Journal of pharmacy & bioallied sciences最新文献

{"title":"Assessment of the Prevalence of the Use of Nasal Decongestants Among Hail Population.","authors":"Farida Habib Khan, Abdullah D Alotaibi, Amal Daher Alshammari, Mohammed Alateeq, Muath Alshmmari, Read Alharbi, Rakhi Issrani","doi":"10.4103/jpbs.jpbs_364_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_364_25","url":null,"abstract":"<p><strong>Background: </strong>Nasal decongestants are widely used to relieve nasal congestion caused by conditions such as allergic rhinitis, sinusitis, and the common cold. These medications function by constricting nasal blood vessels, reducing swelling, and improving airflow. Despite their effectiveness, improper use can result in adverse effects, including rebound congestion and cardiovascular complications.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted among 300 adult residents of Hail, Saudi Arabia, using a structured questionnaire. Participants were selected through simple random sampling. The questionnaire assessed the frequency of nasal decongestant use, types of decongestants preferred, reasons for use, and awareness regarding potential health risks. Data were analyzed using descriptive statistics, and Chi-square tests were performed to evaluate associations between demographic factors and decongestant use.</p><p><strong>Results: </strong>Among the participants, 65% reported regular nasal decongestant use, with 45% preferring topical decongestants (e.g., oxymetazoline) and 55% using oral formulations (e.g., pseudoephedrine). The majority (72%) reported self-medicating without medical consultation, while 60% were unaware of the risk of rebound congestion. Individuals with a history of allergic rhinitis or sinusitis were significantly more likely to use nasal decongestants frequently (<i>P</i> < 0.05). Additionally, 30% of users experienced side effects, including increased heart rate (15%) and nasal irritation (10%).</p><p><strong>Conclusion: </strong>The study highlights a high prevalence of nasal decongestant use in Hail, largely influenced by environmental factors and a lack of public awareness regarding potential risks. The findings underscore the need for targeted public health campaigns and pharmacist-led interventions to promote safer usage practices.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1770-S1772"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Clinical Success of Stainless Steel and Bioflx Crowns in Primary Molars-A Split-Mouth Prospective Randomized Controlled Study.","authors":"Swati Singh, Seema Qamar, Arnab Mondal, Sumit Betal, Amit Prakash, Somya Salwi","doi":"10.4103/jpbs.jpbs_137_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_137_25","url":null,"abstract":"<p><strong>Background: </strong>Stainless steel (SS) crowns are a widely accepted restorative option for primary molars due to their durability and longevity. Recently, Bioflx crowns, a biocompatible alternative, have been introduced, claiming improved esthetics and comparable clinical success. This study aims to compare the clinical success of SS crowns and Bioflx crowns in primary molars over 12 months using a split-mouth design.</p><p><strong>Materials and methods: </strong>A total of 40 children, aged 5-8 years, with bilateral carious primary molars were included in this 12-month prospective split-mouth study. Each child received an SS crown on one side and a Bioflx crown on the contralateral side. Standardized crown placement protocols were followed. Follow-up evaluations were conducted at 3, 6, 9, and 12 months to assess retention, marginal integrity, gingival health, and overall success. Data were statistically analyzed using the Chi-square test and paired <i>t</i>-test, with significance set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>At the 12-month follow-up, clinical success rates were 95% for SS crowns and 92% for Bioflx crowns. Retention was 100% for SS crowns and 98% for Bioflx crowns. Marginal integrity scores were slightly higher for SS crowns (96%) compared to Bioflx crowns (92%). Gingival health was comparable between the two groups, with no significant difference observed (<i>P</i> > 0.05). Patient satisfaction regarding esthetics was significantly higher for Bioflx crowns (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Both SS and Bioflx crowns demonstrated high clinical success rates in restoring primary molars. While SS crowns showed marginally better retention and marginal integrity, Bioflx crowns were preferred for esthetic reasons. Bioflx crowns may serve as an effective alternative to SS crowns, particularly in esthetically sensitive cases.