Journal of pharmacy & bioallied sciences最新文献

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Genetics in Dentistry: A Review of Advances and Implications. 遗传学在牙科:进展和意义的回顾。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-02-10 DOI: 10.4103/jpbs.jpbs_1758_24
Jyotsana Singh, Sajjad Salam, Zameer Pasha, Rohit Sharma, Nazia Khan, Farheen Chunara, Ritik Kashwani
{"title":"Genetics in Dentistry: A Review of Advances and Implications.","authors":"Jyotsana Singh, Sajjad Salam, Zameer Pasha, Rohit Sharma, Nazia Khan, Farheen Chunara, Ritik Kashwani","doi":"10.4103/jpbs.jpbs_1758_24","DOIUrl":"10.4103/jpbs.jpbs_1758_24","url":null,"abstract":"<p><p>Genetic factors have an appreciable role to play in oral health. This article investigates the genetic components of dental caries, periodontal disease, facial physical proportions, and other orofacial afflictions. Some of these disorders have been associated with specific genes. In genomics and molecular biology, the relationship between specific gene products and these kinds of disorders has been discovered. Genetic testing can thus be used to define people at higher risk for specific ailments, allowing for a specific therapeutic approach and early treatment. Gene therapy also offers great potential for treating several genetic diseases that affect oral health in the future. By exploring genetic data, we can get closer to a more effective way of applying it in dental practice.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S181-S183"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative Paresthesia: A Spanner in the Works? Topographic Analysis of Inferior Alveolar Nerve to Predict Its Incidence Following Surgical Excision of Mandibular Third Molar-A Prospective Study. 术后感觉异常:工作中的扳手?下颌第三磨牙手术切除后下牙槽神经的地形分析预测其发生率-一项前瞻性研究。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-04-21 DOI: 10.4103/jpbs.jpbs_1958_24
Roshan Cherian, Soudha Hidayath, Aparna M Krishnakumari, Akshay D Shetty, U Hemavathi, Chouduri S Swaroop
{"title":"Postoperative Paresthesia: A Spanner in the Works? Topographic Analysis of Inferior Alveolar Nerve to Predict Its Incidence Following Surgical Excision of Mandibular Third Molar-A Prospective Study.","authors":"Roshan Cherian, Soudha Hidayath, Aparna M Krishnakumari, Akshay D Shetty, U Hemavathi, Chouduri S Swaroop","doi":"10.4103/jpbs.jpbs_1958_24","DOIUrl":"10.4103/jpbs.jpbs_1958_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the relationship between impacted lower third molars (ILTMs) and the inferior alveolar nerve (IAN), identify radiographic predictors of neurosensory disturbances, and assess their impact on patients' quality of life.</p><p><strong>Materials and methods: </strong>A prospective study was conducted on 350 patients (20-50 years) undergoing surgical extraction of ILTMs between May 2022 and May 2023. Panoramic radiographs were evaluated for seven radiographic signs based on Rood and Shehab criteria. Neurosensory deficits were assessed postoperatively on days 3 and 7, and monitored for up to one year. Quality of life was evaluated using the OHIP questionnaire. Surgical parameters, operator experience, and patient outcomes were analyzed.</p><p><strong>Results: </strong>Postoperative neurosensory disturbances occurred in 10.9% (38/350) of patients, with 2.3% (8/350) persisting at one year. Mesioangular impactions were most common (47.4%), and radiographic features such as deflected roots and interruption of the white line were strongly associated with neurosensory deficits. Senior surgeons achieved better outcomes with fewer complications and shorter surgical times. Patients aged late 20s to early 30s had higher neurosensory disturbance rates, likely due to fully formed roots. Mental health conditions negatively influenced recovery and quality of life.</p><p><strong>Conclusion: </strong>Panoramic radiographs are valuable for preoperative risk assessment of IAN injury during ILTM surgeries. Radiographic features, like deflected roots and white line interruption, are strong predictors of neurosensory deficits. Surgeon experience and mental health significantly impact outcomes, emphasizing the need for careful preoperative planning and psychological support. Larger, multicenter studies with advanced imaging techniques are recommended for further validation.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S538-S540"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Study on the Impact of Orthodontic Treatment Timing on Skeletal and Dental Development in Adolescents. 正畸治疗时机对青少年骨骼和牙齿发育影响的纵向研究。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.4103/jpbs.jpbs_1425_24
