{"title":"Comparative Evaluation of Antimicrobial Efficiency of Various Herbal Root Canal Irrigants.","authors":"Noura Alessa","doi":"10.4103/jpbs.jpbs_1252_25","DOIUrl":"10.4103/jpbs.jpbs_1252_25","url":null,"abstract":"<p><strong>Introduction: </strong>By reducing the bacterial load in root canals, irrigation contributes significantly to the disinfection of the root canal system.</p><p><strong>Objectives: </strong>The current research was done to assess antimicrobial efficiency of various herbal root canal irrigants against <i>E. Faecalis.</i></p><p><strong>Materials and method: </strong><i>Enterococcus faecalis,</i> reference strain ATCC 19433, was combined and cultivated with root canal irrigating solutions containing sodium hypochlorite (NaOCl), triphala, turmeric, and garlic (Allium sativum). After being cultivated on bile auscline agar, the samples were incubated for 24 hours at 37°C. The colony-forming units (CFU) were calculated. A statistical analysis was performed on the collected data.</p><p><strong>Result: </strong>There was highest antimicrobial efficacy and greater reduction of CFU with group IV followed by groups II, I, and III. The difference was statically significant.</p><p><strong>Conclusion: </strong>Tested herbal irrigants were effective in reducing <i>E faecalis</i> count. They can be suggested to use alternative to NaOCl.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"144-146"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early Trichoscopic Changes of Minoxidil Therapy in Male Pattern Hair Loss: A Prospective Cohort Study.","authors":"Neha Shukla, Chandra Shekhar Jaiswal, Jyoti Nagwanshi, Dileep Dandotiya, Ranjana Sharma","doi":"10.4103/jpbs.jpbs_1711_24","DOIUrl":"10.4103/jpbs.jpbs_1711_24","url":null,"abstract":"<p><strong>Background: </strong>Minoxidil 5% is a primary treatment for male pattern hair loss, but initial increased shedding can reduce compliance. While effective, early changes are not visible to the naked eye. Trichoscopy is a rapid, cost-effective tool for diagnosing hair disorders, yet no studies have examined its role in assessing early minoxidil effects. This study aims to evaluate trichoscopic changes in early minoxidil therapy to improve patient compliance.</p><p><strong>Methodology: </strong>A prospective cohort study was conducted from February 2019 to August 2020 at MGM Medical College and MY Hospital, Indore. Male patients with hair loss were evaluated using trichoscopy by a single observer. Other causes of hair loss were excluded.</p><p><strong>Results: </strong>Minor adverse effects were reported in 45.5% of subjects, with 20% experiencing scalp dryness, 11% increased shedding, and 14% both. Overall, 70% of patients were satisfied with minoxidil therapy. The mean hair loss duration was 13 months, and the most common presentation was N-H grade III. Family history was positive in 78 subjects.</p><p><strong>Conclusion: </strong>Trichoscopy enhances early assessment of minoxidil therapy in male pattern hair loss, improving satisfaction and compliance. Positive changes can be observed within one month, encouraging continued treatment adherence.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"108-111"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fentanyl and Propofol Versus Fentanyl and Etomidate for the Insertion Conditions of Laryngeal Mask Airway: A Prospective Observational Study.","authors":"Rashmi Pal, Ankita Verma, Deepali Valecha","doi":"10.4103/jpbs.jpbs_1246_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_1246_25","url":null,"abstract":"<p><strong>Background: </strong>Laryngeal mask airway (LMA) is often used in short surgeries for its easy insertion and minimal invasiveness but successful placement needs reflex suppression and stable vitals. This study compared Fentanyl-Propofol which gives better insertion but may cause hypotension with Fentanyl-Etomidate which maintains hemodynamics but causes more myoclonus.</p><p><strong>Material and methods: </strong>60 American Society of Anesthesiologists I-II patients aged 18-60 years were included in this prospective study. Group A got Fentanyl + Propofol. Group B got Fentanyl + Etomidate. We compared attempts, time, ease, vitals, and side effects.