Journal of pharmacy & bioallied sciences最新文献

{"title":"Integrating Lifestyle Modifications and Advanced Sperm Separation Technology: A Case Study on Overcoming Male Infertility Using the LensHooke CA0 Device.","authors":"Juhi Barai, Akash More, Namrata Choudhary, Aru Chaudhary, Puja Dhamija, Ganesh Laxman Kalaskar","doi":"10.4103/jpbs.jpbs_172_25","DOIUrl":"10.4103/jpbs.jpbs_172_25","url":null,"abstract":"<p><p>This study describes the disadvantages of the centrifugation method along with the utilization of high-technology sperm separation to overcome infertility. A 31-year-old female and a 36-year-old male were presented with primary infertility in Maharashtra. The female had normal hormonal profiles; however, the male had a sperm deoxyribonucleic acid (DNA) fragmentation (SDF) index of 46%, which may be due to lifestyle factors such as occupational exposure to chemicals and alcohol use. The contribution to the rise in the SDF was previously due to conventional density gradient centrifugation. To reduce the SDF, the male was put on two months of treatment including lifestyle modification (stress reduction, diet improvement, exercise, etc.) along with the antioxidants. Following this, the sperm was separated through the LensHooke CA0 device that avoids centrifugation. This reduces oxidative stress and DNA damage using a natural motility-based sorting mechanism. Post-treatment, the SDF decreased dramatically to 17%. The couple became pregnant with IUI. This case shows that the LensHooke CA0 device effectively lowers SDF, while ART outcomes improve. These results highlight that lifestyle modification should be implemented along with modern, minimally invasive sperm separation procedures for male infertility treatment.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S1004-S1007"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Intraovarian Platelet-Rich Plasma (PRP) Therapy: A New Hope for Polycystic Ovary Syndrome (PCOS) Patients.","authors":"Aru Chaudhary, Akash More, Namrata Choudhary, Juhi Barai, Tejaswini Wadhe","doi":"10.4103/jpbs.jpbs_166_25","DOIUrl":"10.4103/jpbs.jpbs_166_25","url":null,"abstract":"<p><p>This case study represents a couple experiencing primary infertility for 4 years, with the male suffering from hypertension and normozoospermic condition, whereas the female suffers from Polycystic Ovary Syndrome (PCOS), which results in low ovarian reserve. The couple underwent the two failed IUI (Intrauterine Insemination) procedures and then was advised to go for Intra-cytoplasmic sperm injection (ICSI). After the first unsuccessful cycle of ICSI, the female patient underwent intraovarian platelet-rich plasma (PRP) therapy to improve the ovarian reserve and enhance egg quality. The second cycle of ICSI following the PRP treatment helped to improve ovarian response with more mature oocytes retrieved. After another ovum pick-up was conducted in which more mature oocytes were retrieved and after multiple embryo transfer (ET) cycles, a positive pregnancy was achieved. The patient was asked to have regular checkups during pregnancy. This study results in the potential benefit of intraovarian PRP therapy in enhancing ovarian function and reserve.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S1015-S1018"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Awareness, and Attitude on Malocclusion in Nursing Students.","authors":"Bhumika Khattar, Aseem Sharma, Geetika Tomer, N R Shrinivaasan, Munaz Mulla, Tanushree Sharma, Mukul Shetty, Simran Ahmed, Mushir Mulla","doi":"10.4103/jpbs.jpbs_1929_24","DOIUrl":"10.4103/jpbs.jpbs_1929_24","url":null,"abstract":"<p><strong>Background: </strong>Malocclusion is one of the developmental abnormalities of the dentoalveolar structures. One of the most abundant sources of healthcare for the general public is nursing students.</p><p><strong>Objective: </strong>Assessment of knowledge, awareness, and attitude on malocclusion among nursing students.</p><p><strong>Materials and methods: </strong>A survey using a cross-sectional questionnaire was administered to 100 nursing school students. The nursing school students were given a pre-structured, self-administered questionnaire with ten items to gauge their awareness, knowledge, and attitude regarding malocclusion.