Mymensingh medical journal : MMJ最新文献

{"title":"Aspirin Helped Cure a High Risk Patient of Coronavirus Disease 2019, Smoothly Through the Ordeal: A Case Report.","authors":"A Husain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Coronavirus disease 2019 is associated with inflammation and thrombosis. Despite Aspirin has excellent anti-inflammatory and anti-thrombotic properties; it is seldom used in treating Covid-19 patients. This case report explains how potential Aspirin is for that purpose. On the 6th day of September 2020 this report presented the case of a 70 year old Bangladeshi man who contracted Covid-19 of late; and then how he managed safe recovery through the illness, since he was high risked with old age and cardiovascular co-morbidity. Although the situation was alarming, the patient enjoyed full cure off the disease with medication that included low dose Aspirin. Even in home settings, he did not experience any complication or untoward event to what he was so vulnerable. Low dose Aspirin played a great role to facilitate his journey smoothly through the ordeal.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"580-583"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors for Quitting Tobacco Consumption among the Male Bangladeshi Garments Workers: A Cross Sectional Study.","authors":"M Imamuzzaman, K F Mukta, M Ansari, S Rahman, C A Chowdhury, M S Basher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite enormous adverse effects, tobacco consumption is increasing with very little success of cessation programs. This is very important to have update knowledge regarding the factors attributed to the failed attempts for quitting tobacco consumption. The study was intended to find out the factors associated with quitting tobacco consumption among the male Bangladeshi garments workers. A descriptive cross-sectional study was carried out among 451 randomly selected workers of four purposively selected garments at Gazipur and Savar, Dhaka. After permission from the garments authorities and informed verbal consent from the selected respondents, data were collected by principal investigator using pre-tested interview schedule through face-to-face interview with privacy. After completion of each interview, questionnaire was cross-checked for completeness, consistency and discrepancy. Participants had freedom to withdraw from the study at any time without explaining any reason and data confidentiality was ensured strictly. The procedure did not have physical, mental and social risks. All other ethical issues and measures for data quality were taken into due consideration. Data were analyzed using computer software SPSS version 25.0 and presented in tables and diagrams. Nearly half 206(45.7%) of the workers were in age group 26 to 33 years with a mean of 28.85±8.03 years. Religion of 387(85.8%) respondents was Islam, while 278(61.6%) had completed secondary education. More than three-fifths 282(62.5%) of the workers were married with a mean family size of 4.24±1.44. As many as 379(84.0%) workers had monthly income less than 15000 Taka with a mean of 13212.86±1573.08 Taka. An overwhelming number 411(91.1%) of respondents started tobacco consumption within the age of 13 to 19 years with mean age of initiation of 16.18±2.67 years. Of 451 workers, 446(98.9%) made an effort to quit tobacco. Of them, for 286(64.1%) workers personal health problem was the influencing factor for quitting attempt. As many as 380(85.2%) workers preferred to quit tobacco consumption through reducing the consumption. Nearly three-fifths 264(59.3%) of workers were failed to quit due to bodily addiction. More than four-fifths 375(83.1%) workers affirmed that they could be able to quit tobacco. Nearly three-fourths 326(72.3%) workers did not consult doctor because they believed that they could do it by themselves. Over two-fifths 181(40.6%) of workers attempted for 4 to 10 times for quitting, while majority 213(47.8%) had maximum duration of abstinence for less than 1 week. It can be concluded that workers initiate smoking as teenagers. Personal health problems influence the workers in quitting tobacco. Moreover, they believed that they themselves are enough to do it without consultation with the physicians. A considerable number of workers had planned for quitting as well as attempted to do so more than once. However, all of them failed to do so due to bodily addiction.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"469-475"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Metabolic Syndrome among Patients with Type 2 Diabetes Mellitus in Bangladesh: A Facility-Based Cross-Sectional Study.","authors":"K Hassan, M S Hossain, R Laboni, S M Ashrafuzzaman, A Deb, S Islam, S Debnath, E Mondal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metabolic disorders like insulin resistance, hypertension, hyperlipidemia and central obesity, are common in diabetic patients. The objective of this study was to determine the frequency and presentations of metabolic syndrome in patients with type 2 diabetic (T2DM) of Bangladesh. This cross-sectional study was conducted in the department of Endocrinology in BIRDEM General Hospital, Bangladesh from July 2019 to June 2020 including 151 T2DM patients. Face-to-face interview, anthropometric measurements and review of laboratory records were used for data collection. Four different criteria were used to define metabolic syndrome: WHO criteria, IDF criteria, NCEP ATP III criteria and Harmonized