Journal of pharmacy & bioallied sciences最新文献_第2页

Functional Outcomes of Total Hip Replacement in Inflammatory Hip Arthritis: Influence of Disease-Modifying Anti-Rheumatic Drugs and Postoperative Analgesic Management. 炎性髋关节关节炎全髋关节置换术的功能结局：改善疾病的抗风湿药物和术后镇痛管理的影响

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_149_26

S Ganesh Kumar, K Balaji Subramaniam, S Pajani, K Arul Vignesh, Panneerselvam Periasamy

{"title":"Functional Outcomes of Total Hip Replacement in Inflammatory Hip Arthritis: Influence of Disease-Modifying Anti-Rheumatic Drugs and Postoperative Analgesic Management.","authors":"S Ganesh Kumar, K Balaji Subramaniam, S Pajani, K Arul Vignesh, Panneerselvam Periasamy","doi":"10.4103/jpbs.jpbs_149_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_149_26","url":null,"abstract":"Background: Inflammatory hip arthritis caused by conditions such as rheumatoid arthritis and ankylosing spondylitis leads to progressive joint destruction, severe pain, and disability. Total hip replacement (THR) is an effective surgical intervention; however, pharmacological factors such as disease-modifying anti-rheumatic drugs (DMARDs), and postoperative analgesic management may influence outcomes.Aim: To evaluate functional outcomes of THR in inflammatory hip arthritis and assess the influence of DMARD therapy and postoperative analgesic requirements.Methodology: A prospective observational study was conducted on 30 patients with inflammatory hip arthritis undergoing primary THR. Functional outcomes were assessed using Harris hip score (HHS), visual analogue scale (VAS), and range of motion. Data on perioperative DMARD use and postoperative analgesic requirements were recorded. Patients were followed for 12 months.Results: Mean HHS improved from 38.6 ± 7.2 preoperatively to 87.4 ± 6.8 at 12 months (P < 0.001). Mean VAS decreased from 8.1 ± 1.0 to 1.3 ± 0.6. Patients on optimized DMARD therapy demonstrated better functional recovery and lower postoperative pain scores. Increased analgesic requirement was observed during early postoperative periods, but reduced significantly over time.Conclusion: THR provides excellent functional improvement in inflammatory hip arthritis. DMARD optimization and effective analgesic management significantly influence postoperative recovery and patient outcomes.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"254-256"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Drug Therapy Awareness, Medication Adherence, and Predictors of Knowledge, Attitude, and Practice on Diabetic Complications in Type 2 Diabetes Mellitus: A Cross-Sectional Study. 评估2型糖尿病患者的药物治疗意识、药物依从性以及对糖尿病并发症的知识、态度和实践的预测因素：一项横断面研究

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_141_26

Subhasankari Govindan, Sudha Bakthavachalam, Sasi Vaithiyalingam

{"title":"Assessment of Drug Therapy Awareness, Medication Adherence, and Predictors of Knowledge, Attitude, and Practice on Diabetic Complications in Type 2 Diabetes Mellitus: A Cross-Sectional Study.","authors":"Subhasankari Govindan, Sudha Bakthavachalam, Sasi Vaithiyalingam","doi":"10.4103/jpbs.jpbs_141_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_141_26","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is associated with significant complications due to poor glycemic control, inadequate pharmacotherapy awareness, and poor medication adherence.Aim: To assess drug therapy awareness, medication adherence, and predictors of knowledge, attitude, and practice regarding diabetic complications.Materials and methods: A cross-sectional study was conducted among 225 T2DM patients using a structured questionnaire. Data were analyzed using Statistical Package for the Social Sciences version 26. Inferential statistics included Pearson correlation and multiple linear regression with 95% confidence intervals.Results: Adequate knowledge was observed in 10.2% of participants, favorable attitude in 33%, and good practice in 18.2%. Medication adherence was poor in 64%. Regression analysis showed hospitalization (β =0.284, 95% CI (confidence interval): 1.37-3.59, P < 0.001) and disease duration (β =0.131, 95% CI: 0.02-1.03, P < 0.05) as significant predictors of knowledge. Practice was negatively influenced by age (β = -0.182, P < 0.01) and occupation (β = -0.335, P < 0.001). Adjusted R 2 values were 0.085 (knowledge), 0.143 (practice), and 0.065 (attitude).Conclusion: Despite moderate pharmacotherapy awareness, poor medication adherence and suboptimal practices persist. Pharmaceutical care interventions are essential to improve outcomes.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"245-247"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cross-Sectional Study of Suicidal Behavior and Common Poisoning Agents (Aluminum Phosphide and Organophosphorus Compounds) in Emergency Settings in North India. 印度北部紧急情况下自杀行为和常见中毒剂（磷化铝和有机磷化合物）的横断面研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_96_26

