Mymensingh medical journal : MMJ最新文献

{"title":"Does Vitamin D₃ Supplementation Improve Cardiac Autonomic Nerve Function in Vitamin D₃ Deficient Asthma COPD Overlap (ACO) Patients? A Randomized Clinical Trial.","authors":"S M Yesmin, S Sultana, S Ferdousi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac autonomic nerve dysfunction has been found associated with chronic obstructive pulmonary disease (COPD) patients as well as vitamin D₃ deficient patients. Heart rate variability (HRV), one of the markers of cardiac autonomic nerve function which is reduced in Asthma COPD overlap (ACO) patients. Sympathovagal balanced was improved in healthy subjects after administration of vitamin D₃. This randomized clinical trial aimed to observe the therapeutic effect of vitamin D₃ supplementation on non linear measures of HRV in 60 male vitamin D₃ deficient (<30 - 10 ng/ml) ACO patients. Patients were given orally either vitamin D₃ capsule or placebo per week for 6 months and serum vitamin D₃ level and non linear measures of HRV were assessed before and after intervention. HRV was measured by power lab 8/35, AD instruments and vitamin D₃ was assessed by chemiluminescent micro-particle immunoassay (CMA) method by auto analyzer. For statistical analysis paired sample 't' test and independent sample 't' test were done. Before intervention vitamin D₃ level and non linear parameters of HRV were similar in all patients but both these outcome measures significantly increased in vitamin D₃ treated but not in placebo treated patients after 6 months. In conclusion, vitamin D₃ supplementation is effective to improve HRV in vitamin D₃ deficient ACO patients.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"530-537"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Induction Chemotherapy with the Berlin-Frankfurt-Munster-95 Regimen in Acute Lymphoblastic Leukemia Patients: A Quasi-Experimental Study.","authors":"N Chowdhury, A Kabir, M M Islam, S Das, M Wasim, M N Karim, M M Alam, M N Islam, J Banik, J Fardous, M K Hassan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Response to induction chemotherapy plays a major role in prognosis of acute lymphoblastic leukemia (ALL). The objective of this study was to explore the outcome of induction chemotherapy with the Berlin-Frankfurt-Munster (BFM) -95 regimen in ALL patients admitted to a tertiary care hospital in Bangladesh. This quasi-experimental study was conducted among 50 ALL patients admitted to Dhaka Medical College Hospital (DMCH), Dhaka, Bangladesh from January 2020 to June 2020. All patients received induction therapy with the Berlin-Frankfurt-Munster-95 regimen following pre-induction prednisolone therapy. Outcomes were defined as complete remission (CR) and undetectable minimal residual disease (MRD). There was significant clinical and hematological improvement after induction chemotherapy with the BFM regimen. A total of 68.0% patients achieved complete remission. Negative MRD was achieved in 66.0% patients. In addition, 72.0% of the patients had a good response to pre-induction prednisolone therapy. Positive outcomes were not associated with the clinical presentation or disease characteristics of the ALL patients. Induction chemotherapy with the BFM-95 regimen is effective in the majority of ALL patients irrespective of clinical presentation or disease characteristics.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"412-419"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-seeking Behavior and Diagnostic Delay of Systemic Lupus Erythematosus in Patients of Bangladesh: A Hospital-Based Cross-Sectional Study.","authors":"A M Ahammad, M N Islam, S Yesmin, S Islam, J Fardous","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patients with systemic lupus erythematosus (SLE) often ignore the initial symptoms of the disease and delay in seeking medical care, which ultimately prolongs the diagnostic delay. The objective of the present study was to explore the health-seeking behavior and the factors associated with diagnostic delay in SLE patients. This cross-sectional study was conducted among 85 patients suffering from SLE who attended the Lupus Clinic of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2012 to June 2013. Socio-demographic and disease-related data were collected by face-to-face interviews. Diagnostic delay was defined as the period of time from onset of initial symptoms of SLE and confirmation of diagnosis. Factors associated with diagnostic delay were determined by appropriate statistical test. Almost 75.0% of the patients visited qualified physicians and their average interval of seeking medical care after the onset of SLE symptoms was 1.4±2.6 months. The average interval between the onset of initial symptoms and the diagnosis of SLE was 12.3 (SD 13.9) months. It was longer in female patients (13.2 months versus 7.3 months in male). Early medical contact and visiting qualified physicians also shortened the diagnostic delay of SLE. Patients presenting with joint pain and fever had a longer diagnostic delay than those who presented with oral ulcers, malar rash and lupus nephritis. Patients' health-seeking behavior, such as delayed medical care seeking, as well as presenting with nonspecific symptoms, such as fever and joint pain, which mimic other diseases, increases the diagnostic delay in SLE patients. These symptoms should be considered for the evaluation of immunological evidence of SLE.