Status of Lipid Profile among Patients with Chronic Kidney Disease.

Abstract

Chronic kidney disease (CKD) is an increasing threat for health-care systems in the world. Primary causes of CKD are diabetes and vascular diseases. So, optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins and adjustments to drug dosing. Patients also require monitoring for complications of CKD, such as hypocalcemia, hyper-kalemia, dyslipidemia, metabolic acidosis, hyper-phosphatemia, vitamin D deficiency, secondary hyper-parathyroidism and anaemia. This cross-sectional study was executed in the Department of Biochemistry, Mymensingh Medical College, in collaboration with the Department of Nephrology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July 2022 to June 2023. The subjects were selected based on inclusion and exclusion criteria by purposive non-random sampling. A sum of 120 subjects was included in this study. Out of them, 60 were selected as case of CKD patients and another 60 apparently normal healthy persons were selected as control. In this study, serum lipid profile was measured for analytical study. All the values were showed as mean±SD and these were serum TC were 149.85±38.84 in Group I and 178.92±41.85mg/dl in Group II; Serum TG were 122.77±36.88 in Group I and 175.93±63.50mg/dl in Group II; Serum LDL-C were 95.13±24.43 in Group I and 115.60±45.62 mg/dl in Group II and Serum HDL-C were 48.62±8.70 and 41.55±2.79mg/dl in Group I and Group II respectively. Statistical analysis was done by using statistical package for social science (SPSS), windows package version 26.0. The statistical significance of the difference between the case and control was evaluated using Student's unpaired 't' test. After careful evaluation, the present study found that mean serum total cholesterol (TC), Triglyceride (TG) and Low density lipoprotein (LDL-C) level were significantly increased and High density lipoprotein (HDL-C) level were significantly decreased in CKD patients.