Journal of pharmacy & bioallied sciences最新文献

{"title":"Artificial Intelligence in Cardiovascular Diagnosis: Innovations and Impact on Disease Screenings.","authors":"Amber Ahmad, Sahil Ahmad, Rida Ahmad, Jahnavi Bodi, Abdulla Mohamed, Ahmad Wasim","doi":"10.4103/jpbs.jpbs_557_25","DOIUrl":"10.4103/jpbs.jpbs_557_25","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI) is making waves in health care, with ECGs and other imaging data leveraged to diagnose or predict cardiovascular diseases (CVDs).</p><p><strong>Materials and methods: </strong>Various AI models as well as algorithms, such as machine learning (ML) and deep learning (DL) algorithms, have shown good results in the detection of diseases like heart failure, atrial fibrillation, coronary artery disease, and valvular heart disease. AI can help alleviate cognitive burdens on clinicians while improving their diagnostic accuracy, examining huge chunks of data and finding patterns that may not be readily apparent, and finding accurate diagnoses and offering cost effective alternatives to traditional methods. AI based ECG interpretation, for example, CNNs, has been used in CVDs, since early identification is essential; algorithms may help detect high-risk individuals, including asymptomatic patients.</p><p><strong>Results and conclusion: </strong>The potential of AI algorithms is also being extended for predicting the onset of diseases in the future and for predicting the long-term prognosis of diseases. Recent landmark studies have shown an opportunity for AI to detect entities such as aortic stenosis, coronary artery disease, and left ventricular active dysfunction. As AI continues to evolve and integrate into clinical practice, there is great potential for it to improve the early detection and management of cardiovascular diseases and, ultimately, patient results and lessen the strain on medical systems.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1900-S1903"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Advanced Platelet-Rich Fibrin and Blood Clot as Scaffolds in Regenerative Endodontics for Immature Necrotic Teeth: A Randomized Clinical Study.","authors":"Seema Qamar, Arnab Mondal, Swati Singh, Amrita Deep, Anisha Kakran, Aditi S Tanwar","doi":"10.4103/jpbs.jpbs_136_25","DOIUrl":"10.4103/jpbs.jpbs_136_25","url":null,"abstract":"<p><strong>Background: </strong>In immature necrotic teeth, the goal of regenerative endodontic treatments (REPs) is to promote root growth. This research compares the efficacy of traditional blood clots and advanced platelet-rich fibrin (A-PRF) as scaffolds for the regeneration of injured nonvital immature teeth.</p><p><strong>Materials and methods: </strong>This randomized clinical experiment comprised 30 injured nonvital immature maxillary incisors from 24 kids between the ages of 8 and 12. The canals were irrigated with 1.5% sodium hypochlorite and 17% EDTA after minor mechanical debridement. For disinfection, calcium hydroxide paste was used. Two sets of teeth-A-PRF (n = 15) and conventional blood clot (n = 15)-were assigned at random. At baseline, three, six, and 12 months, radiographic measurements were made of the root development parameters, such as apical breadth, root length, and root thickness. To evaluate changes over time both within and across groups, statistical analyses were conducted.</p><p><strong>Results: </strong>The investigation was finished by 28 teeth (A-PRF: n = 14, blood clot: n = 14). After a year, teeth treated with A-PRF had a greater increase in root length (18.5% vs. 12.2%), root thickness (15.4% vs. 11.6%), and a decrease in apical width (11.3% vs. 8.1%) than the blood clot group. Nevertheless, there was no statistically significant difference between the two groups (<i>P</i> > 0.05). For the length of the trial, none of the patients in either group had any symptoms.</p><p><strong>Conclusion: </strong>A-PRF and traditional blood clot scaffolds both showed significant enhancements in REP root growth. A-PRF demonstrated marginally better results and is especially helpful when it comes to difficult bleeding induction or when there is a danger of close proximity to critical structures.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1559-S1561"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Locally Delivered Antibiotics in Treating Endodontic-Periodontal Lesions.","authors":"Dipika Yadav, A Abhilash, Emil Santhosh Mani, Krishnan Hari, Ashtha Arya, Karishma","doi":"10.4103/jpbs.jpbs_338_25","DOIUrl":"10.4103/jpbs.jpbs_338_25","url":null,"abstract":"<p><strong>Background: </strong>Because of the intricate interactions between the root canal system and periodontal tissues, endodontic-periodontal lesions (EPLs) provide a diagnostic and treatment challenge. Locally administered antibiotics (LDAs) have drawn interest as an adjuvant to improve treatment results.