Journal of pharmacy & bioallied sciences最新文献

{"title":"Evaluation of Salivary Biomarkers in the Early Detection of Oral Squamous Cell Carcinoma.","authors":"Deepak Kumar, Hiren Hansraj Patadiya, Anshul Sawhney, Hirenkumar R Chavda, Lubna Nazneen, Nivedita Sahoo, Miral Mehta, Ankur Jethlia","doi":"10.4103/jpbs.jpbs_1661_24","DOIUrl":"10.4103/jpbs.jpbs_1661_24","url":null,"abstract":"<p><strong>Background: </strong>The most prevalent malignant tumor affecting the oral cavity is called oral squamous cell carcinoma (OSCC). Improving patient outcomes and survival rates requires early identification. Salivary biomarkers have drawn a lot of interest as noninvasive diagnostic methods for early OSCC detection.</p><p><strong>Materials and methods: </strong>One hundred people participated in a cross-sectional research, 50 of whom had been diagnosed with OSCC and 50 of whom were healthy controls. Samples of unstimulated saliva were taken from each participant. The enzyme-linked immunosorbent test (ELISA) was used to measure the salivary levels of three biomarkers: tissue polypeptide-specific antigen (TPSA), matrix metalloproteinase-9 (MMP-9), and interleukin-6 (IL-6). Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic accuracy of the biomarker levels and compare them across groups using statistical analysis.</p><p><strong>Results: </strong>OSCC patients had substantially higher salivary levels of TPSA (12.5 ± 2.4 ng/mL), MMP-9 (400 ± 30 ng/mL), and IL-6 (35.2 ± 7.1 pg/mL) than healthy controls (TPSA: 4.2 ± 1.1 ng/mL; <i>P</i> < 0.001), MMP-9: 150 ± 20 ng/mL, and IL-6: 10.1 ± 2.3 pg/mL. High diagnostic accuracy was found by ROC analysis for TPSA (AUC = 0.85), MMP-9 (AUC = 0.87), and IL-6 (AUC = 0.89). When these indicators were combined, the early identification of OSCC had a 90% sensitivity and an 88% specificity.</p><p><strong>Conclusion: </strong>Salivary biomarkers with intriguing potential for OSCC early detection include TPSA, MMP-9, and IL-6. They are useful instruments for screening high-risk people because of their noninvasiveness and excellent diagnostic precision. It is advised that further longitudinal research be done to confirm these results and investigate how they may be used in therapeutic settings.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1319-S1321"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Staining and Bleaching protocol on Color Change of Bioactive Resin Composite Restorative Materials.","authors":"Shara Ismael Sajini","doi":"10.4103/jpbs.jpbs_8_25","DOIUrl":"10.4103/jpbs.jpbs_8_25","url":null,"abstract":"<p><strong>Background: </strong>Dental bleaching is a common procedure to enhance aesthetics, but it often interacts with existing composite restorations. While previous studies focused on conventional composites, it is important to evaluate the impact of bleaching on emerging bioactive composites.</p><p><strong>Aims: </strong>To investigate the color change of two bioactive resin composites compared to a conventional one and the effect of two bleaching sessions (two cycles and three cycles) on the stained composite resins.</p><p><strong>Materials and methods: </strong>Three light-cured resin composites-Tetric N-Ceram, Shade A2, Beauty II, shade A2, and Alkasite fluoride-releasing resin (Cention N)-were used for this study. Thirty sample discs were made. CIE, L*a*b* baseline color parameters were recorded by a lab-grade desktop spectrophotometer. The samples were in blueberry juice for 12 days. Fifteen samples were thermocycle and fifteen were bleached twice, each for three cycles. We estimated color change ΔE and whiteness index WID after thermocycling (Tt), before bleaching (T0), after the first bleaching session (T1), and after the second bleaching session (T2). Data was analyzed using one-way ANOVA, post-hoc Tukey's test, and paired <i>t</i>-test (<i>P</i> < 0.05).</p><p><strong>Results: </strong>All composites exhibited detectable color changes after staining and thermocycling, with no significant differences between materials. Bleaching led to significant changes in color and WID across all samples, with Beautifil showing the most substantial change. Moreover, the differences between the first and second bleach were not significant except for Cention N.</p><p><strong>Conclusion: </strong>The effects of staining and bleaching were similar across different resin composites, but the whiteness index indicated significant changes, particularly for Beautifil samples.