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"461-468"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Artificial Intelligence in Scientific Writing.","authors":"M K Khan, J Ferdous, G Mourshed, S B Hossain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Artificial Intelligence (AI) is revolutionizing various fields, including scientific writing, which traditionally relies on human intellectual effort. This review article explores the evolving role of AI in scientific writing, highlighting its applications, challenges and ethical implications. The adoption of AI in scientific writing offers several key advantages that make it attractive to researchers. AI-powered tools are employed to scan large volumes of academic literature quickly and efficiently. AI writing assistants have become increasingly sophisticated in generating human-like text. AI-driven language models can help authors who are not native English speakers to produce high-quality, well-written manuscripts. Another significant benefit is the ability to handle large amounts of data efficiently. Moreover, AI tools reduce the risk of plagiarism by detecting unintentional similarities between newly drafted manuscripts and previously published work. AI systems are also being developed to assist with the peer-review process. Automated tools use AI to analyze manuscripts, checking for completeness, adherence to journal guidelines and even suggesting potential reviewers. Furthermore, AI aids in citation management by helping researchers organize and insert references correctly. Despite the benefits of AI in scientific writing, several ethical considerations and challenges accompany its adoption. A significant concern relates to the potential over-reliance on AI for generating text and performing critical analyses. Additionally, the question of authorship becomes increasingly complex with the involvement of AI in writing. Another significant issue concerns the potential for bias in AI-generated content. AI models are trained on vast amounts of data, which often reflect existing biases in published literature. This is particularly concerning in fields such as healthcare, where biased research could have serious consequences for patient care and treatment outcomes. Finally, the use of AI raises concerns about data privacy and security. As AI continues to evolve, it is essential for the scientific community to establish guidelines that ensure the responsible use of these tools, maximizing their benefits while mitigating potential risks.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"592-597"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Change of Body Mass Index, Serum Uric Acid in Post Menopausal Women.","authors":"S Yesmin, A Nessa, N Khatun, M Paul, S Firoz, A Begum, S S Suchi, I A Tanvir, S T Tithi, N Sultana, S Sadia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Menopause, due to decrease level of estrogen in women between the ages of 45-55 years, is a natural process that is characterized by the complete stoppage of menstrual cycle is called menopause. Because of imbalance of hormone mainly estrogen the efficiency of life is disturbed as a result various postmenopausal syndromes such as irritability, night sweats, vaginal dryness, hot flushes, depression, sleep disturbance and headache can occur in this period. This study was done to evaluate the changes of Body mass index (BMI) and serum uric acid in postmenopausal women in comparison to reproductive women. This analytical type of cross sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Bangladesh from January 2023 to December 2023. A total number of 200 healthy women were enrolled in this study. Among them, one hundred (100) female subjects were taken as control group (Group I) age ranges from 25-45 years and one hundred (100) female subjects were taken as study group (Group II) age ranges from 45-65 years. BMI was calculated by anthropometric measurement such as height and weight was taken in meter and kilogram respectively and serum uric acid is expressed in mg/dl. Output were expressed as mean±SD and by using unpaired students' 't' test, statistical significance of difference among the group was calculated. The mean±SD of BMI of Group I and Group II were 21.91±1.57 kg/m² and 26.92±2.06 kg/m² respectively. In the study group the mean±SD of BMI is notably increased in study group in comparison with control group. The mean±SD of serum uric acid of Group I and Group II were 4.18±1.33 mg/dl and 7.36±0.46 mg/dl respectively. In the study group the mean±SD of serum uric acid was notably increased in study group in comparison with control group. Postmenopausal women with higher BMI and serum uric acid caused by lower level of female sex hormone specially estrogen hormone increased the change of cardiovascular disease, stroke, chronic renal failure, type-2 diabetes mellitus, insulin resistance and metabolic syndrome. So, the assessment of this parameter is important for early detection and prevention of complication related to higher BMI and serum uric acid for leading a healthy life.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 2","pages":"351-354"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Patient with Amyotrophic Lateral Sclerosis Following Suicidal Organophosphorus Compounds Poisoning: A Case Report.","authors":"M Saiduzzaman, S Roy, M Bhattacharjee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving both upper and lower motor neurons. Its underlying etiology is not well established. But certain risk factors including genetic predilection and exposure to certain environmental toxins like Organophosphorus Compounds (OPC) have been postulated. Here we describe a young male patient presented with progressive weakness of all four limbs immediately following survival from OPC ingestion as a suicidal attempt. He also had slurred, indistinct speech without swallowing difficulty and sensory findings. Neurological examination findings are having mixed upper and lower motor neuron signs. EMG (Electromyography) shows features of denervation and reinnervation suggestive of ALS. ALS following single exposure to OPC is a relatively rare finding. Supportive treatments including physiotherapy and psychotherapy were given. This case may strengthen the etiological link between OPC and ALS.