European journal of breast health最新文献

{"title":"Evaluation of Perforator Fasciocutaneous Flaps for Oncoplastic Immediate Reconstruction Following Breast Conservative Surgery in Lower and Lateral Breast Quadrant Lesions Perforator Fasciocutaneous Flaps for OBCS.","authors":"Mahmoud Ali Mohamed Abd El Mohsen, Ismail Ahmed Shafik, Shadin Hamza Hassan Abas, Mostafa Mahmoud Abdelfatah","doi":"10.4274/ejbh.galenos.2025.2025-3-2","DOIUrl":"10.4274/ejbh.galenos.2025.2025-3-2","url":null,"abstract":"<p><strong>Objective: </strong>To compare the oncological safety and the cosmetic outcome of the techniques anterior intercostal artery perforator (AICAP), lateral intercostal artery perforator (LICAP) and thoracodorsal artery perforator (TDAP) flap as a volume replacement technique to eliminate deformity and preserve breast cosmesis by filling the excised defect.</p><p><strong>Materials and methods: </strong>This prospective study included women with lower outer quadrant, lower inner quadrant, and upper outer quadrant tumors who underwent upfront or post-neoadjuvant chemotherapy breast conserving surgery with immediate volume replacement surgery. Patients were allocated into three groups at a ratio of 1:1: Group A (<i>n</i> = 10): women who underwent LICAP flap, group B (<i>n</i> = 10): Women who underwent AICAP, and group C (<i>n</i> = 10): Women who underwent TDAP flap procedures.</p><p><strong>Results: </strong>Regarding postoperative complications, wound infection took place in only one (10%) patient in LICAP group and one (10%) patient in the AICAP group; seroma occurred in only one (10%) patient in LICAP group and one (10%) patient in the TDAP group; and fat necrosis occurred in only one (10%) patient in the TDAP group. Incidence of wound infection, seroma, and fat necrosis was insignificantly different among the studied groups. Breast distortion occurred in one (10%) patient in the AICAP group and not observed in the other groups, and partial flap necrosis occurred in one (10%) patient in the LICAP group and one (10%) patient in the AICAP group and was not observed in the TDAP group. Incidence of distortion and partial flap necrosis were insignificantly different between the studied groups. The conservative treatment of breast cancer core results, surgeon's assessment, patient's satisfaction and breast Q scores did not differ between the three groups.</p><p><strong>Conclusion: </strong>A better cosmetic outcome than level II oncoplastic techniques, the perforator fasciocutaneous flaps, LICAP, AICAP, and TDAP, were effective and safe options for immediate breast reconstruction after breast-conserving surgery. All three techniques showed similar surgical outcomes, low complication rates, and good aesthetic results. Patient satisfaction was high, with no significant differences between the groups.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"265-273"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Breast Imaging: Needs and Opportunities for Refugee Women in Italy and Low-Income Countries.","authors":"Graziella Di Grezia, Teresa Iannnaccone, Gianluca Gatta","doi":"10.4274/ejbh.2025.2025-3-1","DOIUrl":"10.4274/ejbh.2025.2025-3-1","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"281-282"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aromatase Inhibitor-Related Lower Limb Tendinopathies: Ultrasound is on the Agenda.","authors":"Berkay Yalçınkaya, Ahmet Furkan Çolak, Sercan Aksoy, Murat Kara, Levent Özçakar","doi":"10.4274/ejbh.galenos.2025.2024-12-7","DOIUrl":"10.4274/ejbh.galenos.2025.2024-12-7","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"283-284"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techniques for Retaining the Inframammary Fold in Implant-Based Reconstructive Breast Surgery.","authors":"Artem Mishin, Alla Kartasheva, Viktor Okhotin, Igor Ganshin","doi":"10.4274/ejbh.galenos.2025.2025-2-1","DOIUrl":"10.4274/ejbh.galenos.2025.2025-2-1","url":null,"abstract":"<p><p>Both reconstructive and aesthetic implant-based breast surgery are associated with the risk of damage or destruction of the inframammary fold (IMF). Such surgical complications lead to implant disposition and disruption of the natural shape of the breast. Various techniques are used to restore the IMF or prevent its damage, such as tissue rearrangement, sutures, capsular flaps, the use of biological matrices or synthetic meshes. In this review, all current methods of retaining the IMF and the frequency of complications reported over the past ten years are reviewed.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"190-199"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian Model Prediction for Breast Cancer Survival: A Retrospective Analysis.","authors":"Islam Bani Mohammad, Muayyad M Ahmad","doi":"10.4274/ejbh.galenos.2025.2025-2-14","DOIUrl":"10.4274/ejbh.galenos.2025.2025-2-14","url":null,"abstract":"<p><strong>Objective: </strong>Over the recent years, machine learning (ML) models have been increasingly used in predicting breast cancer survival because of improvements in ML algorithms. However, cancer researchers still face a significant challenge in accurately predicting breast cancer patients' survival rates. The purpose was to predict breast cancer survival using a Bayesian network.</p><p><strong>Materials and methods: </strong>This retrospective study included 2,995 patients diagnosed with breast cancer and subsequently hospitalized between January 1, 2012, and December 30, 2024. SPSS Modeler version 18.0 was used to build prediction models. The data were randomly split into a training set (2,097 cases, 70%) and a test set (898 cases, 30%) for developing the Bayesian network model and predicting the overall survival of patients diagnosed with breast cancer. The model included demographic variables (age, marital status, and governorate), laboratory/clinical variables (hemoglobin level, white blood cell count, presence of hypertension, and diabetes mellitus) and the outcome variable, patient survival status (binary value: survived/died). The discriminative ability of models was evaluated by accuracy and the area under the curve (AUC) in terms of superior predictive performance for breast cancer outcomes.