Journal of pharmacy & bioallied sciences最新文献

{"title":"Drug Utilization Pattern and Maternal Outcomes of Obstetric Medications in Antenatal and Postnatal Women at a Tertiary Care Hospital.","authors":"A Saridha Prema, S D Kavitha, P Padmavathi","doi":"10.4103/jpbs.jpbs_124_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_124_26","url":null,"abstract":"<p><strong>Background: </strong>Rational drug use in obstetrics is essential to ensure maternal safety and optimal pregnancy outcomes. Drug utilization studies help evaluate prescribing patterns and identify areas for improvement.</p><p><strong>Objective: </strong>To assess the drug utilization pattern and evaluate maternal outcomes associated with obstetric medications in antenatal and postnatal women at a tertiary care hospital.</p><p><strong>Methods: </strong>A prospective observational study was conducted over six months in a tertiary care hospital. A total of 200 antenatal and postnatal women receiving medications were included. Data on demographics, drug prescriptions, and maternal outcomes were collected. Statistical analysis was performed using SPSS version 25.0. Chi-square test, independent <i>t</i>-test, and multivariate logistic regression were applied. A <i>P</i> value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age was 26.8 ± 4.2 years. The average number of drugs prescribed per patient was 5.2 ± 1.3. Iron supplements (92%) and folic acid (89%) were the most commonly prescribed drugs. Favorable maternal outcomes were observed in 88% of cases. Multivariate analysis revealed antihypertensive use (AOR = 3.56, <i>P</i> = 0.001), polypharmacy (AOR = 2.83, <i>P</i> = 0.006), primigravidity (AOR = 2.14, <i>P</i> = 0.047), and antibiotic use (AOR = 1.89, <i>P</i> = 0.041) as independent predictors of complications.</p><p><strong>Conclusion: </strong>Although maternal outcomes were largely favorable, polypharmacy and high-risk drug use were significantly associated with complications. Rational prescribing practices should be emphasized.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"227-229"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miRNA-377 as an Epigenetic Regulator and Diagnostic Biomarker in the Early Detection and Progression of Diabetic Nephropathy: A Cross-Sectional Analytical Study.","authors":"D Ponnudhali, S Lakshmiprabha, Priya K Dhas, P Nagarajan","doi":"10.4103/jpbs.jpbs_127_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_127_26","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is a leading microvascular complication of diabetes and a major cause of end-stage renal disease. Conventional biomarkers such as albuminuria fail to detect early renal injury. MicroRNA-377 (miRNA-377) has emerged as a potential epigenetic regulator involved in renal fibrosis and extracellular matrix accumulation.</p><p><strong>Aim: </strong>To evaluate circulating miRNA-377 expression across different stages of DN and determine its diagnostic utility.</p><p><strong>Methods: </strong>This analytical cross-sectional study included 132 participants categorized into healthy controls (<i>n</i> = 35), type 2 diabetes mellitus (T2DM) with normoalbuminuria (<i>n</i> = 32), microalbuminuria (<i>n</i> = 32), and macroalbuminuria (<i>n</i> = 33). Plasma miRNA-377 expression was quantified using reverse transcription polymerase chain reaction (RT-PCR) and analyzed by the Livak method. Clinical, biochemical, and renal parameters were assessed. Statistical analysis included ANOVA, Spearman correlation, receiver operating characteristic (ROC) curve, and multinomial regression.</p><p><strong>Results: </strong>miRNA-377 expression showed significant upregulation in microalbuminuria (<i>P</i> = 0.022) and macroalbuminuria (<i>P</i> = 0.014). It demonstrated strong correlation with urinary albumin-to-creatinine ratio (UACR) (<i>r</i> = 0.510, <i>P</i> < 0.001) and moderate correlation with HbA1c (<i>P</i> = 0.04). ROC analysis showed good diagnostic performance (area under the curve [AUC] =0.811). Multinomial regression confirmed miRNA-377 as an independent predictor of DN progression.</p><p><strong>Conclusion: </strong>Circulating miRNA-377 is significantly associated with DN severity and may serve as a promising non-invasive biomarker for early detection and disease stratification.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"230-232"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Evaluation of the Positional Accuracy of Implant Scan Bodies in All-On-Four Patients Using Digital Approach-A Controlled Clinical Trial.","authors":"Y Vijaya Lakshmi, D Sumanth Saketh, N R Dedeepya, P Ramesh, Moulinath Chikati Deepak, T Ankanna","doi":"10.4103/jpbs.jpbs_73_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_73_26","url":null,"abstract":"<p><strong>Aim: </strong>To compare the positional accuracy of the scan body obtained in indirect and direct-indirect digital approaches with that of the direct digital approach.</p><p><strong>Materials and methods: </strong>Twenty implants were placed, each maxilla of four, using All-On-Four concept in five patients. Three impression techniques have been applied to each patient, namely 1) direct digital approach, 2) indirect digital approach, and 3) direct-indirect digital approach. With the use of specialized 3D inspection and metrology software, the difference in scan body position between the groups was calculated.