{"title":"Autogenic Relaxation: A Gateway to Improve Mental Health for the Elderly with Depression and Anxiety.","authors":"Shanmugalakshmi Subbiah, Theranirajan Ethiraj, Shankar Shanmugam Rajendran, Venkatesh Mathankumar, Anbalagan Marudan, Albeenasiril Marianathan, Saraswathi Balasubramanian","doi":"10.4103/jpbs.jpbs_1618_24","DOIUrl":"10.4103/jpbs.jpbs_1618_24","url":null,"abstract":"<p><strong>Background: </strong>Aging presents significant challenges to healthcare, particularly in the underdiagnosis of mental health conditions such as depression and anxiety. Non-pharmacological interventions like autogenic relaxation have been explored as potential therapeutic options for improving mental health outcomes in the elderly.</p><p><strong>Objective: </strong>This study aimed to determine the effectiveness of autogenic relaxation in reducing symptoms of depression and anxiety among elderly individuals and to examine its correlation with demographic and clinical variables.</p><p><strong>Methods: </strong>A quasi-experimental pre-test and post-test control group design was conducted with 120 elderly patients from the National Centre of Ageing in Guindy, Chennai. Participants were randomly assigned to either an experimental group, which underwent autogenic relaxation training, or a control group, which received standard care. Data were collected over four weeks using the Geriatric Depression Scale and the Geriatric Anxiety Scale.</p><p><strong>Results: </strong>Post-intervention analysis revealed significant reductions in symptoms of depression (60.47%) and anxiety (41.80%) in the experimental group, whereas no such improvements were observed in the control group. Furthermore, demographic factors such as age and education level showed a significant positive correlation with the intervention outcomes.</p><p><strong>Conclusion: </strong>Autogenic relaxation is an effective, low-risk intervention for improving geriatric mental health, particularly when tailored to individual demographic characteristics. These findings suggest its potential for wider implementation in elderly care settings.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S694-S696"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aparna Rai, Saloni Jain, Minhaj A Khan, Mohd Abbas Ansari, Astha Agrawal, Aisha Begum
{"title":"Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis.","authors":"Aparna Rai, Saloni Jain, Minhaj A Khan, Mohd Abbas Ansari, Astha Agrawal, Aisha Begum","doi":"10.4103/jpbs.jpbs_1806_24","DOIUrl":"10.4103/jpbs.jpbs_1806_24","url":null,"abstract":"<p><p>This study aimed to identify biomarkers that could enhance the accuracy of diagnosing reversible and irreversible pulpitis. This systematic review was conducted in adherence to the guidelines outlined in PRISMA. A total of twelve studies were included for analysis. A meta-analysis of nine studies showed an overall effect of 9.91 with a <i>P</i> value of less than 0.00001. Eight out of the nine studies favored the control group. The studies exhibited substantial variation, with an I-square value of 99%, indicating significant heterogeneity (<i>P</i> < 0.00001). According to this systemic review, the expression of IL-8, TNF-a, MMP-9, and RAGE gene and protein was increased in pulp samples from teeth clinically diagnosed with irreversible symptomatic pulpitis.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S188-S190"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges of Gingival Surgery Approaches in the Treatment of Peri-Implantitis: A Systematic Review.","authors":"Samira Cheraghi, Ailar Yousefbeigi, Omid Tavakol, Mina Moradi, Asieh Mozaffari, Meysam Mohammadikhah, Pouria Farahani","doi":"10.4103/jpbs.jpbs_405_25","DOIUrl":"10.4103/jpbs.jpbs_405_25","url":null,"abstract":"<p><p>Dental implants are an effective method to replace fixed and removable prostheses that were traditionally used. To properly treat peri-implantitis, early diagnosis, and continuous and timely patient monitoring are essential. This review was conducted to assess the challenges of gingival surgery approaches in the treatment of peri-implantitis to help dentists in this field. A comprehensive search of PubMed, Scopus, and Google Scholar databases was conducted between 2021 and the end of 2024. Two independent reviewers screened the studies based on the abstracts of each of them. In case of discrepancies, a third reviewer also judged the disagreements. Data from the articles were extracted in designed forms so that the key findings of each study could be discussed, including the name of the first author, year of publication, and key findings. Based on the search keywords 541, studies were found from the datasets. 