{"title":"宫内发育迟缓胎儿与正常新生儿脐带血管的组织形态学变化。","authors":"Dinesh Kumar, Jagdish S Soni","doi":"10.4103/jpbs.jpbs_543_25","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Three vessels-one vein and two arteries-allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies.</p><p><strong>Materials and methods: </strong>The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment.</p><p><strong>Results: </strong>This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes.</p><p><strong>Conclusion: </strong>The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S770-S773"},"PeriodicalIF":0.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156640/pdf/","citationCount":"0","resultStr":"{\"title\":\"Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates.\",\"authors\":\"Dinesh Kumar, Jagdish S Soni\",\"doi\":\"10.4103/jpbs.jpbs_543_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Three vessels-one vein and two arteries-allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies.</p><p><strong>Materials and methods: </strong>The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment.</p><p><strong>Results: </strong>This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes.</p><p><strong>Conclusion: </strong>The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders.</p>\",\"PeriodicalId\":94339,\"journal\":{\"name\":\"Journal of pharmacy & bioallied sciences\",\"volume\":\"17 Suppl 1\",\"pages\":\"S770-S773\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156640/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pharmacy & bioallied sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jpbs.jpbs_543_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacy & bioallied sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jpbs.jpbs_543_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates.
Background: Three vessels-one vein and two arteries-allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies.
Materials and methods: The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment.
Results: This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes.
Conclusion: The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders.
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