</p><p><strong>Results: </strong>The average total deviation values for the two groups under examination were 343.15 ± 3.4 μm and 402.79 ± 2.6 μm, respectively. For each of the study groups, the deviation measurement between the superimposed scan bodies revealed statistically significant (<i>P</i> = 0.006) differences. A statistically insignificant difference between the compared groups was found by the <i>post</i> <i>hoc</i> analysis (<i>P</i> = 0.006 and 0.014).</p><p><strong>Conclusion: </strong>The direct-indirect digital impression group displayed the least positional accuracy (402.79 ± 2.6 μm). The accuracy of all three digital impression-making approaches in implant dentistry appears to be clinically acceptable and adequate for all types of implant restorations, especially in All-on-Four treatment modality.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"236-238"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Buerger Allen Exercise as an Adjunct to Standard Pharmacotherapy in Reducing Peripheral Neuropathy Symptoms Among Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Pilot Study.","authors":"Suganthakumari Francis, Anuratha Matipol Dharmalingam","doi":"10.4103/jpbs.jpbs_123_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_123_26","url":null,"abstract":"<p><strong>Background: </strong>Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 Diabetes Mellitus (T2DM) with limited response to pharmacotherapy alone. Adjunct non-pharmacological interventions may enhance treatment outcomes.</p><p><strong>Aim: </strong>To evaluate the effectiveness of Buerger Allen Exercise as an adjunct to standard pharmacotherapy in reducing peripheral neuropathy symptoms among patients with T2DM.</p><p><strong>Materials and methods: </strong>A pilot randomized controlled study with a pretest-posttest repeated measures design was conducted among 20 patients with T2DM and DPN. Participants were randomly allocated into experimental (<i>n</i> = 10) and control (<i>n</i> = 10) groups using a lottery method. Both groups received standard pharmacotherapy, while the experimental group additionally performed Buerger Allen Exercise for 15 days. Neuropathy symptoms were assessed at baseline, day 5, day 10, and day 15 using a structured neuropathy assessment scale. Data were analyzed using repeated measures ANOVA and <i>t</i>-tests.</p><p><strong>Results: </strong>The experimental group showed a statistically significant reduction in neuropathy scores compared to the control group (<i>P</i> < 0.05). A significant time-group interaction was observed, indicating progressive improvement with intervention.</p><p><strong>Conclusion: </strong>Buerger Allen Exercise is an effective short-term adjunct therapy in reducing symptoms of diabetic peripheral neuropathy. Larger studies are required to confirm long-term benefits.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"224-226"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxicity Test of Ethyl Acetate Fraction of <i>Gnetum gnemon</i> L. Seeds on Breast and Colon Cancer Cells: Preliminary Investigation of Catechin Compounds.","authors":"Asep Sukohar, Muhammad Iqbal, Ramadhan Triyandi, Sahidin","doi":"10.4103/jpbs.jpbs_1651_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_1651_25","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer and colon cancer are critical problems today that require effective and safe treatment. Long-term use of synthetic drugs can cause high side effects; therefore, natural-based chemopreventive agents are an option. Melinjo seeds are known for their resveratrol compounds which have been proven as chemopreventive agents. Meanwhile, catechins are polyphenols that are effective as antioxidants and anticancer agents. This study aims to determine the cytotoxic effect of the ethyl acetate fraction of melinjo seeds on breast and colon cancer cells based on the activity of catechin compounds.</p><p><strong>Methods: </strong>This study is experimental. Extraction was carried out by soxhletation method, followed by fractionation using ethanol and ethyl acetate (1:1, v/v). Identification of catechin in the ethyl acetate fraction of melinjo seeds was performed using high-performance liquid chromatography (HPLC). Cytotoxic testing was carried out <i>in vitro</i> by determining the IC₅₀ of fractions against breast (MCF-7) and colon (CACO-2) cancer cells.</p><p><strong>Results: </strong>The results of the study showed that the IC₅₀ of the ethyl acetate fraction of melinjo seeds against MCF-7 and CACO-2 cells was 111.28 and 218.26 ppm, respectively. HPLC elution showed that the standard catechin had a retention time of 7.160 min. The ethyl acetate fraction also showed a retention time close to 7.263, 7.130, and 6.873 min. The concentration of catechin in the ethyl fraction of melinjo seeds was 65.05 ppm. The Fourier transform infrared spectrum showed that the ethyl acetate fraction of melinjo seeds contained catechins.</p><p><strong>Conclusion: </strong>This study proves that the ethyl acetate fraction of melinjo seeds has a moderate cytotoxic effect on MCF-7 breast and CACO-2 colon cancer cells. It is suggested that catechins may play a role in this ytotoxic effect. Further research is needed to determine the cellular action of catechins that supports their cytotoxic effect.