Mymensingh medical journal : MMJ最新文献

{"title":"Prediction of Adverse Maternal Outcome In Women With Preeclampsia By Full PIERS Model.","authors":"M Tabassum, J Ferdaus, F Sultana, N S Nahar, M Saha, T Ferdoues, M E Karim, R Renu, N Akhtar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Preeclampsia is a pregnancy-specific disorder and one of the leading causes of maternal and perinatal morbidity and mortality in Bangladesh. Identification of women at increased risk of developing severe complications from preeclampsia is important to manage timely in appropriate settings. A fullPIERS model is a new tool that could allow real-time maternal risk stratification in preeclampsia to aid caregivers and also guide decisions around triage, transport and treatment. This prospective cohort study was conducted in the Department of Fetomaternal Medicine, Bangladesh Medical University (BMU), Dhaka, Bangladesh to estimate the predictive value of fullPIERS model for adverse maternal outcomes in preeclampsia. A total of 103 admitted women with preeclampsia between 20-40 weeks of gestation were enrolled fulfilling the selection criteria. Immediately after admission fullPIERS scoring was done and adverse maternal outcome observed within 48 hours and 7 days of admission was documented. The fullPIERS score ≥30.0% (according to the NICE guideline) was considered the baseline cut-off score. Among all respondents, 11 patients were observed with high score (≥30.0%) group six developed adverse outcomes and rest of 92 low score (<30.0%) group three developed adverse maternal outcome within 7 days. Patients with a high score had 16.727 times more chance to develop adverse maternal outcomes compared to those with the score <30% (p= <0.001; RR=16.727; 95% CI=4.856 to 57.621). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate at fullPIERS score ≥30.0% was found 66.67%, 93.62%, 50.01%, 96.70% and 91.26%, respectively. In this study the cut-off value of risk score 12.0% in fullPIERS model was determined through ROC curve for the studied population. Among the respondents who had fullPIERS score ≥12.0% had 19.03 times more risk to develop adverse maternal outcomes within 7 days (p=0.001; RR=19.031; 95% CI=4.339-83.460). Hence, reduced cut-off value of fullPIERS score to 12.0% strengthens the predictive values of the model for detection of adverse maternal outcomes with reported the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of 77.78%, 90.43%, 43.63%, 97.71% and 89.33%, respectively. The fullPIERS model is a useful tool to identifying patients who are at risk of greater complications and need for specialized care, thus can reduce maternal morbidity and mortality relating to preeclampsia.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1132-1140"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distance between Infraorbital Margin and Infraorbital Foramen in Dry Human Maxillae of Bangladeshi Population.","authors":"T Shom, S M A Haque, D A Mili, M R Siddiqua, R A Jannat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The infraorbital foramen is a critical anatomical landmark for maxillofacial surgery and regional anesthesia. Population-specific morphometric data are essential for safe clinical practice. This study aimed to determine the distance between the infraorbital margin and infraorbital foramen in the Bangladeshi population. A cross-sectional descriptive study was conducted on 300 fully ossified dry human maxillae (148 left-sided, 152 right-sided) from the Department of Anatomy, Mymensingh Medical College, Bangladesh, using purposive sampling technique from July 2024 to June 2025. The distance from the infraorbital margin to the infraorbital foramen was measured using digital Vernier slide calipers. The mean distance was 6.84±1.58 mm (range: 1.99-10.58 mm) on the left side and 6.68±1.51 mm (range: 2.62-10.58 mm) on the right side. Over 82.0% of left-sided specimens measured 5.5-9.0 mm, while over 94.0% of right-sided specimens measured 4.0-9.25 mm. Statistical analysis was performed using SPSS version 25.0 and comparison between sides was conducted using an unpaired t test. No statistically significant bilateral difference was observed between the left and right sides (p=0.42, which is greater than 0.05). This study establishes baseline morphometric data for the infraorbital foramen position in relation to infraorbital margin in the Bangladeshi population, demonstrating consistency with South Asian populations while showing variations from other ethnic groups. These findings have significant clinical implications for infraorbital nerve block and maxillofacial surgery.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1021-1025"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering Long-Term Beta-Blocker Therapy after Myocardial Infarction in the Era of Modern Trials.","authors":"M M Sarker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>\"No Abstract\".</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"986-987"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue in Bangladesh: From Seasonal Outbreaks to Persistent Threat.","authors":"M K Khan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>\"No Abstract\".