Journal of pharmacy & bioallied sciences最新文献_第10页

Assessment of Salivary Osteocalcin Level Among Smokers and Non-Smokers Undergoing Dental Implants: An Observational Study. 吸烟者和非吸烟者种植牙患者唾液骨钙素水平的评估：一项观察性研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_1511_25

Sipra Sarin, Sahil Sarin, Deepa Venkatesh, Kartiki Mehrotra, Shreanshi Jolly, Abhidi

{"title":"Assessment of Salivary Osteocalcin Level Among Smokers and Non-Smokers Undergoing Dental Implants: An Observational Study.","authors":"Sipra Sarin, Sahil Sarin, Deepa Venkatesh, Kartiki Mehrotra, Shreanshi Jolly, Abhidi","doi":"10.4103/jpbs.jpbs_1511_25","DOIUrl":"10.4103/jpbs.jpbs_1511_25","url":null,"abstract":"Background: To evaluate and compare salivary osteocalcin concentrations in individuals with dental implants, stratified according to smoking status.Materials and methods: In total, 100 participants were recruited, comprising 50 smokers and 50 non-smokers. All the patients underwent dental implant therapy. Collection of salivary samples was done and analyzed for osteocalcin levels. The data obtained were systematically tabulated, and statistical analysis was performed using SPSS software.Results: Group I (non-smokers) consisted of 50 individuals, while Group II (smokers) also comprised 50 individuals. The mean salivary osteocalcin concentration was 2.58 ng/mL in the non-smoker group and 1.69 ng/mL in the smoker group, indicating a substantial reduction among smokers.Conclusion: Patients rehabilitated with dental implants who reported tobacco use exhibited diminished salivary osteocalcin concentrations when compared with their non-smoking counterparts, suggesting an adverse influence of smoking on peri-implant bone metabolic activity.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S75-S77"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study of Catheter-Associated Urinary Tract Infection in a Tertiary Care Center. 三级护理中心导尿管相关尿路感染的研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.4103/jpbs.jpbs_862_25

Singampalli Pavani Dedeepya, Chappa Bhavani Shankar, Pentapalli Krishna Kusuma, Pramod Binayake, Boddu Kiran Kumar, Tata Ramya Sree

{"title":"A Study of Catheter-Associated Urinary Tract Infection in a Tertiary Care Center.","authors":"Singampalli Pavani Dedeepya, Chappa Bhavani Shankar, Pentapalli Krishna Kusuma, Pramod Binayake, Boddu Kiran Kumar, Tata Ramya Sree","doi":"10.4103/jpbs.jpbs_862_25","DOIUrl":"10.4103/jpbs.jpbs_862_25","url":null,"abstract":"Background: \"Catheter-associated urinary tract infections (CAUTIs)\" represent a significant proportion of healthcare-associated infections, contributing to increased morbidity, hospital stay, and mortality. This research aimed to determine the incidence, risk factors, microbiological profile, and outcomes associated with CAUTI in a tertiary care center.Materials and methods: A prospective observational research was conducted over 24 months, enrolling 239 patients catheterized for more than 48 hours. Patients were monitored for clinical signs of CAUTI, and urine cultures were obtained for microbiological analysis.Results: The incidence of CAUTI was 31.79%, with a rate of 12 per 1000 catheter days. Advanced age, prolonged catheterization (>7 days), diabetes mellitus, and emergency catheterization were significant risk factors. \"Escherichia coli (E. coli)\" was the most commonly isolated organism, followed by \"Klebsiella pneumoniae (K.pneu)\" and \"Pseudomonas aeruginosa (P.aeru)\". CAUTI cases exhibited longer hospital stays and higher mortality rates compared to non-CAUTI patients (P = 0.042).Conclusion: Prolonged catheterization, diabetes, and emergency catheter placement are major contributors to CAUTI. Timely catheter removal, strict aseptic techniques, and effective infection control measures are crucial to minimize the burden of CAUTI in hospital settings.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S96-S98"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Gingival Phenotype on Crestal Bone Loss at Implants. 牙龈表型对种植体冠骨丢失的影响。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-12-29 DOI: 10.4103/jpbs.jpbs_1541_25

Mohd Azeem, Sneha Patel, Rishabh Ranjan, Meenal Verma, Gutta Veda Sri, Rakesh Nagaraju, Charumati Dhanushkodi, Nandita Gautam