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1960-S1965"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Microwave Disinfection on Gutta Percha Cones Against <i>Staphylococcus Aureus and Enterococcus Faecalis</i> - <i>An In vitro Study</i>.","authors":"Soundarya Devaraj, Swetha Venkatakrishnan, Shreenijha Ramkumar, Swetha K Bharadwaj, Dakshayani Balaji, Lokhasudhan Govindaraju","doi":"10.4103/jpbs.jpbs_1936_24","DOIUrl":"10.4103/jpbs.jpbs_1936_24","url":null,"abstract":"<p><strong>Background: </strong>Non-metallic dental materials like Gutta percha cones, ceramic crowns, endodontic posts are widely used material for the obturation of root canals, placement of post, crown and it is usually distributed by the manufacturers in sealed containers. Once exposed to dental environment or by handling and storage, there are more chances of getting contaminated by various microorganisms. The success of endodontic therapy depends on maintaining the aseptic condition throughout the procedure. To maintain an aseptic condition during endodontic procedures, chairside disinfection of endodontic material is more important. The aim of the study is to evaluate rapid and effective methods of disinfection of non-metallic dental materials using microwave against test organisms.</p><p><strong>Materials and methods: </strong>A total of 30 sample sizes with 5 per group consisting of gutta percha cones of size #30/0.09 taper were used and contaminated with Enterococcus faecalis and <i>Staphylococcus aureus</i> respectively. Further it was disinfected with 3% sodium hypochlorite (NaOCl), 3% NaOCl under microwave, and Distilled water under microwave for 30 sec and 1 min, respectively. The disinfected Gutta percha cones were evaluated by subculture and quantification of colonies formed.</p><p><strong>Conclusion: </strong>Microwave disinfection proved to be as effective as 3% and 5% Sodium hypochlorite against <i>Staphylococcus aureus</i> and <i>Enterococcus faecalis</i>. Hence, it proves to be a potential alternative way to disinfect gutta percha cones.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1823-S1826"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria.","authors":"Ibrahim Fazal, Vanshi Bangia, Ashutosh Yadav, Divya Batra, Sunil Kar, Sameer Gupta","doi":"10.4103/jpbs.jpbs_162_25","DOIUrl":"10.4103/jpbs.jpbs_162_25","url":null,"abstract":"<p><strong>Background: </strong>Peri-implantitis, a prevalent complication of dental implants, is characterized by inflammation and bone loss caused by bacterial colonization around the implant surface. Nano-hydroxyapatite (nHA)-coated implants have shown promise in enhancing osseointegration and providing antibacterial properties.</p><p><strong>Materials and methods: </strong>A total of 40 dental implants were divided into two groups: Group A (<i>n</i> = 20) comprised nHA-coated implants, and Group B (<i>n</i> = 20) comprised uncoated titanium implants (control). The implants were incubated with <i>Porphyromonas gingivalis</i>, <i>Fusobacterium nucleatum</i>, and <i>Aggregatibacter actinomycetemcomitans in vitro</i> for 7 days. Antibacterial efficacy was assessed by quantifying colony-forming units (CFUs) using culture techniques. Additionally, biofilm formation on implant surfaces was evaluated using scanning electron microscopy (SEM).</p><p><strong>Results: </strong>Group A demonstrated a significant reduction in bacterial adhesion and biofilm formation compared to Group B (<i>P</i> < .05). The mean CFU counts for <i>P. gingivalis</i>, <i>F. nucleatum</i>, and <i>A. actinomycetemcomitans</i> in Group A were 1.2 × 10⁴, 0.9 × 10⁴, and 0.8 × 10⁴, respectively, compared to 3.5 × 10⁴, 2.8 × 10⁴, and 2.4 × 10⁴ in Group B. SEM analysis revealed a thinner biofilm layer on nHA-coated implants, indicating superior antibacterial activity.</p><p><strong>Conclusion: </strong>Nano-hydroxyapatite-coated implants significantly inhibit the growth of peri-implantitis-associated bacteria and reduce biofilm formation, making them a promising alternative for reducing peri-implantitis risk. Further clinical studies are warranted to validate these findings.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1595-S1597"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Efficiency of Propofol and Dexmedetomidine for Hypotensive Anesthesia in ENT Operations.","authors":"P Kamesh Chandra, Dinesh Kumar Patel, Ranjeet Kumar Mohanty, Mohit Kulmi, Ramanpal Singh Makkad","doi":"10.4103/jpbs.jpbs_1751_24","DOIUrl":"10.4103/jpbs.jpbs_1751_24","url":null,"abstract":"<p><strong>Background: </strong>During ENT procedures, hypotensive anesthesia is essential for enhancing operative vision and reducing blood loss. Both dexmedetomidine and propofol are commonly used medications with different modes of action. The effectiveness of these medicines in producing controlled hypotension during ENT operations is assessed in this research.