498 studies were screened using title and abstract evaluation, and finally 14 articles were included in the study. Finally, we have briefly reviewed the challenges of gingival surgery approaches in the treatment of peri-implantitis. It is concluded that successful management of peri-implantitis requires careful clinical assessment, appropriate treatment planning, and selection of effective surgical techniques. Regular periodontal care, careful control of soft and hard tissues, and patient participation in oral hygiene play a key role in prevention and treatment.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S159-S162"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Class II Malocclusion Treatment Using Combined Twin Block and Fixed Orthodontic Appliances: A Case Series.","authors":"Kasturi Mukherjee, Prakash Banerjee, Vikrant Omprakash Shetty, Poulomi Roy, Shyamal Bar, Shweta Sunil Bakre","doi":"10.4103/jpbs.jpbs_401_25","DOIUrl":"10.4103/jpbs.jpbs_401_25","url":null,"abstract":"<p><p>The effect of the Twin Block functional orthodontic appliances is mostly dento-alveolar with small skeletal effect. There are certain clinical indications where functional appliances can be used successfully in class II malocclusion, e.g., in a growing patient. The use of these appliances is greatly dependent on the patient's compliance, and they simplify the fixed appliance phase. The use of functional jaw orthopedics, at the correct time during growth, can ultimately result in achieving a broad beautiful smile, an excellent functional occlusion, a full face with a beautiful jaw line and lateral profile. Here the cases were treated with Twin Block appliance followed by fixed appliance to detail the occlusion. The design and treatment effects were demonstrated in these case reports.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S1046-S1049"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical and Radiographic Evaluation of Effect of Ellagic Acid on Osseointegration Around Dental Implants: An Original Research.","authors":"Mehjubah, Ghanta Chaitanya, Syeda Tawkhira Tabasum, Tupili Murali Krishna, Deepak Kolte, Ashvin Wagh, Rahul Tiwari","doi":"10.4103/jpbs.jpbs_1411_24","DOIUrl":"10.4103/jpbs.jpbs_1411_24","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical and radiographic effects of ellagic acid on osseointegration around dental implants.</p><p><strong>Materials and methods: </strong>A total of 60 patients, aged between 25 and 55 years, requiring dental implants, were designated for the study. They were randomly divided into two sects: The experimental group (30 patients) received dental implants with ellagic acid, and the control group (30 patients) received dental implants without ellagic acid. The peri-implant pocket depth, implant stability, and gingival index were recorded. Radiographic analysis was conducted to measure bone density and marginal bone loss around the implants at 3-, 6-, and 12-months post-implantation.</p><p><strong>Results: </strong>The experimental group showed significantly higher implant stability and bone density compared to the control group at all time points (<i>P</i> < 0.05). The peri-implant pocket depth and gingival index were lower in the experimental group, indicating better periodontal health. Radiographically, the experimental group demonstrated less marginal bone loss compared to the control group.</p><p><strong>Conclusion: </strong>Ellagic acid enhances osseointegration around dental implants, resulting in improved clinical outcomes and reduced marginal bone loss.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S489-S491"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Yoga on Mental Stress, Lipid Profile, and BMI in Wives of BSF Personnel.","authors":"Priti Bhanderi, Rupali Keshavrao Parlewar, Punam Verma, Hitesh Jani, Bhoopendra Patel, Madhu Bala","doi":"10.4103/jpbs.jpbs_327_25","DOIUrl":"10.4103/jpbs.jpbs_327_25","url":null,"abstract":"<p><strong>Background: </strong>To investigate the effects of a one-month yoga protocol on perceived stress, lipid profile, and body mass index (BMI) in wives of Border Security Force personnel in India.