Journal of pharmacy & bioallied sciences最新文献_第8页

A Hospital-Based Cross-Sectional Study on the Suboptimal Use of Eye Protective Devices (EPDs) Among Blue-Collar Professionals in India. 一项以医院为基础的关于印度蓝领专业人员眼罩（EPDs）使用不理想的横断面研究

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-11-19 DOI: 10.4103/jpbs.jpbs_952_25

Kirthi Raj, B K Ravindranath, S Varsha, Heena D Tiwari, Praveen Kumar Varma K Datla, Rahul Tiwari

{"title":"A Hospital-Based Cross-Sectional Study on the Suboptimal Use of Eye Protective Devices (EPDs) Among Blue-Collar Professionals in India.","authors":"Kirthi Raj, B K Ravindranath, S Varsha, Heena D Tiwari, Praveen Kumar Varma K Datla, Rahul Tiwari","doi":"10.4103/jpbs.jpbs_952_25","DOIUrl":"10.4103/jpbs.jpbs_952_25","url":null,"abstract":"Background: Ocular injuries, especially corneal foreign bodies (CFBs), are common among blue-collar professionals in India due to the insufficient use of protective eye equipment. This study aimed to the investigate the incidence and causes of suboptimal Eye Protective Device (EPD) usage.Methods: A cross-sectional study was conducted at a tertiary hospital from January to June 2024, including 102 patients with occupational CFBs. A structured questionnaire assessed demographics, occupational exposure, EPD usage, and awareness levels.Results: The mean age was 37.97 years. Welding (38.23%) and metal grinding (31.37%) were the leading causes of injury. Only 27.45% regularly used EPDs, 17.64% used them occasionally, and 54.90% never used them. Reasons for non-usage included lack of regulations (60.78%), unawareness (17.64%), and financial constraints (15.68%). Notably, 35.29% had previously attempted foreign body removal themselves. Despite 80.39% being aware of EPDs, usage remained low.Conclusion: There is a significant gap between awareness and practice regarding EPD usage. Enforcement of workplace safety laws and provision of affordable EPDs are essential to prevent CFBs and related complications.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S115-S117"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-Loop Anesthesia: Advances in Automated Drug Delivery and Perioperative Monitoring. 闭环麻醉：自动给药和围手术期监测的进展。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.4103/jpbs.jpbs_1491_25

Rahul G Daga, Anitabh Sukhadeve, Amit Suthar

引用次数: 0

Microbiological Profile of Surgical Site Infections Post Laparotomy and Neurosurgery: A Prospective Observational Study. 剖腹手术和神经外科术后手术部位感染的微生物特征：一项前瞻性观察研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.4103/jpbs.jpbs_1379_25

Ashish Agrawal, Suryakant Tiwari, Ashutosh K Srivastava, Jeevan Shetty, Purti Tripathi, Dharmendra S Rajput

{"title":"Microbiological Profile of Surgical Site Infections Post Laparotomy and Neurosurgery: A Prospective Observational Study.","authors":"Ashish Agrawal, Suryakant Tiwari, Ashutosh K Srivastava, Jeevan Shetty, Purti Tripathi, Dharmendra S Rajput","doi":"10.4103/jpbs.jpbs_1379_25","DOIUrl":"10.4103/jpbs.jpbs_1379_25","url":null,"abstract":"Background: Surgical site infections (SSIs) are among the most common postoperative complications, significantly impacting morbidity, hospital stay, and healthcare costs. Identifying the microbiological spectrum and resistance patterns is essential for effective management.Material and methods: This prospective observational study was conducted in a tertiary care hospital in Central India among 78 patients who developed SSIs following elective neurosurgical and laparotomy procedures. Pus/wound swab samples were collected aseptically and processed using standard culture methods. Isolates were identified, and antibiotic susceptibility testing was performed as per CLSI guidelines.Results: Among 78 samples, 62.8% showed growth. E. coli (21.8%) and S. aureus (19.2%) were the most common isolates. Concomitant infections included UTI (46.5%), BSI (51.2%), and VAP (7%). E. coli showed 82.3% sensitivity to piperacillin-tazobactam and 53% to amikacin. S. aureus was 100% sensitive to vancomycin and linezolid. Klebsiella and Pseudomonas showed 75% and 42.8% sensitivity to piperacillin-tazobactam, respectively. Acinetobacter showed 50% sensitivity to meropenem.Conclusion: Gram-negative organisms, particularly E. coli and Klebsiella, were the leading SSI pathogens, with significant resistance to cephalosporins and carbapenems. The high MRSA prevalence highlights the need for stringent infection control and targeted antibiotic stewardship.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S221-S223"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Spectral Domain OCT Changes Following Anti-VEGF Therapy in Diabetic Macular Edema. 糖尿病黄斑水肿抗vegf治疗后光谱域OCT变化的评价。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.4103/jpbs.jpbs_1238_25

