Journal of pharmacy & bioallied sciences最新文献

{"title":"The Role of Yoga in HIV Care: A Narrative Review.","authors":"Shrikanth Muralidharan, Pranab Das, S Prashanth, Bhuvaneshwari Basanayak, Prateek Soni, Sanju Khaiju, Deepak Bangera","doi":"10.4103/jpbs.jpbs_1287_25","DOIUrl":"10.4103/jpbs.jpbs_1287_25","url":null,"abstract":"<p><p>Human Immunodeficiency Virus (HIV) is still a global health issue, and millions of HIV-positive people are afflicted with various physical, psychological, and social impacts. Antiretroviral therapy (ART) has also increased survival and viral suppression but individuals living with HIV (PLWH) still experience chronic inflammation, psychiatric issues, tiredness, and stigma. Practice of yoga using physical postures, breath regulation, and meditation has been used as an adjunct treatment of HIV. This review article discusses the function of Yoga in enhanced quality of life, immune capability, and affective hardiness in PLWH.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S7-S9"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Respiratory and Hemodynamic Variables in Patients Receiving either Volume Control Ventilation or Pressure Control Ventilation during Laparoscopic Surgeries.","authors":"Ruchi Tandon, Tahir A Khan, Chitra Bansal","doi":"10.4103/jpbs.jpbs_1641_25","DOIUrl":"10.4103/jpbs.jpbs_1641_25","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate respiratory and hemodynamic variables in patients receiving volume-controlled ventilation (VCV) versus pressure-controlled ventilation (PCV) during laparoscopic surgeries.</p><p><strong>Methods: </strong>Sixty ASA grade I-II patients, aged 18-60 years, with a body mass index (BMI) under 30, scheduled for elective laparoscopic procedures, were enrolled. Group A was sustained on VCV, but Group B transitioned to PCV after 15 min of VCV. Ventilation parameters were established with a tidal volume of 6 mL/kg, a respiratory rate of 12 breaths per minute, and a PEEP of 5 cm H₂O. Hemodynamic and respiratory parameters (systolic and diastolic blood pressure (SBP, DBP), MAP, heart rate (HR), oxygen saturation (SpO₂), capnography (EtCO₂), and peak airway pressure (Ppeak)) were documented at intervals of 15 min.</p><p><strong>Results: </strong>Group A exhibited markedly elevated heart rate and mean arterial pressure (MAP) at multiple intervals (<i>P</i> < 0.05). EtCO₂ levels were comparable between groups, except upon extubation, where Group B exhibited lower levels. Ppeak levels were significantly elevated with VCV after 30 min (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>PCV demonstrated reduced lower airway pressures and enhanced hemodynamic stability relative to VCV in non-obese ASA I-II individuals.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S194-S196"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Salivary Levels of Titanium and Nickel Levels among Patients Treated with Dental Implants Therapy.","authors":"Sahil Sarin, Sipra Sarin, Deepa Venkatesh, Kartiki Mehrotra, Abhidi, Shreanshi Jolly","doi":"10.4103/jpbs.jpbs_1510_25","DOIUrl":"10.4103/jpbs.jpbs_1510_25","url":null,"abstract":"<p><strong>Background: </strong>The present investigation aimed to evaluate salivary concentrations of titanium and nickel in individuals subjected to endosseous implant therapy.</p><p><strong>Materials and methods: </strong>A total cohort of 100 participants was recruited. Among them, 50 individuals constituted the control cohort without prosthetic intervention, whereas the remaining 50 individuals had undergone placement of a single osseointegrated implant fixture. Unstimulated whole saliva samples were collected from each subject and subsequently analyzed for trace metal quantification of titanium and nickel. The recorded data were systematically tabulated, and statistical interpretation was performed utilizing SPSS analytical software.</p><p><strong>Results: </strong>The study group comprised 69 male and 31 female participants. Subjects rehabilitated with dental implants demonstrated mean salivary titanium concentration of 123.54 ± 258.02 μg/L and mean salivary nickel concentration of 53.97 ± 16.09 μg/L. In comparison, the control cohort without implant placement exhibited relatively diminished levels of both metallic ions.