Suprasidh Suprakasam, Reshma S Kakkachi Parambil, Krishnan Hari, Priya Viswanathan, Irene Abraham, Ebin T Mathai
{"title":"Comparative Long-Term Outcomes of Formocresol, Mineral Trioxide Aggregate, and Laser Pulpotomy Techniques in Primary Teeth.","authors":"Suprasidh Suprakasam, Reshma S Kakkachi Parambil, Krishnan Hari, Priya Viswanathan, Irene Abraham, Ebin T Mathai","doi":"10.4103/jpbs.jpbs_711_24","DOIUrl":"10.4103/jpbs.jpbs_711_24","url":null,"abstract":"<p><strong>Background: </strong>Pulpotomy is a common dental procedure used to treat extensively decayed primary teeth, aiming to preserve the vitality and function of the remaining pulp tissue. Various pulpotomy techniques and materials have been developed, but their long-term outcomes in terms of success rates and complications remain a subject of ongoing research.</p><p><strong>Materials and methods: </strong>A total of 180 primary molars from children aged 4-8 years were treated using three different pulpotomy techniques: Formocresol (<i>n</i> = 60), Mineral Trioxide Aggregate (MTA) (<i>n</i> = 60), and Laser Pulpotomy (<i>n</i> = 60). Follow-ups were conducted at 6, 12, and 24 months posttreatment to evaluate clinical and radiographic success. Clinical success was defined by the absence of pain, swelling, and mobility, while radiographic success was indicated by the lack of internal resorption, furcation radiolucency, and periapical pathology.</p><p><strong>Results: </strong>At the 24-month follow-up, the clinical success rates were 80% for Formocresol, 95% for MTA, and 90% for Laser Pulpotomy. Radiographic success rates were 75% for Formocresol, 92% for MTA, and 88% for Laser Pulpotomy. MTA demonstrated the highest overall success rates, with statistically significant differences compared to Formocresol (<i>P</i> < 0.01) but not Laser Pulpotomy (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Mineral Trioxide Aggregate (MTA) showed superior long-term outcomes compared to Formocresol and comparable results to Laser Pulpotomy for the treatment of primary teeth.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3233-S3235"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahtesham A Qurishi, Mohammed S Al Dira, Amal H Sholan, Shahad E Abzoah, Mahdi A Hakami, Emad Malhan, Shahad M Moafa
{"title":"Effect of Different Pediatric Medications on RMGIC: A Comparative Study.","authors":"Ahtesham A Qurishi, Mohammed S Al Dira, Amal H Sholan, Shahad E Abzoah, Mahdi A Hakami, Emad Malhan, Shahad M Moafa","doi":"10.4103/jpbs.jpbs_688_24","DOIUrl":"10.4103/jpbs.jpbs_688_24","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the impact of commonly prescribed pediatric medications on resin-modified glass ionomer cement (RMGIC), which is widely used in pediatric dentistry in India. The interaction between these medications and RMGIC could affect the material's durability and effectiveness.</p><p><strong>Methodology: </strong>Sixty RMGIC specimens were divided into five groups, each exposed to different pediatric medications: antibiotic syrup, antipyretic syrup, vitamin syrup, antitussive syrup, and distilled water (control). Microhardness and surface roughness were measured before and after a 14-day immersion period. Statistical analysis was conducted using one-way ANOVA and post-hoc Tukey's test.</p><p><strong>Results: </strong>All pediatric medications significantly affected RMGIC, with antitussive syrup showing the most substantial impact. Microhardness decreased by up to 18.40%, and surface roughness increased by up to 21.40%. The control group showed no significant changes.</p><p><strong>Conclusion: </strong>Pediatric medications, particularly those with acidic properties, compromise the durability of RMGIC. Further research is needed to develop more resistant materials or protective measures.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3185-S3187"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shailaben Chaudhary, Shobha Fernandes, Hardikkumar B Patel, Priya Mishra, Nishan R Patel, Yash Bafna, Miral Mehta
{"title":"Comparison of Resin Infiltrant and Sealants on Pre-Cavitated Lesions in Primary Teeth: A Quantitative Analysis Using Atomic Absorption Spectrophotometry.","authors":"Shailaben Chaudhary, Shobha Fernandes, Hardikkumar B Patel, Priya Mishra, Nishan R Patel, Yash Bafna, Miral Mehta","doi":"10.4103/jpbs.jpbs_1329_24","DOIUrl":"10.4103/jpbs.jpbs_1329_24","url":null,"abstract":"<p><strong>Aim: </strong>This study was conducted to analyze the effects of sealants and resin infiltrant on pre-cavitated lesions in primary teeth (AAS) using an atomic absorption spectrophotometer.</p><p><strong>Material and method: </strong>Forty freshly extracted intact human primary molars were used for the study. All the specimens were then divided into four groups of ten specimens. These groups are treated differently. The specimens were stored in artificial saliva throughout the study. The AAS was then used to assess the calcium dissolution of artificial saliva.