Journal of biophotonics最新文献_第2页

Viscoelastic Properties of Normal Skin and Basal Cell Carcinoma Evaluated by Non-Contact Palpation. 非接触触诊法评价正常皮肤和基底细胞癌的粘弹性。

IF 2.3

Journal of biophotonics Pub Date : 2026-06-01 DOI: 10.1002/jbio.70306

Meriem Ayadh, Alexandre Bergheau, Christian Dorado Cortez, Julie Chauvel Picard, Martina D'Onghia, Elisa Cinotti, Jean-Luc Perrot, Hassan Zahouani

{"title":"Viscoelastic Properties of Normal Skin and Basal Cell Carcinoma Evaluated by Non-Contact Palpation.","authors":"Meriem Ayadh, Alexandre Bergheau, Christian Dorado Cortez, Julie Chauvel Picard, Martina D'Onghia, Elisa Cinotti, Jean-Luc Perrot, Hassan Zahouani","doi":"10.1002/jbio.70306","DOIUrl":"10.1002/jbio.70306","url":null,"abstract":"This study provides a large-scale clinical validation of a non-invasive method to characterize the mechanical properties of tumoral and non-tumoral human skin, aiding dermatological diagnosis and establishing a database for future research. The non-contact UNDERSKIN device employs Fourier transform calculations to analyze surface wave dispersion generated by a focused airflow, via a skin-specific inversion model combined with a viscoelastic model. This digital palpation technology provides detailed insight into subsurface particle motion, revealing new mechanical responses of basal cell carcinomas (BCC). Conducted ex vivo on over 160 BCC and 40 healthy skin specimens, the results quantify the viscoelastic behavior of each skin layer. Although dermatologists can assess tissue firmness through palpation, they currently cannot objectively quantify it or determine its origins. This technique provides that missing quantification, linking tactile perception to specific biomechanical properties. By measuring where firmness originates within skin layers, this work offers valuable support for improving diagnosis, prognosis, treatment planning, surgical decisions, and the advancement of teledermatology applications.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 6","pages":"e70306"},"PeriodicalIF":2.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Swin Transformer With Multi-Scale Dilated Convolution for White Blood Cell Hyperspectral Image Classification. 基于多尺度展开卷积的三维Swin变压器用于白细胞高光谱图像分类。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70280

Yushi Yang, Danfei Huang, Yi Xie, Lijia Qiu, Jiaxuan Yan, Ziyang Liu

引用次数: 0

Investigation of the Therapeutic Effects of Transcorneal Electrical Stimulation on Alzheimer's Disease Using Optical Coherence Tomography. 应用光学相干断层扫描研究经角膜电刺激治疗阿尔茨海默病的疗效。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70274

Ping Si, Ni He, Jiabiao Liu, Qingyun Wang, Jingchao Lin, Cuixia Dai

引用次数: 0

In Vivo Mapping of Vasculature and Mechanics for Skin Tumor Using Optical Coherence Tomography. 利用光学相干断层扫描对皮肤肿瘤的血管系统和力学进行体内测绘。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70279

Xiaochen Meng, Zeqi Su, Yilin Liang, Chongyang Wang, Jiawei Ma, Fan Fan, Jiang Zhu

{"title":"In Vivo Mapping of Vasculature and Mechanics for Skin Tumor Using Optical Coherence Tomography.","authors":"Xiaochen Meng, Zeqi Su, Yilin Liang, Chongyang Wang, Jiawei Ma, Fan Fan, Jiang Zhu","doi":"10.1002/jbio.70279","DOIUrl":"10.1002/jbio.70279","url":null,"abstract":"Optical coherence tomography (OCT) is widely used in dermatology, but conventional OCT-based angiography and elastography are performed independently, limiting real-time assessment of vascular and mechanical properties within the same region. As microvascular and biomechanical changes often occur simultaneously during inflammation, fibrosis, and tumor progression, separate measurements may introduce spatial mismatch and reduce diagnostic accuracy. Here, we present a multifunctional OCT approach that enables the simultaneous acquisition of structural and elasticity information within a single scan, utilizing a streamlined sample arm and a customized protocol. Vascular networks are extracted using an intensity-based Doppler variance algorithm, while elasticity maps are generated through phase-based strain analysis. The method was validated using a bilayer tissue-mimicking phantom and tumor-bearing mouse skin, demonstrating simultaneous mapping of vascular and elastic features within the same region. This compact system offers an efficient tool for non-invasive skin assessment, with strong potential for enhancing diagnostic accuracy and functional evaluation.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 5","pages":"e70279"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superior Induction of Apoptosis by Blue Light Compared to Red Light Photodynamic Therapy in Cutaneous Squamous Cell Carcinoma Keratinocytes. 蓝光对皮肤鳞状细胞癌角质形成细胞的诱导作用优于红光光动力疗法。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70272

Julia Stolyar, Margaret Kabakova, Paras Patel, Julie Saadia-Hazkour, Evan Austin, Jared Jagdeo

引用次数: 0

Combined Low-Level Laser and Ultrasound Therapy for Growing Pains in Children Aged Four to Twelve Years: A Pilot Study. 低水平激光与超声联合治疗4 - 12岁儿童生长痛的初步研究。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70275

Esther Angelica Luiz Ferreira, Lucas Pereira Liberal, Antonio Eduardo de Aquino Junior, Rodrigo Bezerra de Menezes Reiff, Fernanda Mansano Carbinatto, Ricardo Patrezi Zanatta, Matheus Henrique Camargo Antonio, Noahn Gabriel Silva Pereira, Maycon Rodrigo Sarracini, Vanderlei Salvador Bagnato