</p><p><strong>Results: </strong>The Bayesian model exhibited the best discriminatory performance among the nine models, with an AUC of 0.859 and the highest accuracy of 96.661%. In the context of feature importance, white blood cell value at the time of diagnosis was the most important feature for predicting the survival of breast cancer. Patients who had below-normal hemoglobin and above-normal white blood count values had a higher death probability than patients who had normal white blood count and hemoglobin values. The presence of hypertension and diabetes mellitus in patients with breast cancer led to a reduced survival probability.</p><p><strong>Conclusion: </strong>The Bayesian model outperformed the other models in predicting the survival probability of breast cancer. Routine laboratory testing and demographic data can be included in a ML model to predict breast cancer survival. Accurate prediction of breast cancer survival is vital for clinical decision-making.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":"255-264"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Gestational Gigantomastia Complicating Pregnancy: A Challenging Case Refractory to Conservative Management.","authors":"Sathasivam Pravanan, Lakindu Grero, Widuranga Wijerathna, Kasun Ranaweera, Jeewantha Senavirathna, S H Rukman Sanjeewa, Kanchana Wijesinghe","doi":"10.4274/ejbh.galenos.2025.2025-4-4","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-4-4","url":null,"abstract":"<p><p>Gestational gigantomastia (GG) is a rare condition characterized by excessive and rapid breast enlargement during pregnancy, resulting in significant physical discomfort, functional limitations, and significant psychological impact. We present a case of a 33-year-old multiparous woman in her third pregnancy, who developed severe bilateral GG by 16 weeks of gestation. Despite initial conservative management, including analgesia and pharmacological (bromocriptine) therapy, the condition worsened causing functional impairment and recurrent mastitis requiring repeated hospital admissions. The pregnancy was electively induced due to physical limitations at 35 weeks of gestation; however, the labour was complicated by obstruction, necessitating an emergency Cesarean section. Postpartum the patient developed severe lactational mastitis complicated by sepsis necessitating intensive care unit admission. After recovery and cessation of breastfeeding, she elected to undergo Wise-pattern bilateral reduction mammoplasty with free nipple-areolar complex grafting four months into her postpartum period. The procedure provided substantial functional relief and a favorable esthetic outcome. This case highlights the potential complexity of managing GG and the need for individualized care. Although conservative treatments may offer temporary relief, surgical intervention is often necessary in severe cases.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tissue Expression of HMBG1 protein in Patients With Breast Cancer.","authors":"Gülden Diniz, İsmail Güzeliş, Dudu Solakoğlu Kahraman, Duygu Ayaz, Umut Varol, Mustafa Değirmenci","doi":"10.4274/ejbh.galenos.2025.2025-4-2","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-4-2","url":null,"abstract":"<p><strong>Objective: </strong>High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein involved in chromatin remodeling, transcription, DNA replication, and repair. The purpose of this study was to assess the relationship between tissue expression of HMGB1, clinical outcomes, and histopathological characteristics in patients with breast cancer.</p><p><strong>Materials and methods: </strong>The study included 282 patients with breast cancer. An <i>in vitro</i> diagnostic HMGB1 antibody was applied to the slides of tumor specimens.</p><p><strong>Results: </strong>Overexpression of HMGB1 was found in tumor cells of 123 (43.6%) patients. HMGB1 was only expressed in the nucleus in most tumors (88.7%), while in 32 (11.3%) tumors HMBG1 expression was cytoplasmic and/or extracellular. Severe inflammatory infiltration of the peritumoral stroma was observed in 76 (27%) patients. There was a correlation between remarkable inflammatory cell infiltration in the tumor microenvironment and HMGB1 overexpression, regardless of the molecular subtype, as well as the extranuclear location of HMGB1 expression (<i>p</i> = 0.023). HMGB1 expression was not found to be associated with overall or disease-free survival. However, axillary lymph node metastasis was significantly more common in tumors with intense inflammation (<i>p</i> = 0.024).</p><p><strong>Conclusion: </strong>The proportion of breast cancer patients with HMGB1 expression was lower in the present study than that reported previously. Furthermore, we did not detect a relationship between HMGB1 expression and prognosis. However, the relationship between HMGB1 expression and prognosis had been previously reported only in aggressive breast cancers. It is suggested that understanding the significance of HMGB1 expression in breast cancer may open new treatment opportunities, especially in aggressive and/or triple negative tumors.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the \"Breast Imaging: Correlation Between Axillary Lymph Nodes Apparent Diffusion Coefficient and Pathological Lymphovascular Invasion in Patients With Invasive Breast Cancer\".","authors":"Ahmet Bozer","doi":"10.4274/ejbh.galenos.2025.2025-3-12","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-3-12","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aromatase Inhibitor-Related Alveolar Hemorrhage or ANCA-Associated Vasculitis?","authors":"Raikan Büyükavcı","doi":"10.4274/ejbh.galenos.2025.2025-4-6","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-4-6","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Giant Cell Tumor of the Breast: Report of a Rare Case and Review of the Literature.","authors":"Sangeeta Pradhan, Meenakshi Rao, Sudeep Khera, Mahendra Lodha, Parmod Kumar, Taruna Yadav, Vinay N Gowda","doi":"10.4274/ejbh.galenos.2025.2025-2-9","DOIUrl":"https://doi.org/10.4274/ejbh.galenos.2025.2025-2-9","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}