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1562-S1564"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Comparison of Different Implant Abutment Materials on Gingival Fibroblast Attachment.","authors":"Padmaksha Laskar, Kodithyala Hareesh Kumar, Tushar Kakkar, Mrunal Dave, Ruchi Patel, Naina Pattnaik, Mahesh Ghadage, Dipooja Patil","doi":"10.4103/jpbs.jpbs_2001_24","DOIUrl":"10.4103/jpbs.jpbs_2001_24","url":null,"abstract":"<p><strong>Background: </strong>Implant abutment materials significantly influence peri-implant tissue health, particularly the attachment and behavior of gingival fibroblasts. An optimal material can enhance biocompatibility and reduce inflammation, ensuring long-term success. This study compares the effects of titanium, zirconia, and polyetheretherketone (PEEK) abutments on gingival fibroblast attachment <i>in vitro</i>.</p><p><strong>Materials and methods: </strong>Standardized disks of titanium, zirconia, and PEEK abutment materials were prepared. Primary gingival fibroblasts were cultured and seeded on the disks in a 24-well plate format, with each material in triplicate. Cell attachment was assessed after 24 and 48 hours using fluorescence microscopy and a quantitative cell adhesion assay. Surface roughness (Ra) and hydrophilicity of the disks were evaluated to correlate with fibroblast behavior. Arbitrary values for attached cell counts and surface characteristics were analyzed using ANOVA and <i>post hoc</i> tests (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Titanium demonstrated the highest fibroblast attachment (mean cell count: 1.25 × 10⁴ ± 0.5 × 10³ at 24 hours), followed by zirconia (mean cell count: 1.15 × 10⁴ ± 0.4 × 10³). PEEK showed significantly lower attachment (mean cell count: 0.85 × 10⁴ ± 0.3 × 10³). Surface roughness and hydrophilicity were highest for titanium (Ra: 0.3 μm, contact angle: 72°), followed by zirconia (Ra: 0.25 μm, contact angle: 80°), and lowest for PEEK (Ra: 0.2 μm, contact angle: 90°).</p><p><strong>Conclusion: </strong>Titanium and zirconia provide favorable conditions for gingival fibroblast attachment, with titanium slightly outperforming zirconia due to superior surface properties. PEEK, while biocompatible, demonstrates reduced fibroblast attachment, suggesting limited suitability for areas requiring strong soft tissue integration. These findings underscore the importance of material selection in achieving optimal peri-implant tissue health.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1472-S1474"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Cohort Study on Serum Glycosylated Fibronectin as a Biomarker for Early Prediction of Preeclampsia.","authors":"Vibhuti Thakur, Kavyashree, Poonam Mathur","doi":"10.4103/jpbs.jpbs_277_25","DOIUrl":"10.4103/jpbs.jpbs_277_25","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia (PE) is a significant hypertensive disorder of pregnancy contributing to maternal and neonatal morbidity and mortality. Early detection and intervention are crucial to reducing the burden of this disease. Glycosylated fibronectin (GlyFn) has emerged as a potential biomarker for the early prediction of PE.</p><p><strong>Materials and methods: </strong>A prospective cohort study was conducted in the Department of Obstetrics and Gynaecology at MGM Medical College and MTH Hospital, Indore. A total of 140 pregnant women with risk factors for PE were enrolled between December 2022 and March 2023. Serum GlyFn levels were measured using an ELISA-based method. Participants were categorized based on GlyFn levels into normal (<250 μg/mL), and positive groups (250-350 μg/mL, 350-500 μg/mL, >500 μg/mL). GlyFn levels were monitored every 4 weeks, and clinical outcomes, including PE onset, maternal complications, and fetal outcomes, were analyzed. Statistical analysis was performed using ANOVA, Pearson correlation, and Chi-square tests.</p><p><strong>Results: </strong>The majority of participants were nulliparous (33.3%), with a mean age of 24.3 years. Elevated GlyFn levels (>250 μg/mL) were significantly associated with the development of PE (<i>P</i> < .001). The sensitivity, specificity, positive predictive value, and negative predictive value of GlyFn at a cutoff of 250 μg/mL were 92.3, 88.9, 96, and 80%, respectively. The average gestational age (GA) at GlyFn positivity was inversely correlated with the GA at PE onset, with early detection providing a larger intervention window. Maternal complications included postpartum hemorrhage (21.44%) and thrombocytopenia (15%), while fetal complications included preterm birth (23.65%) and intrauterine growth restriction (9.3%).