A Novel Quantitative Hemodynamic Evaluation Method of Laser Therapy for Scars Based on Diffuse Correlation Spectroscopy.

In this study, we proposed a hemodynamic evaluation method for scar laser therapy based on diffuse correlation spectroscopy (DCS) quantitatively. In vivo experiments were conducted to validate the feasibility of the proposed method by monitoring microvascular blood flow (BF) before and immediately after the laser therapy via a custom-built DCS device. Six participants were enrolled with two kinds of laser therapy treatments, one of which is aimed to induce vasoconstriction, while the other is intended to promote vasodilation. The scar BF reduced by 43.27% and the power spectral density (PSD) of that reduced by 72% for the vasoconstriction laser therapy treatment, while the scar BF increased 338.73% and PSD increased by 917% for the vasodilation laser therapy treatment. Finally, experimental results indicated that DCS enables reliable quantitative evaluation for laser therapy of scars. We are confident that DCS will assist clinicians in understanding the microvascular hemodynamic conditions of scars.