</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"984-985"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Iron Indices among Non-Dialysis Chronic Kidney Disease Patients with Anemia.","authors":"M K Hassan, A K M Kamruzzaman, M A Haque, S S Lipi, M N Islam, M Rahman, M S Zaman, M Rahman, T Tabassum","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The objective of this study was to assess the trends in iron indices among non-dialysis chronic kidney disease (ND-CKD) patients with anemia attending a tertiary hospital in northern Bangladesh. This cross-sectional study was conducted on patients with ND-CKD and concurrent anemia, over a period of six months in the Department of Medicine at Rangpur Medical College Hospital, Rangpur, Bangladesh. A total of 50 patients were selected through purposive sampling. The staging of CKD and the severity of anemia were determined according to the criteria established by the National Kidney Foundation and the World Health Organization. Data collection was facilitated using a pre-structured questionnaire, and statistical analysis was carried out using SPSS version 25.0. Mean age of the patients was 47 years, with slight male predominance. Overall low iron indices were observed in 22% of the patients where 16% had absolute iron deficiency and 6% had functional deficiency. Median serum ferritin was 193 (616) ng/ml. Mean levels of serum iron, total iron binding capacity (TIBC) and transferrin saturation (TSAT) were 80.80±34.40μg/dl, 266.84±71.62μg/dl and 30.54±10.36%. Serum ferritin & TIBC tended to increase and iron and TSAT tended to decrease with the progression of CKD. But no statistical significance was noted (p>.05). Iron deficiency is prevalent in ND-CKD patients with anemia in Northern Bangladesh, indicating a need for regular monitoring and tailored management. Early intervention is crucial to improve patient outcomes and prevent severe anemia.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1234-1240"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Risk Stratification Value of Serum 8-Hydroxy-2-Deoxyguanosine in Women with Suspected Breast Carcinoma in Bangladesh: A Cross-Sectional Analytical Study.","authors":"S Ferdoushi, K F Khanam, F Haque, S Debnath, R E Mortaz, F Afroz, S M Ashrafozzaman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Breast carcinoma is a leading cause of carcinoma-related morbidity and mortality among women worldwide, with a rising burden in low- and middle-income countries. Early differentiation between malignant and benign breast lesions remains a major challenge in resource-constrained settings, where access to imaging and histopathology is often limited. Oxidative DNA damage plays a key role in carcinogenesis and serum 8-hydroxy-2-deoxyguanosine (8-OHdG) has emerged as a potential non-invasive biomarker; however, evidence from Bangladesh is scarce. The objective of this study was to evaluate the diagnostic value of serum 8-hydroxy-2-deoxyguanosine and its association with clinicodemographic and histopathological characteristics among women with suspected breast carcinoma. This cross-sectional analytical study was conducted among 81 women presenting with clinically suspected breast lumps at Bangladesh Medical University, Dhaka, Bangladesh from July 2023 to June 2024. Participants underwent histopathological examination and were classified into breast carcinoma (n=42) and benign breast disease (n=39) groups. Serum 8-OHdG levels were measured using an enzyme-linked immunosorbent assay. Diagnostic performance was assessed using receiver operating characteristic analysis. Associations between 8-OHdG and clinical variables were examined using correlation analysis and multivariable logistic regression. The mean age of participants was higher in the breast carcinoma group compared with the benign group (44.33±9.03 vs 35.59±10.43 years; p=0.0003). Serum 8-OHdG levels were significantly elevated in breast carcinoma (7.40±1.57 ng/mL) compared with benign disease (5.16±1.53 ng/mL; p<0.001. At a cut-off value of 6.0 ng/mL, serum 8-OHdG showed a sensitivity of 71.4% and specificity of 69.2%, with an overall diagnostic accuracy of 70.4%. Increasing age, postmenopausal status and family history were significantly associated with malignancy. Serum 8-OHdG is significantly elevated in breast carcinoma and demonstrates good sensitivity for differentiating malignant from benign breast lesions. It may serve as a practical, non-invasive biomarker for diagnostic triage, particularly in resource-limited settings.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1263-1269"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Urinary Reagent Strip Applied to Cerebrospinal Fluid Analysis for the Detection of Bacterial Meningitis in Children.","authors":"S M Masum, M N Islam, M J Alam, M A Rabbani, M R Islam, J Morshed","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bacterial meningitis is a medical emergency in children and requires early diagnosis and prompt treatment to reduce mortality and neurological complications. In resource-limited settings, urinary reagent strips applied to Cerebrospinal fluid (CSF) may offer a rapid bedside alternative for preliminary diagnosis. This study aimed to assess the diagnostic accuracy of urinary reagent strip testing in CSF analysis for the detection of bacterial meningitis in children, compared with standard laboratory methods. This cross-sectional descriptive study was conducted in the Department of Paediatrics, Mymensingh Medical College Hospital, Bangladesh from June 2024 to August 2025. A total of 82 children aged 1 month to 12 years with clinical features suggestive of meningitis were enrolled by purposive sampling. Urinary reagent strip test results showed highly significant association with laboratory CSF findings for glucose, protein and leukocytes (p<0.001) and also with CSF culture (p<0.001). The sensitivity, specificity, PPV and NPV of strip CSF glucose were 89.3%, 61.1%, 54.3% and 91.7%; of strip CSF protein were 96.4%, 44.4%, 47.4% and 96.0%; and of strip CSF leukocytes were 92.9%, 57.4%, 53.1% and 93.9%, respectively. ROC analysis demonstrated good diagnostic accuracy, with area under the curve (AUC) values of 0.752 for strip CSF glucose, 0.704 for strip CSF protein and 0.779 for strip CSF leukocytes. Urinary reagent strip testing of CSF showed good diagnostic accuracy in children with suspected meningitis. It showed high sensitivity and high negative predictive value with significant agreement with standard laboratory findings and CSF culture. Therefore, it may be used as a rapid bedside screening tool, especially in emergency and resource-limited settings, although it cannot replace conventional laboratory analysis and CSF culture for definitive diagnosis.