>Lower serum vitamin D levels were associated with higher systolic blood pressure. It can be suggested that vitamin D exerts an influence on blood pressure, supporting the hypothesis of VDR hypersensitivity.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S831-S833"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancements in Targeted Therapy for Oral Cancer: A Mini Review.","authors":"Sakshi G Ingole, Ashwini A Aher, Sunil N Thitame","doi":"10.4103/jpbs.jpbs_1935_24","DOIUrl":"10.4103/jpbs.jpbs_1935_24","url":null,"abstract":"<p><p>Targeted therapy has become the latest revolution in the management of oral cancer by focusing on the molecular characteristic of the tumor to provide treatment with an accuracy that spares normal healthy tissue. This article discusses current advances in targeted medicine, with focusing on EGFR inhibitors, immune checkpoint inhibitors, and more biomarker-drug-directed therapies. Some of the important advances in enhancing the combination of these therapies with the conventional treatments including surgery, radiation, and chemotherapy are being described here. Furthermore, such features as tailoring medicine for patient needs in order to enhance therapeutic efficacy and counter drug resistance are pointed out as vision with a relatively bright prognosis for increasing survival rates as well as a quality of life of oral cancer patients.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S49-S51"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikitha Sruthi Anand, K Dinesh, N Thileepan, K Rangasamy
{"title":"Assessment of Academic Stress and Anxiety among School-Going Children in Salem District: A Cross-Sectional Study.","authors":"Nikitha Sruthi Anand, K Dinesh, N Thileepan, K Rangasamy","doi":"10.4103/jpbs.jpbs_2014_24","DOIUrl":"10.4103/jpbs.jpbs_2014_24","url":null,"abstract":"<p><strong>Background: </strong>Academic stress and anxiety are prevalent among students and can significantly impact their mental health and academic performance. This study explores the prevalence of academic stress and anxiety and identifies associated factors among students.</p><p><strong>Objective: </strong>To assess the levels of academic stress and anxiety in students and determine the key demographic and academic variables influencing these outcomes.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 2,000 children aged 10-12 years across various schools. Data were collected using validated tools, including the Academic Stress Scale (ASS) and Generalized Anxiety Disorder-7 (GAD-7) scale. Statistical analysis included descriptive statistics, t-tests, and multivariate regression to identify significant predictors.</p><p><strong>Results: </strong>Elevated levels of academic stress and anxiety were observed, with 68% of students reporting moderate-to-severe academic stress and 45% showing moderate-to-severe anxiety. Female students exhibited higher stress and anxiety levels compared to males (<i>P</i><0.01). Major predictors included academic workload, fear of failure, and lack of social support.</p><p><strong>Conclusion: </strong>Academic stress and anxiety are pervasive issues among children, necessitating targeted interventions to address workload management, mental health support, and coping strategies.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S317-S319"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rakhi Soni, Mimoh Sharma, Tabassum, Renu Singh, Bipin K Yadav, Rajesh K Thakur
{"title":"Assessment of Low Level Laser Therapy on Periodontal Inflammation and Healing after Scaling and Root Planing in Chronic Periodontitis Patients - A Clinico Biochemical Study.","authors":"Rakhi Soni, Mimoh Sharma, Tabassum, Renu Singh, Bipin K Yadav, Rajesh K Thakur","doi":"10.4103/jpbs.jpbs_1930_24","DOIUrl":"10.4103/jpbs.jpbs_1930_24","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to determine how Low-level laser therapy (LLLT) post- Scaling and root planning (SRP) affected the inflammatory periodontal tissue caused by chronic periodontitis.</p><p><strong>Methodology: </strong>The study involved 56 sites in 28 patients with almost bilaterally symmetrical moderate pocket depths. The sites were split into two groups at random. SRP was administered alone to Group I, while SRP with LLLT were administered to Group II. In addition to recording the clinical parameters [plaque index (PI), sulcus bleeding index (SBI), and probing pocket depth (PPD)], GCF sample was taken at baseline, 3 to 4 weeks, and 6 to 7 weeks from baseline. The visual analogue scale (VAS) was scored for both groups on the final day of LLLT, which was 7 days following SRP. All GCF samples were then sent for TGF-β1 and PGE2 biochemical analysis.