European journal of breast health最新文献

{"title":"Breast Cancer Screening: What Are the Areas for Improvement in France?","authors":"Carole Mathelin","doi":"10.4274/ejbh.galenos.2026.2026-4-9","DOIUrl":"10.4274/ejbh.galenos.2026.2026-4-9","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"372-373"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Preoperative MRI in Early Breast Cancer: Who Truly Benefits?","authors":"Burak Çelik, Sevcan Koç, Yusuf Hüseyin Berrak, Gizem Yaşa, Medine Böge, Ece Dilege","doi":"10.4274/ejbh.galenos.2026.2026-2-5","DOIUrl":"10.4274/ejbh.galenos.2026.2026-2-5","url":null,"abstract":"<p><strong>Objective: </strong>In light of existing evidence on the use of preoperative magnetic resonance imaging (MRI) in breast cancer (BC) patients undergoing upfront surgery, this study evaluated whether adding MRI to conventional imaging improved the definition of disease extent, subsequent surgical management, and survival outcomes.</p><p><strong>Materials and methods: </strong>This retrospective study reviewed patients with stage I-II BC who underwent upfront surgery between January 2014 and September 2025. Patients were divided into an MRI cohort and a non-MRI cohort, and clinicopathologic characteristics, the diagnostic performance of ultrasound and MRI in detecting additional malignant foci, the type of surgery, and recurrence during follow-up were compared.</p><p><strong>Results: </strong>A total of 261 patients were included, with 149 assigned to the MRI cohort and 112 to the non-MRI cohort. Patients in the MRI group were younger, more often premenopausal, and more likely to have dense breasts. MRI detected additional malignant foci, including ductal carcinoma <i>in situ</i> and invasive carcinoma, in 38 patients of 149 (25.48%). MRI findings led to the conversion from planned lumpectomy to mastectomy in 16/149 patients (10.7%), mainly due to the detection of new multicentric disease. With a median follow-up of 30-36 months, there has been no significant difference between the two cohorts concerning local recurrence (<i>p</i>>0.99) or distant metastasis (<i>p</i> = 0.39).</p><p><strong>Conclusion: </strong>Preoperative MRI occasionally changed surgical plans but offered no diagnostic advantage over standard imaging, supporting its selective rather than routine use in upfront BC surgery.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"407-416"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Chest Wall Perforator Flaps in Breast Surgery: Military Cancer Centre Experience.","authors":"Saleh Habahbeh, Muthanna Ababneh, Ahmad Kofahi, Abdullah Bani Fares, Mohannad Bawaneh, Mothana Yousef Al-Nawaflh, Mohammad Isam Bany Doumi","doi":"10.4274/ejbh.galenos.2026.2026-2-11","DOIUrl":"10.4274/ejbh.galenos.2026.2026-2-11","url":null,"abstract":"<p><strong>Objective: </strong>Chest wall perforator flaps (CWPFs) are a muscle-sparing alternative in oncoplastic breast surgery (OPBS). CWPFs offer favourable cosmetic and surgical outcomes while minimising donor-site morbidity. Despite their increasing global adoption, there is a paucity of data from the Middle East and North Africa (MENA) region. This retrospective, descriptive case series aimed to assess our institutional experience with CWPFs, emphasising their feasibility, versatility, and surgical and cosmetic results in breast surgery.</p><p><strong>Materials and methods: </strong>This retrospective case series included all patients who underwent CWPF-based OPBS at the Military Cancer Centre between December 2017 and January 2025. Data on patient demographics, tumour characteristics, surgical indications, flap types and techniques, complications, and patient satisfaction were collected.</p><p><strong>Results: </strong>CWPF procedures were performed on 69 patients. The most popular flap type (78.3%) was the lateral intercostal artery flap. Indications included volume replacement (84.1%), implant coverage (4.3%), implant salvage (2.9%), wound closure (7.2%), and deformity correction (1.4%). Most flaps were intended to be turnover flaps (75.4%) rather than propeller flaps (24.6%). No flap loss was noted; the complication rates were low, and the re-excision rate was 0%. Over 85% of patients reported good-to-excellent satisfaction with cosmetic outcomes.</p><p><strong>Conclusion: </strong>CWPFs are reliable and versatile techniques in breast-conserving surgery and OPBS, serving as a surgical solution for various reconstructive indications. The findings from this study emphasise the need for broader adoption of CWPFs in Jordan and the MENA region and demonstrate the effective use of CWPFs at a national centre in Jordan.