Criteria. Frequency distribution for categorical variables and mean with standard deviation (SD) for continuous variables were calculated. Chi-squared test was used to explore the factors associated with metabolic syndrome. Overall prevalence of metabolic syndrome in our included patients was 70.0% according to the WHO criteria, 79.5% according to the IDF criteria, 74.8% according to the NCEP ATP III criteria and 90.7% according to the Harmonized Criteria. Central obesity was the most prevalent component of metabolic syndrome among our patients followed by hyperglycemia, hypertension, low HDL and high TG level. Prevalence was high in elderly and female patients. Metabolic syndrome is highly prevalent among T2DM patients of Bangladesh. Adequate screening for early diagnosis and management is crucial to mitigate the burden of morbidity and mortality related to metabolic syndrome.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"538-544"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Helicobacter Pylori in Gastroduodenal Biopsy Samples of Dyspeptic Patients by Rapid Urease Test and Polymerase Chain Reaction in a Tertiary Care Hospital of Bangladesh.","authors":"S J Ferdaus, N Haque, M R Karim, M Nadiuzzaman, N Islam, M S Alam, A Islam, M S Malek, M S Ahsan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic infection of H. pylori can cause various gastrointestinal diseases including chronic gastritis, peptic ulcer diseases, MALT lymphoma and gastric carcinoma. The study was aimed to detect H. pylori infection among dyspeptic patients in Mymensingh. Analysis was performed by Rapid urease test (RUT) and Polymerase chain reaction (PCR) and confirmed by Sanger sequencing of DNA fragments. This study cross sectional, descriptive type of observational study was conducted in the Department of Microbiology, Mymensingh Medical College, Bangladesh from March 2022 to February 2023. Endoscopic gastroduodenal biopsy samples were collected from dyspeptic patients attending at Gastroenterology department of Mymensingh Medical College Hospital, Bangladesh who fulfilled the inclusion criteria. RUT test and Polymerase chain reaction (PCR) were used for detection of H. pylori. Out of 221 samples, 80(36.19%) were considered as H. pylori positive cases whereas, 71(32.12%) cases were PCR positive and 72(32.57%) cases were RUT positive. Out of 80(36.19%) H. pylori positive cases, gastritis (65%) was the most common endoscopic finding followed by duodenal ulcer (15%), gastric ulcer (8.8%), reflux oesophagitis (8.8%), suspected gastric cancer (1.3%), normal mucosa (1.3%) respectively by any of two tests (RUT and PCR). DNA sequences of different PCR amplified product and phylogenetics analysis showed strains diversity compared to other reference sequences of H. pylori from different regions of the world. More than one third of the dyspeptic patients in Mymensingh were having H. pylori infection. This study will be helpful for understanding the current trend of H. pylori in Bangladesh.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"365-374"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total and Segmental Colonic Transit Time in Patients with Constipation Attending in Dhaka Medical College Hospital: A Case Control Study.","authors":"J M A Islam, M J Alam, M R Karim, F Ahmed, M G Kibria, M M Rahman, H Aftab, A S M Salimullah, V Nesa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Constipation is a regular medical sickness all over the world. Primary constipation may by normal transit constipation, slow transit constipation and fecal evacuation disorder. Categorization into these types is important for subsequent management. Among the methods of measurement of colonic transit time radiopaque marker study is simple and easy to perform. This case control observational study was conducted in the department of Gastroenterology, Dhaka Medical College and Hospital, Bangladesh from March 2018 to March 2019 to measure the colonic transit time of patient of constipation and to compare it with healthy control. Constipation can be sub-classified with colonic transit time. Patient of chronic constipation were divided into functional constipation and constipation predominant irritable bowel syndrome according to symptoms based diagnostic criteria. Patients with constipation underwent routine investigation including colonoscopy to exclude organic disease. Two gelatin capsules (each containing 10 radio-opaque markers) were ingested by patient at 0, 12 and 24 hours. At 36 hours from the time of taking of first dose of markers abdominal radiograph was taken to calculate retained marker and colonic transit time in each segment of colon. Colonic transit time calculated using, Colonic transit time (or segmental transit time) = 12/20 × (n) hours, where n is the sum of the markers on the X-ray film (or in the delineated segment) this formula. Healthy control undergone same procedure. Comparison of results was done using paired and unpaired 't'-test. In this study with this method, mean total Colonic transit time of healthy participant found 9.98 hours (min 1.8, max 18) and patient with constipation is 11.5 hours (min 0.0 hour, max 23.4 hour). The difference is not significant. Total colonic transit time in \"slow transit time\" patients is 22 hours (min 20, max 23.4) and 8.87 hours (min 0, max 16.2) in normal transit time patients. Segmental colonic transit of case group are right segment 4.7 hours (min 0, max 3.6), left segment 3.1 hour (min 0, max 10.2) and rectosigmoid segment 3.8 hour (min 0, max 14). The corresponding value in healthy control are 3.3 hour (0.6 min, max 7.2), 2.2 hour (min 0.6, max 4.8) and 4.3 hour (min 0, max 12) respectively. In real life colonic transit time can not be 0 hour, but with this method it can be 0, if the number retained marker is 0 then calculated colonic transit time can be 0 hour. No significant difference found between male and female, smoker and non-smoker of both groups.