Journal of pharmacy & bioallied sciences最新文献_第6页

Short-Term Effects of Betamethasone Administration on Fetal Heart Rate Patterns in Preterm Contraction. 倍他米松对早产期胎儿心率模式的短期影响。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-04-01 Epub Date: 2026-01-05 DOI: 10.4103/jpbs.jpbs_1609_25

S Biruntha, V Jiji, N T Arunadevi, Biji Kuriakose, Mary Velanganni

{"title":"Short-Term Effects of Betamethasone Administration on Fetal Heart Rate Patterns in Preterm Contraction.","authors":"S Biruntha, V Jiji, N T Arunadevi, Biji Kuriakose, Mary Velanganni","doi":"10.4103/jpbs.jpbs_1609_25","DOIUrl":"10.4103/jpbs.jpbs_1609_25","url":null,"abstract":"Background: Preterm labor is a leading cause of neonatal morbidity and mortality worldwide. Antenatal corticosteroid therapy, particularly betamethasone, is widely used to improve neonatal outcomes.Aim: To evaluate the short-term effects of maternal betamethasone administration on fetal heart rate variability using nonstress test (NST) tracings in preterm labor.Methods: A prospective study was conducted on 62 pregnant women with preterm contractions between 28-34 weeks of gestation admitted to St. John's Medical College Hospital. Participants received two intramuscular doses of betamethasone (12 mg each, 12 hours apart). Serial cardiotocography recordings were performed at baseline and at 12, 24, 36, 48, 60, 72, and 84 hours after administration. NST parameters assessed included baseline FHR, beat-to-beat variability, accelerations, and decelerations. Data were analyzed using ANOVA and paired proportion tests, with significance set at P < 0.05.Results: Betamethasone administration was associated with a transient reduction in baseline FHR and beat-to-beat variability, most pronounced at 24-36 hours postadministration, with subsequent normalization by 72 hours (P < 0.0001). Accelerations also decreased initially but recovered over time, while decelerations remained absent across all recordings.Conclusion: Maternal betamethasone causes temporary, reversible alterations in fetal heart rate variability and accelerations without adverse perinatal outcomes.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"150-152"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aphrodisiac Drug and Dental Health: A Systematic Review. 春药与牙齿健康：系统综述。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-04-01 Epub Date: 2025-11-19 DOI: 10.4103/jpbs.jpbs_936_25

M R Murali, Kolasani Balaram, Rahul Tiwari, Heena D Tiwari, Radhika Omprakashji Daga, Akanksha Joon, Anil M Managutti

{"title":"Aphrodisiac Drug and Dental Health: A Systematic Review.","authors":"M R Murali, Kolasani Balaram, Rahul Tiwari, Heena D Tiwari, Radhika Omprakashji Daga, Akanksha Joon, Anil M Managutti","doi":"10.4103/jpbs.jpbs_936_25","DOIUrl":"10.4103/jpbs.jpbs_936_25","url":null,"abstract":"Aphrodisiac drugs, including both synthetic agents such as sildenafil and herbal formulations like ginseng, are widely used for enhancing sexual function. Emerging evidence suggests these agents may also impact oral and periodontal health, though the relationship remains underexplored. To systematically evaluate the effects of aphrodisiac drugs on dental and oral health outcomes. This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was performed to identify studies from 2000 to 2025. Inclusion criteria encompassed original studies involving aphrodisiac drugs with reported oral health outcomes. Reviews, animal studies, in vitro research, and clinical trials were all considered. Ten studies met the eligibility criteria. Sildenafil was associated with reduced alveolar bone loss and inflammation in preclinical models. Ginsenosides demonstrated strong anti-inflammatory, antimicrobial, and osteogenic activity. One clinical trial found red ginseng mouth rinse comparable to chlorhexidine in plaque control. Overall, ginseng-derived compounds showed promise in managing periodontitis and maintaining oral health. Both synthetic and herbal aphrodisiac agents exhibit potential oral health benefits, especially in periodontal therapy. Further clinical research is essential to confirm their safety, efficacy, and applicability in dental care.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"90-92"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orphan Drugs and Diseases: A Systematic Review. 孤儿药与疾病：系统综述。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-04-01 Epub Date: 2025-11-19 DOI: 10.4103/jpbs.jpbs_937_25

Heena Dixit Tiwari, Manoj Kumar Sahoo, M R Murali, Rahul Tiwari, Kamatham Manjusha, M C Prashant