Garima Mandloi, Aashi Jain, Anjaly Sharma, Eva Rani Tirkey, Siddharth Jain

{"title":"Evaluation of Spectral Domain OCT Changes Following Anti-VEGF Therapy in Diabetic Macular Edema.","authors":"Garima Mandloi, Aashi Jain, Anjaly Sharma, Eva Rani Tirkey, Siddharth Jain","doi":"10.4103/jpbs.jpbs_1238_25","DOIUrl":"10.4103/jpbs.jpbs_1238_25","url":null,"abstract":"Background: Diabetic macular edema (DME) is a leading cause of visual impairment in diabetic retinopathy. Spectral-domain optical coherence tomography (SD-OCT) enables high-resolution assessment of retinal microstructural changes. Antivascular endothelial growth factor (anti-VEGF) therapy is the standard treatment for DME; however, anatomical and functional outcomes vary. This study evaluates SD-OCT morphological changes following anti-VEGF therapy and their correlation with visual outcomes.Materials and methods: A prospective observational study was conducted on 100 eyes of 92 DME patients at a tertiary care center. All patients received three monthly intravitreal injections of bevacizumab (1.25 mg/0.05 ml). Baseline and post-treatment evaluations included best-corrected visual acuity (BCVA) and SD-OCT imaging. OCT biomarkers such as central macular thickness (CMT), cystoid macular edema (CME), subretinal fluid (SRF), disorganization of retinal inner layers (DRIL), ellipsoid zone (EZ) disruption, external limiting membrane (ELM) status, and hyperreflective foci (HRF) were assessed.Results: Post-treatment analysis showed significant reduction in CMT and resolution of CME and SRF in many cases. Partial restoration of EZ and ELM, as well as decreased HRF and DRIL, were associated with improved BCVA. Central-involving DME and EZ disruption were significantly associated with poorer outcomes.Conclusion: Anti-VEGF therapy leads to measurable anatomical improvements on SD-OCT in DME. Specific OCT biomarkers can aid in predicting visual response and guiding management.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S212-S214"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Clinical Evaluation of Platelet-Rich Fibrin with and Without Bioactive Glass Graft (PerioGlas) In Managing Mandibular Grade II Furcation Defects. 富血小板纤维蛋白伴与不伴生物活性玻璃（玻璃周）移植治疗下颌骨II级功能缺损的临床比较评价。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_1729_25

Manimekalai, Abhijit Datta, Shanvi Ray, Monica Sinha, Mariea Francis, Radhika P M Sooranagi

{"title":"Comparative Clinical Evaluation of Platelet-Rich Fibrin with and Without Bioactive Glass Graft (PerioGlas) In Managing Mandibular Grade II Furcation Defects.","authors":"Manimekalai, Abhijit Datta, Shanvi Ray, Monica Sinha, Mariea Francis, Radhika P M Sooranagi","doi":"10.4103/jpbs.jpbs_1729_25","DOIUrl":"10.4103/jpbs.jpbs_1729_25","url":null,"abstract":"Introduction: Furcation involvement, being one of the most common complications of periodontal disease, is managed by a variety of materials, including autografts, allografts, xenografts, and barrier membranes. The bioactive glass ceramic bone graft PerioGlas exhibits both osteoconductive and biointeractive qualities, and platelet-rich fibrin (PRF) may facilitate the healing of both soft and hard tissues. Objective: The purpose of this clinical study was to compare the results of PRF alone and PRF with PerioGlas in mandibular Grade II furcation defects.Methods: Ten patients with bilateral mandibular molar furcations participated in a split-mouth study, which evaluated radiographic and clinical parameters at baseline, three months, and six months.Results: At six months, both groups had significantly improved, with PRF + PerioGlas producing more bone fill and a smaller defect.Conclusion: PRF works well on a standalone basis, but when combined with PerioGlas, it offers better regenerative results in Grade II furcation defects.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S203-S205"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Root Ring Technique for Immediate Implant Placement: A Novel Horizontal Socket Shield Concept. 即刻种植的根环技术：一种新的水平窝护盾概念。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.4103/jpbs.jpbs_1550_25

Mohamad El Moheb, Aymane El Moheb, Rakhi Issrani

引用次数: 0

Ménière's Disease: Treatment Options, Dietary Restrictions, and Lifestyle Modifications. msamniires病：治疗选择，饮食限制和生活方式改变。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_1593_25

Sahil Kongala

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Long-Term Evaluation of Full Pulpotomy in Mature Permanent First Molars with Symptomatic Irreversible Pulpitis. 成熟恒磨牙全切牙术治疗症状性不可逆牙髓炎的远期疗效评价。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_1544_25

