European journal of breast health最新文献

{"title":"What Changes are Mandatory in Breast Surgery Training? An International Survey and Recommendations of the French Academy of Surgery and the Senologic International Society.","authors":"Tolga Ozmen, Caroline Bouche, Megane Buttignol, Bolivar Arboleda-Osorio, Mauricio Magalhaes Costa, Henry Coudane, Darius Dian, Xishan Hao, Shigeru Imoto, Olivier Jardé, Hubert Johanet, Esther Meka, Alexander Mundinger, Ruben Orda, Vahit Ozmen, Tadeusz Pienkowski, Schlomo Schneebaum, Charlotte Vaysse, Susie Brousse, Atilla Soran, Carole Mathelin","doi":"10.4274/ejbh.galenos.2025.2025-3-4","DOIUrl":"10.4274/ejbh.galenos.2025.2025-3-4","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer management has significantly evolved, particularly in surgical techniques, but breast surgery training remains unstandardized worldwide. This study, promoted by the Senologic International Society (SIS) and the French National Academy of Surgery (FNAS) aimed to evaluate training variability in the world and to provide ten recommendations to improve breast surgery training.</p><p><strong>Materials and methods: </strong>A 32-question electronic survey was sent between July-August 2023 to the SIS and FNAS network, covering personal experience, training practices, accreditation programs, and fellowship requirements.</p><p><strong>Results: </strong>A total of 121 breast specialists from 42 countries participated, including mainly general surgeons (56%) and gynecologists (23%). Most respondents (66%) had over 15 years of experience, and 75% were male. While 50% reported that breast surgery fellowships were not mandatory, countries with requirements often stipulated a one or two-year experience and a minimum cases number. Multidisciplinary training was often lacking, with only half of countries requiring rotations in radiology, oncology, or pathology. Disparities in training quality and accreditation were evident, particularly in regions without formal breast surgery programs.</p><p><strong>Conclusion: </strong>High-volume centers and specialized surgeons consistently demonstrated improved outcomes, including lower mortality and recurrence rates for patients treated for breast cancer. Rising breast cancer incidence, combined with advances in surgical and multidisciplinary care, highlights the urgency for standardized training. Evidence shows that structured programs with volume thresholds, multidisciplinary approach, and modern surgical techniques improve patient survival and satisfaction. The survey underscores the need for international guidelines to ensure equitable, high-quality care. SIS and FNAS recommend a standardized breast surgery education framework with ten actionable proposals to address disparities, optimize training, and enhance global care quality.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"200-210"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aromatase Inhibitor-Related Lower Limb Tendinopathies: Ultrasound is on the Agenda.","authors":"Berkay Yalçınkaya, Ahmet Furkan Çolak, Sercan Aksoy, Murat Kara, Levent Özçakar","doi":"10.4274/ejbh.galenos.2025.2024-12-7","DOIUrl":"10.4274/ejbh.galenos.2025.2024-12-7","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"283-284"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techniques for Retaining the Inframammary Fold in Implant-Based Reconstructive Breast Surgery.","authors":"Artem Mishin, Alla Kartasheva, Viktor Okhotin, Igor Ganshin","doi":"10.4274/ejbh.galenos.2025.2025-2-1","DOIUrl":"10.4274/ejbh.galenos.2025.2025-2-1","url":null,"abstract":"<p><p>Both reconstructive and aesthetic implant-based breast surgery are associated with the risk of damage or destruction of the inframammary fold (IMF). Such surgical complications lead to implant disposition and disruption of the natural shape of the breast. Various techniques are used to restore the IMF or prevent its damage, such as tissue rearrangement, sutures, capsular flaps, the use of biological matrices or synthetic meshes. In this review, all current methods of retaining the IMF and the frequency of complications reported over the past ten years are reviewed.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"190-199"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian Model Prediction for Breast Cancer Survival: A Retrospective Analysis.","authors":"Islam Bani Mohammad, Muayyad M Ahmad","doi":"10.4274/ejbh.galenos.2025.2025-2-14","DOIUrl":"10.4274/ejbh.galenos.2025.2025-2-14","url":null,"abstract":"<p><strong>Objective: </strong>Over the recent years, machine learning (ML) models have been increasingly used in predicting breast cancer survival because of improvements in ML algorithms. However, cancer researchers still face a significant challenge in accurately predicting breast cancer patients' survival rates. The purpose was to predict breast cancer survival using a Bayesian network.</p><p><strong>Materials and methods: </strong>This retrospective study included 2,995 patients diagnosed with breast cancer and subsequently hospitalized between January 1, 2012, and December 30, 2024. SPSS Modeler version 18.0 was used to build prediction models. The data were randomly split into a training set (2,097 cases, 70%) and a test set (898 cases, 30%) for developing the Bayesian network model and predicting the overall survival of patients diagnosed with breast cancer. The model included demographic variables (age, marital status, and governorate), laboratory/clinical variables (hemoglobin level, white blood cell count, presence of hypertension, and diabetes mellitus) and the outcome variable, patient survival status (binary value: survived/died). The discriminative ability of models was evaluated by accuracy and the area under the curve (AUC) in terms of superior predictive performance for breast cancer outcomes.</p><p><strong>Results: </strong>The Bayesian model exhibited the best discriminatory performance among the nine models, with an AUC of 0.859 and the highest accuracy of 96.661%. In the context of feature importance, white blood cell value at the time of diagnosis was the most important feature for predicting the survival of breast cancer. Patients who had below-normal hemoglobin and above-normal white blood count values had a higher death probability than patients who had normal white blood count and hemoglobin values. The presence of hypertension and diabetes mellitus in patients with breast cancer led to a reduced survival probability.