Akanksha Sharma, Abdul Qadir Jilani, Christopher Peter, Vikram Singh

{"title":"A Cross-Sectional Study of Suicidal Behavior and Common Poisoning Agents (Aluminum Phosphide and Organophosphorus Compounds) in Emergency Settings in North India.","authors":"Akanksha Sharma, Abdul Qadir Jilani, Christopher Peter, Vikram Singh","doi":"10.4103/jpbs.jpbs_96_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_96_26","url":null,"abstract":"Objectives: To analyze clinical presentation, modes of suicidal attempts, poisoning agents, and associated psychiatric comorbidities among individuals presenting with suicide attempts.Methods: This cross-sectional study was conducted over three months in the Department of Psychiatry of a tertiary care hospital. A total of 259 participants aged ≥18 years were enrolled after medical stabilization. Sociodemographic and clinical data were collected. Common poisoning agents were noted. Depression and stress were assessed using Beck Depression Inventory (BDI) and Perceived Stress Scale (PSS). Data were analyzed using Statistical Package for Social Sciences (SPSS) 25.0, with P < 0.05 considered significant.Results: Mean age was 32.61 ± 9.30 years; 134 (51.74%) were males. Hanging was the most common (120, 46.33%) method, followed by poisoning (82, 31.66%). Poisoning agents were Aluminum Phosphide (n = 50) and Organophosphorus (n = 32). Past psychiatric history was present in 89 (34.36%) participants. Mean BDI was 29.14 ± 6.24 and mean PSS 28 ± 5.6. BDI and PSS showed a positive correlation (r = 0.184, P = 0.003).Conclusion: Suicide attempts were common among young adults with moderate to severe depression and high stress levels, emphasizing the need for early psychiatric intervention. The poisoning agents used were aluminum phosphide and organophosphorus compounds.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"197-199"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiological Profile of Ultrasonography in First Trimester Bleeding. 早期妊娠出血的超声影像分析。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_51_26

R Sindhuja, T Shriram, K Cibi

{"title":"Radiological Profile of Ultrasonography in First Trimester Bleeding.","authors":"R Sindhuja, T Shriram, K Cibi","doi":"10.4103/jpbs.jpbs_51_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_51_26","url":null,"abstract":"Background: First-trimester bleeding is a common obstetric problem affecting nearly one-fourth of pregnancies, with causes ranging from benign conditions to serious complications. Ultrasonography, including grayscale and Doppler imaging, plays a key role in early diagnosis.Aim: To evaluate ultrasonographic findings in women presenting with first-trimester bleeding and assess the radiological profile on ultrasound.Materials and methods: This descriptive cross-sectional study was conducted in the Department of Radiology, Aarupadai Veedu Medical College and Hospital, Puducherry. Eighty-eight antenatal women with vaginal bleeding and gestational age <14 weeks were evaluated using transabdominal and transvaginal ultrasonography. Fetal viability, crown-rump length, pregnancy location, placental position, uterine artery Doppler, and associated maternal or cervical factors were assessed. Data were analyzed using descriptive statistics and Chi-square test, with P < 0.05 considered significant.Results: Fetal cardiac activity was present in 83% of cases. Intrauterine pregnancies constituted 86.4%, while ectopic pregnancies accounted for 13.6%. Threatened abortion was the most common diagnosis (37.5%), followed by missed abortion (21.6%). Normal uterine artery Doppler findings were seen in 88.6% of cases, with no significant association between maternal age and pregnancy outcome (P = 0.761).Conclusion: Ultrasonography is an indispensable, non-invasive tool for evaluating first-trimester bleeding, facilitating accurate diagnosis and timely management.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"175-177"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of Kirschner Wire and Mini-Plate Fixation in Hand Fractures: Functional Outcomes and Postoperative Analgesic Requirements. 克氏针与微型钢板内固定治疗手部骨折的比较研究：功能结果和术后镇痛需求。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_148_26