</p><p><strong>Results: </strong>Group A had better insertion, first attempt success 90% versus 60%, time 23.27s versus 80.63s, and ease 96.67% versus 66.67%. Group B showed more myoclonus (43.33%), jaw tightness, and limb movements. Hemodynamics gets better with etomidate.</p><p><strong>Conclusion: </strong>Fentanyl-Propofol is better for smooth LMA insertion. Etomidate useful in unstable patients but may need caution due to insertion issues.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"112-114"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental Injuries: A Database Research.","authors":"Shilpa Shetty, Khushboo Changani, Anjum Patan, Pratik Agrawal, Anil M Managutti, Rahul Tiwari","doi":"10.4103/jpbs.jpbs_552_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_552_25","url":null,"abstract":"<p><strong>Background: </strong>Traumatic dental injuries (TDIs) often compromise the dentin-pulp complex, necessitating innovative therapeutic approaches. Stem cell therapy has emerged as a promising solution for regenerative endodontics.</p><p><strong>Objective: </strong>This research investigates the application of stem cell therapy in regenerating dentin for patients with TDIs by using a retrospective analysis of clinical outcomes.</p><p><strong>Methods: </strong>A retrospective data analysis was performed on 120 cases involving TDIs treated with stem cell-based interventions. Key parameters included patient demographics, clinical outcomes, and histological findings. Statistical significance was assessed using a <i>P</i> value of <0.05.</p><p><strong>Results: </strong>Significant improvement in dentin regeneration was observed in 85% of cases treated with stem cell therapy. Histological findings confirmed the formation of tubular dentin in 75% of cases. Younger patients exhibited superior outcomes compared to older cohorts.</p><p><strong>Conclusion: </strong>Stem cell therapy demonstrates significant potential for regenerating dentin in TDIs. Future studies should explore long-term outcomes and optimization of protocols.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"102-104"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scientific Validation of <i>Antarnakhamushti Pramana</i> in <i>Madanaphala Pippali Churna</i> for Emesis Therapy.","authors":"Shweta Parwe, Shoaib Sheikh, Milind Nisargandha","doi":"10.4103/jpbs.jpbs_359_25","DOIUrl":"10.4103/jpbs.jpbs_359_25","url":null,"abstract":"<p><p><i>Charakacharya</i> has told six different <i>vamaka dravyas: Madanaphala</i>, <i>Jimutaka</i>, <i>Ikshwaku</i>, <i>Dhamargava</i>, <i>Vatsaka,</i> and <i>Krutavedhan</i>. Out of these <i>dravyas, Madanaphala</i> is the most common <i>dravya</i> used for <i>Vamana</i>. To determine the average dose of <i>Madanaphala Pippali churna</i> for <i>Vamana.</i> It was found that 2-3 g is sufficient for the average dose <i>Vamana</i>. With this, dose Vamana is a comfortable procedure for Prakriti, age and gender.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"87-89"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adeeba Shabnam, Nipun Addla, Etikala Pravallika Reddy, Abdulla Mohammad Usman Nalband, Sheetal Mujoo, Radhe Shyam Singh
{"title":"ENHANCED: Assessment of Effects of Reducing Opioid Use Through Multimodal Anesthesia in Recovery Protocols: A Clinical Study.","authors":"Adeeba Shabnam, Nipun Addla, Etikala Pravallika Reddy, Abdulla Mohammad Usman Nalband, Sheetal Mujoo, Radhe Shyam Singh","doi":"10.4103/jpbs.jpbs_563_25","DOIUrl":"10.4103/jpbs.jpbs_563_25","url":null,"abstract":"<p><strong>Background: </strong>Opioid-based analgesia has been a cornerstone of postoperative pain management. However, its extensive use is associated with significant risks, including dependency and adverse side effects. Multimodal anesthesia (MMA) strategies, combining various pharmacological and non-pharmacological interventions, have been proposed to reduce opioid use, while maintaining effective analgesia.</p><p><strong>Methods: </strong>Clinical research was led with subjects undergoing elective surgeries. Patients were divided into two groups: one receiving traditional opioid-based anesthesia (TOA) and the other utilizing MMA. Pain scores, recovery time, and opioid consumption were assessed.