</p><p><strong>Materials and methods: </strong>Sixty patients with EPL diagnoses were split into two groups at random: Group A received standard endodontic and periodontal care, whereas Group B had standard therapy with the application of an LDA. After extensive debridement, LDAs containing minocycline hydrochloride were injected into periodontal pockets. At baseline, one month, and three months after treatment, clinical measures such as radiographic bone fill, clinical attachment level (CAL), and probing depth (PD) were measured.</p><p><strong>Results: </strong>At the three-month follow-up, Group B showed a greater reduction in PD (3.8 ± 0.6 mm vs. 2.5 ± 0.7 mm in Group A, <i>P</i> < 0.05) and a significant gain in CAL (2.9 ± 0.5 mm vs. 1.8 ± 0.6 mm, <i>P</i> < 0.05). Radiographic analysis revealed enhanced bone fill in Group B compared to Group A (<i>P</i> < 0.05). No adverse reactions to the antibiotic application were reported.</p><p><strong>Conclusion: </strong>When compared to conventional therapy alone, the use of LDAs as an adjuvant in the treatment of EPLs greatly enhances clinical and radiological results. By encouraging attachment growth and decreasing PD, LDAs improve periodontal repair. Additional long-term research is required to validate these results.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1767-S1769"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Demineralized Freeze-Dried Bone Allograft Combined with 0.75% Boric Acid Gel versus Demineralized Freeze-Dried Bone Allograft Alone in the Management of Subclass-B Furcation Defects.","authors":"Prasanna Sawant, Pallavi Kamble, Nitin Gorwade, Sachin B Mangalekar, Saumya Shankar, Shruti Kumbhare","doi":"10.4103/jpbs.jpbs_1824_24","DOIUrl":"10.4103/jpbs.jpbs_1824_24","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to compare the efficacy of demineralized freeze-dried bone allograft (DFDBA) combined with 0.75% boric acid gel versus DFDBA alone in managing subclass-B furcation defects.</p><p><strong>Methods: </strong>A split-mouth clinical trial design was adopted, involving 20 sites with bilateral Grade B furcation defects in first or second mandibular molars. The control group received DFDBA treatment only, while the test group was treated with 0.75% boric acid gel in addition to DFDBA. Clinical parameters, including Plaque Index, Modified Gingival Index, Russell's Periodontal Index, probing pocket depth (PPD), clinical attachment level (CAL), and relative attachment level (RAL), were measured at baseline, 3 months, and 6 months post-treatment. Bone fill from the furcation fornix to the base of the defect was evaluated radiographically at the same intervals.</p><p><strong>Results: </strong>Both treatment approaches demonstrated success in promoting bone regeneration. However, the addition of 0.75% boric acid gel did not significantly enhance bone fill compared to DFDBA alone. The primary determinant of bone regeneration was attributed to the intrinsic characteristics of DFDBA and the precision of clinical application, rather than the adjunctive effects of boric acid gel.</p><p><strong>Conclusion: </strong>While boric acid gel's antibacterial and anti-inflammatory properties contributed to improved post-operative comfort, they did not result in measurable advantages in bone regeneration.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1439-S1441"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Fracture Resistance in Endodontically Treated Teeth: An Analysis of Different Restorative Materials.","authors":"Sajal Chaudhary, Pankaj Mishra, Santosh Kumar Singh, Purnima Verma, Ruba Khan, Ayushi Upadhayay","doi":"10.4103/jpbs.jpbs_216_25","DOIUrl":"10.4103/jpbs.jpbs_216_25","url":null,"abstract":"<p><strong>Background: </strong>Endodontically treated teeth are susceptible to fractures due to loss of structural integrity. Reinforcing these teeth with appropriate restorative materials is crucial for restoring their function and longevity. The study was undertaken to compare the fracture resistance of endodontically treated teeth restored with different restorative materials.</p><p><strong>Materials and methods: </strong>This study involved five groups: a control group with no reinforcement, and four experimental groups restored with fiber-reinforced composite, bulk fill flowable composite, self-adhering flowable composite, and resin-modified glass ionomer cement (RMGIC). Single-rooted premolars were standardized and subjected to compressive forces using a Universal Testing Machine to measure their fracture resistance.</p><p><strong>Results: </strong>All restorative materials significantly improved fracture resistance compared to the control group. Bulk fill flowable composite exhibited the highest fracture resistance, followed by fiber-reinforced composite, flowable composite, and RMGIC.</p><p><strong>Conclusion: </strong>The study demonstrates the importance of material selection in enhancing the fracture resistance of endodontically treated teeth. Bulk fill flowable composite was found to be the most effective in resisting fractures, suggesting its suitability for high-load-bearing applications in clinical practice.