Journal of biophotonics最新文献_第3页

Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections. 用于快速鉴定感染的滑膜液样本非接触式漫反射光谱仪

Journal of biophotonics Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1002/jbio.202400213

Erin E Drewke, Robert L Brand, Caroline G Geels, Hanna K Jensen, Kevin Wong, Jarret D Sanders, Narasimhan Rajaram

{"title":"Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections.","authors":"Erin E Drewke, Robert L Brand, Caroline G Geels, Hanna K Jensen, Kevin Wong, Jarret D Sanders, Narasimhan Rajaram","doi":"10.1002/jbio.202400213","DOIUrl":"10.1002/jbio.202400213","url":null,"abstract":"Severe joint infections, such as septic arthritis, require rapid diagnostic testing of the synovial fluid aspirated from joints level so that a surgical team can be assembled quickly. We present a diffuse reflectance spectroscopy (DRS) system for noncontact determination of infection. Using a light-tight syringe holder and fiber optic probe, diffusely reflected light from 475 to 655 nm was acquired from 18 patient samples through the wall of a syringe in a noncontact and sterile manner. We determined the reflectance ratios at two different wavelengths-R 490/R 600 and R 580/R 600 and found statistically significant differences (p < 0.05) in both ratios between the infected and noninfected groups. Critically, the R 490/R 600 and R 580/R 600 ratios were significantly correlated with clinical biomarkers-the white blood cell (WBC) and red blood cell (RBC) counts, respectively. This study demonstrates the potential of DRS as a rapid diagnostic tool for joint infections.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An In Vitro Study of 355-nm Laser Ablation of Atherosclerotic Lesions Model. 355纳米激光消融动脉粥样硬化病变模型的体外研究

Journal of biophotonics Pub Date : 2024-10-29 DOI: 10.1002/jbio.202400329

Fangying Wei, Jiajun He, Shiyong Zhao, Peng Lei, Qingjie Zhang, Guangxi Li, Xiaopeng Li, Xin Ding, Jianquan Yao

引用次数: 0

Effects of FOLFOX Chemotherapy on Tumor Oxygenation and Perfused Vasculature: An In Vivo Study by Optical Techniques. FOLFOX 化疗对肿瘤氧合和灌注血管的影响：利用光学技术进行的体内研究。

Journal of biophotonics Pub Date : 2024-10-29 DOI: 10.1002/jbio.202400339

Irina Druzhkova, Kseniya Bylinskaya, Anton Plekhanov, Alexey Kostyuk, Mikhail Kirillin, Valeriya Perekatova, Aleksandr Khilov, Anna Orlova, Anastasiya Polozova, Anastasiya Komarova, Uliyana Lisitsa, Marina Sirotkina, Marina Shirmanova, Ilya Turchin

{"title":"Effects of FOLFOX Chemotherapy on Tumor Oxygenation and Perfused Vasculature: An In Vivo Study by Optical Techniques.","authors":"Irina Druzhkova, Kseniya Bylinskaya, Anton Plekhanov, Alexey Kostyuk, Mikhail Kirillin, Valeriya Perekatova, Aleksandr Khilov, Anna Orlova, Anastasiya Polozova, Anastasiya Komarova, Uliyana Lisitsa, Marina Sirotkina, Marina Shirmanova, Ilya Turchin","doi":"10.1002/jbio.202400339","DOIUrl":"https://doi.org/10.1002/jbio.202400339","url":null,"abstract":"The effects of cytotoxic chemotherapy on tumor vasculature and oxygenation are in the focus of modern investigations because vascular structure and distribution of oxygen influence tumor behavior and treatment response. The aim of our study was to monitor changes in the vascular component of colorectal tumor xenografts induced by a clinical combination of chemotherapy drugs FOLFOX in vivo using two complementary techniques: diffuse reflectance spectroscopy (DRS) and optical coherence tomography-based microangiography (OCT-MA). These techniques revealed a slower decrease in tumor blood oxygenation in treated tumors as compared to untreated ones, faster suppression of tumor vasculature perfusion and increase in water content as a result of treatment, and decrease in total hemoglobin in untreated tumors. Immunohistochemical analysis of hypoxia-inducible factor HIF-2α detected tissue hypoxia as a consequence of inappropriate oxygen supply in the treated tumors. The obtained results show the prospects for monitoring of treatment efficacy using DRS and OCT-MA.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Quantitative In Vivo Assessment of Diabetic and Non-Diabetic Skin Wound Healing Using Phasor-FLIM Approach. 利用 Phasor-FLIM 方法对糖尿病和非糖尿病皮肤伤口愈合进行体内定量评估