</p><p><strong>Result: </strong>A comparison of Group III and Group IV established a statistically significant difference found in the amount of calcium dissolution in artificial saliva. Group III showed lesser calcium dissolution from enamel compared to Group IV in artificial saliva.</p><p><strong>Conclusion: </strong>Resin infiltration showed more resistance to the release of calcium from enamel as compared to Clinpro Sealant in artificial saliva.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3874-S3876"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Harnessing Ayurveda in Acute Management of Type 1 Trigeminal Neuralgia: Insights from a Single-Case Report.","authors":"Rohit Arun Waskar, Ashvini Pardhekar, Mayuri Deshpande","doi":"10.4103/jpbs.jpbs_896_24","DOIUrl":"10.4103/jpbs.jpbs_896_24","url":null,"abstract":"<p><p>Trigeminal neuralgia causes severe facial pain, affecting daily life and leading to anxiety and depression. The latest classification differentiates between primary and secondary forms. Treatments, including anticonvulsants and surgery, have mixed results. Ayurveda links this condition to an excess of Vata dosha in the cranial nerves.</p><p><strong>Aim and objectives: </strong>To discover the potential of Ayurveda in the acute management of Type 1 trigeminal neuralgia.</p><p><strong>Material and methods: </strong>A 41-year-old woman with intermittent pricking pain and tingling in the right lower jaw was diagnosed with Type 1 trigeminal neuralgia. She received Shamana and Shodhan Chikitsa as per Ayurvedic principles for 15 days.</p><p><strong>Observation and results: </strong>Pain and shock-like sensations decreased, reducing the social fear of pain and improving quality of life. Transient numbness occurred early.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S4078-S4080"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Hima Madhuri, Athira Suresh, Parul Tikoo, Kumar Ankit, P Subham, Aashish Kemmu
{"title":"Pain Relief and Efficacy of Surgical vs Nonsurgical Management of TMJ Disorders: A Systematic Review.","authors":"D Hima Madhuri, Athira Suresh, Parul Tikoo, Kumar Ankit, P Subham, Aashish Kemmu","doi":"10.4103/jpbs.jpbs_966_24","DOIUrl":"10.4103/jpbs.jpbs_966_24","url":null,"abstract":"<p><p>Temporomandibular disorders (TMDs) affect the jaw muscles and joints, with treatments ranging from surgery to nonsurgical methods like physiotherapy and medication. A systematic review of studies from January 2020 to May 2024 compared these treatments' effectiveness in relieving pain and improving function. From 7,459 initial records, 18 studies were included, examining interventions like NSAIDs, low-level laser therapy, botulinum toxin A, and occlusal splints. Results varied, highlighting the need for personalized treatment and standardized outcomes to improve patient care.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3071-S3073"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mandar Vilas Ambike, Jayshree Sachin Kharche, Shraddha Shripad Kulkarni, T Vijaya Sagar, K Vijayakumar, Suresh Babu Kondaveeti
{"title":"Implementation of Case-Based Learning in 1<sup>st</sup>-Year MBBS Students -Future of Medical Professionals Learning Methods in Indian Medical Colleges?","authors":"Mandar Vilas Ambike, Jayshree Sachin Kharche, Shraddha Shripad Kulkarni, T Vijaya Sagar, K Vijayakumar, Suresh Babu Kondaveeti","doi":"10.4103/jpbs.jpbs_923_24","DOIUrl":"10.4103/jpbs.jpbs_923_24","url":null,"abstract":"<p><strong>Background: </strong>Case Based Learning (CBL) is the best method for correlation of knowledge with clinical scenarios. The present study is planned to implement case-based learning in 1<sup>st</sup>-Year MBBS students and find out the perception of the students as a guideline to incorporate this activity in the curriculum.</p><p><strong>Material and methods: </strong>The study was conducted among 1<sup>st</sup>-Year MBBS students. The students who consented to participate were divided into 23 groups each containing 5-6 participants. The case along with the reference material was allotted to the groups of students sequentially. Faculty was allotted to each group of students for their help and discussion on the given case. The completed activity was uploaded on Moodle for all the students to go through. After 25 weeks, students' perception of the activity were obtained with the help of validated questionnaire through Google Forms. Data was analyzed in SPSS software.</p><p><strong>Results: </strong>85% of students felt that CBL helped them understand clinical applications, enhanced problem-solving skills and retention of knowledge. More than 85% of students were comfortable with CBL in terms of relevance to the curriculum, mode of conduction, and development of interest. Over 90% of students mentioned that provided resources and faculty were helpful.</p><p><strong>Conclusion: </strong>The study concludes that successful implementation of case-based learning is possible for 1<sup>st</sup>-Year MBBS medical students. Students perceived CBL as a motivating and effective teaching-learning method.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3449-S3451"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul A K Kader, Sandeep Chandran, K K Ridhun Unnikrishnan, Nikita A Mannur, Anusar Gupta, Savadamoorthi Kamatchi Subramani