</p><p><strong>Conclusion: </strong>Serum GlyFn is a promising biomarker for early prediction of PE, enabling timely interventions to improve maternal and fetal outcomes. A GlyFn cutoff of 250 μg/mL showed high diagnostic accuracy. Further research is required to validate its clinical utility and integrate it into routine antenatal care.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1710-S1712"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study.","authors":"Shruti Gupta, S G Jyothi, Arif Siddiqui, Anishka Dhanai, Hemlata Yadav, Utkarsh Singh","doi":"10.4103/jpbs.jpbs_255_25","DOIUrl":"10.4103/jpbs.jpbs_255_25","url":null,"abstract":"<p><strong>Background: </strong>Chronic periodontitis is a common inflammatory condition that is worsened in smokers owing to the harmful impact of smoking on periodontal tissues. Curcumin gel has shown promise as a local medication delivery method owing to its anti-inflammatory, antioxidant, and antibacterial effects.</p><p><strong>Materials and methods: </strong>A randomized clinical study was performed on 40 smokers diagnosed with chronic periodontitis. Participants were categorized into two groups: Group A (n = 20) had scale and root planing (SRP) only, while Group B (n = 20) got SRP in conjunction with curcumin gel as a local medication delivery supplement. Clinical measures, including as probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI), were evaluated at baseline, 4 weeks, and 8 weeks. Curcumin gel was administered in periodontal pockets with probing pocket depth (PPD) ≥5 mm in patients of Group B.</p><p><strong>Outcomes: </strong>At 8 weeks, Group B exhibited a significant decrease in PPD (mean reduction: 3.5 mm) compared to Group A (mean reduction: 2.0 mm). The improvement in clinical attachment level (CAL) was more pronounced in Group B (mean gain: 2.8 mm) compared to Group A (mean gain: 1.5 mm). Group B had a substantial drop in GI scores (mean reduction: 1.2) vs to Group A (mean reduction: 0.8). The supplementary use of curcumin gel led to statistically significant improvements in all clinical indicators (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Curcumin gel as a localized medication delivery adjunct significantly improves the clinical results of scaling and root planing in the treatment of chronic periodontitis in smokers.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1683-S1685"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Maxillary Sinus Septa in Northeast Indian Population - A Retrospective CBCT Evaluation.","authors":"Saumya Verma, Sri Krishna Koppula, Srishti, Kumari Shalini, William S Maugham, Shovan Maity","doi":"10.4103/jpbs.jpbs_1704_24","DOIUrl":"10.4103/jpbs.jpbs_1704_24","url":null,"abstract":"<p><strong>Aim: </strong>Presence of anatomic disparities inside the maxillary sinus, notably septae, has been described to increase the risk of sinus membrane damage in the course of sinus elevation technique.</p><p><strong>Materials and methods: </strong>A total of 1160 CBCT scans (580 male and 580 female) aged between 25 to 70 years were selected retrospectively between February 2020 - August 2022 from the dental records department of our institution. Presence of septum, its location, its height from the various sinus walls was evaluated.</p><p><strong>Result: </strong>Amongst 1160 subjects studied, septa were present among 103 subjects. Hence, the prevalence in study population was 8.88% (<i>n</i> = 103) and prevalence of septa amongst males was significantly higher than females.</p><p><strong>Conclusion: </strong>The results of the present study illustrate extensive anatomical disparities in the prevalence of maxillary sinus septa.