Journal of biophotonics Pub Date : 2024-10-29 DOI: 10.1002/jbio.202400227

Hala Zuhayri, Tatiana B Lepekhina, Viktor V Nikolaev, Houssain Baalbaki, Anastasia I Knyazkova, Alexey V Borisov, Natalya A Krivova, Yury V Kistenev

引用次数: 0

Deep Learning With Optical Coherence Tomography for Melanoma Identification and Risk Prediction. 深度学习与光学相干断层扫描用于黑色素瘤识别和风险预测。

Journal of biophotonics Pub Date : 2024-10-27 DOI: 10.1002/jbio.202400277

Pei-Yu Lai, Tai-Yu Shih, Yu-Huan Chang, Chung-Hsing Chang, Wen-Chuan Kuo

引用次数: 0

Hybrid Raman and Partial Wave Spectroscopy Microscope for the Characterization of Molecular and Structural Alterations in Tissue. 用于表征组织中分子和结构变化的混合拉曼和部分波谱显微镜。

Journal of biophotonics Pub Date : 2024-10-27 DOI: 10.1002/jbio.202400330

Elena Kriukova, Mikhail Mazurenka, Sabrina Marcazzan, Sarah Glasl, Michael Quante, Dieter Saur, Markus Tschurtschenthaler, Gerwin J Puppels, Dimitris Gorpas, Vasilis Ntziachristos

{"title":"Hybrid Raman and Partial Wave Spectroscopy Microscope for the Characterization of Molecular and Structural Alterations in Tissue.","authors":"Elena Kriukova, Mikhail Mazurenka, Sabrina Marcazzan, Sarah Glasl, Michael Quante, Dieter Saur, Markus Tschurtschenthaler, Gerwin J Puppels, Dimitris Gorpas, Vasilis Ntziachristos","doi":"10.1002/jbio.202400330","DOIUrl":"https://doi.org/10.1002/jbio.202400330","url":null,"abstract":"We present a hybrid Raman spectroscopy (RS) and partial wave spectroscopy (PWS) microscope for the characterization of molecular and structural tissue alterations. The PWS performance was assessed with surface roughness standards, while the Raman performance with a silicon crystal standard. We also validated the system on stomach and intestinal mouse tissues, two closely-related tissue types, and demonstrate that the addition of PWS information improves RS data classification for these tissue types from R2 = 0.892 to R2 = 0.964 (norm of residuals 0.863 and 0.497, respectively). Then, in a proof-of-concept experiment, we show that the hybrid system can detect changes in intestinal tissues harvested from a tumorigenic Villin-Cre, Apcfl/wt mouse. We discuss how the hybrid modality offers new abilities to identify the relative roles of PWS morphological features and Raman molecular fingerprints, possibly allowing for their combination to enhance the study of carcinogenesis and early cancer diagnostics in the future.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tutorial on the Use of the Photon Diffusion Approximation for Fast Calculation of Tissue Optical Properties. 关于使用光子扩散近似法快速计算组织光学特性的教程。

Journal of biophotonics Pub Date : 2024-10-26 DOI: 10.1002/jbio.202400257

Maria R Pinheiro, Maria I Carvalho, Luís M Oliveira

引用次数: 0

Optical Biosensors for Detection of Cancer Biomarkers: Current and Future Perspectives. 用于检测癌症生物标记物的光学生物传感器：当前和未来展望。