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1650-S1652"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Anti-inflammatory Efficacy of Steroids, COX-2 Selective, and Nonselective NSAIDs in Contusion Spinal Cord Injury: An Experimental Analysis.","authors":"Sreelakshmi Kokkatt Balachandran, Krithika Iyer, Sowbarnika Arul Senthil, Akshaya Priya Ramalingam, Sankar Venkatachalam","doi":"10.4103/jpbs.jpbs_604_25","DOIUrl":"10.4103/jpbs.jpbs_604_25","url":null,"abstract":"<p><strong>Context: </strong>The inclusion of an anti-inflammatory agent shall be inevitable in a combinatorial approach toward treating spinal cord injury (SCI). However, the best among the commonly used anti-inflammatory agents, namely, steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenases-2 (COX-2) selective NSAIDs is not known due to the lack of comparative studies.</p><p><strong>Aim: </strong>It was intended to compare the efficacy of three classes of anti-inflammatory drugs in SCI by estimating the relevant cytokines.</p><p><strong>Materials and methods: </strong>Sprague Dawley rats subjected to contusion SCI were treated with methylprednisolone (steroid), or diclofenac (general COX-inhibitor), or meloxicam (selective COX-2 inhibitor). After three days of postlesion, the efficacy of the drugs was assessed by quantifying the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1) β, IL-6, IL-10, transforming growth factor-beta (TGF-β), and COX-2 through Western blotting.</p><p><strong>Statistical analysis used: </strong>The data were analyzed using one-way analysis of variance to determine statistical significance, and post-hoc analysis was performed using Tukey's test.</p><p><strong>Results: </strong>Pro-inflammatory cytokines (TNF-α, IL-6, and IL-1) upregulated by SCI were reduced only by meloxicam treatment. Upregulation of anti-inflammatory cytokines (IL-10, TGF-β) observed in injury was unaffected by methylprednisolone and diclofenac but was downregulated in the meloxicam group although statistically not significant.</p><p><strong>Conclusion: </strong>By reducing the levels of pro-inflammatory cytokines and a mild increase in the levels of TGF-β, meloxicam outperforms the other two drugs tested. Reduced anti-inflammatory IL-10 levels in the meloxicam treatment were the only concern. Spinal inflammation may be more resilient and further studies are required to formulate a consistent anti-inflammatory therapy to treat contusion SCI.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1877-S1881"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bioengineered Scaffolds for Mandibular Defect Reconstruction: A Clinical Study.","authors":"Prasanth Panicker, Feby Francis, Mandapathi S Kumar, Rajana M Kumar","doi":"10.4103/jpbs.jpbs_247_25","DOIUrl":"10.4103/jpbs.jpbs_247_25","url":null,"abstract":"<p><strong>Background: </strong>Reconstruction of mandibular defects is a complex challenge in maxillofacial surgery, requiring innovative approaches to restore functional and aesthetic outcomes. Bioengineered scaffolds represent a promising solution by mimicking the extracellular matrix and facilitating bone regeneration.</p><p><strong>Materials and methods: </strong>A prospective clinical study was conducted on 30 patients (18 males and 12 females, aged 25-60 years) with mandibular defects caused by trauma or pathology. Patients were treated with bioengineered scaffolds composed of hydroxyapatite and collagen, seeded with autologous mesenchymal stem cells. The scaffolds were customized for each defect using 3D printing technology. Clinical and radiographic assessments were performed at 1, 3, 6, and 12 months postoperatively, evaluating parameters such as defect closure, bone regeneration, and functional restoration. Data were analyzed using paired t-tests to assess statistical significance.</p><p><strong>Results: </strong>At the 12-month follow-up, 87% of patients showed complete defect closure with a mean bone regeneration rate of 76% ± 8%. Functional restoration, measured by masticatory efficiency and mandibular mobility, improved by 70% ± 5% compared to preoperative levels. Complications included mild infection in 10% of cases and scaffold displacement in 7%, both managed conservatively. Radiographic analysis confirmed progressive mineralization and integration of scaffolds with native bone.</p><p><strong>Conclusion: </strong>Bioengineered scaffolds demonstrate significant potential for mandibular defect reconstruction, achieving high rates of bone regeneration and functional recovery. Although minor complications were noted, the overall outcomes affirm the feasibility and efficacy of this approach, warranting further large-scale studies.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1677-S1679"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Outcomes Following Emergency Cesarean Delivery: Evaluating the Enhanced Recovery After Surgery Protocol in a Randomized Controlled Trial.","authors":"G D Abilashini, Divya Raghavendra Rao, Vijayalakshmi Gnanasekaran","doi":"10.4103/jpbs.jpbs_540_25","DOIUrl":"10.4103/jpbs.jpbs_540_25","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the impact of the enhanced recovery after surgery (ERAS) protocol on maternal outcomes following emergency cesarean delivery (CD).