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1328-S1330"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinosarcoma of Uterus and Ovary-Clinical, Morphological, and Immunohistochemical Study of Case Series.","authors":"Thamilselvi Ramachandran, Anbu Lenin Kulandaivel, Poovizhi Inbasekaran, Jayamani Baskaran, Panneerselvam Periasamy","doi":"10.4103/jpbs.jpbs_1658_24","DOIUrl":"10.4103/jpbs.jpbs_1658_24","url":null,"abstract":"<p><p>Ovarian carcinosarcoma (MMMT-malignant mixed Müllerian tumors) is highly aggressive, rare tumor, affecting postmenopausal women with the incidence peak in the sixth decade with significant morbidity and mortality. Uterine carcinosarcomas are rare tumors comprising less than 5% of uterine malignancies. Ovarian cancer is the seventh cause of death and morbidity in females worldwide.To study about the clinical, morphological, and immunohistochemical study of case series of ovarian and uterine carcinosarcoma. Retrospective study of three cases. In first case a 50-year-old woman presented with a left ovarian tumor with a clinical diagnosis of carcinoma of ovary, USG-malignant ovarian tumor. Cancer antigen-125 (Ca-125) was elevated. She underwent surgery and final diagnosis was ovarian carcinosarcoma with high-grade papillary serous carcinoma of endometrium. In second case a 56-year-old woman presented with mass descending per vaginum-three years, abdominal pain-three months. Clinical diagnosis of malignant tumor of the right ovary was made. Ca-125 was elevated. She underwent surgery and the final diagnosis was right ovarian carcinosarcoma with a heterologous component and omental metastatic deposit. In third case a 48-year-old woman presented with continuous bleeding per vaginum for two months. Diagnosed as abnormal uterine bleeding- leiomyoma. She underwent panhysterectomy with lymph nodes removal and final diagnosis was uterine carcinosarcoma. Ovarian carcinosarcomas are very aggressive tumors that are usually diagnosed at an advanced stage due to its asymptomatic nature, its lack of active screening, and early detection techniques. The survival rate after diagnosis varies by stage of disease and uterine and ovarian carcinosarcomas.er horizons involving younger patients with asymptomatic severe AS, and long term outcomes of valve durability and moderate AS in combination with cardiac failure bicuspid aortic valve stenosis and pure native aortic regurgitation are however still under research.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S2021-S2024"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Fracture Resistance in Teeth Obturated with Graphene Oxide-Modified Sealers.","authors":"Jasmine Marwaha, Divya Batra, Deepankar Dass, Shivani Parmar, Ashtha Arya, Ataul Hafeez Imran","doi":"10.4103/jpbs.jpbs_153_25","DOIUrl":"10.4103/jpbs.jpbs_153_25","url":null,"abstract":"<p><strong>Background: </strong>For long-term success, endodontically treated teeth must be resistant to fracture. The creation of new materials with potential mechanical qualities, such sealers modified with graphene oxide, might increase the longevity of obturated teeth. The purpose of this research is to examine the fracture resistance of teeth that have been sealed using traditional sealers versus sealers modified with graphene oxide.</p><p><strong>Materials and methods: </strong>Using the ProTaper Gold rotary device, thirty recently removed mandibular premolars were prepped and decoronated to standardize root length. Three groups of 10 samples each were randomly selected: Group 1 was the control group, which did not have any obturation; Group 2 was the group that had teeth sealed with a traditional bioceramic sealer; and Group 3 was the group that had teeth sealed with a sealer modified by graphene oxide. The lateral compaction method was used to fill each root with gutta-percha. To replicate oral circumstances, the samples underwent 500 cycles of thermocycling between 5°C and 55°C. A universal testing machine was used to test for fracture resistance, exerting compressive force at a crosshead speed of 1 mm/min till failure.</p><p><strong>Results: </strong>The following were the average fracture resistance values: 300 N ± 25 N was the value for Group 1 (control), 450 N ± 30 N for Group 2 (traditional sealer), and 550 N ± 35 N for Group 3 (graphene oxide-modified sealer). Group 2 had superior resistance than Group 1 (<i>P</i> < 0.05), whereas Group 3's fracture resistance was substantially higher than that of Groups 1 and 2 (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>When compared to traditional sealers, graphene oxide-modified sealers greatly increase the fracture resistance of teeth that have had endodontic treatment. According to these results, graphene oxide may be a useful supplement for enhancing the endodontic sealers' mechanical qualities.