Dhayananth Rathinavel, K Balaji Subramaniam, S Pajani, K Arul Vignesh, Panneerselvam Periasamy

{"title":"Comparative Study of Kirschner Wire and Mini-Plate Fixation in Hand Fractures: Functional Outcomes and Postoperative Analgesic Requirements.","authors":"Dhayananth Rathinavel, K Balaji Subramaniam, S Pajani, K Arul Vignesh, Panneerselvam Periasamy","doi":"10.4103/jpbs.jpbs_148_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_148_26","url":null,"abstract":"Background: Metacarpal and phalangeal fractures are common upper limb injuries that significantly affect hand function. Surgical fixation using Kirschner wires (K-wires) and mini-plates is widely practiced, but their comparative effectiveness in terms of functional recovery and postoperative analgesic requirements remains debated.Aim: To compare functional outcomes and postoperative analgesic requirements in patients undergoing K-wire versus mini-plate fixation for metacarpal and phalangeal fractures.Methodology: A prospective comparative study was conducted on 50 adult patients with unstable metacarpal or phalangeal fractures. Patients were divided into two groups: Group A (K-wire fixation, n = 25) and Group B (mini-plate fixation, n = 25). Outcomes assessed included total active motion (TAM), visual analog scale for pain, time to union, and analgesic requirements. Follow-up was conducted at 1, 3, 6, and 12 months.Results: Both groups showed progressive improvement. K-wire fixation demonstrated significantly better TAM at 12 months (54.70 ± 10.94 vs 28.09 ± 5.62; P < 0.001). Mini-plate fixation showed faster fracture union. Analgesic requirements were higher in the mini-plate group during the early postoperative period. Complication rates were comparable.Conclusion: K-wire fixation offers superior long-term functional outcomes and reduced analgesic requirements, whereas mini-plate fixation provides earlier fracture stability and faster union. Implant selection should be individualized.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"251-253"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Antimicrobial Susceptibility Testing Performance for Short Incubation of Gram-Negative Pathogens from Bloodstream Infections at a Tertiary Care Center in Telangana. 泰伦加纳邦三级保健中心血液感染中革兰氏阴性病原体的短期潜伏期鉴定和药敏试验性能

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_48_26

Neelima Sudharshan, Sayeeda Munawar, Mvnl Ram Mohan, Sd Fatima Tasneem, C Padmasri, P Umabala, C Sudharshan Raj

{"title":"Identification and Antimicrobial Susceptibility Testing Performance for Short Incubation of Gram-Negative Pathogens from Bloodstream Infections at a Tertiary Care Center in Telangana.","authors":"Neelima Sudharshan, Sayeeda Munawar, Mvnl Ram Mohan, Sd Fatima Tasneem, C Padmasri, P Umabala, C Sudharshan Raj","doi":"10.4103/jpbs.jpbs_48_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_48_26","url":null,"abstract":"Background and objectives: Blood culture is the \"gold standard\" for diagnosing bacteremia. This study evaluates the performance of shortened incubation cultures in pathogen identification (ID) and antimicrobial susceptibility testing (AST) using the VITEK®2 system.Material and methodology: A prospective study was conducted from November 2021 to October 2022, focusing Gram-negative pathogens. Flagged blood-culture bottles subjected to Gram-stain and simultaneous microbial workup by conventional 24-h protocol and faster 3-4 h and 7-8-h methods.Results: The data analysis encompassed 207 Gram-negative pathogens, Escherichia coli being the most prevalent isolate at 39.6%. Overall essential-agreement rates were 95.7% and 95.0%, and categorical-agreement rates were 96.2% and 96.0% for the respective incubation periods.Conclusions: Rapid pathogen ID and AST of positive blood cultures using shorter incubation times on solid media can significantly reduce turnaround time.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"185-187"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacotherapeutic Evaluation of Topical Insulin Versus Medicinal Honey Dressing in the Management of Diabetic Foot Ulcers among Patients with Diabetes Mellitus: A Randomized Controlled Trial. 局部胰岛素与药用蜂蜜敷料治疗糖尿病足溃疡的药物治疗评价：一项随机对照试验。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_89_26