Bakheeta Al Mansoori, Lina Ahmad Nashbat, Fayeq Migdadi

{"title":"Long-Term Evaluation of Full Pulpotomy in Mature Permanent First Molars with Symptomatic Irreversible Pulpitis.","authors":"Bakheeta Al Mansoori, Lina Ahmad Nashbat, Fayeq Migdadi","doi":"10.4103/jpbs.jpbs_1544_25","DOIUrl":"10.4103/jpbs.jpbs_1544_25","url":null,"abstract":"Objectives: To evaluate the long-term clinical and radiographic success of full pulpotomy as a definitive treatment for symptomatic irreversible pulpitis in mature permanent first molars among pediatric patients.Methods: A retrospective study of 51 patients (10-16 years) treated at Al Dhafra Hospitals, Abu Dhabi, UAE (2017-2023) was conducted. After coronal pulp removal, hemostasis was achieved with 5.25% sodium hypochlorite, and Mineral Trioxide Aggregate (MTA) was placed over pulp stumps. Definitive restorations were completed in the same visit. Patients were followed clinically and radiographically for up to seven years.Results: Of 51 treated molars, 49 (95.2%) remained asymptomatic with no radiographic pathology. One failure (1.96%) occurred due to coronal restoration loss, leading to pulp necrosis. No significant association was found between treatment success and variables such as age, sex, tooth type, or preoperative signs.Conclusion: Full pulpotomy using MTA shows excellent long-term success in mature permanent first molars with irreversible pulpitis, providing a biologically conservative and reliable alternative to root canal therapy.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S168-S170"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of a Combined Medical and Surgical Protocol in the Management of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study. 内外科联合治疗药物相关性颌骨骨坏死的疗效：一项回顾性研究

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-05 DOI: 10.4103/jpbs.jpbs_1532_25

Devang R Deshpande, Harika Gadde, Lakshmi A Gonuguntla, Devisri P Peram, Joshi V Ram Dhara, Samreen I Shaik

{"title":"The Efficacy of a Combined Medical and Surgical Protocol in the Management of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study.","authors":"Devang R Deshpande, Harika Gadde, Lakshmi A Gonuguntla, Devisri P Peram, Joshi V Ram Dhara, Samreen I Shaik","doi":"10.4103/jpbs.jpbs_1532_25","DOIUrl":"10.4103/jpbs.jpbs_1532_25","url":null,"abstract":"Background: Medication-related osteonecrosis of the jaw (MRONJ) is a serious and debilitating condition characterized by exposed bone in the maxillofacial region in patients with a history of antiresorptive or antiangiogenic therapy. While various management strategies exist, there is no universally accepted standard of care.Methods: A retrospective chart review was conducted for 30 patients diagnosed with MRONJ, who were treated at our institution between 2024 and 2025. All patients received a standardized protocol consisting of a medical regimen (pre- and post-operative antibiotics, chlorhexidine mouthwash, and a drug holiday) followed by surgical intervention (sequestrectomy or debridement with primary wound closure).Results: The primary outcome, complete resolution, was achieved in 83.3% of patients, with a recurrence rate of 16.7%. The mean healing time was approximately 10.4 weeks. Post-operative complications were infrequent but did occur, including wound dehiscence (13.3%), postoperative infection (10%), and pain (26.7%). These results suggest that the combined medical and surgical protocol is a highly effective treatment for MRONJ, yielding a favorable resolution rate with manageable complications.Conclusion: The combined medical and surgical protocol is a highly effective and reliable treatment strategy for MRONJ. The high rate of complete resolution and low rate of complications support this approach as a viable management option.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S239-S241"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study between Chonchal Cartilage Tympanoplasty and Temporalis Facia Tympanoplasty by Underlay Technique. 软骨鼓室成形术与颞面鼓室成形术的对比研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.4103/jpbs.jpbs_852_25

Nasreen Begum

{"title":"Comparative Study between Chonchal Cartilage Tympanoplasty and Temporalis Facia Tympanoplasty by Underlay Technique.","authors":"Nasreen Begum","doi":"10.4103/jpbs.jpbs_852_25","DOIUrl":"10.4103/jpbs.jpbs_852_25","url":null,"abstract":"Background: Tympanoplasty is a standard surgical intervention for chronic otitis media (COM) with tympanic membrane perforation. Among various grafting materials, temporalis fascia and conchal cartilage are widely used. This research compares the anatomical and functional outcomes of underlay tympanoplasty using these two grafts.Objectives: To evaluate and compare the graft uptake rate and hearing outcomes of conchal cartilage versus temporalis fascia grafts in type I tympanoplasty using the underlay technique.Methods: A prospective comparative research was conducted on 60 subjects diagnosed with COM. Subjects were randomly allocated into two groups: batch TC (n = 30) underwent tympanoplasty using conchal cartilage, and batch TT (n = 30) underwent tympanoplasty using temporalis fascia. Graft uptake and hearing improvement were assessed postoperatively using pure tone audiometry at three months.Results: Graft uptake was higher in the cartilage group (93.3%) than in the fascia group (83.3%), with statistical significance (P = 0.041). Hearing improvement and air-bone gap closure were comparable in both groups, with no significant difference (P > 0.05).Conclusion: Conchal cartilage provides superior anatomical outcomes with comparable hearing results to temporalis fascia, making it a reliable graft choice in underlay tympanoplasty.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S120-S122"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0