</p><p><strong>Results: </strong>This study demonstrated a significant reduction in PI, SBI, PPD, VAS score, PGE2 and TGF- β1 level in GCF in group I after SRP. Similarly in group II, which received LLLT with SRP, showed a significant decrease in all clinical and biochemical parameters. Intergroup comparison showed no significant difference in PI, SBI, TGF-β1 levels in the GCF. However, there was a significant difference in PPD, VAS score, and PGE2 level results.</p><p><strong>Conclusion: </strong>Our study concluded that LLLT may be effective in reducing inflammation when used as an adjunct to SRP.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S492-S494"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Oral Health Disparities and Barriers to Care among Underserved Populations in Urban and Rural Settings.","authors":"Digvijaysinh Parmar, Jenny Lalmalsawmi Sailo, Sahithya Sakhamuri, Chandan Dalapati, Smita Durga Dutta, Shivam Arya, Heena Dixit","doi":"10.4103/jpbs.jpbs_1449_24","DOIUrl":"10.4103/jpbs.jpbs_1449_24","url":null,"abstract":"<p><strong>Introduction: </strong>Oral health disparities persist between urban and rural populations, particularly among underserved communities. Geographic isolation, financial constraints, and lack of access to dental services contribute significantly to these disparities. Rural populations often encounter greater barriers in accessing healthcare facilities, whereas urban underserved groups face challenges such as overburdened public health systems. This study aims to assess and compare the disparities in oral health outcomes and the barriers to care faced by underserved populations in both urban and rural settings.</p><p><strong>Methods: </strong>A cross-sectional comparative study was conducted using data from various peer-reviewed literature studies on oral health disparities among underserved urban and rural populations. Three parameters were evaluated: socioeconomic status, insurance coverage, and geographic access to dental services. The data were analyzed using Chi-square tests, with statistical significance determined at a <i>P</i> value of < 0.05.</p><p><strong>Results: </strong>Statistical analysis demonstrated significant disparities in oral health outcomes and access to care between urban and rural populations, with rural communities experiencing worse outcomes in terms of insurance coverage, income levels, and proximity to dental care facilities. Differences in oral health status, such as untreated dental caries and periodontal disease, were also significantly higher in rural populations compared to urban groups.</p><p><strong>Conclusion: </strong>Efforts to reduce oral health disparities must consider the unique challenges faced by both urban and rural underserved populations. Targeted public health interventions and policies that address geographic, financial, and systemic barriers to care are essential to improving oral health equity.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S445-S447"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between Sleep Quality and Mental Health among Medical Students: A College Based Study in Himachal Pradesh, India.","authors":"Punam Verma, Hitesh Jani, Priti Bhanderi, Bhoopendra Patel, Rupali Parlewar","doi":"10.4103/jpbs.jpbs_310_25","DOIUrl":"10.4103/jpbs.jpbs_310_25","url":null,"abstract":"<p><strong>Background: </strong>This cross-sectional study investigated the association between the sleep quality and mental health among medical students in Himachal Pradesh, India.</p><p><strong>Methods: </strong>Using standardized instruments Pittsburgh sleep quality index and depression anxiety stress scale-21 (PSQI and DASS-21), we assessed 400 medical students.</p><p><strong>Results: </strong>Results revealed that 76.75% of students were poor sleepers (PSQI >5), with a mean global PSQI score of 7.91 ± 3.85. Mental health assessment showed 63% experiencing anxiety, 32% stress, and 27% depression. Multinomial logistic regression revealed significant associations between the sleep latency and mental health outcomes, with increased sleep latency raising odds of depression (22%), anxiety (28%) and stress (35%).</p><p><strong>Conclusion: </strong>Poor sleep especially sleep latency strongly predicted mental health problems among medical students.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S363-S365"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}