</p><p><strong>Results: </strong>Patients in the MMA group demonstrated significantly lower opioid consumption (<i>P</i> < 0.05) and improved recovery times compared to the traditional group. Pain scores were comparable across both groups, with a slight advantage observed in the MMA cohort.</p><p><strong>Conclusion: </strong>MMA effectively reduces opioid requirements without compromising pain control, potentially enhancing postoperative recovery. Further studies are warranted to establish long-term outcomes.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"131-133"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Single-Dose Preoperative Dexamethasone in Managing Pain, Swelling, and Trismus After Impacted Mandibular Third Molar Surgery: A Clinical Study.","authors":"Prashant B Tamgadge, Bhavik Ramanlal Patel, Eklavya Sharma, Harish Kumar, Parth Tushar Parekh, Sameer Gupta, Amardeep Arun","doi":"10.4103/jpbs.jpbs_466_25","DOIUrl":"10.4103/jpbs.jpbs_466_25","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of a single preoperative intramuscular injection of dexamethasone in reducing trismus, swelling, and pain following the surgical removal of impacted mandibular third molars.</p><p><strong>Materials and methods: </strong>This research had 60 participants aged 18-30 years, all requiring bilateral extraction of mandibular third molars. A single-blind methodology was employed, assigning the right side as the test site to receive 4 mg of intramuscular dexamethasone, while the left side served as the control, receiving a placebo of sterile water. Assessments for pain, mouth opening, and swelling were conducted before the procedure and again on the 2<sup>nd</sup> and 7<sup>th</sup> postoperative days, utilizing the Visual Analog Scale (VAS), interincisal distance measurements, and specific facial landmarks for swelling evaluation.</p><p><strong>Results: </strong>The test site exhibited significantly lower pain scores compared to the control site on both the 2<sup>nd</sup> and 7<sup>th</sup> days. Mouth opening was significantly improved in the dexamethasone group, and facial swelling was significantly reduced by the 7<sup>th</sup> day (<i>P</i> < 0.05). No adverse reactions were reported.</p><p><strong>Conclusion: </strong>A single preoperative dose of dexamethasone effectively reduces postoperative trismus, swelling, and pain, enhancing recovery and patient satisfaction. Its use is recommended for third molar surgeries to manage postoperative sequelae.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"105-107"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Biruntha, V Jiji, N T Arunadevi, Biji Kuriakose, Mary Velanganni
{"title":"Short-Term Effects of Betamethasone Administration on Fetal Heart Rate Patterns in Preterm Contraction.","authors":"S Biruntha, V Jiji, N T Arunadevi, Biji Kuriakose, Mary Velanganni","doi":"10.4103/jpbs.jpbs_1609_25","DOIUrl":"10.4103/jpbs.jpbs_1609_25","url":null,"abstract":"<p><strong>Background: </strong>Preterm labor is a leading cause of neonatal morbidity and mortality worldwide. Antenatal corticosteroid therapy, particularly betamethasone, is widely used to improve neonatal outcomes.</p><p><strong>Aim: </strong>To evaluate the short-term effects of maternal betamethasone administration on fetal heart rate variability using nonstress test (NST) tracings in preterm labor.</p><p><strong>Methods: </strong>A prospective study was conducted on 62 pregnant women with preterm contractions between 28-34 weeks of gestation admitted to St. John's Medical College Hospital. Participants received two intramuscular doses of betamethasone (12 mg each, 12 hours apart). Serial cardiotocography recordings were performed at baseline and at 12, 24, 36, 48, 60, 72, and 84 hours after administration. NST parameters assessed included baseline FHR, beat-to-beat variability, accelerations, and decelerations. Data were analyzed using ANOVA and paired proportion tests, with significance set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>Betamethasone administration was associated with a transient reduction in baseline FHR and beat-to-beat variability, most pronounced at 24-36 hours postadministration, with subsequent normalization by 72 hours (<i>P</i> < 0.0001). Accelerations also decreased initially but recovered over time, while decelerations remained absent across all recordings.