Overcoming Cervical Stenosis: A Case Study of Transmyometrial Embryo Transfer in Infertility Treatment.

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Journal of pharmacy & bioallied sciences Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI:10.4103/jpbs.jpbs_173_25
Devanshi Shah, Akash More, Namrata Choudhary, Ganesh Kalaskar, Puja Dhamija
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Abstract

Cervical stenosis can be congenital or acquired, often resulting from previous surgeries, radiation therapy, or infections. It presents a significant challenge for embryo transfer during in vitro fertilization (IVF) procedures. This case study highlights the successful use of transmyometrial embryo transfer (TMET) as an alternative approach in a patient with severe cervical stenosis, leading to a positive clinical pregnancy outcome. A 36-year-old woman with primary infertility for four years underwent three failed IVF attempts due to severe cervical stenosis. Despite multiple attempts at conventional transcervical embryo transfer, the procedures were unsuccessful, resulting in complications such as cervical bleeding and uterine contractions. Her husband's semen analysis was normal. Following detailed counseling, the decision was made to proceed with TMET under ultrasound guidance. A catheter was inserted through the myometrium directly into the uterine cavity for embryo placement. The TMET procedure was performed without complications. Embryo transfer was successful, and the patient demonstrated a positive clinical pregnancy outcome. Early pregnancy monitoring revealed appropriate gestational sac development, and no further complications were reported. This case illustrates the effectiveness of TMET in overcoming anatomical barriers caused by cervical stenosis. TMET offers a viable alternative for patients who experience recurrent implantation failure due to failed transcervical transfers. Careful patient selection and the use of ultrasound guidance are essential for maximizing success rates and minimizing complications. Further research and comparative studies are recommended to establish standardized protocols and assess long-term outcomes of TMET in similar cases. TMET proved effective for a patient with severe cervical stenosis, leading to a successful pregnancy. Ultrasound guidance and careful patient selection were key to the procedure's success.

克服宫颈狭窄:经子宫肌瘤胚胎移植治疗不孕症的案例研究。
颈椎狭窄可以是先天性的,也可以是后天的,通常是由以前的手术、放射治疗或感染引起的。它提出了体外受精(IVF)过程中胚胎移植的重大挑战。本病例研究强调了经子宫肌瘤胚胎移植(TMET)作为严重宫颈狭窄患者的替代方法的成功应用,导致积极的临床妊娠结局。一位36岁的女性,原发不孕症四年,由于严重的宫颈狭窄,接受了三次失败的体外受精尝试。尽管多次尝试传统的经宫颈胚胎移植,但手术失败,导致并发症,如宫颈出血和子宫收缩。她丈夫的精液分析是正常的。经过详细的咨询,我们决定在超声指导下进行TMET。通过子宫肌层将导管直接插入子宫腔进行胚胎植入。TMET手术无并发症。胚胎移植成功,患者表现出积极的临床妊娠结局。妊娠早期监测显示妊娠囊发育正常,无其他并发症报道。本病例说明TMET在克服颈椎狭窄引起的解剖障碍方面的有效性。TMET为因经宫颈移植失败而复发性植入失败的患者提供了一种可行的替代方案。仔细的病人选择和使用超声引导是必不可少的,以最大限度地提高成功率和减少并发症。建议进行进一步的研究和比较研究,以建立标准化的方案,并评估类似病例的TMET的长期结果。TMET被证明对严重颈椎狭窄的患者有效,导致成功怀孕。超声引导和仔细的病人选择是手术成功的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.40
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