Kumar Adarsh, Jashan D Goyal, Guramrit P Kaur, Thammineni Neeharika, Sweta Samal, Praveen K V Datla, Preetham Ravuri
{"title":"Longitudinal Study on the Impact of Orthodontic Treatment Timing on Skeletal and Dental Development in Adolescents.","authors":"Kumar Adarsh, Jashan D Goyal, Guramrit P Kaur, Thammineni Neeharika, Sweta Samal, Praveen K V Datla, Preetham Ravuri","doi":"10.4103/jpbs.jpbs_1425_24","DOIUrl":"10.4103/jpbs.jpbs_1425_24","url":null,"abstract":"<p><strong>Introduction: </strong>The timing of orthodontic treatment can significantly impact skeletal and dental development, particularly during the adolescent growth spurt. This study investigates the influence of early, mid, and late-treatment initiation on mandibular growth, dental alignment, and occlusal correction in adolescents.</p><p><strong>Methods: </strong>A total of 60 adolescents were divided into three groups based on their skeletal maturity: early, mid, and late. Key parameters including mandibular growth, dental alignment, and occlusal changes were measured at baseline, mid-treatment, and post-treatment. A two-year follow-up was conducted, and a cephalometric analysis was performed.</p><p><strong>Results: </strong>The early-treatment group showed the most significant skeletal changes, particularly in mandibular growth. The mid and late groups demonstrated better dental alignment outcomes. Statistical analysis revealed significant differences in mandibular growth between groups (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Treatment timing plays a critical role in determining skeletal and dental outcomes. Early treatment enhances skeletal changes, while later treatment is more effective for dental alignment.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S460-S462"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimized Design and Development of Ropinirole Loaded Nanoparticles for Restless Leg Syndrome. 罗匹尼罗纳米颗粒治疗不宁腿综合征的优化设计与开发。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI: 10.4103/jpbs.jpbs_320_25
Christina Das, V Muruganantham
{"title":"Optimized Design and Development of Ropinirole Loaded Nanoparticles for Restless Leg Syndrome.","authors":"Christina Das, V Muruganantham","doi":"10.4103/jpbs.jpbs_320_25","DOIUrl":"10.4103/jpbs.jpbs_320_25","url":null,"abstract":"<p><strong>Background: </strong>Restless Leg Syndrome (RLS) has a major impact on the quality of life and requires innovative approaches to improve symptom management. This study focuses on the design and development of Ropinirole-loaded nanoparticles for targeted intranasal delivery to enhance therapeutic outcomes in RLS patients.</p><p><strong>Materials and methods: </strong>Ropinirole, a dopamine agonist, was incorporated into chitosan nanoparticles with the help of the Box-Behnken design (BBD) to optimize key parameters such as particle size, polydispersity index (PDI), entrapment efficiency of the drug, and drug release kinetics. Characterization of the nanoparticles involved Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and other common techniques. Intranasal delivery was selected to circumvent the blood-brain barrier and deliver the drug across the nasal epithelial lining into the central nervous system.</p><p><strong>Results: </strong>The optimized nanoparticles had desirable physicochemical properties: sustained drug release, high entrapment efficiency, and thermal stability. These nanoparticles exhibited significant potential to reduce symptoms in RLS patients and minimize systemic side effects in the preclinical assessments.</p><p><strong>Conclusion: </strong>The current study points to the potential of Ropinirole-loaded nanoparticles as a delivery system for treating RLS. Further clinical studies are warranted to confirm these results and establish both short- and long-term safety and efficacy.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S372-S374"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment). 乳腺癌患者治疗前后谷胱甘肽s -转移酶及其同工酶(Pi)及肿瘤标志物(CA15-3、HE4)的研究