{"title":"Investigation of the Potential of Nanoparticles as a New Drug Delivery System for Endodontic Treatment.","authors":"Abdul A K Kader, Sandeep Chandran, K K Ridhun Unnikrishnan, Nikita A Mannur, Anusar Gupta, Savadamoorthi Kamatchi Subramani","doi":"10.4103/jpbs.jpbs_941_24","DOIUrl":"10.4103/jpbs.jpbs_941_24","url":null,"abstract":"<p><strong>Background: </strong>The application of nanoparticles in endodontic treatment presents a novel approach to drug delivery, potentially enhancing the efficacy of therapeutic agents.</p><p><strong>Materials and methods: </strong>In this study, we synthesized and characterized nanoparticles of chitosan, calcium phosphate, and silver using standard protocols. The nanoparticles were then loaded with an antimicrobial agent, chlorhexidine, and incorporated into an endodontic sealer. The antibacterial efficacy of the nanoparticle-enhanced sealer was tested against <i>Enterococcus faecalis</i> using a disk diffusion method. Additionally, the penetration depth of nanoparticles into dentinal tubules was assessed using scanning electron microscopy (SEM).</p><p><strong>Results: </strong>The synthesized nanoparticles exhibited a uniform size distribution, with an average diameter of 50 nm for chitosan, 30 nm for calcium phosphate, and 20 nm for silver nanoparticles. The antibacterial tests showed that the nanoparticle-loaded sealer achieved a 40% greater inhibition zone against <i>Enterococcus faecalis</i> compared to the control sealer without nanoparticles. SEM analysis revealed that the nanoparticles penetrated dentinal tubules to a depth of approximately 500 μm, significantly more than the conventional sealer.</p><p><strong>Conclusion: </strong>Nanoparticles demonstrate significant potential as a drug delivery system in endodontic treatment, enhancing both the antibacterial efficacy and penetration depth of therapeutic agents.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3446-S3448"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tushar K Bandiwadekar, David P Tauro, Sachin K Malagi, Abhinav Dubey, Kolla Advait, Sumit Bhatt
{"title":"Radiological and Surgical Assessment of Proximity of Roots of Mandibular Third Molar to the Inferior Alveolar Canal in Impacted Teeth.","authors":"Tushar K Bandiwadekar, David P Tauro, Sachin K Malagi, Abhinav Dubey, Kolla Advait, Sumit Bhatt","doi":"10.4103/jpbs.jpbs_943_24","DOIUrl":"10.4103/jpbs.jpbs_943_24","url":null,"abstract":"<p><strong>Background and objective: </strong>A mandibular canal around the lower third molar roots house the inferior alveolar nerve (IAN). There is a risk of nerve injury during surgical tooth extraction.</p><p><strong>Methods: </strong>The College of Dental Sciences at Davangere's Department of Oral and Maxillofacial Surgery served as the outpatient setting for this investigation. The study comprised one hundred participants who were going to have their mandibular third molars surgically extracted. The risk of IAN injury was evaluated by comparing the radiographic findings from preoperative orthopantomography and intraoral periapical radiographs with intraoperative observations.</p><p><strong>Results: </strong>The study revealed that the patient's age did not have a significant correlation with the risk of nerve injury. However, cases involving bony impactions were found to have a higher risk of IAN damage. Additionally, mesioangular impactions and radiographic indicators, such as root deflection, were associated with an elevated risk of nerve injury.</p><p><strong>Conclusion: </strong>To reduce the risk of IAN injury during the extraction of mandibular third molars, it is essential to have a detailed understanding of the relevant anatomical features and to plan the surgical procedure meticulously.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3473-S3475"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Different Obturation Techniques on the Sealing Ability of Root Canal Filling Materials.","authors":"Regula Sri Lakshmi, Bhaskar Das, Apurva Jadhav, Harsha Haridas, Sabari Murugesan, Savadamoorthi Kamatchi Subramani","doi":"10.4103/jpbs.jpbs_1007_24","DOIUrl":"10.4103/jpbs.jpbs_1007_24","url":null,"abstract":"<p><strong>Background: </strong>The performance of root canal filling materials in sealing is crucial for the effectiveness of endodontic procedures as it prevents the escape of microorganisms and guarantees the durability of the treatment.