K Chandramathi, B Tamilarasi, P Padmavathi

{"title":"Pharmacotherapeutic Evaluation of Topical Insulin Versus Medicinal Honey Dressing in the Management of Diabetic Foot Ulcers among Patients with Diabetes Mellitus: A Randomized Controlled Trial.","authors":"K Chandramathi, B Tamilarasi, P Padmavathi","doi":"10.4103/jpbs.jpbs_89_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_89_26","url":null,"abstract":"Background: Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus and a major cause of morbidity and lower limb amputation. Effective pharmacological interventions that enhance wound healing are essential for DFU management. Topical insulin has been shown to promote cellular proliferation and angiogenesis, whereas medicinal honey possesses antimicrobial, anti-inflammatory, and tissue regenerative properties.Objective: To compare the effectiveness of topical insulin therapy and medicinal honey dressing in promoting wound healing among patients with DFU.Methods: A randomized controlled superiority trial with a four-group pre-test and post-test design was conducted among 120 patients with Wagner grade I and II DFU. Participants were allocated into four experimental arms (n = 30 each). Experimental arms I and III received topical insulin dressing, whereas experimental arms II and IV received medicinal honey dressing. Wound healing was evaluated using the Bates-Jensen Wound Assessment Tool (BWAT) before and after intervention.Results: Both interventions significantly improved wound healing scores (P < 0.001). In the insulin groups, the paired t-test values were 16.91 and 15.91, while the honey dressing groups showed greater improvement with t-values of 22.35 and 28.17. The post-test mean wound scores were significantly lower in the honey dressing groups compared to the insulin groups, indicating enhanced healing.Conclusion: Both topical insulin and medicinal honey dressing are effective pharmacological adjuncts for DFU management. However, medicinal honey dressing demonstrated superior efficacy in promoting wound healing among patients with diabetes mellitus.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"221-223"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of Medication Adherence and Glycemic Control in Type 2 Diabetes Mellitus Patients on Oral Hypoglycemics versus Insulin Therapy. 口服降糖药与胰岛素治疗对2型糖尿病患者服药依从性及血糖控制的比较研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_121_26

Arpana Ashokbhai Patel, Rohan Mody, Jay Priteshkumar Shukla, Dhruv Chaudhari, Nirmit Udaybhai Patel

{"title":"Comparative Study of Medication Adherence and Glycemic Control in Type 2 Diabetes Mellitus Patients on Oral Hypoglycemics versus Insulin Therapy.","authors":"Arpana Ashokbhai Patel, Rohan Mody, Jay Priteshkumar Shukla, Dhruv Chaudhari, Nirmit Udaybhai Patel","doi":"10.4103/jpbs.jpbs_121_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_121_26","url":null,"abstract":"Background: Adherence to medication is a critical factor that affects the glycemic control in patients with type 2 diabetes mellitus (T2DM) and influences both short-term and long-term complications. The objective of the study was to assess the impact of medication adherence and glycemic control in patients with T2DM on oral hypoglycemic agents (OHAs) and insulin.Materials and methods: This 12-month prospective study involved 220 T2DM patients at a tertiary care hospital. The study cohort was divided into those on OHAs (n = 120) and insulin therapy (n = 100). Adherence was measured by the Morisky Medication Adherence Scale, and glycemic control was measured by levels of glycated hemoglobin (HbA1c).Results: The average age of the participants was 55.2 ± 11.8 years, and males were overrepresented (60%). Adherence was high among 68% of patients receiving OHAs and 52% of those receiving insulin (P = 0.02). The average HbA1c was lower in the OHA group (7.4% ±1.1%) than in the insulin group (8.2% ± 1.4%, P < 0.001). Glycemic control was also better in patients with high adherence (HbA1c 7.1% ± 0.9%) than low adherence (8.6% ± 1.3%, P < 0.001). Complexity of treatment, dose frequency, and injection fear were some factors that affected adherence in the insulin group.Conclusion: This study demonstrates that adherence is higher in patients treated with OHA and that it is associated with better glycemic control. Interventions to improve adherence in the insulin group are crucial for better management of diabetes.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"194-196"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Management of Acute Endodontic Infections in Children and Adults: A Comparative Clinical Study. 儿童和成人急性牙髓感染的药物治疗：一项比较临床研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-07-10 DOI: 10.4103/jpbs.jpbs_125_26