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI: 10.4103/jpbs.jpbs_1792_24
Dattu Hawale, Leela Abichandani, Ranjit Ambad
{"title":"Study of Glutathione S-Transferase, Its Isoenzyme (Pi) and Tumor Marker (CA15-3, HE4) in Breast Carcinoma Patients (Before and After Treatment).","authors":"Dattu Hawale, Leela Abichandani, Ranjit Ambad","doi":"10.4103/jpbs.jpbs_1792_24","DOIUrl":"10.4103/jpbs.jpbs_1792_24","url":null,"abstract":"<p><p>Breast cancer is a prevalent malignancy among women worldwide, with prognosis and survival heavily influenced by early diagnosis and effective treatment. This study evaluates the diagnostic and prognostic significance of glutathione S-transferase (GST), its isoenzyme GST-Pi, and tumor markers CA15-3 and HE4 in breast carcinoma patients before and after treatment. It also explores the correlation of these biomarkers with liver enzymes (SGOT, SGPT, LDH, ALP), commonly associated with hepatic metastasis. A quasi-experimental design will include 311 participants from the Vidarbha region, clinically diagnosed with breast carcinoma. Blood samples will be analyzed using enzyme-linked immunosorbent assay (ELISA) and automated biochemical analyzers to estimate levels of GST, GST-Pi, CA15-3, HE4, and liver enzymes. The study aims to identify reliable biomarkers for monitoring therapeutic efficacy, assessing prognosis, and predicting recurrence in breast carcinoma. This research may contribute to developing cost-effective diagnostic approaches, particularly beneficial in resource-limited healthcare settings.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S909-S912"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study Protocol: Evaluating Cellular Fragmentation in Embryos Resulting from Intracytoplasmic Sperm Injection (ICSI): A Study of Degree, Pattern, Distribution, and Clinical Pregnancy Outcomes. 研究方案:评估卵胞浆内单精子注射(ICSI)导致的胚胎细胞碎裂:程度、模式、分布和临床妊娠结局的研究。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-04-21 DOI: 10.4103/jpbs.jpbs_312_25
Ganesh Kalaskar, Akash More, Namrata Choudhary, Lakhan P Padwal
{"title":"Study Protocol: Evaluating Cellular Fragmentation in Embryos Resulting from Intracytoplasmic Sperm Injection (ICSI): A Study of Degree, Pattern, Distribution, and Clinical Pregnancy Outcomes.","authors":"Ganesh Kalaskar, Akash More, Namrata Choudhary, Lakhan P Padwal","doi":"10.4103/jpbs.jpbs_312_25","DOIUrl":"10.4103/jpbs.jpbs_312_25","url":null,"abstract":"<p><strong>Background: </strong>Infertility affects approximately one in six couples worldwide, with assisted reproductive technologies (ART) providing effective solutions. Intracytoplasmic sperm injection (ICSI) is a widely used ART method; however, cytoplasmic fragmentation in embryos can influence implantation success and clinical pregnancy outcomes. The degree, pattern, and distribution of fragmentation remain crucial factors in embryo selection and success rates.</p><p><strong>Objectives: </strong>This study evaluates cytoplasmic fragmentation in ICSI embryos and its impact on embryo development and pregnancy outcomes. The objectives include: assessing the extent of fragmentation in relation to implantation and pregnancy success, analyzing fragmentation patterns predictive of miscarriage or live birth, and standardizing measurement criteria for improved embryo selection in ART.</p><p><strong>Methodology: </strong>This prospective observational study will be conducted at Wardha Test Tube Baby Center, AVBRH, Sawangi, over six months. The study will include couples undergoing ICSI, with embryo fragmentation assessed microscopically based on degree, pattern, and distribution. Clinical outcomes, including implantation rates and pregnancy success, will be analyzed using statistical methods such as Chi-square tests and regression analysis.</p><p><strong>Expected result: </strong>It is anticipated that minimal fragmentation (<10%) will correlate with higher implantation and pregnancy rates, while severe fragmentation (>50%) will negatively impact outcomes. Localized fragmentation may have less detrimental effects than diffuse fragmentation, and inner cell mass fragmentation is expected to affect fetal development more significantly than trophectoderm fragmentation.