</p><p><strong>Result: </strong>Just 21% of the 100 kids were prepared to receive orthodontic treatment in the future. The others believed that orthodontic treatment was not necessary given their careers or the culture in which they lived. Their awareness and attitude were mediocre.</p><p><strong>Conclusion: </strong>The study's total sample population was somewhat aware of malocclusion and open to receiving orthodontic treatment.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S326-S328"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graftless Solutions for Rehabilitation of Atrophied Maxilla - Zygomatic Versus Subperiosteal Implants - A Systematic Review.","authors":"M V S Sudhir, Rajendra B Prasad, Niranjani Krothapalli, Perukasrujan Kumar","doi":"10.4103/jpbs.jpbs_1802_24","DOIUrl":"10.4103/jpbs.jpbs_1802_24","url":null,"abstract":"<p><strong>Purpose: </strong>Rehabilitation of severely atrophic maxillae is challenging when graft-based techniques are unsuitable. This review compares zygomatic and subperiosteal implants for clinical outcomes, complications, and procedural considerations.</p><p><strong>Methods: </strong>A systematic search in major databases identified studies on zygomatic and subperiosteal implants, analyzing survival rates, complications, and patient satisfaction.</p><p><strong>Results: </strong>Zygomatic implants (623 patients) showed a 96.1% survival rate, with sinusitis as a common complication. Subperiosteal implants (257 patients) had a 97.8% short-term survival rate, with soft tissue dehiscence as the main issue. CAD/CAM improved subperiosteal implant outcomes.</p><p><strong>Conclusions: </strong>Both implants are effective, with zygomatic implants offering established long-term success and subperiosteal implants emerging as a customizable alternative. Further studies are needed for validation.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S207-S210"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Cervical Stenosis: A Case Study of Transmyometrial Embryo Transfer in Infertility Treatment.","authors":"Devanshi Shah, Akash More, Namrata Choudhary, Ganesh Kalaskar, Puja Dhamija","doi":"10.4103/jpbs.jpbs_173_25","DOIUrl":"10.4103/jpbs.jpbs_173_25","url":null,"abstract":"<p><p>Cervical stenosis can be congenital or acquired, often resulting from previous surgeries, radiation therapy, or infections. It presents a significant challenge for embryo transfer during in vitro fertilization (IVF) procedures. This case study highlights the successful use of transmyometrial embryo transfer (TMET) as an alternative approach in a patient with severe cervical stenosis, leading to a positive clinical pregnancy outcome. A 36-year-old woman with primary infertility for four years underwent three failed IVF attempts due to severe cervical stenosis. Despite multiple attempts at conventional transcervical embryo transfer, the procedures were unsuccessful, resulting in complications such as cervical bleeding and uterine contractions. Her husband's semen analysis was normal. Following detailed counseling, the decision was made to proceed with TMET under ultrasound guidance. A catheter was inserted through the myometrium directly into the uterine cavity for embryo placement. The TMET procedure was performed without complications. Embryo transfer was successful, and the patient demonstrated a positive clinical pregnancy outcome. Early pregnancy monitoring revealed appropriate gestational sac development, and no further complications were reported. This case illustrates the effectiveness of TMET in overcoming anatomical barriers caused by cervical stenosis. TMET offers a viable alternative for patients who experience recurrent implantation failure due to failed transcervical transfers. Careful patient selection and the use of ultrasound guidance are essential for maximizing success rates and minimizing complications. Further research and comparative studies are recommended to establish standardized protocols and assess long-term outcomes of TMET in similar cases. TMET proved effective for a patient with severe cervical stenosis, leading to a successful pregnancy. Ultrasound guidance and careful patient selection were key to the procedure's success.