</p><p><strong>Conclusion: </strong>The Bayesian model outperformed the other models in predicting the survival probability of breast cancer. Routine laboratory testing and demographic data can be included in a ML model to predict breast cancer survival. Accurate prediction of breast cancer survival is vital for clinical decision-making.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"255-264"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Gestational Gigantomastia Complicating Pregnancy: A Challenging Case Refractory to Conservative Management.","authors":"Sathasivam Pravanan, Lakindu Grero, Widuranga Wijerathna, Kasun Ranaweera, Jeewantha Senavirathna, S H Rukman Sanjeewa, Kanchana Wijesinghe","doi":"10.4274/ejbh.galenos.2025.2025-4-4","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-4-4","url":null,"abstract":"<p><p>Gestational gigantomastia (GG) is a rare condition characterized by excessive and rapid breast enlargement during pregnancy, resulting in significant physical discomfort, functional limitations, and significant psychological impact. We present a case of a 33-year-old multiparous woman in her third pregnancy, who developed severe bilateral GG by 16 weeks of gestation. Despite initial conservative management, including analgesia and pharmacological (bromocriptine) therapy, the condition worsened causing functional impairment and recurrent mastitis requiring repeated hospital admissions. The pregnancy was electively induced due to physical limitations at 35 weeks of gestation; however, the labour was complicated by obstruction, necessitating an emergency Cesarean section. Postpartum the patient developed severe lactational mastitis complicated by sepsis necessitating intensive care unit admission. After recovery and cessation of breastfeeding, she elected to undergo Wise-pattern bilateral reduction mammoplasty with free nipple-areolar complex grafting four months into her postpartum period. The procedure provided substantial functional relief and a favorable esthetic outcome. This case highlights the potential complexity of managing GG and the need for individualized care. Although conservative treatments may offer temporary relief, surgical intervention is often necessary in severe cases.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tissue Expression of HMBG1 protein in Patients With Breast Cancer.","authors":"Gülden Diniz, İsmail Güzeliş, Dudu Solakoğlu Kahraman, Duygu Ayaz, Umut Varol, Mustafa Değirmenci","doi":"10.4274/ejbh.galenos.2025.2025-4-2","DOIUrl":"10.4274/ejbh.galenos.2025.2025-4-2","url":null,"abstract":"<p><strong>Objective: </strong>High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein involved in chromatin remodeling, transcription, DNA replication, and repair. The purpose of this study was to assess the relationship between tissue expression of HMGB1, clinical outcomes, and histopathological characteristics in patients with breast cancer.</p><p><strong>Materials and methods: </strong>The study included 282 patients with breast cancer. An <i>in vitro</i> diagnostic HMGB1 antibody was applied to the slides of tumor specimens.</p><p><strong>Results: </strong>Overexpression of HMGB1 was found in tumor cells of 123 (43.6%) patients. HMGB1 was only expressed in the nucleus in most tumors (88.7%), while in 32 (11.3%) tumors HMBG1 expression was cytoplasmic and/or extracellular. Severe inflammatory infiltration of the peritumoral stroma was observed in 76 (27%) patients. There was a correlation between remarkable inflammatory cell infiltration in the tumor microenvironment and HMGB1 overexpression, regardless of the molecular subtype, as well as the extranuclear location of HMGB1 expression (<i>p</i> = 0.023). HMGB1 expression was not found to be associated with overall or disease-free survival. However, axillary lymph node metastasis was significantly more common in tumors with intense inflammation (<i>p</i> = 0.024).</p><p><strong>Conclusion: </strong>The proportion of breast cancer patients with HMGB1 expression was lower in the present study than that reported previously. Furthermore, we did not detect a relationship between HMGB1 expression and prognosis. However, the relationship between HMGB1 expression and prognosis had been previously reported only in aggressive breast cancers. It is suggested that understanding the significance of HMGB1 expression in breast cancer may open new treatment opportunities, especially in aggressive and/or triple negative tumors.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the \"Breast Imaging: Correlation Between Axillary Lymph Nodes Apparent Diffusion Coefficient and Pathological Lymphovascular Invasion in Patients With Invasive Breast Cancer\".","authors":"Ahmet Bozer","doi":"10.4274/ejbh.galenos.2025.2025-3-12","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-3-12","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aromatase Inhibitor-Related Alveolar Hemorrhage or ANCA-Associated Vasculitis?","authors":"Raikan Büyükavcı","doi":"10.4274/ejbh.galenos.2025.2025-4-6","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-4-6","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Giant Cell Tumor of the Breast: Report of a Rare Case and Review of the Literature.","authors":"Sangeeta Pradhan, Meenakshi Rao, Sudeep Khera, Mahendra Lodha, Parmod Kumar, Taruna Yadav, Vinay N Gowda","doi":"10.4274/ejbh.galenos.2025.2025-2-9","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-2-9","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Angiosarcoma: Four Case Series and Literature Review.","authors":"Imen Bannour, Salma Ferjani, Hafedh Abbassi, Ekram Guerbej, Dorra Chiba, Sassi Boughizane, Badra Bannour","doi":"10.4274/ejbh.galenos.2025.2025-2-6","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-2-6","url":null,"abstract":"<p><p>The mammary angiosarcoma is a rare malignant mesenchymal tumor that develops from the vascular tissue of the breast. It represents 0.004 to 1% of all malignant breast tumors and 8 to 10% of breast sarcomas. It can be primary in a 40-year-old woman or radiation-induced in an older woman who has undergone conservative treatment for breast cancer, including conservative surgery and adjuvant radiotherapy. Herein, we present four cases involving breast angiosarcoma in young and relatively older women and the different treatment they received. Our discussion encompasses the epidemiological, diagnostic, and therapeutic facets of this rare and aggressive tumor type.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}