</p><p><strong>Conclusion: </strong>The outcomes of this investigation indicate that salivary titanium and nickel concentrations are significantly elevated in patients treated with endosseous dental implants compared to individuals without such prosthetic rehabilitation.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S227-S229"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Microbial Counts in GCF of Patients with Onlay- Retained Fixed Partial Denture Fabricated with Monolithic Zirconia and DMLS - An <i>Ex vivo</i> Study.","authors":"Ankita Thakur, Shilpi K Pandey, Avantika Mishra, Kolasani Balaram, Heena D Tiwari, Rahul Tiwari, M C Prashant","doi":"10.4103/jpbs.jpbs_953_25","DOIUrl":"10.4103/jpbs.jpbs_953_25","url":null,"abstract":"<p><strong>Background: </strong>Onlay-retained resin-bonded fixed partial dentures (RBFPDs) are a conservative option for posterior tooth replacement. However, their impact on periodontal health, especially microbial colonization in the gingival crevicular fluid (GCF), remains underexplored. This study compares the microbial load in GCF around RBFPDs fabricated from Monolithic Zirconia and Direct Metal Laser Sintering (DMLS).</p><p><strong>Materials and methods: </strong>An <i>ex vivo</i> study was conducted on 80 patients, divided into two equal groups receiving either Zirconia or DMLS-based RBFPDs. GCF samples were collected at baseline, one week, and three months post-cementation. Samples were cultured on Blood and MacConkey agar. Microbial counts were recorded using a digital colony counter and analyzed using SPSS v24 (IBM Corp., Armonk, NY, USA). Independent and paired t-tests were applied; <i>P</i> ≤ 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Microbial counts were consistently higher in the DMLS group at all time points. Statistically significant differences were observed at baseline and 1-week post-cementation in both Blood and MacConkey agar cultures. At three months, microbial differences were not significant but remained higher in the DMLS group.</p><p><strong>Conclusion: </strong>Monolithic Zirconia showed superior periodontal compatibility due to lower microbial accumulation, making it a preferred material for onlay-retained RBFPDs.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S112-S114"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Perception of Ayurveda Graduates Regarding Simulation-Based Teaching-Learning.","authors":"Gaurav Sawarkar, Vaishali Kuchewar, Shraddha Patel, Punam Sawarkar","doi":"10.4103/jpbs.jpbs_549_25","DOIUrl":"10.4103/jpbs.jpbs_549_25","url":null,"abstract":"<p><strong>Background: </strong>An outcome-based curriculum, supplemented by Simulation-Based Teaching and Learning (SBTL), enhances clinical skills, critical thinking, and decision-making in Ayurveda education through hands-on, realistic training.</p><p><strong>Aim: </strong>This qualitative study sought to investigate Ayurveda graduates' attitudes toward SBTL in their educational journey.</p><p><strong>Methodology: </strong>Two hundred and thirty-six Ayurveda undergraduates participated in the study, and closed and open-ended questions were used to collect training feedback on a five-point Likert scale. Ten recent pass-out Ayurveda graduates who had experienced SBTL during their training participated in semistructured interviews and focus group discussions.</p><p><strong>Observation: </strong>Thematic analysis revealed several themes, including SBTL's effectiveness in improving clinical skills, its impact on confidence and readiness for practice, challenges encountered, and recommendations for improvement.</p><p><strong>Conclusion: </strong>Overall, participants viewed SBTL positively, emphasizing its importance in bridging the gap between theory and practice in Ayurveda education.