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"491-501"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Fasting plasma glucose and Serum total cholesterol in Female with Type 2 Diabetes Mellitus.","authors":"S S Suchi, A Nessa, S Firoz, S T Tithi, I A Tanvir, S Yesmin, F R Momo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One of the most catastrophic non-communicable diseases in the world is type 2 diabetes mellitus (DM). It results in financial loss, incapacity, and death. Fasting blood sugar is one of the diagnostic criteria for type 2 diabetes. Cholesterol is necessary for overall health but high cholesterol can be harmful leading to atherosclerotic disease. This study intended to determine the relationship between fasting plasma glucose and serum total cholesterol in patients with type 2 diabetes in the Mymensingh locality. This cross-sectional analytical study was carried out in the department of Physiology, Mymensingh Medical College, Bangladesh, from July 2023 to June 2024. A total 200 subjects age ranged from 30-65 years were selected and from them 100 were grouped as Control group, Group I (female without diabetes) and 100 were grouped as Study group, Group II (female with diabetes). The data were calculated and analyzed by using SPSS version 26. Laboratory analysis of fasting plasma glucose was done by GOD-POD method and serum total cholesterol by CHOD-POD method. Data were expressed in mean±SD and statistical significance of difference among the groups were calculated by unpaired Students 't' test. Correlation of serum total cholesterol with fasting plasma glucose was done by Pearson's correlation coefficient test. The mean value of fasting plasma glucose of control group and study group were 4.94±0.24 and 8.40±0.91 mmol/L respectively. The mean value of serum total cholesterol in control group and study group were 164.28±15.88 and 225.89±16.69 mg/dl respectively. In study group both values were significantly increased than control group. Fasting plasma glucose was positively correlated with serum total cholesterol. By this study we founded significant correlation of fasting serum glucose and serum total cholesterol in female with type 2 diabetes mellitus.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"360-364"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Bivalirudin in Female Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention.","authors":"A B M Mostofa, K K Karmoker, R Afrin, A Hossain, A Alam, B Dutta, T Parvin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Being women is an independent predictor of adverse events during percutaneous coronary intervention (PCI). Whether newer anticoagulant bivalirudin is safe and effective in female acute coronary syndrome (ACS) patients undergoing PCI, as compared with conventional heparin, is less well defined in Bangladeshi population. Our aim was to evaluate safety and efficacy of Bivalirudin in female ACS patients undergoing PCI. One hundred (100) female ACS patients were enrolled in this randomized controlled study, which underwent PCI from May to November, 2019 at BSMMU. Among them 35 patients were randomly assigned to receive bivalirudin and 65 patients were in control group to receive heparin with or without eptifibatide (GPI, glycoprotein IIb/IIIa inhibitor). The outcome measures were incidence of 30-day hemorrhagic complications, stent thrombosis and major adverse cardiac and cerebral events (MACCEs). Bivalirudin treatment was associated with significantly lower incidences of 30-day net adverse clinical events (NACEs) (5.7% vs. 27.6%, p=0.009) and bleeding (2.8% vs. 16.9%, p=0.03) compared with the control regimen. The incidence of MACCEs (2.8% vs. 15.4%, p=0.05) and stent thrombosis (0.0% vs. 3.1%, p=0.295) were comparable between the two groups. Multivariate analysis showed that bivalirudin (OR: 0.264, 95% CI: 0.071-0.977, p=0.04), trans-radial access (OR: 0.056, 95% CI: 0.003-0.967, p=0.04) and statin (OR: 0.009, 95% CI: 0.0005-0.168, p=0.001) were independent protective factors for 30-day NACEs. Bivalirudin is safe and effective in female ACS patients undergoing PCI as it reduces hemorrhagic complications without increase ischemic events (MACCEs) as compared with conventional heparin.