{"title":"Influence of Gingival Phenotype on Crestal Bone Loss at Implants.","authors":"Mohd Azeem, Sneha Patel, Rishabh Ranjan, Meenal Verma, Gutta Veda Sri, Rakesh Nagaraju, Charumati Dhanushkodi, Nandita Gautam","doi":"10.4103/jpbs.jpbs_1541_25","DOIUrl":"10.4103/jpbs.jpbs_1541_25","url":null,"abstract":"Aim: Crestal reduction at implants occurs within the first year of pressure due beginning physiologic remodelling phase following surgical trauma and function loading of the crestal bone.Materials and methods: Ninety-seven individuals were assessed for 4.1 mm bone-level implantation. Participants were separated onto three categories according to how much vertically gingival width: test T1, test T2, along with control C. A radiographic analysis was done afterwards implant placement, two months afterwards recovery, prostheses repair, and a follow-up appointment for one year. The Mann-Whitney U-test was employed, with a threshold of significance of 0.05.Results: While the variations among T2 and C hadn't been relevant either mesially (P = 0.861) or distal (P = 0.827), the variations were substantial (P = 0.000) comparing T1/T2 and T1/C.Conclusion: The breakdown of bones may be significantly lowered when osteo-level prostheses are put in inherently dense tissue rather than thinner biotypes.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S51-S53"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interconnection Between Social Skills, Functional Impairment, and Theory of Mind in Bipolar I Disorder. 双相情感障碍患者的社交技能、功能障碍和心理理论之间的联系。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_711_25

Gursabeen Kaur, Mitthat Miglani, Palak Upadhyay, Manpreet Kaur, Pankaj Kumar, Bholeshwar Prasad Mishra

引用次数: 0

Evaluation of Liver Fibrosis and Metabolic Risk in Non-Alcoholic Fatty Liver Disease. 非酒精性脂肪性肝病的肝纤维化和代谢风险评估

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-05 DOI: 10.4103/jpbs.jpbs_1659_25

Gagan Bansal, Vinayak M Jedhe, Mohamad Akram

{"title":"Evaluation of Liver Fibrosis and Metabolic Risk in Non-Alcoholic Fatty Liver Disease.","authors":"Gagan Bansal, Vinayak M Jedhe, Mohamad Akram","doi":"10.4103/jpbs.jpbs_1659_25","DOIUrl":"10.4103/jpbs.jpbs_1659_25","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver disorders worldwide. In India, its burden is rising fast due to increasing metabolic problems like diabetes, obesity, and dyslipidemia. The disease varies from simple fat accumulation to steatohepatitis and cirrhosis. This study aimed to assess the clinical, biochemical and imaging profile of NAFLD patients in a tertiary hospital at Dehradun, Uttarakhand.Methods: A hospital-based cross-sectional study was done for 12 months in the Department of General Medicine, Himalayan Institute of Medical Sciences. Ninety-one adults (≥18 years) diagnosed with NAFLD on ultrasonography were included. Patients with alcohol intake, viral hepatitis, or hepatotoxic drug use were excluded. Demographic data, laboratory values, and imaging findings were recorded. Fibrosis was assessed using liver elastography and NAFLD Fibrosis Score (NFS).Results: Out of 91 patients, 56 (61.5%) were males, mean age 53.1 ± 11.6 years. All had type 2 diabetes and 73 (80.3%) were diabetic for ≥6 years. Dyslipidemia seen in 57.1% and albuminuria in 60.4%. On ultrasonography, 69 patients (75.8%) had Grade II/III steatosis. Elastography showed significant fibrosis (≥F3) in 31 (34.1%) and NFS showed advanced fibrosis in 16 (17.6%). Mean HbA1c was 9.2% showing poor glycemic control.Conclusion: NAFLD patients in north India had high metabolic burden with poor diabetes control, dyslipidemia, and early kidney changes. About one-third already showed significant fibrosis. Early screening and integrated management focusing on metabolic control are essential to prevent disease progression.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S218-S220"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review on a Variety of Alternate Fluoride Options Effective in Preventing Dental Caries. 对预防龋齿的各种替代氟化物的系统评价。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.4103/jpbs.jpbs_926_25

Kumudhati Tiwari, Shweta Annaldasula, Nilu Bhadani, Bhargavi Dasari, Aarthi Duddukuri, Izaz Shaik