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S233-S235"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Early Childhood Caries Risk Through Dermatoglyphics: A Short Review.","authors":"Archana B Javvadi, B Sunitha, Alekhya Kondapaneni, Syed A Ahmed, Lakshmi Pulagam, Bhanu P Seera","doi":"10.4103/jpbs.jpbs_1291_25","DOIUrl":"10.4103/jpbs.jpbs_1291_25","url":null,"abstract":"<p><p>Even though oral healthcare has advanced significantly, early childhood caries (ECC) is still a common and chronic dental problem that affects young children worldwide. Its multifactorial etiology, which includes behavioral, environmental, and genetic factors, makes prevention and early detection very difficult. The scientific study of fingerprint and palm patterns, known as dermatoglyphics, has attracted a lot of attention because it develops at the same time as primary teeth in utero. The ectoderm is the source of both dermal ridges and dental enamel, which start to form at the same time during pregnancy, indicating that fingerprint patterns may reflect abnormalities in tooth development. This research aims to close the gap between genetic markers and early oral health treatments by re-examining the possibility of dermatoglyphics as a non-invasive, affordable diagnostic tool for identifying children at risk of ECC.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S35-S37"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Sleep Disorders with Temporomandibular Joint Pain Dysfunction Syndrome.","authors":"Mazen Anwar Abdullah Albadi, May Muteb Abuthnain, Mozon Mubarak Abdullatif Alshahrani, Joud Faisal Abdullah Alrajhi, Ghada Mohammed Jaber Alshehri, Rakhi Issrani","doi":"10.4103/jpbs.jpbs_1573_25","DOIUrl":"10.4103/jpbs.jpbs_1573_25","url":null,"abstract":"<p><p>Temporomandibular disorders (TMD) are frequently related to sleep disorders, such as bad/sleep quality, insomnia, sleep apnea, and bruxism. In this systematic review, we integrated the evidence from seven seminal studies, all of which indicated worse sleep quality and increased pain sensitivity in TMD patients, and the degenerative joint changes are associated with stress and poor sleep. Although the association is bilateral, the evidence that the bruxism and obstructive sleep apnea are also bilateral is not consistent. Overall, the results illuminate the significance of the diligent assessment of sleep in TMD treatment and strengthen the value of a multimodal therapy in ANV treatment.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S26-S28"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional Flap vs Entire Papilla Preservation Technique in Vertical Bone Defects with DFDBA and PRF: A Clinico-Radiographic Study.","authors":"Nimmala S Naidu, Gummadi Anusha, Dalli B S Reddy, V Mohan Krishna Reddy, Mahanthi Vanditha, Bacchu V Sushma","doi":"10.4103/jpbs.jpbs_1587_25","DOIUrl":"10.4103/jpbs.jpbs_1587_25","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to compare the conventional flap and entire papilla preservation technique to treat vertical defects with demineralized freeze-dried bone allograft (DFDBA) and platelet-rich fibrin (PRF).</p><p><strong>Material and methods: </strong>Fourteen patients having bilateral vertical defects were selected with a split-mouth design. Fourteen paired defects were treated randomly using DFDBA + PRF with the entire papilla preservation technique (Group A) or conventional flap (Group B). Clinical parameters recorded plaque index (PI), sulcus bleeding index (SBI), pocket depth (PD), and clinical attachment level (CAL) at baseline, six, and nine months after surgery. Radiographic parameters recorded defect fill, alveolar crest height change, and defect fill at six and nine months.</p><p><strong>Results: </strong>Both groups had statistically significant (<i>P</i> < 0.05) reductions in mean PI, SBI, PD, defect depth (radiographic), and CAL gain. The mean defect fill percentage at six and nine months (75.07 ± 12.55 vs. 87.20 ± 7.05) was significantly higher in Group A compared to Group B (68.83 ± 15.26 at 6 vs 81.28 ± 11.54). The mean interdental papilla recession was greater in Group B at both six and nine months (5.64 ± 1.00 mm vs 6.64 ± 1.00 mm) as compared to Group A (1.86 ± 0.66 mm vs 2.71 ± 0.61 mm). Significant reductions were observed in mean PD and gain in alveolar crest levels in Group A as compared to Group B at nine months.</p><p><strong>Conclusion: </strong>The study had certain limitations, but the conclusion is that both groups showed enhanced periodontal regeneration with DFDBA and PRF, but due to preservation of papilla in Group A, there was decreased interdental recession as compared to Group B.