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"393-406"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Management After Rupture of Silicone Gel-Filled Breast Implants in a Surgically Treated Cohort: A Retrospective Study.","authors":"Minh Tuong Tran, Martina Chotarova, Stefan Harsanyi, Dominika Mitevova, Martin Bohac","doi":"10.4274/ejbh.galenos.2026.2026-1-12","DOIUrl":"10.4274/ejbh.galenos.2026.2026-1-12","url":null,"abstract":"<p><strong>Objective: </strong>Breast implant rupture is clinically significant complication that is often asymptomatic making diagnosis challenging. The primary objective of this study was to describe the clinical presentation, preoperative imaging findings, and operative findings in this surgically selected cohort. A secondary objective was to assess the apparent concordance of magnetic resonance imaging (MRI) and ultrasound findings with intraoperative rupture status in this surgically selected cohort. Additional exploratory analyses examined symptom categories, implant age, and implant placement in relation to operative and imaging findings.</p><p><strong>Materials and methods: </strong>This retrospective observational study evaluated a cohort of women with suspected or confirmed silicone breast implant rupture who underwent operative management at the Department of Plastic Surgery, Faculty of Medicine, Comenius University, University Hospital Bratislava, Ružinov, between 2020 and 2025. Because only patients who proceeded to surgery were included, the cohort represents a selected referral population rather than an unselected surveillance population.</p><p><strong>Results: </strong>The mean patient age was 50.6 years, with a mean implant age of 14.7 years. Within this surgically selected cohort, MRI demonstrated higher apparent sensitivity and positive predictive value than those of ultrasound; however, diagnostic performance varied across subgroups and the findings should be interpreted cautiously because of the small sample size and selection bias. In patients with local symptoms, the apparent diagnostic performance was lower, particularly for ultrasound.</p><p><strong>Conclusion: </strong>Breast implant rupture showed heterogeneous clinical presentations in this retrospective cohort of surgically treated patients, ranging from asymptomatic, imaging-detected rupture to cases associated with local symptoms, capsular contracture, or systemic complaints. MRI showed a higher apparent concordance with intraoperative rupture status than ultrasound in this selected cohort; however, the findings are limited by selection and verification bias. Subgroup analyses were exploratory, and clinical management should remain individualized; prospective studies are needed to guide evidence-based imaging and treatment strategies.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"434-440"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations on Tomosynthesis-Guided Vacuum-Assisted Excision for B3 Breast Lesions.","authors":"Erina Alushi, Tommaso Perretta","doi":"10.4274/ejbh.galenos.2026.2026-7-15","DOIUrl":"10.4274/ejbh.galenos.2026.2026-7-15","url":null,"abstract":"","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"523-524"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-Onset Radiation-Induced Angiosarcoma of the Breast: A Case Report and Literature Review.","authors":"Samar Algahtani, Khaled Ali, Faisal Azam, Ahlam Dohal, Jamila Alazhri","doi":"10.4274/ejbh.galenos.2026.2025-11-9","DOIUrl":"10.4274/ejbh.galenos.2026.2025-11-9","url":null,"abstract":"<p><p>Secondary breast angiosarcomas are rare tumors, and more likely to occur after breast-conserving surgery. They are commonly a late adverse event of radiation therapy that typically presents after ten years of treatment. We report a case of radiation-induced breast angiosarcoma presenting as early as 30 months following the completion of postoperative radiotherapy for breast cancer. Angiosarcoma has a potentially significant risk for local and metastatic recurrence despite total mastectomy. Therefore, a low threshold for suspicion is essential for prompt diagnosis and appropriate treatment.