</p><p><strong>Study implication: </strong>This study will enhance understanding of fragmentation characteristics in ICSI embryos, contributing to improved embryo selection strategies and higher ART success rates. The findings may support refining embryo grading criteria to optimize clinical outcomes.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S924-S927"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study Protocol: Evaluation of AI-Driven Grading Compared to Manual Grading in Predicting Embryo Viability and Successful Implantation and Clinical Pregnancy Outcomes in IVF Using Static Microscopic Images. 研究方案:评估人工智能驱动的分级与人工分级在使用静态显微图像预测体外受精胚胎活力、成功着床和临床妊娠结局方面的比较。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-04-12 DOI: 10.4103/jpbs.jpbs_386_25
Puja Dhamija, Akash More, Namrata Choudhary, Tejaswini Wadhe, Devanshi R Shah
{"title":"Study Protocol: Evaluation of AI-Driven Grading Compared to Manual Grading in Predicting Embryo Viability and Successful Implantation and Clinical Pregnancy Outcomes in IVF Using Static Microscopic Images.","authors":"Puja Dhamija, Akash More, Namrata Choudhary, Tejaswini Wadhe, Devanshi R Shah","doi":"10.4103/jpbs.jpbs_386_25","DOIUrl":"10.4103/jpbs.jpbs_386_25","url":null,"abstract":"<p><strong>Background: </strong>Infertility affects 8-12% of couples globally, with 5-10% seeking Assisted Reproductive Technology (ART) annually. In-vitro fertilization (IVF) is the most common infertility treatment, involving the retrieval of oocytes and their fertilization in a laboratory setting. Embryo selection, crucial for IVF success, is traditionally performed manually by embryologists using the Gardner Scale. However, this process is subject to variability. Time-lapse microscopy and artificial intelligence (AI)-based methods are being explored for improved embryo selection, though AI's full potential has not been realized across diverse clinical settings.</p><p><strong>Objectives: </strong>The primary objective of this study is to compare AI-based embryo grading with conventional manual grading by embryologists in predicting clinical pregnancy outcomes.</p><p><strong>Methodology: </strong>This prospective study will be conducted at an IVF clinic in Sawangi, Wardha, Maharashtra, involving 222 participants aged 23-40 years undergoing Intra-Cytoplasmic Sperm Injection (ICSI). Embryos on Day 5 (blastocyst stage) will be imaged and graded using Life Whisperer Genetics (LWG), an AI-based tool, and by skilled embryologists using the ASEBIR criteria. The success rate of clinical pregnancy, confirmed by the presence of a gestational sac, will be the primary outcome.</p><p><strong>Expected results: </strong>The study is expected to show increased predictive efficiency, rigor, and consistency with AI-driven grading of Day 5 embryos, providing a more economical solution for IVF.</p><p><strong>Study implications: </strong>This study focuses on enhancing embryo selection using Life Whisperer Genetics (LWG), which could potentially improve embryo assessment in IVF. Further research is needed to incorporate other embryonic developmental stages for a more comprehensive evaluation process.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S956-S959"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study the Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome (PCOS). 多囊卵巢综合征(PCOS)患者血清Caspase-1、IL-10、HOMA-IR、FAI、血脂异常、氧化应激状态的相关性研究
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-02-21 DOI: 10.4103/jpbs.jpbs_1996_24
Neelam Gusain, Ashish P Anjankar, Ranjit S Ambad, Roshan K Jha, Rakesh Jha