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S253-S256"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the Clinical and Angiographic Patterns of Coronary Artery Disease in Smokeless Tobacco Users and Smokers.","authors":"Fnu Pawandeep, Karanbir S Purewal, Arashdeep Singh, Samreet Sandhu, Ameya Kasture, Sanjana Avajigari","doi":"10.4103/jpbs.jpbs_769_25","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_769_25","url":null,"abstract":"<p><strong>Aim: </strong>To determine whether patients who use smokeless tobacco have different clinical and angiographic profiles of coronary artery disease (CAD) compared with smokers.</p><p><strong>Material and methods: </strong>This cross-sectional, prospective study was conducted on 40 patients with CAD using smokeless tobacco products and 40 patients with CAD who were smokers. Demographic information, history, and present smoking status of tobacco were also obtained. As a means of determining the severity and extent of CAD in all patients, coronary angiography was performed as previously described. Blood samples were collected for lipid profile and fasting blood glucose, and other investigations were also given.</p><p><strong>Results: </strong>The angiographic characteristics also revealed no difference in single-, double-, and triple-vessel disease distribution between the two groups. Smokers consumed tobacco in a larger quantity and had a slightly higher proportion of more severe stenosis (>70%) compared to users of smokeless tobacco, but this was statistically insignificant.</p><p><strong>Conclusion: </strong>CAD risk profiles of smokeless tobacco users and smokers are comparable, thus establishing that smokeless tobacco has similar cardiovascular risk to tobacco smoking.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S245-S248"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Periodontal Intervention on HbA1c Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study.","authors":"Ruchi Raval, Mahalinga Bhat, Subraya Bhat Giliyar, Kumari Upasana, Vishal Singh, Ayon Gupta","doi":"10.4103/jpbs.jpbs_1318_25","DOIUrl":"10.4103/jpbs.jpbs_1318_25","url":null,"abstract":"<p><strong>Background: </strong>Periodontal diseases, initiated by microbial plaque biofilm, are inflammatory conditions affecting the supporting structures of teeth. Diabetes mellitus is a significant risk factor for periodontitis, and a bidirectional relationship exists where chronic periodontal inflammation may impair glycemic control. However, the impact of periodontal treatment on glycemic outcomes remains inconclusive. This study aimed to assess the effect of non-surgical periodontal therapy on metabolic control, as measured by HbA1c levels, in patients with type 2 diabetes and mild-to-moderate generalised chronic periodontitis.</p><p><strong>Materials and methods: </strong>A randomized controlled clinical trial was conducted at the Department of Periodontology, Manipal College of Dental Science, Manipal, Karnataka, India, with ethical clearance from the Institutional Ethics Committee (IEC No. 151/2011). One hundred eligible participants, aged 30 to 70 years, diagnosed with type 2 diabetes (HbA1c 6.5-7.5%) and mild to moderate chronic periodontitis (clinical attachment loss [CAL] 1-4 mm per AAP 1999 classification), were recruited. Participants were randomized into two groups (<i>n</i> = 50 each): a test group receiving non-surgical periodontal therapy (scaling and root planing) and a control group receiving no periodontal intervention. HbA1c levels were assessed at baseline and 3 months using high performance liquid chromatography. Clinical periodontal parameters (plaque index, gingival index, modified sulcus bleeding index, CAL, and probing pocket depth) were also assessed. Data were analysed using SPSS version 14, with paired <i>t</i>-tests for within-group comparisons and independent <i>t</i>-tests for intergroup differences, with <i>P</i> < 0.05 considered statistically significant. Results and.</p><p><strong>Conclusion: </strong>The test group showed greater improvements in all periodontal parameters compared to controls, though HbA1c levels did not differ significantly over three months. Overall, the findings indicate a modest link between better periodontal health and a slight HbA1c reduction in well-controlled diabetes.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S215-S217"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}