Carcinosarcoma of Uterus and Ovary-Clinical, Morphological, and Immunohistochemical Study of Case Series.

Ovarian carcinosarcoma (MMMT-malignant mixed Müllerian tumors) is highly aggressive, rare tumor, affecting postmenopausal women with the incidence peak in the sixth decade with significant morbidity and mortality. Uterine carcinosarcomas are rare tumors comprising less than 5% of uterine malignancies. Ovarian cancer is the seventh cause of death and morbidity in females worldwide.To study about the clinical, morphological, and immunohistochemical study of case series of ovarian and uterine carcinosarcoma. Retrospective study of three cases. In first case a 50-year-old woman presented with a left ovarian tumor with a clinical diagnosis of carcinoma of ovary, USG-malignant ovarian tumor. Cancer antigen-125 (Ca-125) was elevated. She underwent surgery and final diagnosis was ovarian carcinosarcoma with high-grade papillary serous carcinoma of endometrium. In second case a 56-year-old woman presented with mass descending per vaginum-three years, abdominal pain-three months. Clinical diagnosis of malignant tumor of the right ovary was made. Ca-125 was elevated. She underwent surgery and the final diagnosis was right ovarian carcinosarcoma with a heterologous component and omental metastatic deposit. In third case a 48-year-old woman presented with continuous bleeding per vaginum for two months. Diagnosed as abnormal uterine bleeding- leiomyoma. She underwent panhysterectomy with lymph nodes removal and final diagnosis was uterine carcinosarcoma. Ovarian carcinosarcomas are very aggressive tumors that are usually diagnosed at an advanced stage due to its asymptomatic nature, its lack of active screening, and early detection techniques. The survival rate after diagnosis varies by stage of disease and uterine and ovarian carcinosarcomas.er horizons involving younger patients with asymptomatic severe AS, and long term outcomes of valve durability and moderate AS in combination with cardiac failure bicuspid aortic valve stenosis and pure native aortic regurgitation are however still under research.