{"title":"Study the Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome (PCOS).","authors":"Neelam Gusain, Ashish P Anjankar, Ranjit S Ambad, Roshan K Jha, Rakesh Jha","doi":"10.4103/jpbs.jpbs_1996_24","DOIUrl":"10.4103/jpbs.jpbs_1996_24","url":null,"abstract":"<p><strong>Introduction: </strong>Polycystic Ovary Syndrome (PCOS) is a major health concern for women worldwide, particularly those of childbearing age. PCOS is a common endocrine disorder that has widely known reproductive, metabolic, cardiovascular adverse effects that lead to significant morbidity. There is continued research into the nature of this disorder and still many gaps to fill in the understanding of the exact ways in which PCOS develops.</p><p><strong>Materials and methods: </strong>This study aims to investigate this uncharted horizon of PCOS by analysing the association between serum Caspase-1, IL-10, and biochemical indices relative to insulin resistance (HOMA-IR), hyperandrogenism (FAI), dyslipidemia, and oxidative stress in our female population. It expands on the significance of inflammation and insulin resistance, together with dyslipidemia, in the advancement and signs and symptoms of PCOS. Given the dearth of research that has explored the relationship between Caspase-1 and IL-10 in Indian women with established PCOS, this research preserves a central position. Its goal to improve the knowledge of the disease's inflammatory and metabolic mechanisms and promote biomarkers and therapeutic targets discovery. The preface to this work in emphasizing the desire to contribute to medical science in its capacity to treat disease patients, in arguing that interdisciplinary collaboration between biochemistry, endocrinology, and gynaecology to improve to patient care.</p><p><strong>Expected outcome: </strong>Our goal is to reveal possible approaches to reduce the impact of PCOS to improve the outcomes of its diagnostic, treatment and preventive methodologies for millions of afflicted women.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S921-S923"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults - A Dose-Dependent Study. 甜盾:增强口腔健康与成人的生物活性HETAFU糖果-剂量依赖性研究。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-04-25 DOI: 10.4103/jpbs.jpbs_16_25
Sowjanya Lakkoju, Deepika Bolisetty, Ranjith Kumar
{"title":"Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults - A Dose-Dependent Study.","authors":"Sowjanya Lakkoju, Deepika Bolisetty, Ranjith Kumar","doi":"10.4103/jpbs.jpbs_16_25","DOIUrl":"10.4103/jpbs.jpbs_16_25","url":null,"abstract":"<p><p>Functional foods incorporating probiotics, essential oils, and DHA, PhosphatidylSerine have been explored as innovative approaches to improving oral health. This study evaluates the effects of consuming two versus five HETAFU candies daily on oral microbial levels over eight weeks. To compare the impact of moderate (two candies/day) and higher (five candies/day) HETAFU candy consumption on oral microbial populations, focusing on Streptococcus mutans, Lactobacillus, Actinomycetes, and Candida. A total of 200 participants were randomly divided into two groups: Group 1 consumed two candies daily, and Group 2 consumed five candies daily. Microbial levels were measured at baseline, 2 weeks, 4 weeks, and 8 weeks using microbiological techniques. Statistical analysis included <i>Z</i> scores and <i>P</i> values to determine the significance of microbial changes between groups. Both groups showed significant reductions in <i>Streptococcus mutans</i> and <i>Candida</i>, with a concurrent decrease in <i>Lactobacillus</i> and <i>Actinomycetes</i> levels over time. However, Group 2 demonstrated greater microbial shifts, indicating enhanced modulation of the oral microbiome with higher candy consumption. Higher consumption of HETAFU candies (five/day) provides superior benefits in reducing pathogenic microbes and promoting beneficial bacteria compared to moderate consumption (two/day). This suggests a dose-dependent relationship, with increased intake offering additional protective effects against oral microbial imbalances. Functional foods like HETAFU candies represent a promising adjunct to oral hygiene practices.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S133-S136"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Art of Quality Health Science Article Writing for Peer-Reviewed Professional Journals: A Review Article. 为同行评议的专业期刊撰写优质健康科学文章的艺术:一篇综述文章。
IF 0.7
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.4103/jpbs.jpbs_651_24
Shreya Buvariya, M C Prasant, Arun G Krishna, Akshay Kumar Mavani, Gosai Mayurgiri Vilasgiri, Gopal Singh Thakur, Rahul Tiwari
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