{"title":"Orphan Drugs and Diseases: A Systematic Review.","authors":"Heena Dixit Tiwari, Manoj Kumar Sahoo, M R Murali, Rahul Tiwari, Kamatham Manjusha, M C Prashant","doi":"10.4103/jpbs.jpbs_937_25","DOIUrl":"10.4103/jpbs.jpbs_937_25","url":null,"abstract":"Rare diseases, though individually infrequent, collectively affect over 300 million people worldwide. The development of orphan drugs to treat these conditions is hampered by regulatory inconsistencies, high costs, and limited clinical trial populations. To systematically review the current landscape of orphan drugs and rare diseases, focusing on definitions, therapeutic approaches, health economic evaluations, and stakeholder perspectives. A systematic review was conducted using 70 reference-screened articles, out of which 10 were selected based on relevance to rare diseases or orphan drug policy, economics, or clinical management. Study types included systematic and scoping reviews, observational studies, and health economic evaluations. Data extraction focused on definitions, healthcare roles, cost analyses, and clinical outcomes. Definitions of rare diseases varied globally, impacting drug approval processes. Economic evaluations revealed disparities in funding orphan drugs. Studies emphasized the growing role of pharmacists and stakeholders in therapeutic access. High-cost burdens, ethical considerations, and diagnostic advancements were recurring themes. Pediatric and syndromic rare conditions, like Duchenne muscular dystrophy and Turner syndrome, were notably covered. Effective rare disease care requires harmonized definitions, ethical pricing models, interdisciplinary healthcare roles, and evidence-based policies to ensure equitable access and sustainability.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"93-95"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Panchashirishadi Agad: A Systematic Review of its Anti-Allergic and Immunomodulatory Potential of Albizia lebbeck. 小檗抗过敏和免疫调节潜能的系统综述。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-04-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_1562_25

Shanti Manyala, Sonali Chalakh

{"title":"Panchashirishadi Agad: A Systematic Review of its Anti-Allergic and Immunomodulatory Potential of Albizia lebbeck.","authors":"Shanti Manyala, Sonali Chalakh","doi":"10.4103/jpbs.jpbs_1562_25","DOIUrl":"10.4103/jpbs.jpbs_1562_25","url":null,"abstract":"Panchashirishadi Agad is a classical Ayurvedic formulation traditionally used in the management of allergic and toxin-mediated disorders, with Albizia lebbeck (Shirisha) as its principal constituent. Various parts of the plant-including bark, leaves, seeds, roots, and pods-are described in Ayurveda for diverse therapeutic actions. A systematic review was conducted in accordance with PRISMA guidelines to evaluate clinical and preclinical evidence supporting the anti-allergic and antihistaminic potential of Albizia lebbeck. Electronic databases such as PubMed, Scopus, and Google Scholar were searched for relevant studies published up to May 2025. Seventeen studies met the inclusion criteria, comprising six clinical and eleven preclinical investigations. The bark and leaves demonstrated consistent anti-inflammatory, mast cell stabilizing, and antihistaminic effects, with clinical evidence showing improvement in pulmonary function among asthma patients using stem bark preparations. Overall, Panchashirishadi Agad, primarily through the pharmacological actions of Albizia lebbeck, shows promise as a multi-targeted herbal intervention for allergic conditions; however, further well-designed clinical trials are required to confirm its efficacy and safety.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 2","pages":"96-98"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Healing Outcomes of Periapical Lesions with Different Histopathological Features Following Endodontic versus Surgical Management. 不同组织病理学特征的根尖周围病变在根管治疗和手术治疗后的愈合效果比较。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-02-14 DOI: 10.4103/jpbs.jpbs_1584_25

Osama Magdy Monir Mostafa, Kavita Pankaj Sonwane, Danish Muzaffar, Mrunal Dave, Priyatam Karade, Medum Shabharish Shyam Kumar, Iram Ansari

{"title":"Comparative Healing Outcomes of Periapical Lesions with Different Histopathological Features Following Endodontic versus Surgical Management.","authors":"Osama Magdy Monir Mostafa, Kavita Pankaj Sonwane, Danish Muzaffar, Mrunal Dave, Priyatam Karade, Medum Shabharish Shyam Kumar, Iram Ansari","doi":"10.4103/jpbs.jpbs_1584_25","DOIUrl":"10.4103/jpbs.jpbs_1584_25","url":null,"abstract":"Aim: This study aimed to compare the healing outcomes of periapical lesions with different histopathological features, focusing on the effectiveness of nonsurgical endodontic therapy versus surgical management.Methodology: This observational study compared the healing of histologically confirmed periapical lesions after nonsurgical or surgical treatment. Patients were followed for ≥12 months. Healing was assessed clinically and radiographically at 6 and 12 months and classified as complete, incomplete, or no healing. Chi-square tests compared outcomes between treatment groups (P < 0.05).Results: Analysis revealed that nonsurgical management showed high success in periapical granulomas and pocket cysts, whereas surgical approaches provided superior outcomes in true cysts and persistent lesions. A comparative table demonstrated that complete healing was significantly more predictable when treatment modality was tailored to the lesion's histopathology.Conclusion: Histopathological differentiation of periapical lesions plays a critical role in guiding treatment strategy. While nonsurgical therapy remains effective for most inflammatory lesions, surgical intervention is more beneficial for true cysts, underscoring the importance of lesion-specific management.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S159-S161"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Epidemiological Profile of Liver Dysfunction in Dengue Fever - A Cross-Sectional Study. 登革热患者肝功能障碍的临床和流行病学特征-一项横断面研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.4103/jpbs.jpbs_1653_25