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"511-517"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Mammary Myofibroblastoma Masquerading as Malignancy.","authors":"Vinay N Gowda, Poonam Abhay Elhence, Balamurugan T, Taruna Yadav, Dharma Ram Poonia","doi":"10.4274/ejbh.galenos.2025.2025-9-16","DOIUrl":"10.4274/ejbh.galenos.2025.2025-9-16","url":null,"abstract":"<p><p>We report a case of myofibroblastoma (MFB) of the breast in a 58-year-old man who presented with a large painless lump in the left breast. Radiologic breast imaging showed a well-circumscribed mass with no microcalcifications. Microscopic examination revealed fascicles of spindle cell neoplasm with intervening thick bundles of hyalinized collagen and interspersed vessels. Pertinent immunohistochemistry markers showed positivity for CD34, estrogen receptor, progesterone receptor and androgen receptor. A diagnosis of MFB of the breast was rendered. It is crucial to differentiate MFB from other entities in the breast like fibroadenoma, phyllodes tumor, gynecomastia, carcinoma and sarcoma for its appropriate management.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"501-504"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Surgery in Metastatic Breast Cancer.","authors":"Eray Balcı, Abdullah Sami Maden, Mehmet Ali Eryilmaz","doi":"10.4274/ejbh.galenos.2026.2026-2-7","DOIUrl":"10.4274/ejbh.galenos.2026.2026-2-7","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the effect of local-regional management of the primary tumor on the prognosis of patients with metastatic breast cancer. The primary outcome measure was overall survival, while progression-free survival was assessed as a secondary end-point.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed metastatic breast cancer patients who underwent local-regional treatment over a 10-year period (May 2013 to May 2023). Sociodemographic and clinicopathological data were extracted from medical records and automated hospital systems. Statistical analyses were performed using SPSS.</p><p><strong>Results: </strong>The study cohort consisted of 76 patients, with a mean age of 50 years and a median follow-up period of 58 months. The progression-free survival rate was 58%, while overall survival reached 75%, and the 5-year survival rate was 80%. Importantly, no deaths were observed among patients who achieved a pathological complete response during follow-up. Analysis of survival outcomes revealed that overall survival was significantly reduced in patients with axillary lymph node metastasis compared to those without (<i>p</i> = 0.02), in individuals with triple-negative breast cancer compared to those with hormone receptor-positive tumors (<i>p</i> = 0.03), in patients with T4 tumors compared to those with other T stages (<i>p</i> = 0.04), and in patients who experienced recurrence or distant metastasis during follow-up relative to those who did not (<i>p</i><0.01).</p><p><strong>Conclusion: </strong>In metastatic breast cancer, surgical resection of the primary tumor was associated with improved overall survival and progression-free survival. While a response to systemic chemotherapy was a favorable prognostic factor, increased tumor size, axillary lymph node positivity, triple-negative status, and the development of new metastasis and/or recurrence during follow-up were associated with poorer outcomes.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"386-392"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified LYMPHA for Prevention of Breast Cancer-Related Lymphedema After Axillary Dissection: Initial Feasibility Experience from South Asia.","authors":"Niharika Rajan Garach, Jay Rashmi Anam, Imaan Rumani, Esha Trivedi, Nilesh Chordiya, Emily Klosterman, Ameer Gomberawalla, Reshma Suvarna, Eli Avisar","doi":"10.4274/ejbh.galenos.2026.2026-4-8","DOIUrl":"10.4274/ejbh.galenos.2026.2026-4-8","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer-related lymphedema is an important survivorship concern after axillary lymph node dissection. Conventional LYMPHA and immediate lymphatic reconstruction can reduce this risk, but adoption in low- and middle-income settings is limited by the need for microsurgical personnel, equipment, additional operating time, and cost. This study reports an initial feasibility assessment of simplified LYMPHA (S-LYMPHA) performed by breast surgical oncologists using indocyanine green guidance.