{"title":"Combined Low-Level Laser and Ultrasound Therapy for Growing Pains in Children Aged Four to Twelve Years: A Pilot Study.","authors":"Esther Angelica Luiz Ferreira, Lucas Pereira Liberal, Antonio Eduardo de Aquino Junior, Rodrigo Bezerra de Menezes Reiff, Fernanda Mansano Carbinatto, Ricardo Patrezi Zanatta, Matheus Henrique Camargo Antonio, Noahn Gabriel Silva Pereira, Maycon Rodrigo Sarracini, Vanderlei Salvador Bagnato","doi":"10.1002/jbio.70275","DOIUrl":"10.1002/jbio.70275","url":null,"abstract":"Growing pains are a frequent form of musculoskeletal pain in children, with an uncertain etiology and currently limited therapeutic options. Considering the need for non-pharmacological approaches, the potential of low-level laser therapy combined with ultrasonic therapy stands out as a possible therapeutic technique for this condition. The objective of this study was to analyze the safety and efficacy of this treatment in children diagnosed with growing pains in order to justify the development of further research on the same topic. After confirmation of the diagnosis, participants were randomized into a treatment group, treated with the laser and ultrasound-emitting equipment, and a placebo group. Pain was assessed at three time points and recorded in a diary for 30 days. The results indicated clinical safety and possible efficacy, reinforcing the need for further clinical trials on the subject.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 5","pages":"e70275"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. 利用热成像技术评估微循环的健康和功能。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70270

Douglas B Kell, Etheresia Pretorius

{"title":"Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging.","authors":"Douglas B Kell, Etheresia Pretorius","doi":"10.1002/jbio.70270","DOIUrl":"10.1002/jbio.70270","url":null,"abstract":"The microcirculation, composed of vessels below 100 μm in diameter, sustains tissue perfusion and metabolic exchange. Its dysfunction is increasingly implicated in chronic, inflammatory, and thrombotic disorders such as diabetes, sepsis, cardiovascular disease, and Long COVID. Accurate, noninvasive assessment of microvascular health is therefore clinically significant. Infrared thermal imaging provides a rapid, contact-free, and physiologically coherent means of visualizing temperature distributions that reflect underlying blood flow. Because thermal gradients directly correspond to perfusion heterogeneity, this approach offers an interpretable surrogate for assessing microvascular function. Here, we review the physical principles of thermal imaging, summarize its application to the peripheral circulation, and compare it with established modalities including nailfold capillaroscopy and laser-based techniques. We also outline its utility across diverse pathologies associated with fibrinaloid microclot complexes and endothelial injury. Thermal imaging thus emerges as an inexpensive/scalable tool for evaluating microcirculatory dysfunction in both research and (where approved) in clinical settings.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 5","pages":"e70270"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Photodynamic Therapy in the Treatment of Diabetic Foot Ulcers: A Pilot Randomized Clinical Trial. 抗菌光动力疗法治疗糖尿病足溃疡：一项随机临床试验。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70278

Maria Girlane Sousa Albuquerque Brandão, Mayra Gonçalves Menegueti, Roberto Bueno Filho, Luciano Rocha Mendonça, Ana Carolina Gomes, Idevania G Costa, Soraia Assad Nasbine Rabeh

{"title":"Antimicrobial Photodynamic Therapy in the Treatment of Diabetic Foot Ulcers: A Pilot Randomized Clinical Trial.","authors":"Maria Girlane Sousa Albuquerque Brandão, Mayra Gonçalves Menegueti, Roberto Bueno Filho, Luciano Rocha Mendonça, Ana Carolina Gomes, Idevania G Costa, Soraia Assad Nasbine Rabeh","doi":"10.1002/jbio.70278","DOIUrl":"10.1002/jbio.70278","url":null,"abstract":"This pilot randomized clinical trial evaluated photodynamic therapy (PDT) in diabetic foot ulcers (DFUs), comparing an intervention group (IG, n = 5) with a control group (CG, n = 4). Participants were followed for 7 weeks. The IG received PDT, while the CG underwent conventional care. The microbiological profile was assessed by biopsy before and after treatment, and wound progression was evaluated using the Bates-Jensen Wound Assessment Tool. In the IG, only one participant showed an increase in the number of bacterial species, while the others maintained the count with changes in species composition. In the CG, two participants presented an increase in bacterial species. All participants in the IG showed a reduction in ulcer size, with an average decrease of more than 63%, whereas two participants in the CG exhibited an increase in lesion area. These results suggest clinically relevant differences, supporting PDT as a promising adjuvant strategy for antimicrobial stewardship in DFUs.","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 5","pages":"e70278"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on Carotid Blood Flow Detection Based on Interferometric Diffuse Speckle Contrast Analysis and Its Application in Preventing Ischemic Stroke. 基于干涉散射散斑对比分析的颈动脉血流检测及其在缺血性脑卒中预防中的应用研究。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70277

Guang Han, Wei Zhang, Qinglong Yang, Ruijuan Chen, Yifan Wu, Huiquan Wang, Zhe Zhao

引用次数: 0

Correction to "The Synergistic Effect of Photodynamic and Sonodynamic Inactivation Against Candida albicans Biofilm". 更正“光动力和声动力灭活对白色念珠菌生物膜的协同作用”。

IF 2.3

Journal of biophotonics Pub Date : 2026-05-01 DOI: 10.1002/jbio.70276

引用次数: 0