Shweta V Sagare, Balram Choudhary, Arpita Srivastava, Sugandha Sharma, Ayshita Khetarpal, Mohd Zeeshan Ahmad

{"title":"Pharmacological Management of Acute Endodontic Infections in Children and Adults: A Comparative Clinical Study.","authors":"Shweta V Sagare, Balram Choudhary, Arpita Srivastava, Sugandha Sharma, Ayshita Khetarpal, Mohd Zeeshan Ahmad","doi":"10.4103/jpbs.jpbs_125_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_125_26","url":null,"abstract":"Background: Acute endodontic infections are among the most common dental emergencies requiring prompt pharmacological intervention alongside operative treatment. Variations in host response, drug metabolism, and microbial flora between children and adults necessitate tailored pharmacological strategies.Methods: A prospective observational study was conducted on 120 patients presenting with acute endodontic infections, divided into two groups: children (n = 60; age 6-12 years) and adults (n = 60; age 18-60 years). Patients were managed with standardized pharmacological protocols including antibiotics (amoxicillin or amoxicillin-clavulanate), analgesics (ibuprofen or paracetamol), and adjunctive therapy when required. Clinical outcomes, including pain reduction (Visual Analog Scale [VAS] score), swelling resolution, and need for antibiotic escalation, were assessed over 5 days. Statistical analysis was performed using independent t-test and Chi-square test.Results: Mean baseline pain scores were compared between children (7.8 ± 1.1) and adults (8.1 ± 1.3; P = 0.18). By day 5, pain reduction was significantly greater in adults (VAS: 1.2 ± 0.6) compared to children (1.8 ± 0.9; P = 0.004). Swelling resolution occurred in 91.7% of adults and 83.3% of children (P = 0.18). Antibiotic escalation was required in 10% of children and 5% of adults (P = 0.31). Adverse drug reactions were minimal in both groups.Conclusion: Pharmacological management of acute endodontic infections is effective in both children and adults; however, adults demonstrate faster symptomatic relief. Tailored dosing and close monitoring are essential in pediatric populations.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"263-265"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Compare the Postoperative Sore Throat and Hoarseness in Difficult-Airway Adults Undergoing General Anesthesia with or without an Intubating Laryngeal Mask Airway Left Over the Endotracheal Tube. 比较气管插管后留喉罩或不留喉罩全麻成人术后喉咙痛及声音嘶哑的情况。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-07-01 Epub Date: 2026-04-22 DOI: 10.4103/jpbs.jpbs_19_26

Pallavi Paruthi, Sahil Maingi, Sajal Maingi, Amita Gupta

{"title":"To Compare the Postoperative Sore Throat and Hoarseness in Difficult-Airway Adults Undergoing General Anesthesia with or without an Intubating Laryngeal Mask Airway Left Over the Endotracheal Tube.","authors":"Pallavi Paruthi, Sahil Maingi, Sajal Maingi, Amita Gupta","doi":"10.4103/jpbs.jpbs_19_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_19_26","url":null,"abstract":"Background: Extubation in difficult airways patients may provoke cough and laryngospasm. To reduce airway irritation after intubation, Blockbuster Intubating Laryngeal Mask Airway (BBILMA) is mainly used.Materials and methods: Patients with difficult airway were divided into two groups with 20 patients in each. BBILMA was left inside the endotracheal tube even after extubation in the LT group. Mask airway was removed once the intubation was done in the ET group. Postoperative sore throat, cough, hoarseness, leak pressure, and hemodynamics were noted up to 48 hours in both the groups.Results: Both groups showed comparable demographics and extubation characteristics. Oropharyngeal leak pressures were almost similar-30.5 ± 5.4 (LT) and 28.8 ± 7.2 (ET). Fiberoptic scores were likewise comparable at 3.2 ± 0.7 (LT) and 3.1 ± 0.8 (ET). At 48 hours, the LT group reported cough in one patient and sore throat in four, with no hoarseness; the ET group reported cough in two patients, sore throat in four, and hoarseness in one.Conclusion: BBILMA does not increase postoperative throat discomfort when left in situ after extubation. Thereby, it is safe in difficult-airway cases.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"200-202"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0