{"title":"A Systematic Review on a Variety of Alternate Fluoride Options Effective in Preventing Dental Caries.","authors":"Kumudhati Tiwari, Shweta Annaldasula, Nilu Bhadani, Bhargavi Dasari, Aarthi Duddukuri, Izaz Shaik","doi":"10.4103/jpbs.jpbs_926_25","DOIUrl":"10.4103/jpbs.jpbs_926_25","url":null,"abstract":"Conventional fluoride therapies are effective in preventing dental caries but present limitations, such as esthetic concerns and fluoride sensitivity This has led to the development of alternate agents with comparable or improved preventive potential. To systematically review and evaluate the effectiveness of alternate fluoride-based and fluoride-free interventions in the guidelines. A prevention of dental caries. This review adhered to PRISMA 2020 comprehensive literature search was conducted across five databases and grey literature sources. Studies included randomized controlled trials, in vitro experiments, and systematic reviews without meta-analysis that examined the efficacy of agents, such as \"silver diamine fluoride (SDF),\" \"nano-silver fluoride (NSF),\" grape seed extract, hydroxyapatite, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), probiotics, and bioactive glasses Data were extracted regarding intervention type, mechanism, outcomes, and patient acceptability. Twenty studies met inclusion criteria. SDF was found to be noninferior to conventional sealants, while NSF offered superior esthetic outcomes with better caries arrest. Hydroxyapatite, CPP-ACP, and bioactive glasses demonstrated significant remineralization potential. Natural agents, such as theobromine and grape seed extract, showed antimicrobial and surface hardening benefits. Probiotics effectively reduced cariogenic bacterial load. Alternative caries-preventive strategies, especially NSF, CPP-ACP, and natural agents, demonstrate strong potential. Further long-term clinical trials are needed.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S17-S19"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neglected Tropical Diseases: A Systematic Review. 被忽视的热带病：系统综述。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-11-19 DOI: 10.4103/jpbs.jpbs_940_25

Sandip Ganpatbhai Patel, Mahir Modi, Kavya Darji, Saumil Darji, Yerrolla Jyotsna, Pradeep Subbaiah, Heena Dixit Tiwari

{"title":"Neglected Tropical Diseases: A Systematic Review.","authors":"Sandip Ganpatbhai Patel, Mahir Modi, Kavya Darji, Saumil Darji, Yerrolla Jyotsna, Pradeep Subbaiah, Heena Dixit Tiwari","doi":"10.4103/jpbs.jpbs_940_25","DOIUrl":"10.4103/jpbs.jpbs_940_25","url":null,"abstract":"Neglected Tropical Diseases (NTDs) affect over a billion people globally, primarily in low- and middle-income countries. These diseases contribute significantly to morbidity, disability, and poverty, yet receive inadequate attention in global health policies and funding frameworks. A systematic literature search was conducted in PubMed, Scopus, and Web of Science for studies published between 2018 and 2024. Inclusion criteria comprised original research, policy reviews, and global reports on WHO-recognized NTDs. A total of 15 articles were included, selected based on methodological rigor and relevance. Data were synthesized into thematic categories, including burden, interventions, and policy. Studies revealed significant geographical and health disparities, with disruptions due to COVID-19, underfunding, and poor integration into primary care. Effective strategies included WASH integration, translational technologies, and policy alignment with Universal Health Coverage. Research gaps persist in pediatric populations and community-level participation. Addressing NTDs requires resilient, multisectoral approaches embedded within primary healthcare systems. Global efforts must prioritize equity, local adaptation, and sustainable financing to meet 2030 elimination targets.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S23-S25"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiographic Evaluation of Periapical Healing Following Single vs Multiple Visit Root Canal Treatment: A PAI Based Study. 单次与多次根管治疗后根尖周愈合的影像学评价：一项基于PAI的研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.4103/jpbs.jpbs_1567_25

Charan Teja Bobba, Ankita Grace Vijay, Varsha Aher, Jaskaran Singh, Ayushi Kejriwal, K Srinivasan, Aditya Ranjan

{"title":"Radiographic Evaluation of Periapical Healing Following Single vs Multiple Visit Root Canal Treatment: A PAI Based Study.","authors":"Charan Teja Bobba, Ankita Grace Vijay, Varsha Aher, Jaskaran Singh, Ayushi Kejriwal, K Srinivasan, Aditya Ranjan","doi":"10.4103/jpbs.jpbs_1567_25","DOIUrl":"10.4103/jpbs.jpbs_1567_25","url":null,"abstract":"Introduction: This randomized controlled clinical trial compared the radiographic periapical healing outcomes of single-visit versus multiple-visit root canal treatments for teeth with apical periodontitis.Materials and methods: Thirty patients with single-rooted teeth diagnosed with primary apical periodontitis were randomly allocated to either a single-visit (n = 15) or a multiple-visit (n = 15) group. Periapical healing was radiographically evaluated using the Periapical Index (PAI) score at baseline and at 6 and 12-month follow-up appointments.Results: The results showed no statistically significant difference in the radiographic healing rates between the two groups at either follow-up period. The success rates (PAI score ≤2) were 93.3% for the single-visit group and 86.7% for the multiple-visit group at 12 months (P > 0.05).Conclusion: These findings suggest that both treatment protocols are equally effective in achieving periapical healing, challenging the necessity of an inter-appointment intracanal medicament.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S206-S208"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of QMix with Canal Brush for Removal of Debris and Smear Layer in Root Canals Instrumented with ProTaper Next and WaveOne File. QMix配合根管刷去除ProTaper Next和WaveOne锉根管内碎片和涂抹层的效果

