Journal of biophotonics最新文献_第4页

Effects of Acute Photobiomodulation on Heart Rate Variability in Physically Active Individuals: A Randomized and Controlled Clinical Trial. 急性光生物调节对体力活动者心率变异性的影响：一项随机对照临床试验。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 DOI: 10.1002/jbio.70242

Reobbe Aguiar Pereira, Aparecida Maria Catai, Juliana Cristina Milan-Mattos, Adriana Keila Dias, Nivaldo Antonio Parizotto

{"title":"Effects of Acute Photobiomodulation on Heart Rate Variability in Physically Active Individuals: A Randomized and Controlled Clinical Trial.","authors":"Reobbe Aguiar Pereira, Aparecida Maria Catai, Juliana Cristina Milan-Mattos, Adriana Keila Dias, Nivaldo Antonio Parizotto","doi":"10.1002/jbio.70242","DOIUrl":"10.1002/jbio.70242","url":null,"abstract":"Photobiomodulation (PBM) therapy is widely investigated for tissue recovery, performance enhancement, and post-exercise optimization. This study assessed whether PBM applied to the vagus nerve in the infra-auricular region, combined with resistance exercise, modulates cardiac autonomic function in healthy, physically active adults. In this acute randomized controlled trial, 34 volunteers were enrolled: 17 underwent PBM or sham PBM in a crossover design, while a control group (n = 17) received PBM without exercise. PBM was delivered with a total energy dose of 12 J. Heart rate variability (HRV) was analyzed in time, frequency, and non-linear domains. Results showed a slight reduction (p = 0.011) in approximate entropy (ApEn) in the PBM group compared with controls, but no significant differences were observed in other HRV indices. These findings suggest that PBM applied to the vagus nerve induces minimal acute modulation of autonomic complexity. Further studies with different dosimetries and exercise protocols are warranted.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 3","pages":"e70242"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Cerebral Blood Flow With Near-Infrared Light Therapy in Mouse Model of a Chronic Hypoxia-Induced Bilateral Common Carotid Artery Stenosis. 近红外光增强小鼠双侧颈总动脉慢性缺氧狭窄模型脑血流量的研究。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 Epub Date: 2025-12-14 DOI: 10.1002/jbio.202500291

Hong Bae Kim, Ku Youn Baik, Chang Kyu Sung

引用次数: 0

Wearable Laser Doppler Flowmetry and Fluorescence Spectroscopy Devices: Instrumentation and Methodology of Application in Clinical and Space Research. 穿戴式激光多普勒血流测量和荧光光谱装置：仪器和方法在临床和空间研究中的应用。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1002/jbio.70209

Elena V Zharkikh, Yulia I Loktionova, Vyacheslav S Yanushin, Kirill S Kireev, Victor V Sidorov, Andrey V Dunaev

引用次数: 0

Raman Spectral Signatures of Human Neutrophils: A Single-Cell Approach. 人类中性粒细胞的拉曼光谱特征：单细胞方法。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 DOI: 10.1002/jbio.70251

Lenka Vaňková, Jiří Bufka, Pavla Šigutová, Monika Holubová, Věra Křížková

{"title":"Raman Spectral Signatures of Human Neutrophils: A Single-Cell Approach.","authors":"Lenka Vaňková, Jiří Bufka, Pavla Šigutová, Monika Holubová, Věra Křížková","doi":"10.1002/jbio.70251","DOIUrl":"10.1002/jbio.70251","url":null,"abstract":"Introduction: With their noninvasive capabilities for molecular-level analysis of biological tissues and cells, Raman spectroscopy and microscopy have become important tools in medicine and medical diagnostics.Methods: In this work, we describe a reliable and repeatable technique for Raman spectroscopic profiling of human neutrophils in peripheral blood smears. 1200 single-cell spectra from 12 healthy donors were obtained using Raman microscopy, and the results showed consistent spectral features of key biomolecules such as proteins, nucleic acids, carotenoids, and cytochrome c.Results: We used t-distributed stochastic neighbor embedding and principal component analysis to assess interindividual variability; both techniques showed minimal spectral divergence between donors and high reproducibility. This study lays the methodological groundwork for upcoming Raman microscopy applications enabling non-invasive assessment of immune cell states in health and disease.Conclusion: Our results demonstrate the potential of Raman microscopy in clinical diagnostics, specifically for tracking the metabolic states of cells.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 3","pages":"e70251"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Assessment of Vascularity in Actinic Keratosis Using Dynamic Optical Coherence Tomography: Practical Considerations and Theoretical Insights. 使用动态光学相干断层扫描对光化性角化病血管性的纵向评估：实际考虑和理论见解。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 DOI: 10.1002/jbio.70240