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S1011-S1014"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Satisfaction and Functional Outcomes with Implant-Supported Overdentures versus Conventional Complete Dentures.","authors":"Mansi Rajput, Khadiza Begum, Sadananda Hota, Amit Kumar, Balaji S Munde, Sirisha Kommuri, Hina N Abdul","doi":"10.4103/jpbs.jpbs_1428_24","DOIUrl":"10.4103/jpbs.jpbs_1428_24","url":null,"abstract":"<p><strong>Introduction: </strong>The choice between implant-supported overdentures and conventional complete dentures plays a significant role in patient satisfaction and functional outcomes. Implant-supported overdentures are increasingly used due to their stability, comfort, and improved chewing efficiency. This study aims to evaluate the differences in patient-reported satisfaction and functional outcomes between these two types of prostheses.</p><p><strong>Methods: </strong>A cohort of 150 edentulous patients was evaluated using either implant-supported overdentures or conventional complete dentures. Patients completed a satisfaction questionnaire, and masticatory function was assessed through standardized masticatory performance tests. Data were analyzed using descriptive statistics and comparative analysis.</p><p><strong>Results: </strong>Patients with implant-supported overdentures reported significantly higher satisfaction, particularly in comfort, stability, and chewing ability. Masticatory efficiency was also notably better in the implant group. However, conventional dentures showed adequate results in terms of cost and accessibility.</p><p><strong>Conclusion: </strong>Implant-supported overdentures offer superior satisfaction and functional outcomes compared to conventional complete dentures, making them a preferred option for long-term edentulous rehabilitation.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S467-S469"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Corticosteroid Utilization in Dermatology: An Observational Study from a Teaching Hospital in Bhopal, India.","authors":"Abhishek Mishra, Hemlata Verma, Pawan Kumar Maurya, Yogesh Jain, Anna Alex","doi":"10.4103/jpbs.jpbs_1647_24","DOIUrl":"10.4103/jpbs.jpbs_1647_24","url":null,"abstract":"<p><strong>Background: </strong>Corticosteroids are commonly prescribed within dermatology, and rational prescribing practices can maximize therapeutic benefits while minimizing adverse effects. This study aimed to evaluate the prescribing patterns of corticosteroids for various skin disorders.</p><p><strong>Materials and methods: </strong>A prospective cross-sectional study was conducted in the collaboration of the department of pharmacology and the dermatology department of a tertiary care teaching hospital, reviewing 277 cases. Data were collected regarding demographics, medical history, and medications prescribed. Descriptive statistical analysis was employed to summarize the findings in terms of frequency and percentage.</p><p><strong>Results: </strong>The most common indications for corticosteroid use included dermatitis and psoriasis. Prednisolone and betamethasone were the most frequently prescribed medications. Among the treatment routes, the majority of therapies were administered topically. No adverse reactions were reported.</p><p><strong>Conclusion: </strong>Given the extensive range of corticosteroids and dosage forms available for treating dermatological conditions, rational therapy should prioritize the appropriate selection of drugs based on factors, such as potency, effectiveness, and cost.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S834-S836"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering Full Mouth Rehabilitation with Zygomatic Implants using Full Digital Work Flow: A Case Report with 3-Year Follow Up.","authors":"Alka Gupta, Unnati Gedam, Shweta Pandey, Jaivrat Gupta, Neelam Chandwani","doi":"10.4103/jpbs.jpbs_931_24","DOIUrl":"10.4103/jpbs.jpbs_931_24","url":null,"abstract":"<p><p>Full mouth rehabilitation using zygomatic implants has emerged as a transformative solution for patients with severe maxillary atrophy or insufficient bone quality, where traditional implant techniques are not feasible. Zygomatic implants, anchored in the zygomatic bone, provide a stable foundation for prosthetic reconstruction, bypassing the need for extensive bone grafting procedures. Digital technology enables precise diagnostics, virtual treatment planning, guided surgery, and the fabrication of highly accurate prostheses. This case report details a pioneering full mouth rehabilitation using zygomatic implants, implemented through a comprehensive digital workflow. Over a three-year follow-up period, we evaluate the clinical outcomes, prosthetic success, and patient satisfaction.