</p><p><strong>Materials and methods: </strong>Sixty individuals between the ages of 18 and 60 who were having elective ENT operations participated in a prospective randomized clinical study. Patients were split into two groups: 30 patients in Group A got an infusion of propofol, and 30 patients in Group B received an infusion of dexmedetomidine. During surgery, hemodynamic measures such as heart rate (HR) and mean arterial pressure (MAP) were monitored. A visual analog scale (VAS) with a range of 0 (poor) to 10 (excellent) was used to evaluate the quality of the surgical field. Recovery periods were compared, and blood loss was noted. A paired <i>t</i>-test and Chi-square test were used for statistical analysis, and a significance threshold of <i>P</i> < 0.05 was established.</p><p><strong>Results: </strong>The mean MAP for Group B was 60 ± 4 mmHg (<i>P</i> < 0.05), while the mean MAP for Group A was 65 ± 5 mmHg. Group A's mean heart rate was 72 ± 8 bpm, whereas Group B's was 68 ± 6 bpm (<i>P</i> = 0.03). Group B's average surgical field quality VAS score (8.5 ± 0.7) was substantially higher than Group A's (7.8 ± 0.9) (<i>P</i> = 0.01). Group B saw a 15% decrease in total blood loss when compared to Group A (<i>P</i> = 0.04). Group B took 12 ± 3 minutes longer to recover than Group A (10 ± 2 minutes), although the difference was not statistically significant (<i>P</i> = 0.08).</p><p><strong>Conclusion: </strong>During ENT procedures, dexmedetomidine was superior to propofol in terms of lowering intraoperative blood loss, enhancing surgical field quality, and producing controlled hypotension. Its usage, nevertheless, could be linked to somewhat longer recovery periods. In ENT procedures, dexmedetomidine is regarded as an excellent drug for hypotensive anesthesia.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1424-S1426"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Efficacy of Bioceramic versus Resin-Based Sealers in Endodontic Treatments: A Comparative Analysis.","authors":"Anjna Sharma, Pankaj Mishra, Rishiraj S Karki, Santosh K Singh","doi":"10.4103/jpbs.jpbs_254_25","DOIUrl":"10.4103/jpbs.jpbs_254_25","url":null,"abstract":"<p><strong>Background: </strong>Root canal therapy relies heavily on the effectiveness of the sealer used to ensure successful treatment outcomes. Bioceramic and resin-based sealers are commonly employed, each offering distinct advantages and drawbacks. This study aimed to compare the effectiveness of bioceramic versus resin-based sealers in root canal therapy, focusing on microbial leakage, seal integrity, postoperative pain, and healing rates.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted involving 120 patients who required root canal therapy. They were randomly assigned to receive either bioceramic or resin-based sealers. The primary outcomes were microbial leakage and seal integrity, evaluated through clinical and radiographic examinations. Secondary outcomes included postoperative pain and healing rates, monitored over a six-month follow-up period.</p><p><strong>Results: </strong>Bioceramic sealers significantly reduced microbial leakage and enhanced seal integrity compared to resin-based sealers (<i>P</i> < 0.05). Additionally, patients in the bioceramic group reported significantly less postoperative pain. However, there were no significant differences in healing rates between the two groups.</p><p><strong>Conclusion: </strong>Bioceramic sealers demonstrate superior clinical outcomes in terms of microbial leakage prevention and seal integrity, suggesting that they may be more beneficial than resin-based sealers in root canal therapy. These findings support the use of bioceramic materials for improving patient outcomes in endodontic treatments.