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Mymensingh medical journal : MMJ Pub Date : 2025-04-01

S A Mitu, M R Hoque, M Banu, M Y Mili, A T Jenea, T Z Sharmi, F R Momo, S A Mahi

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摘要

慢性肾脏病（CKD）对全球医疗保健系统的威胁与日俱增。导致慢性肾脏病的主要原因是糖尿病和血管疾病。因此，慢性肾脏病的最佳治疗方法包括降低心血管风险、治疗白蛋白尿、避免使用潜在的肾毒素以及调整药物剂量。患者还需要监测慢性肾脏病的并发症，如低钙血症、高钾血症、血脂异常、代谢性酸中毒、高磷血症、维生素 D 缺乏、继发性甲状旁腺功能亢进和贫血。这项横断面研究于 2022 年 7 月至 2023 年 6 月在孟加拉国迈门辛医学院生物化学系与迈门辛医学院附属医院肾脏内科合作开展。根据纳入和排除标准，通过有目的的非随机抽样选出受试者。本研究共纳入 120 名受试者。其中，60 人被选为慢性肾脏病患者，另外 60 名表面正常的健康人被选为对照组。本研究对血清脂质概况进行了分析研究。所有数值均以平均值（±SD）表示，其中血清 TC 在 I 组为 149.85±38.84，在 II 组为 178.92±41.85mg/dl；血清 TG 在 I 组为 122.77±36.88，在 II 组为 175.93±63.50mg/dl。血清低密度脂蛋白胆固醇（LDL-C）Ⅰ组为（95.13±24.43）毫克/分升，Ⅱ组为（115.60±45.62）毫克/分升；血清高密度脂蛋白胆固醇（HDL-C）Ⅰ组为（48.62±8.70）毫克/分升，Ⅱ组为（41.55±2.79）毫克/分升。统计分析采用社会科学统计软件包（SPSS）26.0 版进行。病例与对照组之间差异的统计学意义采用学生非配对 "t "检验。经过仔细评估，本研究发现，慢性肾脏病患者的平均血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白（LDL-C）水平明显升高，而高密度脂蛋白（HDL-C）水平明显降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Status of Lipid Profile among Patients with Chronic Kidney Disease.

Chronic kidney disease (CKD) is an increasing threat for health-care systems in the world. Primary causes of CKD are diabetes and vascular diseases. So, optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins and adjustments to drug dosing. Patients also require monitoring for complications of CKD, such as hypocalcemia, hyper-kalemia, dyslipidemia, metabolic acidosis, hyper-phosphatemia, vitamin D deficiency, secondary hyper-parathyroidism and anaemia. This cross-sectional study was executed in the Department of Biochemistry, Mymensingh Medical College, in collaboration with the Department of Nephrology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July 2022 to June 2023. The subjects were selected based on inclusion and exclusion criteria by purposive non-random sampling. A sum of 120 subjects was included in this study. Out of them, 60 were selected as case of CKD patients and another 60 apparently normal healthy persons were selected as control. In this study, serum lipid profile was measured for analytical study. All the values were showed as mean±SD and these were serum TC were 149.85±38.84 in Group I and 178.92±41.85mg/dl in Group II; Serum TG were 122.77±36.88 in Group I and 175.93±63.50mg/dl in Group II; Serum LDL-C were 95.13±24.43 in Group I and 115.60±45.62 mg/dl in Group II and Serum HDL-C were 48.62±8.70 and 41.55±2.79mg/dl in Group I and Group II respectively. Statistical analysis was done by using statistical package for social science (SPSS), windows package version 26.0. The statistical significance of the difference between the case and control was evaluated using Student's unpaired 't' test. After careful evaluation, the present study found that mean serum total cholesterol (TC), Triglyceride (TG) and Low density lipoprotein (LDL-C) level were significantly increased and High density lipoprotein (HDL-C) level were significantly decreased in CKD patients.

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Mymensingh medical journal : MMJ

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