Maria Davis, Sajit Varghese, Melbin P Thankachan

{"title":"Clinical and Epidemiological Profile of Liver Dysfunction in Dengue Fever - A Cross-Sectional Study.","authors":"Maria Davis, Sajit Varghese, Melbin P Thankachan","doi":"10.4103/jpbs.jpbs_1653_25","DOIUrl":"10.4103/jpbs.jpbs_1653_25","url":null,"abstract":"Background: Dengue fever is a major public health concern in tropical and subtropical regions, including Kerala, India. Hepatic involvement is a common but variable feature of the disease, ranging from asymptomatic transaminitis to acute liver failure.Methods: We conducted a single-center, observational, cross-sectional study over a 6-month period. Adult patients (≥18 years) with laboratory-confirmed dengue fever (NS1 antigen or IgM ELISA positive) were enrolled consecutively. Detailed clinical and demographic data were collected. Liver function tests, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), were monitored. Hepatic dysfunction was defined as an elevation of AST or ALT >2.5 times the upper limit of normal (>100 IU/L).Results: A total of 216 patients were included (mean age 42.5 ± 16.1 years; 56.5% male). The overall incidence of hepatic dysfunction was 64.4% (139/216). A characteristic pattern of AST elevation greater than ALT was observed, with peak AST levels noted on day 4 of admission. The most common symptoms were fever (100%), myalgia (76.4%), and fatigue (69.9%). Patients with hepatic dysfunction had a significantly longer duration of hospital stay compared to those without (median 5 days vs. 3 days; P = 0.005). Furthermore, the need for platelet transfusion was significantly higher in the group with hepatic involvement (12.2% vs. 1.3%; P = 0.005). No mortalities were recorded in the cohort.Conclusion: Hepatic dysfunction is a frequent complication among hospitalized dengue patients in South Kerala and is associated with a more protracted clinical course, including longer hospital stays and a greater need for platelet transfusions.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S179-S181"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Early Childhood Oral Habits and Developing Malocclusions: A Pediatric-Orthodontic Cohort Analysis. 儿童早期口腔习惯与发展错牙合的相关性：一项儿科-正畸队列分析。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.4103/jpbs.jpbs_1508_25

Vijender Kumar, Kangjam James Singh, Kinjal Jani, Ashim Roy, Roshni Mahajan, Teena Purohit, Vikram Singh

{"title":"Correlation Between Early Childhood Oral Habits and Developing Malocclusions: A Pediatric-Orthodontic Cohort Analysis.","authors":"Vijender Kumar, Kangjam James Singh, Kinjal Jani, Ashim Roy, Roshni Mahajan, Teena Purohit, Vikram Singh","doi":"10.4103/jpbs.jpbs_1508_25","DOIUrl":"10.4103/jpbs.jpbs_1508_25","url":null,"abstract":"Aim: To use a cohort-based orthodontic analysis to examine the association between early childhood oral habits (such as mouth breathing, tongue thrusting, dummy use, and thumb sucking) and the occurrence, kind, and severity of developing malocclusions in a pediatric population.Methodology: A 2-year cohort study followed 220 children (ages 3-6) with full primary dentition and no orthodontic history. Examinations at baseline, 12, and 24 months assessed malocclusion, while caregiver questionnaires recorded oral habits. Logistic regression, adjusted for age, sex, and socioeconomic status, analyzed the impact of habits persisting over 3 years.Results: Malocclusion prevalence rose from 37.7% to 48.2%. Dummy use past age 3 was linked to posterior crossbite (OR = 3.58), and thumb/finger sucking past age 4 to anterior open bite (OR = 4.21). Tongue thrusting related to anterior open bite and mouth breathing to narrow maxilla and overjet. Duration and frequency predicted severity more than habit type.Conclusion: Prolonged oral habits greatly increase malocclusion risk. Stopping them before age 3 or 4 can prevent dentoalveolar changes and reduce future orthodontic needs.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S185-S187"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Mixed-Method Study on Perception Toward Postpartum Follow-Up Screening for Diabetes among Women Diagnosed with Gestational Diabetes Mellitus in Warangal District, Telangana. 泰伦加纳邦瓦朗加尔地区妊娠期糖尿病妇女产后糖尿病随访筛查认知的混合方法研究