Gavrielle R Untracht, Gabriella Fredman, John R Zibert, Merete Haedersdal, Vinzent Kevin Ortner

{"title":"Longitudinal Assessment of Vascularity in Actinic Keratosis Using Dynamic Optical Coherence Tomography: Practical Considerations and Theoretical Insights.","authors":"Gavrielle R Untracht, Gabriella Fredman, John R Zibert, Merete Haedersdal, Vinzent Kevin Ortner","doi":"10.1002/jbio.70240","DOIUrl":"10.1002/jbio.70240","url":null,"abstract":"Longitudinal monitoring of actinic keratosis (AK) is a part of patient management, scientific studies, and the development of new treatment strategies. Dynamic optical coherence tomography (D-OCT), an imaging method that enables noninvasive assessment of microvasculature, in conjunction with automated quantitative analysis, shows promise as an objective and robust method for monitoring AKs. Critical to quantitative longitudinal assessments is a dataset in which good-quality images are available at all time points. Yet, to date, few resources exist to train clinical researchers on how to ensure robust D-OCT data collection. In this study, we identify hallmarks of poor image quality to guide data curation and avoid biasing study results. We highlight strategies for imaging lesions with significant hyperkeratosis. Finally, we discuss characteristic features present in D-OCT images of AK that may complicate quantitative analysis. We hope that this work will facilitate the use of D-OCT in the objective longitudinal assessment of AK.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 3","pages":"e70240"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Brain Network Analysis of Resting-State fNIRS Reveals Cortical Compensation and Integration Imbalance in Acute Stroke. 静息状态fNIRS多模态脑网络分析揭示急性脑卒中的皮质代偿和整合失衡。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 DOI: 10.1002/jbio.70248

Zhexue Huang, Hui Sun, Guangyue Zhu, Xiaoshun Tang, Zhengchen Li, Qian Liang, Hang Liang, Junhui She, Yuhui Chen, Xijin Wang

{"title":"Multimodal Brain Network Analysis of Resting-State fNIRS Reveals Cortical Compensation and Integration Imbalance in Acute Stroke.","authors":"Zhexue Huang, Hui Sun, Guangyue Zhu, Xiaoshun Tang, Zhengchen Li, Qian Liang, Hang Liang, Junhui She, Yuhui Chen, Xijin Wang","doi":"10.1002/jbio.70248","DOIUrl":"10.1002/jbio.70248","url":null,"abstract":"This study utilized resting-state functional near-infrared spectroscopy to investigate the alterations in brain functional networks resulting from acute stroke. By implementing a comprehensive multimodal analytical approach, we assessed functional connectivity, effective connectivity, and graph-theoretical topology in resting-state fNIRS data. A total of 26 patients with acute stroke and 18 age- and sex-matched healthy controls participated in the study. The findings indicated a significant increase in effective connectivity from the affected supplementary motor area and a decrease in nodal degree centrality in the affected premotor cortex. While the global small-world topology remained intact, no notable differences in functional connectivity were observed between the groups. Notably, effective connectivity and graph-theoretical metrics proved to be more sensitive than functional connectivity in identifying acute stroke pathology. These results suggest a cortical compensation mechanism characterized by enhanced effective connectivity, even in the presence of impaired nodal integration in motor-related regions during the acute phase.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 3","pages":"e70248"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femtosecond Optical Kerr Effect in Alzheimer's Brain Tissue. 阿尔茨海默氏症脑组织中的飞秒光学克尔效应。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 DOI: 10.1002/jbio.70244

Sandra Mamani, Laura A Sordillo, Robert R Alfano

引用次数: 0

Synergistic Effects of Near-Infrared Photobiomodulation and Allogeneic Fibrin Serum on Osteogenic Differentiation of Human Dental Pulp Stem Cells. 近红外光生物调节剂和同种异体纤维蛋白血清对人牙髓干细胞成骨分化的协同作用。

IF 2.3

Journal of biophotonics Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1002/jbio.202500340

Hong Bae Kim, Chang Kyu Sung

引用次数: 0

Non-Invasive and Rapid Quantitative Elasticity Analysis of Seborrheic Keratosis Based on Optical Coherence Elastography: An Exploratory Study. 基于光学相干弹性成像的脂溢性角化病无创快速定量弹性分析：一项探索性研究。