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"169-174"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Magnetic Resonance Imaging in Acute Head Injury Patients with Normal Computed Tomography Brain Findings.","authors":"M Ashwanth Narayanan, T Shriram, J R Rohith, J Sakthi Saravanan","doi":"10.4103/jpbs.jpbs_52_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_52_26","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a major cause of morbidity and mortality. Computed tomography (CT) is the first-line imaging modality in acute head injury; however, patients with altered neurological status may show normal CT findings. Magnetic resonance imaging (MRI), with superior soft-tissue contrast, can detect subtle intracranial injuries missed on CT.</p><p><strong>Aim: </strong>To evaluate the role of MRI in head injury patients with altered Glasgow Coma Scale (GCS) scores and normal CT findings.</p><p><strong>Materials and methods: </strong>This hospital-based cross-sectional study was conducted in the Department of Radiology, Aarupadai Veedu Medical College and Hospital, Puducherry, from November 2023 to May 2024. Ninety-two patients aged 18-60 years with acute traumatic head injury, altered GCS, and normal CT brain findings were included. MRI was performed using a 1.5-T scanner with T1 Weighted Imaging (T1W), T2 Weighted Imaging (T2W), T2 Fluid Attenuated Inversion Recovery (T2-FLAIR), Diffusion Weighted Imaging (DWI), and Susceptibility Weighted Imaging (SWI) sequences. MRI findings were correlated with GCS scores. Data were analyzed using descriptive statistics and Chi-square test, with <i>P</i> < 0.05 considered significant.</p><p><strong>Results: </strong>MRI detected small contusions (81.5%), edema (80.4%), thin SDH (60.9%), microhemorrhages (48.9%), nonhemorrhagic DAI (46.7%), hemorrhagic DAI (34.8%), brainstem injury (41.3%), and thin SAH (28.3%). Hemorrhagic DAI, nonhemorrhagic DAI, microhemorrhages, and edema showed significant association with GCS scores (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>MRI is an essential complementary modality in acute head injury with normal CT findings, improving diagnostic accuracy, prognostication, and clinical management.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"178-181"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Structured School-Based Emotional Intelligence Intervention on Stress Reduction and Psychological Well-being Among Adolescents: A Randomized Controlled Pilot Study.","authors":"G Mahalakshmi, P Padmavathi","doi":"10.4103/jpbs.jpbs_134_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_134_26","url":null,"abstract":"<p><strong>Background: </strong>Adolescent stress and compromised psychological well-being are emerging public health concerns with long-term neurobehavioral implications. Emotional intelligence (EI)-based interventions have shown promise but remain underutilized in structured school settings in India.</p><p><strong>Aim: </strong>To evaluate the effectiveness of a structured school-based EI program on stress reduction and psychological well-being among adolescents.</p><p><strong>Methods: </strong>A randomized controlled pilot study was conducted among 26 adolescents (13 experimental, 13 control) in a selected school in Coimbatore. Baseline and postintervention assessments were conducted using standardized tools: Students' Stress Rating Scale and Brief Psychological Well-being Scale. The intervention consisted of a structured EI training module delivered over multiple sessions. Statistical analysis included paired and unpaired <i>t</i>-tests and Chi-square tests.</p><p><strong>Results: </strong>Postintervention, the experimental group demonstrated a significant reduction in stress scores (<i>t</i> = 18.10, <i>P</i> < 0.05) and a significant improvement in psychological well-being (<i>t</i> = 21.42, <i>P</i> < 0.05) compared to controls. The intervention resulted in a 57% reduction in stress and a 44% improvement in well-being scores.</p><p><strong>Conclusion: </strong>The school-based EI program was highly effective in improving psychological well-being and reducing stress among adolescents. Integration of EI training into school curricula is recommended as a preventive mental health strategy.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"233-235"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bond Strength of Different Surface-Treated Translucent Zirconia Blocks Luted with Universal Resin Cement to Glass-Reinforced Core Composite Before and After Aging: An <i>In vitro</i> Study.","authors":"Anusha Yalamanchi, Kamalashankar Palaneeswaran, Anjan K Thyagaraajen, V Vetriselvi, Prateek N Daga, Guru P Ramani, Nagappan Nagappan","doi":"10.4103/jpbs.jpbs_77_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_77_26","url":null,"abstract":"<p><strong>Background: </strong>Zirconia crowns are increasingly popular due to their optical properties, minimal preparation, high strength, and biocompatibility.</p><p><strong>Aim: </strong>To evaluate the effect of silane alone and silane with subsequent heat treatment on the shear bond strength of translucent zirconia luted to a glass-reinforced core composite with universal resin cement.