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-29 DOI: 10.4103/jpbs.jpbs_1725_25

R Ambika Kumari, Vishwas Sangappa Madhudi, Alan Winston David, K S Ashwini, Anagha Jukanti, Jyoti Warad

{"title":"Efficacy of QMix with Canal Brush for Removal of Debris and Smear Layer in Root Canals Instrumented with ProTaper Next and WaveOne File.","authors":"R Ambika Kumari, Vishwas Sangappa Madhudi, Alan Winston David, K S Ashwini, Anagha Jukanti, Jyoti Warad","doi":"10.4103/jpbs.jpbs_1725_25","DOIUrl":"10.4103/jpbs.jpbs_1725_25","url":null,"abstract":"Introduction: QMix is a newer formulation known to be a more effective irrigant. A polypropylene canal brush facilitates the introduction of surfactant in the canal.Objective: To assess the efficacy of QMix with canal brush to eliminate smear layer and debris in a root canal that is instrumented with ProTaper Next and WaveOne files under scanning electron microscope.Methods: Forty single-rooted premolars were allocated into four groups:1) ProTaper Next file, 2) ProTaper Next file + Rotary Canal Brush, 3) WaveOne file, 4) WaveOne file + Rotary Canal Brush. All files were used up to size 40 in their respective tapering. For irrigation, sodium hypochlorite (5.25%) was used throughout instrumentation and QMix was used after instrumentation. The rotary canal brush in assigned groups was used for 30 sec along with QMix, followed by irrigation with 5ml distilled water. The roots were sectioned into two halves and analyzed under SEM.Results: The mean scores for debris and smear layer were lesser in WaveOne and WaveOne with canal brush groups compared to other groups.Conclusion: The use of canal brush created cleaner canal walls than without canal brush. The most superior results were delivered by WaveOne rotary file.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S62-S65"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Profile of Early Surgical Site Infections Following Elective Neurosurgery and Laparotomy: An Observational Study. 择期神经外科和剖腹手术后早期手术部位感染的患病率和概况：一项观察性研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.4103/jpbs.jpbs_1378_25

Ashish Agrawal, Sandeep Thakre, Jeevan Shetty, Purti Tripathi, Ashutosh K Srivastava

{"title":"Prevalence and Profile of Early Surgical Site Infections Following Elective Neurosurgery and Laparotomy: An Observational Study.","authors":"Ashish Agrawal, Sandeep Thakre, Jeevan Shetty, Purti Tripathi, Ashutosh K Srivastava","doi":"10.4103/jpbs.jpbs_1378_25","DOIUrl":"10.4103/jpbs.jpbs_1378_25","url":null,"abstract":"Background: Surgical site infections (SSIs) are among the most common healthcare-associated infections, contributing to significant morbidity and prolonged hospital stays. This study aimed to determine the prevalence and risk factors associated with early SSIs in patients undergoing elective neurosurgery and laparotomy at a tertiary care center in central India.Material and methods: This prospective observational study was conducted over one year, including 721 patients who underwent elective neurosurgical or laparotomy procedures. Data on demographics, comorbidities, type of surgery, antibiotic prophylaxis timing, and surgical duration were collected. SSIs were identified using CDC/NHSN criteria, and microbiological evaluation was performed for infected cases.Results: The overall prevalence of SSIs was 15.53%, with higher incidence among patients aged 21-60 years and males. Diabetes mellitus was the most common comorbidity in SSI patients. SSIs were more frequent in laparotomy cases compared to neurosurgery. Notably, over half of the infected patients had received prophylactic antibiotics within 30 minutes before incision.Conclusion: SSIs remain a substantial postoperative complication, particularly in diabetic and laparotomy patients. Adherence to comprehensive infection control practices beyond antibiotic timing is crucial to minimize infection risk.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S224-S226"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0