</p><p><strong>Materials and methods: </strong>The present <i>in vitro</i> investigation included the preparation of 90 human single-rooted teeth using a standardized process. These teeth were then randomly separated into three groups (n = 30) according to the obturation technique: Group A (Lateral Compaction), Group B (Thermafil), and Group C (Continuous Wave of Condensation). Furthermore, each group was separated into two subgroups based on the specific kind of root canal filling material employed: Subgroup 1 (Gutta-Percha) and Subgroup 2 (Resilon). The sealing capacity was evaluated using a dye penetration technique, with measurements conducted at three specific time intervals: 24 hours, 1 week, and 4 weeks after the obturation process. Statistical analysis of the data was conducted using analysis of variance and <i>post hoc</i> tests to identify significant differences across groups.</p><p><strong>Results: </strong>The findings showed that the Continuous Wave of Condensation method (Group C) had the lowest dye penetration, with an average depth of penetration of 1.2 mm. The Thermafil technique (Group B) followed closely with a penetration depth of 1.8 mm, while the Lateral Compaction technique (Group A) achieved a penetration depth of 2.5 mm. In terms of sealing ability, Gutta-Percha demonstrated superior performance compared to Resilon, achieving average penetration depths of 1.5 mm and 2.0 mm, respectively. Statistical analysis showed statistically significant differences between the groups (<i>P</i> < 0.05), with the Continuous Wave of Condensation approach utilizing Gutta-Percha showing the highest level of sealing effectiveness.</p><p><strong>Conclusion: </strong>In conclusion, the Continuous Wave of Condensation approach showed a substantial improvement in the sealing efficacy of root canal fillings when compared to the Lateral Compaction and Thermafil procedures.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3568-S3570"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G R Ishwarya Dhevi, Ponnudurai Arangannal, J Jeevarathan
{"title":"Comparative Analysis of Cytotoxicity and Odontogenic Differentiation of Novel Bioceramic Material on Human Dental Pulp Stem Cells - An <i>In Vitro</i> Study.","authors":"G R Ishwarya Dhevi, Ponnudurai Arangannal, J Jeevarathan","doi":"10.4103/jpbs.jpbs_1078_24","DOIUrl":"10.4103/jpbs.jpbs_1078_24","url":null,"abstract":"<p><strong>Background and objective: </strong>Bioceramic materials have revolutionized the field of endodontics by successfully transforming the outcomes of pulp therapies. Novel biomaterials are evolving by modifying the conventional mineral trioxide aggregate (MTA) to overcome their existing limitations, the major ones being prolonged setting and cytotoxic radiopacifiers. Dental white portland cement (DWPC) is a novel formulated bioceramic material introduced as an enhanced MTA alternative. This in vitro study aims to investigate the cytotoxicity and odontogenic differentiation of novel formulation DWPC with MTA Angelus, Biodentin (BD) and white portland cement (WPC) on human dental pulp stem cells (HDPSCs).</p><p><strong>Materials and methods: </strong>HDPSCs were cultured in Dulbecco's modified eagle's medium (DMEM) with fetal bovine serum (FBS) and antibiotics at 37°C, 90% humidity in a 5% CO<sub>2</sub> incubator. Experimental samples were prepared as disks. The viability of HDPSCs was measured by Mosmann's tetrazolium toxicity (MTT) assay, and odontogenic potential was assessed using alkaline phosphatase (ALP) activity at 24 hours, 7-, 14-, and 21-day intervals. The mean and standard deviations were statistically analyzed by one-way ANOVA and <i>post hoc</i> Scheffe tests using IBM SPSS Software (IBM statistical package for social sciences) - Version 24.0 with a significance level set as <i>P</i> < 0.05.</p><p><strong>Results: </strong>All four groups tested using MTT assay showed no toxicity and possess odontogenic potential in all the experimental durations. Experimental group DWPC presented with the highest mean cell viability and ALP activity at all intervals followed by WPC, MTA, and BD (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>DWPC presented good bioactivity in terms of cell viability and ALP activity. Thus, DWPC could be a promising endodontic material. However, further research is warranted to explore the clinical applicability.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 4","pages":"S3951-S3955"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}