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1276-1282"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Hypertrophy and Proteinuria in Hypertensive Patient with Retinopathy in Tertiary Care Hospital.","authors":"M M I Fakir, A Kahhar, A Das, A Haque, M A Islam, S Dey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypertensive retinopathy almost always associated with other target organ damage. Relationship of hypertensive retinopathy with left ventricular hypertrophy (LVH) and proteinuria was inconclusive in previous studies. The objective of the study was to assess the relation of Left Ventricular Hypertrophy and Proteinuria in Hypertensive Patient with Retinopathy in Tertiary Care Hospital. This is a cross-sectional observational study and conducted at the Department of Medicine and Cardiology in Dhaka Medical College Hospital. Study period was 01 year started from July 2016 to June 2017. Total 100 hypertensive retinopathy patients were included in the study. Following informed written consent, physical examination, relevant investigations were done. In all cases, Ethical issues were maintained properly and collected data were analyzed by SPSS 20.0. Among 100 participants, mean ±SD age was 57.15±12.989 years (age range 29-85) and 61.0% were male and 39.0% were female. Mean ±SD value of systolic and diastolic blood pressure in Grade (G)-1, G-2 and G-3 hypertension were 150.8±5.4) and 94.0±2.6 mm Hg, 170.3±4.9 and 101.0±4.7 mm Hg and 188.0±7.0 and 102.6±6.5 mm Hg respectively and it is significantly associated with severity of LVH (p value <0.001 in both systolic blood pressure (SBP) and diastolic blood pressure (DBP). Proteinuria is also associated with severity of hypertension (p<0.001) but there were no association of Hypertensive retinopathy with LVH and proteinuria (p value 0.32 and 0.27 respectively). Hypertensive retinopathy is not associated with LVH and proteinuria, though further large cohort is recommended for final comment.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1161-1171"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mysterious Case of Giant Scalp Devil's Horn with Intracranial Extension Removed by Surgical Excision.","authors":"M S A Siddique, M S Hossain, M K Hossen, K Hassan, M S Uddin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cutaneous horn or sebaceous horns are rare form of lesion consisting of keratotic material resembling that of an animal horn. The shape is conical or cylindrical Hyperkeratosis of variable size. The lesion typically occurs in sun exposed areas. Herewith we report a case of cutaneous horn in the scalp praieto occipital region with underlying bony erosion and intracranial extension. A 60-year-old male patient presented to the neurosurgery department in February 2024 with altered consciousness, a history of chronic headaches, blurred vision, and scalp swelling. Under general anaesthesia the outer fungating part of the lesion was excised initially followed by craniotomy and internal decompression of the lesion done by suction and cauterisation, the central part of the lesion was nearly avascular and was cheezy white. Then the poorly vascularised thick membrane was excised by gentle traction and cauterisation from the sorrounding adjacent gliotic area of left parietal lobe laterally, from the falx medially and from corpus callosum inferiorly. With meticulous hemostasis wound closure done by scalp rotation flap keeping cranioplasty in situ.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1304-1306"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of Serum Calcium and Magnesium Levels among Children with Febrile Seizures.","authors":"M S H Chowdhury, M N Islam, J Morshed, M M Hasan, M Mahbub, M R Islam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Febrile seizures are the most common seizure disorder in early childhood and are a frequent cause of pediatric hospital admission. Alterations in electrolyte balance, particularly ionized calcium and serum magnesium, may influence neuronal excitability and seizure threshold, but data remain inconsistent, especially in the Bangladeshi context. This study aims to evaluate the status of ionized calcium and serum magnesium levels in children with febrile seizures and to assess their association and diagnostic accuracy compared to febrile children without seizures. This hospital-based analytical case-control study was conducted in the Department of Paediatrics, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from September 2021 to February 2022. Eighty children aged 6-60 months were enrolled, including 40 cases with febrile seizures and 40 age- and sex-matched febrile controls without seizures. Serum ionized calcium and serum magnesium levels were measured in both groups. Children with febrile seizures had significantly lower mean ionized calcium (4.48±0.31 g/dL vs. 4.67±0.20 mg/dL; p=0.002) and serum magnesium levels (1.66±0.34 mg/dL vs. 1.99±0.29 mg/dL; p<0.001) compared to controls. Hypocalcemia (45.0% vs. 15.0%; OR=4.5, p=0.005) and hypomagnesemia (40.0% vs. 12.5%; OR=4.6, p=0.008) were significantly more frequent among cases. A progressive decline in mean ionized calcium and serum magnesium levels were observed from simple febrile seizures to complex seizures and febrile status epilepticus. ROC analysis demonstrated moderate diagnostic accuracy for ionized calcium (AUC=0.68) and serum magnesium (AUC=0.78). Both ionized calcium and serum magnesium levels were significantly lower in children with febrile seizures, these biomarkers demonstrated moderate predictive value and may serve as supportive indicators in the evaluation of children with febrile seizures.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"35 4","pages":"1283-1289"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}