</p><p><strong>Methodology: </strong>Pre-post-interventional study with 200 female participants. Participants followed a 60-min daily yoga routine for one month, including asanas, pranayama, and meditation. Measurements were taken before and after the intervention, including the perceived stress scale, lipid profile, fasting blood sugar (FBS), BMI, and cardiovascular parameters. Statistical analysis used the Shapiro-Wilk test for normality. As data was non-normally distributed, the Wilcoxon signed-rank test assessed changes after one month. <i>P</i> < 0.05 was significant. Effect sizes were calculated using rank-biserial correlation.</p><p><strong>Results: </strong>The study found significant improvements. Perceived Stress Scale scores dropped by 60.73%, showing major stress relief. Lipid levels improved, with high-density lipoprotein rising by 2.53%, low-density lipoprotein dropping by 9.01%, and total cholesterol decreasing by 2.46%. Cardiovascular health benefited as systolic blood pressure fell by 5.09% and pulse rate by 1.91%. FBS dropped by 2.29%, while BMI showed a slight 0.54% reduction. Effect sizes varied from small to very large, with most parameters showing medium to large effects. Statistical significance (<i>P</i> < 0.05) was noted for most measures.</p><p><strong>Conclusion: </strong>The yoga intervention effectively improved stress levels, lipid profiles, and cardiovascular parameters, with varying impacts on other physiological markers. The study suggests yoga can enhance physical, mental, emotional, and spiritual wellness by reducing stress and improving health parameters. Limitations in generalizing results were noted due to the short study duration.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S290-S292"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roshan Mandloi, Shivangi Rajput, Bhavana Patel, Sarika Rawat, Sonu Rawat
{"title":"Effects of Continuous Use of Oral Drospirenone/Estradiol on Lipid Profile, Body Weight, and BP in Females from Early Menopause.","authors":"Roshan Mandloi, Shivangi Rajput, Bhavana Patel, Sarika Rawat, Sonu Rawat","doi":"10.4103/jpbs.jpbs_1627_24","DOIUrl":"10.4103/jpbs.jpbs_1627_24","url":null,"abstract":"<p><strong>Background: </strong>DRSP (drospirenone) is a progestin that has antiandrogenic and anti-mineralocorticoid activity. When used combined with estradiol (E2), drospirenone helps in relieving symptoms of menopause.</p><p><strong>Aim: </strong>To assess the effects of continuous use of oral drospirenone/estradiol on lipid profile, body weight, and BP to minimize cardiovascular risk in females with early menopause.</p><p><strong>Methods: </strong>The present study assessed 128 menopausal females with a mean amenorrhoeic period, mean BMI, and mean age of 2.46 ± 2.44 years, 25.06 ± 2.92 kg/m2, and 49.17 ± 4.60 years, respectively. Effects of combined oral drospirenone/estradiol in 1 mg dose were assessed on lipid levels, hormones, anthropometric data, heart rate, and BP variability in early menopausal females with untreated stage 1 hypertension. All subjects were assessed before and after 12 months of therapy.</p><p><strong>Results: </strong>DRSP/E2 resulted in significant BP reduction during 6 and 12 months of therapy, with systolic and diastolic BP reduction in -4.50 to -8.50 and -4.0 to -5.0 mm Hg, respectively. No significant change in nocturnal 24-hour BP, significant day-time and night-time reduction at follow-up in HR, significant reduction in BMI, apolipoprotein B, and cholesterol were observed.</p><p><strong>Conclusions: </strong>The present study concludes that continuous and long-term therapy using oral drospirenone/estradiol leads to a significant reduction in cardiovascular diseases and better BP control.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S739-S741"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Sagittal Guidance vs Twin-Lock Twin-Block Device on Alveolar Bone Near Lower Incisors in Adolescents Having Class II Div 1 Malocclusion.","authors":"Gauravardhan Kulkarni, Ram Kishore Ratre, Aastha Purohit, Rahul Tiwari, Charu Srivastava, Abha Chansoria, Sanjana Bhargava, Nandita Gautam","doi":"10.4103/jpbs.jpbs_233_25","DOIUrl":"10.4103/jpbs.jpbs_233_25","url":null,"abstract":"<p><strong>Aim: </strong>This research aimed to evaluate the effects of modified Sagittal-guidance twin-block (SGTB) appliance on class II skeletal and dental alterations among developing pt.