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2025-11-19 DOI: 10.4103/jpbs.jpbs_946_25

Yerrolla Jyotsna, Yashika Sheetal, Srinath Nagapurkar, Heena D Tiwari, Ramita Sood, Anil M Managutti, Rahul Tiwari

{"title":"A Mixed-Method Study on Perception Toward Postpartum Follow-Up Screening for Diabetes among Women Diagnosed with Gestational Diabetes Mellitus in Warangal District, Telangana.","authors":"Yerrolla Jyotsna, Yashika Sheetal, Srinath Nagapurkar, Heena D Tiwari, Ramita Sood, Anil M Managutti, Rahul Tiwari","doi":"10.4103/jpbs.jpbs_946_25","DOIUrl":"10.4103/jpbs.jpbs_946_25","url":null,"abstract":"Background: Gestational diabetes mellitus (GDM) significantly increases the risk of developing type 2 diabetes mellitus (T2DM) in later life. Postpartum follow-up screening plays a vital role in early detection and prevention, yet uptake remains low in many regions of India, including Telangana.Objectives: To assess the perception toward postpartum diabetes screening among women with prior GDM and to estimate the proportion of women who underwent timely follow-up testing.Methods: A cross-sectional mixed-method study was conducted among 90 GDM-diagnosed women from two public tertiary hospitals in the Warangal district. Data were collected through a structured telephonic questionnaire and analyzed using descriptive statistics and logistic regression. In-depth interviews with six healthcare providers were conducted to explore system-level insights.Results: Although 85.56% of participants underwent blood sugar testing postpartum, only 53.33% did so after discharge, and just 40% met the recommended ≥6-week follow-up timeline. Home-based testing was most common (47.92%), and only 4.17% utilized public health facilities. Women advised by doctors were significantly more likely to perceive screening as necessary (OR: 33.2, P = 0.001).Conclusion: There is a pressing need to strengthen postpartum diabetes follow-up through improved provider counseling, structured recall systems, and community health worker involvement.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S123-S125"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Oral Lesions in Patients with Psoriasis: A Cross-Sectional Clinical Study. 银屑病患者口腔病变患病率：一项横断面临床研究。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.4103/jpbs.jpbs_1599_25

Reem M Alqahtani, R S Albalawi, S S Alanzi, Mohammed Ghazi Sghaireen, Namdeo Prabhu

引用次数: 0

Implant Stability and Elevation Outcomes of Crestal Sinus Floor Elevation with Densah Burs in Sites with Limited Residual Bone Height: A Prospective Clinical Study. 一项前瞻性临床研究：在残余骨高度有限的部位用Densah Burs抬高嵴窦底的种植体稳定性和抬高效果。

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Journal of pharmacy & bioallied sciences Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.4103/jpbs.jpbs_1572_25

Khurram Latif Shah, Futun Eid Alanazi, Shouq Hussain Alkhaldi, Najem Ghanem, Danah Abdullah Alderaan, Rakhi Issrani

{"title":"Implant Stability and Elevation Outcomes of Crestal Sinus Floor Elevation with Densah Burs in Sites with Limited Residual Bone Height: A Prospective Clinical Study.","authors":"Khurram Latif Shah, Futun Eid Alanazi, Shouq Hussain Alkhaldi, Najem Ghanem, Danah Abdullah Alderaan, Rakhi Issrani","doi":"10.4103/jpbs.jpbs_1572_25","DOIUrl":"10.4103/jpbs.jpbs_1572_25","url":null,"abstract":"Background: Rehabilitation of the posterior maxilla with dental implants is often challenged by limited residual bone height (RBH) and sinus floor obliquity.Aim: To evaluate clinical outcomes of crestal sinus floor elevation (SFE) using Densah burs with simultaneous implant placement in sites with oblique sinus floor morphology and RBH of 4-7 mm.Methods: A prospective clinical study was conducted on 60 patients requiring posterior maxillary implants. Patients were randomized into two groups: Group I (Densah burs alone) and Group II (Densah burs with adjunctive grafting). Outcomes assessed included final seating torque, vertical elevation achieved, and resonance frequency analysis (RFA) scores.Results: The cohort included 25 men and 35 women (20-65 years). Elevation gain was significantly greater in Group I (4.22 ± 0.55 mm) than Group II (3.96 ± 0.29 mm; P = 0.042). RFA scores were significantly higher in Group II (74.33 ± 4.86) compared with Group I (67.76 ± 4.05; P < 0.001). Seating torque showed no significant difference.Conclusion: Crestal SFE with Densah burs is a predictable technique for cases with 4-7 mm RBH.","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"18 Suppl 1","pages":"S150-S152"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0