</p><p><strong>Materials and methods: </strong>This was a prospective, single-arm feasibility cohort study. Consecutive eligible patients undergoing planned axillary lymph node dissection or completion axillary dissection after a positive intraoperative sentinel node assessment were enrolled from July 2024 to September 2025. Arm circumferences were measured preoperatively and at 3 and 6 months, at three fixed points. After confirmation that axillary dissection was required, methylene blue and indocyanine green were injected into the ipsilateral upper limb. Arm lymphatics were identified, preserved, and invaginated into a suitable axillary venous tributary after nodal dissection. The primary outcomes of this interim report were technical feasibility, short-term safety, and clinical lymphedema at 6 months.</p><p><strong>Results: </strong>Thirty-seven patients underwent attempted S-LYMPHA. The median age was 51 years. Nineteen patients (51.4%) received neoadjuvant chemotherapy and 26 patients (70.3%) underwent mastectomy. Sixteen patients (43.2%) required axillary dissection after nodal metastasis was detected on intraoperative sentinel node assessment. Arm lymphatics were identified in all patients. The mean number of lymphatics identified was 2.6 (range 1-5), and the mean number of lymphovenous anastomoses created was 1.5 (range 1-3). More than one anastomosis was performed in 16 (43.2%) patients. At a uniform 6-month follow-up, one patient had clinical lymphedema, corresponding to an observed incidence of 2.7% (exact 95% confidence interval, 0.07-14.16). No dye-related adverse reaction or local complication attributable to the lymphatic reconstruction was observed.</p><p><strong>Conclusion: </strong>S-LYMPHA was technically feasible and safe in this initial South Asian feasibility cohort. These early data should be interpreted as evidence of implementability and short-term safety rather than proof of lymphedema prevention. Larger comparative cohorts with longer follow-up are required to define efficacy, durability, and oncologic safety.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"441-446"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline Quality of Life and Its Predictors among Jordanian Women with Breast Cancer: Findings from an Ongoing Randomized Controlled Trial.","authors":"Mo'tasem AlDaieflih, Murad Younis, Jawad Abu Shennar, Farah M Abdallah, Abdallah AlGhawadreh, Ahmad Miqdadi, Mohannad Aldiqs, Bushra Alhusamiah, Seirsa Al-Quran","doi":"10.4274/ejbh.galenos.2026.2026-3-6","DOIUrl":"10.4274/ejbh.galenos.2026.2026-3-6","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer is the most common cancer among women in Jordan. Survivors often experience impaired quality of life (QoL) due to various sociodemographic and clinical factors. Understanding QoL at the time of diagnosis is essential for developing effective interventions. This study aimed to assess baseline QoL and to identify predictors of QoL among Jordanian women with breast cancer prior to any intervention.</p><p><strong>Materials and methods: </strong>This cross-sectional analysis examined baseline data from an ongoing randomized controlled trial registered with Australian New Zealand clinical trials registry. Two hundred women with breast cancer completed the Arabic versions of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and EORTC QLQ-BR23 questionnaires at study entry, prior to randomization and intervention. Sociodemographic and clinical variables were collected and analyzed using SPSS version 24. Multiple regression analysis was performed to identify predictors of QoL.</p><p><strong>Results: </strong>The mean age of participants was 48.0±8.3 years. The global QoL score was 57.4/100. Higher scores were observed for role and social functioning, whereas emotional functioning had the lowest scores. The most frequently reported symptoms were insomnia, fatigue, and pain multivariate linear regression identified younger age (positively associated) and total breast symptoms (negatively associated) as significant independent predictors of QLQ-C30 global QoL. For QLQ-BR23, the overall model was significant, although no individual predictor reached statistical significance.</p><p><strong>Conclusion: </strong>Jordanian women with breast cancer experience moderate impairment in QoL at study entry, primarily influenced by symptom burden and age. These baseline findings provide a foundation for interpreting intervention effects in the ongoing randomized controlled trial. Routine assessment of symptoms and culturally sensitive supportive care are recommended to improve patient outcomes.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"22 4","pages":"426-433"},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}