</p><p><strong>Methodology: </strong>A total of 25 adolescent adults in class II div 1 made up the sample, which split equally between the twin-block (TB) and SGTB groups. The course therapy lasted 11.56 ± 1.73 months.</p><p><strong>Results: </strong>There was no discernible distinction between T1 and T2 in terms of lingual bone height, lingual and overall dental bony volume, and whole alveolar bone width (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>In maturing children having class II div 1, labial bone decrease surrounding the mandibular incisors was noted following intervention with the two kinds of prostheses.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S388-S390"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of Vegetarian and Nonvegetarian Diets on hs-CRP Levels, Lipid Profiles, and Cardiovascular Health in Adults.","authors":"Sunil Chakole, Namrata Anjankar, Ashish Anjankar, Harshal Narkhede, Sanket Mahajan","doi":"10.4103/jpbs.jpbs_470_25","DOIUrl":"10.4103/jpbs.jpbs_470_25","url":null,"abstract":"<p><strong>Aim: </strong>The study aims to explore the impact of vegetarian and non-vegetarian diets on high-sensitivity C-reactive protein (hsCRP) levels and lipid profiles to understand how different dietary patterns contribute to heart health and inflammation.</p><p><strong>Objective: </strong>To assess the effects of long-term vegetarian and non-vegetarian diets on hsCRP levels and lipid profile markers, including total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride levels, in order to determine their potential role in reducing cardiovascular disease risk.</p><p><strong>Materials and methods: </strong>This research was conducted at the Department of Biochemistry, Maharashtra, India. A total of 70 participants aged between 25 and 45 years were included, with an equal distribution of vegetarians and non-vegetarians. Participants followed their designated diet for a period of seven years. Fasting blood samples were collected and analyzed using highly sensitive enzyme-linked immunosorbent assay (ELISA) tests and automated laboratory equipment to measure hsCRP and lipid profile levels.</p><p><strong>Results: </strong>The study found that vegetarian participants exhibited significantly lower hsCRP levels (1.2 ± 0.4 mg/L) compared to non-vegetarians (2.8 ± 0.6 mg/L). Additionally, vegetarians had more favorable lipid profiles, characterized by lower total cholesterol, LDL, and triglyceride levels, as well as higher HDL levels. These findings suggest that vegetarian diets contribute to reduced inflammation and enhanced heart health by improving lipid markers.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S284-S286"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hitesh M Desarda, Sumit S Shetgar, Siddharth U Chaudhari, Rahul K Chaudhari, Bathini Chandrahas, V V Alekhya Burli
{"title":"Evaluation of Human Tooth Properties to Use as an Autogenous Graft - An <i>In Vitro</i> Study.","authors":"Hitesh M Desarda, Sumit S Shetgar, Siddharth U Chaudhari, Rahul K Chaudhari, Bathini Chandrahas, V V Alekhya Burli","doi":"10.4103/jpbs.jpbs_1781_24","DOIUrl":"10.4103/jpbs.jpbs_1781_24","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, bone graft materials prepared from permanent teeth have come into focus, and clinical and histological outcomes of this material have been confirmed by some studies. The aim of present study is to evaluate the characteristics of autogenous tooth graft material to use as a bone graft.</p><p><strong>Material and methods: </strong>Extracted teeth were taken into consideration with the informed consent from the patients. Immediately after extraction, teeth were processed with a novel technique to prepare the graft. Characteristics of this tooth graft material were then compared with those of DFDBA graft with the use of SEM and EXD study.</p><p><strong>Result: </strong>SEM and EXD studies have shown the similarity in surface characteristics and elemental composition when compared to novel DFDBA graft.</p><p><strong>Conclusion: </strong>Autogenous tooth graft should can be a good alternative to other graft materials.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S878-S880"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}