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1589-S1591"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Universal Periotome and Conventional Techniques in Single-Rooted Tooth Extractions: A Randomized Controlled Study.","authors":"Swati Sahu, Ankita Barodiya, Animesh Barodiya, Mrunal Dave, Bharani K Bhattu, Rajat Mohanty, Mahesh Ghadage, Dipooja Patil","doi":"10.4103/jpbs.jpbs_19_25","DOIUrl":"10.4103/jpbs.jpbs_19_25","url":null,"abstract":"<p><strong>Background: </strong>Tooth extraction, one of the most commonly performed dental procedures, is often associated with trauma to the dentoalveolar complex, resulting in pain, gingival laceration, and alveolar bone loss.</p><p><strong>Materials and methods: </strong>This randomized controlled study included 100 patients requiring nonsurgical extraction of single-rooted maxillary or mandibular teeth.</p><p><strong>The patients were divided into two groups: </strong>Group A (test group, n = 50) underwent extractions using a universal periotome, while Group B (control group, n = 50) underwent extractions with a periosteal elevator. Pain was assessed using the Visual Analog Scale at 3, 6, and 24 hours and on the 7^th day postextraction. Additional parameters included duration of surgery, gingival laceration severity, and analgesic consumption. Data were analyzed using SPSS Version 21.0.</p><p><strong>Results: </strong>The mean duration of surgery was significantly shorter in Group A (4.97 ± 0.96 minutes) compared to Group B (11.47 ± 1.66 minutes; <i>P</i> < 0.0001). Gingival laceration scores were lower in Group A (1.26 ± 0.56) than in Group B (1.72 ± 0.97; <i>P</i> = 0.005). Postoperative pain was consistently lower in Group A across all time points, with pain scores nearly absent by Day 7 (Group A: 0.00 ± 0.00 vs Group B: 0.22 ± 0.42; <i>P</i> < 0.0001). Analgesic consumption was also reduced in Group A, where no patients required analgesics by Day 7, compared to 22% in Group B (P < 0.0001). Minimal postoperative complications were observed, with only one case of dry socket reported in Group B.</p><p><strong>Conclusion: </strong>The universal periotome demonstrated superior outcomes compared to conventional techniques, significantly reducing operative time, postoperative pain, gingival lacerations, and analgesic consumption. This minimally invasive technique preserves alveolar and gingival architecture, making it an effective alternative for single-rooted tooth extractions.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1484-S1486"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Orthodontic Aligner Treatment on Oral Health-Related Quality of Life.","authors":"Kabir Suman Dash, Osric DCosta, Ashwini Dhopte, Shivani Kumari, Mrunal Dave, Hiroj Bagde, Mahesh Ghadage, Dipooja Patil, Ramanpal Singh Makkad","doi":"10.4103/jpbs.jpbs_1834_24","DOIUrl":"10.4103/jpbs.jpbs_1834_24","url":null,"abstract":"<p><strong>Background: </strong>Orthodontic aligners have gained popularity due to their aesthetic appeal and convenience compared to traditional braces.</p><p><strong>Materials and methods: </strong>One hundred patients (aged 18 to 30 years) receiving aligner-assisted orthodontic treatment participated in a prospective trial. The oral health impact profile-14 (OHIP-14) questionnaire was filled out by participants at baseline, three months, and six months during the course of therapy. Functional limits, pain, psychological discomfort, physical impairment, and social consequences were among the variables that were evaluated. Paired t-tests were used in statistical studies to assess how OHRQoL changed over time.</p><p><strong>Results: </strong>At three months, 60% of participants reported significant improvement in psychological comfort, with an average OHIP-14 score reduction from 25.4 ± 3.5 to 18.7 ± 2.9 (<i>P</i> < 0.001). Functional limitations decreased by 30% at six months, showing a significant improvement in chewing and speech, with mean scores dropping from 15.6 ± 2.1 to 11.3 ± 2.3 (<i>P</i> < 0.05). Social impact scores also improved by 25%, with participants reporting fewer disruptions in social interactions and self-consciousness.</p><p><strong>Conclusion: </strong>Orthodontic aligners positively impact the oral health-related quality of life of patients, particularly by enhancing psychological comfort and reducing functional limitations. This suggests that aligners are an effective orthodontic treatment option for patients seeking improvements in both aesthetic and quality-of-life aspects.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1445-S1447"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}