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 1","pages":"272-275"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Hearing Recovery Two Years Following Onset of Bilateral Sudden Sensorineural Hearing Loss: Miracle May Happen any Time.","authors":"H A R Talukder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sudden sensorineural hearing loss is a medical emergency. Incidence is very low. Unilateral SSNHL is common and mostly idiopathic. Spontaneous recovery rate is 30-65% within 2 weeks. Bilateral SSNHL is a rare subset, less than 5% of reported SSNHL and higher association with systemic disease. Prognosis is very poor following treatment. Recovery of hearing after 3 months following SSNHL is a very rare entity. Spontaneous hearing gain after a long time is a miracle that happened in the reported case. A 12-year-old female child suddenly recovered serviceable hearing few days prior to the date of cochlear implant surgery following SSNHL. She developed a very rare bilateral sudden sensorineural hearing loss two years back. Bilateral sudden sensorineural hearing loss is a rare subset though unilateral SSHL is little common. Recovery of hearing occurs mostly within two weeks, very rare beyond sixty days. Our case reported sudden hearing gain about two years after insidious SSNHL. Explanations not clear provably reestablishment of vascularity to cochlear or spontaneous elimination of underlying cause. No available data found, further study is needed.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 1","pages":"285-289"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of High-Sensitivity C-reactive protein in Patient with Early Parkinson's disease.","authors":"M M Emran, S S Malik, M Wahiduzzaman, G K Paul, N Fatema","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a common neurodegenerative disorder. The pathogenesis of PD is unknown till now. The high-sensitivity C-reactive protein (CRP) is a non-specific biochemical marker of inflammation. It is used for the screening of organ diseases and the monitoring of responses to treatment in cases of inflammation and infection. This study aimed to evaluate the relationship of high-sensitivity C-reactive protein in early Parkinson disease. A total of seventy-six early Parkinson's disease patients were enrolled in this Cross-sectional observational study which was carried out in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from September 2014 to March 2016. We assessed high sensitivity CRP of early Parkinson's disease patients as an inflammatory marker. This study was performed with 76 early Parkinson disease patients. Among them, male and female were 69.7% and 30.3% respectively. The mean ±SD age of patients was 53.25±11.53 years with an age range of 24 to 77 years. The mean ±SD value of high-sensitivity C-reactive protein was estimated 2.76±3.57 mg/L with the range of 0.21 to 20.90mg/L. We also calculate the 95% CI in the range of 1.96 to 3.56mg/L. Also, a positive and highly significant correlation were seen in between duration of tremor and High sensitivity CRP (r=0.430, p<0.001) and between duration of bradykinesia and High sensitivity CRP (r=0.426, p<0.001) which indicate increase duration causes increase level of high-sensitivity C-reactive protein value. In conclusion, above findings suggests that neuro-inflammation plays a significant role in the pathogenesis of early Parkinson's disease progression.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 1","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV Vaccination in a Case of JORRP, a Variety of RRP in Bangladesh Medical College Hospital: A Case Report.","authors":"S Jebunnaher, T Mohammad, M A Jaigirdar, M A Islam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recurrent respiratory papillomatosis (RRP) is a rare disease which is caused by human papilloma virus (HPV). It is a warty growth in the upper airway may cause significant airway obstruction or voice change. Though it is rare but one with severe morbidity and occasional mortality. It is caused mostly by HPV 6 and 11. Juvenile-onset recurrent respiratory papillomatosis (JoRRP) which is Juvenile form of RRP affects children, most common between the ages of 1 to 4 years.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 1","pages":"290-294"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Drug Use Pattern in Dermatology Out-Patient Department: A Cross-Sectional Study in a Tertiary Care Teaching Hospital, Dhaka, Bangladesh.","authors":"H Begum, M A Baker, A N Asma, Z Rahman, A N Dina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Now-a-days, all over the world, skin disease are the fourth most common cause of disability. A significant amount of patient attending the dermatology outdoor of any major hospital in a daily basis. Irrational drug prescribing is a common contemplation in clinical practice. The present research work was commenced to study the drug use pattern and rationality of prescriptions of the patients be at Dermatology Out-Patient Department (OPD) of a tertiary care hospital. It was an observational, single center study, conducted among 600 patients attending the Dermatology OPD of Enam Medical College and Hospital (EMCH), Bangladesh for a period of six months by interviewing the patients and detailed were filled in predesigned form. Overall 600 drug instructions were collected and surveyed for demographic as well as dermatological profile. Antihistamine (16.95%), antibacterial (14.69%), antifungal (10.73%) and corticosteroids (8.47%) were the most recurrent class of drugs ordered. Combination form (oral + topical) was mostly instructed (61.80%). Polypharmacy was seen (3.54 drugs per prescription) in our study, very few drugs (1.97%) name were written by generic name. antihistamine were most frequently advised drug groups. Least amount of drugs was prescribed from Essential Drug List (EDL) of Bangladesh. Interim auditing is necessary to promote standard prescription.</p>","PeriodicalId":94148,"journal":{"name":"Mymensingh medical journal : MMJ","volume":"34 1","pages":"220-226"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}