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1680-S1682"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Quality of Life in Advanced Laryngeal and Oral Cancer Undergoing Extensive Surgeries.","authors":"Usha Armo, Harbansh Kumar Singh, Arpita Singh, Nageshwar Venkatesh Reddy, Sushil Kumar Sahoo, A R Lingaraju, Mahesh Ghadage, Dipooja Patil","doi":"10.4103/jpbs.jpbs_1738_24","DOIUrl":"10.4103/jpbs.jpbs_1738_24","url":null,"abstract":"<p><strong>Background: </strong>Advanced laryngeal and oral cancers significantly affect the patients' quality of life (QoL) due to the functional and psychosocial implications of the disease and its treatment. Surgical interventions, particularly extensive resections and reconstructions, are critical for disease control but may further impact QoL. This study aims to evaluate the QoL in patients undergoing extensive surgeries for advanced laryngeal and oral cancers.</p><p><strong>Materials and methods: </strong>A prospective cohort study was conducted, including 100 patients with advanced laryngeal and oral cancers undergoing extensive surgeries at a tertiary care hospital. QoL was assessed preoperatively and at three and six months postoperatively using the EORTC QLQ-C30 and EORTC QLQ-H and N35 questionnaires. Variables, such as functional scales, symptom scales, and global health status, were analyzed. Arbitrary values for QoL scores ranged from 0 (worst) to 100 (best). Data were analyzed using paired t-tests and repeated-measures ANOVA to evaluate changes over time.</p><p><strong>Results: </strong>The mean global health status score improved from 45 (±10) preoperatively to 60 (±12) at six months postoperatively (<i>P</i> < 0.05). Functional scales, such as swallowing and speech, showed significant improvements (swallowing: 40 ± 8 to 65 ± 10; speech: 50 ± 10 to 70 ± 9). Symptom scales for pain and fatigue demonstrated a significant reduction over the study period (pain: 70 ± 12 to 40 ± 8; fatigue: 65 ± 11 to 50 ± 9). However, social and emotional functioning scores remained suboptimal due to the stigma and psychological burden associated with cancer.</p><p><strong>Conclusion: </strong>Extensive surgeries for advanced laryngeal and oral cancers positively impact QoL by improving functional abilities and reducing symptoms. However, persistent challenges in social and emotional well-being highlight the need for comprehensive rehabilitative and supportive care post-surgery.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1412-S1414"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Anxiety-Induced Hemodynamics Response in Known Hypertensive Patients Undergoing Surgical Removal of Impacted Mandibular Third Molar Surgery: An Observational Study.","authors":"E S Shobha, M D Anagha, Vinod Rangan, Yashas N Raj, Meghana Patil, B K Ramnarayan","doi":"10.4103/jpbs.jpbs_476_25","DOIUrl":"10.4103/jpbs.jpbs_476_25","url":null,"abstract":"<p><strong>Background: </strong>Hemodynamic parameters such as systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and oxygen saturation (SpO₂) are critical in evaluating cardiovascular stability during surgical procedures. Anxiety, a common psychological condition, has been linked to hemodynamic fluctuations, particularly in hypertensive patients.</p><p><strong>Materials and methods: </strong>This observational study included 27 hypertensive patients scheduled for impacted third molar extraction under local anesthesia. Anxiety levels were assessed preoperatively using the Amsterdam Preoperative Anxiety and Information Scale (APAIS). Hemodynamic parameters (SBP, DBP, HR, and SpO₂) were measured preoperatively, intraoperatively, and postoperatively using a sphygmomanometer and pulse oximeter. Statistical analysis was conducted using the Wilcoxon signed rank test and Mann-Whitney test, with a significance threshold of <i>P</i> < 0.05.</p><p><strong>Results: </strong>A significant increase in HR was observed from preoperative (74.07 ± 3.78 bpm) to intraoperative (76.78 ± 6.08 bpm, <i>P</i> = 0.005), and from preoperative to postoperative (94.70 ± 3.75 bpm, <i>P</i> < 0.001). SpO₂ levels significantly decreased from preoperative (94.89 ± 4.40%) to postoperative (75.70 ± 5.68%, <i>P</i> < 0.001). Although SBP increased intraoperatively (129.26 ± 7.21 mmHg) compared to preoperative levels (127.52 ± 10.08 mmHg), the difference was not statistically significant (<i>P</i> > 0.05). However, a significant decline in SBP was noted postoperatively (126.52 ± 7.91 mmHg, <i>P</i> = 0.006). No significant variations in DBP were recorded across time points (<i>P</i> > 0.05). Gender-based comparisons revealed no significant differences in anxiety scores (<i>P</i> > 0.05), except for postoperative HR, which was significantly higher in females (95.61 ± 2.99 bpm) compared to males (92.89 ± 4.59 bpm, <i>P</i> = 0.043).