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"545-553"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Quality Assurance Scheme of Government Medical Colleges of Mymensingh Division.","authors":"U J Ferdaus, M K Khan, J Ferdous, P Das, M N Hossain, M S Ameen, A Rahman, M A Hossain, M Ferdous, R Yeasmin, N Sultana, A A Mamun, I Hossain, S Paul, T B Faruk, M A Panna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Maintaining quality assurance is among the most critical things the medical education system has to do. Quality control can be controlled by institutional monitoring, which should include course evaluation, peer review and assessment. This study was designed to assess the status of the quality assurance scheme of government medical colleges of Mymensingh division. This cross-sectional descriptive type of observational study was conducted in the Mymensingh Medical College (MMC), Mymensingh; Jamalpur Medical College (JMC), Jamalpur and Netrakona Medical College (NMC), Netorkona, Bangladesh for one year from January 2023 to December 2023. All departments in Mymensingh Medical Colleges were optimal where some vital department was not present in JMC and NMC, such as virology, neurology, physical medicine, gastro-enteroloy, endocrinology, hematology etc. All 3 medical colleges had ongoing Quality Assurance Scheme MMC had no committee meeting in last 12 months, JMC and NMC had committees meetings held three in all phases. A good percentage of students had passed all professional examinations in last year in these 3 medical colleges. All 3 medical colleges had pair Colleges had Pair College with each other. In MMC and JMC had gone through the external review visit and also these two had faculty members fill up personal review form. Medical Education Unit (MEU) was established in MMC and JMC, but no MEU was established in NMC. All 3 medical colleges had annual sports, indoor-outdoor games and annual cultural program. The current status of the quality assurance scheme of MMC is optimal, whereas other medical colleges need to be improved. All three government medical colleges of Mymensingh division had ongoing quality assurance schemes including student performance, external reviews, faculty development, co-curriculum and extra-curriculum activities.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"324-330"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Gamma Glutamyl Transferase with Gestational Diabetes Mellitus.","authors":"H Koly, T R Das, N Haque, N Hosain, M F Islam, S S Tithi, M S Bari, Y D Jannat, N J Khan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is the most common metabolic disorder resulting in adverse consequences on both maternal and fetal outcome. Oxidative stress plays an important role in the pathophysiology of gestational diabetes mellitus by inducing insulin resistance in the peripheral tissue and impairing insulin secretion from pancreatic β-cell. Serum gamma glutamyl transferase (GGT) plays an important role in oxidative stress and recently it has been recognized as a marker of oxidative stress. GGT can be used as an indicator of the GDM. High level of GGT is a new risk factor for GDM, which is cheap, rapid and easily available parameter for monitoring the GDM patients. This case control study was carried out in the Department of Obstetrics and Gynecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh from May 2019 to February 2020. A total of 76 pregnant women were enrolled in this study, out of which 38 women with GDM was considered as Group A and rest 38 women with normal pregnancy was considered as Group B. Gamma glutamyl transferase concentration was measured in all the study subjects. Statistical analysis of the results was obtained by using Microsoft Excel and Statistical Packages for Social Sciences (SPSS-22.0). The mean GGT was 25.0±7.46U/L with ranged from 13-41U/L in Group A and 12.95±3.23U/L with range from 7-19U/L in Group B. The difference was statistically significant between two groups. A positive significant Pearson's correlation was found between FBS and GGT in Group A. There was also positive significant Pearson's correlation found between 2 hours ABF with GGT in Group A. In Group A serum GGT level >16U/L had 4.42 times significantly increased to develop GDM. GGT was higher in GDM group than normal pregnancy. Monitoring GGT levels in pregnancy may help to identify women with increased risk of developing GDM.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"502-508"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Vitamin D₃ Supplementation Improve Cardiac Autonomic Nerve Function in Vitamin D₃ Deficient Asthma COPD Overlap (ACO) Patients? A Randomized Clinical Trial.","authors":"S M Yesmin, S Sultana, S Ferdousi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac autonomic nerve dysfunction has been found associated with chronic obstructive pulmonary disease (COPD) patients as well as vitamin D₃ deficient patients. Heart rate variability (HRV), one of the markers of cardiac autonomic nerve function which is reduced in Asthma COPD overlap (ACO) patients. Sympathovagal balanced was improved in healthy subjects after administration of vitamin D₃. This randomized clinical trial aimed to observe the therapeutic effect of vitamin D₃ supplementation on non linear measures of HRV in 60 male vitamin D₃ deficient (<30 - 10 ng/ml) ACO patients. Patients were given orally either vitamin D₃ capsule or placebo per week for 6 months and serum vitamin D₃ level and non linear measures of HRV were assessed before and after intervention. HRV was measured by power lab 8/35, AD instruments and vitamin D₃ was assessed by chemiluminescent micro-particle immunoassay (CMA) method by auto analyzer. For statistical analysis paired sample 't' test and independent sample 't' test were done. Before intervention vitamin D₃ level and non linear parameters of HRV were similar in all patients but both these outcome measures significantly increased in vitamin D₃ treated but not in placebo treated patients after 6 months. In conclusion, vitamin D₃ supplementation is effective to improve HRV in vitamin D₃ deficient ACO patients.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"530-537"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}