Journal of biophotonics Pub Date : 2024-10-23 DOI: 10.1002/jbio.202400243

Dharsini Narayana Moorthy, Durgalakshmi Dhinasekaran, P N Blessy Rebecca, Ajay Rakkesh Rajendran

{"title":"Optical Biosensors for Detection of Cancer Biomarkers: Current and Future Perspectives.","authors":"Dharsini Narayana Moorthy, Durgalakshmi Dhinasekaran, P N Blessy Rebecca, Ajay Rakkesh Rajendran","doi":"10.1002/jbio.202400243","DOIUrl":"https://doi.org/10.1002/jbio.202400243","url":null,"abstract":"Optical biosensors are emerging as a promising technique for the sensitive and accurate detection of cancer biomarkers, enabling significant advancements in the field of early diagnosis. This study elaborates on the latest developments in optical biosensors designed for detecting cancer biomarkers, highlighting their vital significance in early cancer diagnosis. When combined with targeted nanoparticles, the bio-fluids can help in the molecular stage diagnosis of cancer. This enhances the discrimination of disease from the normal subjects drastically. The optical sensor methods that are involved in the disease diagnosis and imaging of cancer taken for the present review are surface plasmon resonance, localized surface plasmon resonance, fluorescence resonance energy transfer, surface-enhanced Raman spectroscopy and colorimetric sensing. The article meticulously describes the specific biomarkers and analytes that optical biosensors target. Beyond elucidating the underlying principles and applications, this article furnishes an overview of recent breakthroughs and emerging trends in the field. This encompasses the evolution of innovative nanomaterials and nanostructures designed to augment sensitivity and the incorporation of microfluidics for facilitating point-of-care testing, thereby charting a course towards prospective advancements.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Ischemic Stroke Evaluation by a Model-Based Photoacoustic Tomography Algorithm. 通过基于模型的光声断层扫描算法加强缺血性脑卒中评估

Journal of biophotonics Pub Date : 2024-10-22 DOI: 10.1002/jbio.202400203

Yuanyuan Li, Yi Lin, Boyi Li, Ting Feng, Dan Li, Ying Li, Yi Wu, Dean Ta

{"title":"Enhancing Ischemic Stroke Evaluation by a Model-Based Photoacoustic Tomography Algorithm.","authors":"Yuanyuan Li, Yi Lin, Boyi Li, Ting Feng, Dan Li, Ying Li, Yi Wu, Dean Ta","doi":"10.1002/jbio.202400203","DOIUrl":"https://doi.org/10.1002/jbio.202400203","url":null,"abstract":"Ischemic stroke (IS) is characterized by the sudden interruption of blood supply to the brain, resulting in neurological impairments and even mortality. Photoacoustic computed tomography (PACT) integrates the high contrast of optical imaging and the penetration of ultrasound imaging, enabling non-invasive IS evaluation. However, the image reconstruction quality significantly affects the oxyhemoglobin saturation (sO2) estimation. This study investigates a model-based with total variation minimized by augmented Lagrangian and alternating direction (MB-TVAL3) approach and compared it with the widely used back-projection (BP) and delay-and-sum (DAS) algorithms. Both simulations and in vivo experiments are conducted to validate the performance of the MB-TVAL3 algorithm, showing a higher sO2 estimation accuracy and sensitivity in detecting infarct area compared to BP and DAS. The findings of this study emphasize the impact of acoustic inverse problem on the accuracy of sO2 estimation and the proposed approach offers valuable support for IS evaluation and cerebrovascular diagnosis.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Optical Attenuation and Skin Thickness in Type 2 Diabetes Mellitus Patients Using Optical Coherence Tomography. 利用光学相干断层扫描评估 2 型糖尿病患者的光学衰减和皮肤厚度。

Journal of biophotonics Pub Date : 2024-10-22 DOI: 10.1002/jbio.202400267

Minghui Chen, Yue Shen, Jianguo Zhu, Tingwei Su, Yifei Zhang, Weiqing Wang, Chang Chen, Lin Zhou

引用次数: 0