</p><p><strong>Conclusion: </strong>Anxiety significantly impacts HR and SpO₂ levels in hypertensive patients undergoing impacted third molar extraction. Although SBP changes were significant postoperatively, DBP remained stable across time points.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1817-S1819"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Different Pit and Fissure Sealants for Caries Prevention in Community Settings.","authors":"Abdulraheem A Alwafi","doi":"10.4103/jpbs.jpbs_332_25","DOIUrl":"10.4103/jpbs.jpbs_332_25","url":null,"abstract":"<p><strong>Background: </strong>Pit and fissure sealants are widely used as a preventive measure against dental caries, especially in high-risk populations. Various types of sealants, including resin-based, glass ionomer, and bioactive materials, have been introduced with differing levels of retention and caries prevention efficacy. This study evaluates and compares the effectiveness of different sealant materials in preventing occlusal caries in a community-based setting.</p><p><strong>Materials and methods: </strong>A total of 400 school-aged children (6-12 years) were enrolled and randomly assigned to three groups based on the type of pit and fissure sealant used: Group A (resin-based sealant), Group B (glass ionomer sealant), and Group C (bioactive sealant). The sealants were applied following manufacturer instructions, and retention rates along with caries incidence were assessed at 6 and 12 months. Statistical analysis was performed using Chi-square tests and ANOVA to determine significant differences between groups.</p><p><strong>Results: </strong>At the 6-month follow-up, retention rates were highest in Group A (85%), followed by Group C (80%) and Group B (70%). At 12 months, retention declined to 75%, 72%, and 60% for Groups A, C, and B, respectively. Caries incidence after one year was lowest in Group A (7%), followed by Group C (9%) and Group B (15%), with statistically significant differences (<i>P</i> < 0.05). Resin-based and bioactive sealants demonstrated superior retention and caries prevention compared to glass ionomer sealants.</p><p><strong>Conclusion: </strong>All three types of sealants provided caries prevention benefits, but resin-based and bioactive sealants exhibited better retention and efficacy over time. Community-based programs should prioritize these materials for effective long-term caries prevention in children. Further research is needed to assess cost-effectiveness and long-term outcomes in diverse populations.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1761-S1763"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Dimensional Accuracy and Feasibility of an in House Desktop Printer for Preoperative Planning and Precontouring of Implants for Craniomaxillofacial Surgery.","authors":"Shahana Parveen, Dinesh Kumar, Mausumi Iqbal, Ayushi Mishra, Yogesh Garg, Shailesh Jain","doi":"10.4103/jpbs.jpbs_250_25","DOIUrl":"10.4103/jpbs.jpbs_250_25","url":null,"abstract":"<p><strong>Background: </strong>3D printing soon after its inception has spread globally as a useful tool in preoperative planning. Thus, this study aims to evaluate the accuracy and efficacy of the 3D printed models in preoperative surgical planning and prebending of implant adaptation for craniomaxillofacial surgery.</p><p><strong>Methods: </strong>A prospective study including 10 patients requiring complex maxillofacial management. A preoperative CBCT/CT scan of the patient was obtained in DICOM format was obtained, and data were converted to STL format by using Mimics software. Time taken for the surgery and amount of blood loss were also recorded. All patients were followed up at intervals of 1 week, 1 month, and 3 months for assessing facial symmetry.</p><p><strong>Results: </strong>Average time and blood loss during the operative procedure that was observed were 217.5 min and 405 mL, respectively. Evaluation of facial symmetry showed good facial symmetry (90%) and showed fair facial symmetry (10%), and there was the restoration of facial symmetry to a preoperative premorbid state.</p><p><strong>Conclusions: </strong>The present study suggests the advantages and outcomes of 3D printing technology surpass the limitations and thus recommends the use of a 3D printed model for preoperative planning for minor as well as major and complex craniomaxillofacial surgery.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1727-S1729"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}