</p><p><strong>Materials and methods: </strong>The study was conducted at ACS Medical College and Hospital, Chennai, from September 2023 to September 2024. A total of 100 participants undergoing emergency cesarean deliveries were randomly assigned to either the ERAS group or the control group. Statistical analysis was assessed using an Independent <i>t</i>-test to compare the two groups.</p><p><strong>Results: </strong>Women in the ERAS group had a significantly shorter hospital stay (and higher maternal satisfaction). Postoperative complications were fewer in the ERAS group. Pain scores were lower at 6, 12, and 24 h post-surgery in the ERAS group when compared to the control group. The ERAS group also had faster bowel function recovery and earlier breastfeeding initiation.</p><p><strong>Conclusion: </strong>The ERAS protocol significantly improves maternal outcomes following emergency CD, including faster recovery, reduced pain, and improved maternal satisfaction.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1849-S1851"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Radix Entomolaris in Patients at a Multidisciplinary Tertiary Care Hospital of Jharkhand, India.","authors":"Butta Viswanath, Sumit Mohan, Harsh Priyank, Gaurav Kumar","doi":"10.4103/jpbs.jpbs_269_25","DOIUrl":"10.4103/jpbs.jpbs_269_25","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the incidence of radix entomolaris in mandibular molars in patients reporting to a tertiary care center in Jharkhand.</p><p><strong>Materials and methods: </strong>2640 mandibular molars were assessed using intraoral periapical digital radiography where the total incidence of radix entomolaris and the ratio of their occurrence among gender and location were evaluated.</p><p><strong>Results: </strong>The overall incidence of radix entomolaris was found to be 2.5% with its prevalence in 1.14% females and 1.36% male participants. A nonsignificant difference in the incidence of radix entomolaris was also observed between females and males on the right and left sides.</p><p><strong>Conclusion: </strong>This study confirms a 2.5% prevalence of radix endomolaris, thus warranting requirement of a thorough radiological and clinical assessment before initiation of endodontic therapy.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1704-S1706"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Antimicrobial Properties of Surface-Modified Dental Implants.","authors":"Jeeth Rai, Anju N Kilari, Himanshi Sachdev, Waseem A Quazi, Bharani K Bhattu, Naina Pattnaik, Miral Mehta, Laxmikant Late","doi":"10.4103/jpbs.jpbs_105_25","DOIUrl":"10.4103/jpbs.jpbs_105_25","url":null,"abstract":"<p><strong>Background: </strong>Dental implants have revolutionized restorative dentistry, but peri-implantitis caused by bacterial colonization remains a significant challenge. Surface modification of implants has emerged as a promising strategy to enhance their antimicrobial properties, ensuring better long-term outcomes. This study evaluates the antimicrobial efficacy of surface-modified dental implants against common oral pathogens.</p><p><strong>Materials and methods: </strong>Thirty dental implants were divided into three groups: Group A (unmodified titanium implants), Group B (titanium implants coated with silver nanoparticles), and Group C (titanium implants coated with zinc oxide nanoparticles). The antimicrobial activity of each group was assessed using an agar diffusion test against <i>Streptococcus mutans</i> and <i>Porphyromonas gingivalis</i>. Colony-forming units (CFUs) were counted after 48 hours of incubation. Statistical analysis was performed using ANOVA to compare the antimicrobial efficacy between groups, with a significance level set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>Group A showed minimal antimicrobial activity, with mean inhibition zones of 1.5 ± 0.3 mm for <i>S. mutans</i> and 1.2 ± 0.4 mm for <i>P. gingivalis</i>. Group B exhibited significantly higher antimicrobial activity, with mean inhibition zones of 10.5 ± 0.8 mm for <i>S. mutans</i> and 9.3 ± 0.7 mm for <i>P. gingivalis</i> (<i>P</i> < 0.05). Group C demonstrated moderate activity, with inhibition zones of 6.8 ± 0.5 mm for <i>S. mutans</i> and 5.9 ± 0.6 mm for <i>P. gingivalis</i>. The reduction in CFUs followed a similar trend, with Group B showing the highest reduction.</p><p><strong>Conclusion: </strong>Surface-modified dental implants, particularly those coated with silver nanoparticles, exhibit enhanced antimicrobial properties compared to unmodified implants. This suggests that incorporating antimicrobial coatings can be a viable strategy to reduce peri-implantitis and improve implant success rates. Further <i>in vivo</i> studies are recommended to validate these findings.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 2","pages":"S1544-S1546"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}