</p><p><strong>Materials and methods: </strong>Thirty zirconia blocks (12 mm × 12 mm × 3 mm) were milled using a computer-aided design/computer-aided manufacturing machine and fully sintered from a zirconia blank. The specimens were divided into three groups based on the surface pretreatments performed-non-surface-treated group (Group 1), silanized group (Group 2), and silanized and heat-treated group (Group 3).</p><p><strong>Results: </strong>Shear bond strength was significantly influenced by silanization and heat treatment. Group 3 showed the highest shear bond strength, followed by Group 2, while Group 1 showed the least bond strength.</p><p><strong>Conclusions: </strong>Silanization with 1% silane significantly enhanced the bonding of composite resin to zirconia. Heat treatment further increased the bond strength of silane-pretreated zirconia.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"239-241"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Strategies for Postoperative Pain Control in Patients Undergoing Cardiac Surgery: A Mixed Methods Systematic Review of Clinical Efficacy, Opioid Consumption, Patient Experience, and Nursing Care.","authors":"Saranya Rajendran, Kamala Kuppusamy, SanthoshKumar Jayakumar","doi":"10.4103/jpbs.jpbs_68_26","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_68_26","url":null,"abstract":"<p><p>Postoperative pain following cardiac surgery remains a major challenge that can delay recovery, increase opioid use, and hinder rehabilitation. This systematic review evaluated mixed methods evidence on pharmacological pain management strategies and their integration with nursing care in adult patients undergoing cardiac surgery. A comprehensive search of PubMed, Scopus, Web of Science, CINAHL, and Google Scholar was conducted from database inception to December 2025 following PRISMA 2020 guidelines. Four mixed methods studies met the inclusion criteria. Pharmacological interventions included opioids, paracetamol, nonsteroidal anti-inflammatory drugs, gabapentinoids, ketamine, dexmedetomidine, and multimodal analgesic regimens. These approaches were associated with reduced postoperative pain, 15-38% lower opioid consumption, shorter intensive care unit stays, and improved rehabilitation. Qualitative findings emphasized patients' concerns regarding opioid dependence and sedation while highlighting the importance of nurse-led education and individualized pain assessment. Overall, multimodal opioid-sparing analgesic strategies integrated with patient-centered nursing care appear to enhance postoperative recovery after cardiac surgery, although further high-quality mixed methods research is required to strengthen the evidence.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"157-159"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of a Single-Center Voriconazole TDM Bioassay for Hospitalized Patients with Invasive Fungal Infections.","authors":"Sevitha Venkatesan, Arati Bhadade, Madhu Panthi, Saurabh Saigal, Sagar Khadanga, Sachin Bansal, Anand Kumar Maurya, Deepak Kumar, Gajendra Singh, Deepti Joshi, Abhishek Goyal, Alkesh Khurana, Pradeep Saxena, Shikha Malik, Radha Sarawagi Gupta, Neha Upadhyay, Anju Singh, Tadepalli Karuna","doi":"10.4103/jpbs.jpbs_1699_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_1699_25","url":null,"abstract":"<p><strong>Introduction: </strong>Information on the plasma ranges of prescribed voriconazole prophylactic and therapeutic drug levels among the patients with invasive fungal infections (IFIs) is sparsely documented from central India.</p><p><strong>Methods: </strong>This prospective observational database study was conducted over a period of 18 months at the ICMR Mycology Advanced Resource Center of a tertiary care hospital in central India. It included 25 voriconazole samples from 18 patients undergoing routine therapeutic drug monitoring (TDM). Clinico-mycological characteristics, target concentration ranges for prophylactic and therapeutic prescriptions, and clinical outcomes were evaluated among enrolled patients.</p><p><strong>Results: </strong>Out of the 25 samples, 8 (32%) were random and 17 (68%) were trough samples. 33.3% (6/18) had repeat samples sent for analysis. Out of the 18 patients enrolled, 10 (55%) received prophylactic, while 8 (44%) were received therapeutic doses of voriconazole. Overall mean concentration of voriconazole in trough samples was 3.93 μg/ml, and in random samples was 2.38 μg/ml. Both these values were within the normal range. Commonest drug-drug interaction (DDI), between proton pump inhibitor (PPI) use and voriconazole was evident in supratherapeutic voriconazole concentrations. With small sample size, exploratory nature of this study and without a multivariable analysis; the association of PPIs alone for supratherapeutic voriconazole concentrations cannot be established.</p><p><strong>Conclusion: </strong>The research highlighted notable pharmacokinetic variances between children and adults who received voriconazole, particularly concerning the rate of absorption, bioavailability, and metabolism. This study emphasizes the need for antifungal TDM in developing nations with resource limited settings in better understanding of IFI management.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 3","pages":"160-168"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}