</p><p><strong>Conclusion: </strong>Maternal betamethasone causes temporary, reversible alterations in fetal heart rate variability and accelerations without adverse perinatal outcomes.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"150-152"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protocol of Comparative Efficacy of the <i>Timirghnatraifalam Ghruta</i> verses <i>Triphaladi Ghruta</i> Systemically Together with <i>Padabhyanga</i> in the Control of Non-Pathological Myopia.","authors":"Amit Chandankhede, Roshna Bhutada, Praveena Kher","doi":"10.4103/jpbs.jpbs_1198_25","DOIUrl":"10.4103/jpbs.jpbs_1198_25","url":null,"abstract":"<p><p>Myopia, usually called shortsightedness, is the maximum common vicinity eye sickness within facet the globe with good sized social, educational, and monetary impact. As per Ayurveda, myopia can be correlated with <i>Pratham Patalagata Timira</i> presenting symptoms of blurred vision, squinting, eye rubbing, and impaired vision. Even though ophthalmology has advanced significantly in the modern era, there is currently no effective and widely recognized treatment for myopia. Existing treatment for myopia correction leads to corneal scarring, corneal infections from contact lens use, and persistent ocular haze from refractive surgery. Many local therapeutic procedures like <i>Nasya, Anjana, Akshi-tarpana,</i> etc., have been advised for the management of <i>Timira</i> with its published clinical evidence. However, this procedures needs to be done under experts vigilance on regular basis which sometimes is not friendly with patients times, convenience, routine, cost etc. Present protocol put up oral administration of <i>Chakshushya ghruta</i> (medicated ghee prepared from ingredients beneficial to eyes) instead of established procedures of <i>Kriyakalpa</i> (local procedures of eyes). It is framed with the objective to observe comparative efficacy of <i>Timirghnatraifalam Ghruta</i> verses <i>Triphaladi Ghruta</i> systemically together with <i>Padabhyanga</i> (foot massage) in management of non-pathological myopia.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"153-155"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M R Murali, Kolasani Balaram, Rahul Tiwari, Heena D Tiwari, Radhika Omprakashji Daga, Akanksha Joon, Anil M Managutti
{"title":"Aphrodisiac Drug and Dental Health: A Systematic Review.","authors":"M R Murali, Kolasani Balaram, Rahul Tiwari, Heena D Tiwari, Radhika Omprakashji Daga, Akanksha Joon, Anil M Managutti","doi":"10.4103/jpbs.jpbs_936_25","DOIUrl":"10.4103/jpbs.jpbs_936_25","url":null,"abstract":"<p><p>Aphrodisiac drugs, including both synthetic agents such as sildenafil and herbal formulations like ginseng, are widely used for enhancing sexual function. Emerging evidence suggests these agents may also impact oral and periodontal health, though the relationship remains underexplored. To systematically evaluate the effects of aphrodisiac drugs on dental and oral health outcomes. This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was performed to identify studies from 2000 to 2025. Inclusion criteria encompassed original studies involving aphrodisiac drugs with reported oral health outcomes. Reviews, animal studies, <i>in vitro</i> research, and clinical trials were all considered. Ten studies met the eligibility criteria. Sildenafil was associated with reduced alveolar bone loss and inflammation in preclinical models. Ginsenosides demonstrated strong anti-inflammatory, antimicrobial, and osteogenic activity. One clinical trial found red ginseng mouth rinse comparable to chlorhexidine in plaque control. Overall, ginseng-derived compounds showed promise in managing periodontitis and maintaining oral health. Both synthetic and herbal aphrodisiac agents exhibit potential oral health benefits, especially in periodontal therapy. Further clinical research is essential to confirm their safety, efficacy, and applicability in dental care.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"90-92"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}