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S979-S981"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Operative Assessment of Anatomical Position of Inferior Alveolar Nerve Using Cone Beam Computed Tomography During Bilateral Sagittal Split Osteotomy Surgery.","authors":"B John Rozar Raj, Shanmugasundaram Somasundaram, Bharan Ravindran, Sai Krishna Yelagala, T Guru Prasad, Krishna Kumar Vb Raja","doi":"10.4103/jpbs.jpbs_1709_24","DOIUrl":"10.4103/jpbs.jpbs_1709_24","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to assess the pre-operative assessment of the anatomical position of the inferior alveolar nerve using computed tomography during bilateral sagittal split osteotomy surgery.</p><p><strong>Materials and methods: </strong>The inferior alveolar nerve was delineated on a pre-operative CBCT scan from the position of the lingual first visible to the mental foramen on both sides. The buccolingual and supero-inferior distances from the inferior alveolar nerve canal were measured bilaterally at four different locations. The location of the nerve during the partial and complete split was recorded based on the CT data.</p><p><strong>Results: </strong>There was a higher average distance in 47 and 37 locations, respectively, between the buccal cortex and the IAN canal. There were statistically significant differences in the mean distance between the lingual cortex and the IAN canal in 45 and 35 regions, respectively. Ten patients had no visible nerve on the right side after the partial split, whereas eight patients had no visible nerve on the left side. There was statistically no difference between the right and left sides. Only eight individuals on the left side had the nerve located in the distal section, compared to eleven on the right. There were statistically significant variations between the left and right sides.</p><p><strong>Conclusion: </strong>The location and trajectory of the IAN canal can be ascertained with pre-operative CT imaging before BSSO surgery, which lowers the possibility of direct IAN bundle damage during the procedure.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S272-S274"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Vitamin D Deficiency Among Children (0-12 Years) in Secondary Care Hospital: A Cross-Sectional Study Over One Year Period.","authors":"Yousef Alrohaimi, Badar A Almuqhem","doi":"10.4103/jpbs.jpbs_144_25","DOIUrl":"10.4103/jpbs.jpbs_144_25","url":null,"abstract":"<p><strong>Objective: </strong>This study was carried out to assess the prevalence of vitamin D deficiency and insufficiency in study group of children aged 0 to 12 years.</p><p><strong>Methods: </strong>This cross-sectional study was conducted to identify associations between serum 25-hydroxy vitamin D (25-OHD), calcium, phosphorus, and alkaline phosphatase levels by gender in the study population and to assess the prevalence of vitamin D deficiency and insufficiency in the study group of children aged 0 to 12 years visiting secondary care hospital in 1 year between February 2015 and March 2016 in King Khalid Hospital in Majmaah city. Serum 25-OHD, calcium, and phosphorus concentrations, serum alkaline phosphatase (ALP) levels were measured.</p><p><strong>Results: </strong>The median (range) concentrations of 25-OHD were 28.83 in males and 27.02 in females (<i>P</i> = 0.65). The prevalence of mild, moderate, and severe vitamin D deficiencies among the study population was 38.7%, 45.3%, and 10.7%, respectively. There was no significant correlation of serum 25-OHD, calcium, phosphorus, and alkaline phosphatase levels was observed with gender in the study population. No gender-based differences were observed in the serum levels of 25-OHD, calcium, phosphorus, or alkaline phosphatase.</p><p><strong>Conclusion: </strong>Vitamin D deficiency and insufficiency were highly prevalent among children aged 0 to 12 years. No significant gender-based differences were found in vitamin D or related biochemical markers. These results emphasize the importance of routine screening and preventive measures in pediatric care.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"17 Suppl 1","pages":"S802-S805"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}