European journal of breast health最新文献

{"title":"From Plasmacytoma to Rib Tuberculosis: The Case of A Breast Mass With An Unexpected Diagnosis.","authors":"Hafedh Abbassi, Badra Bannour, Sarra Yacoub, Ekram Guerbej, Imen Bannour, Samir Hidar, Moncef Mokni","doi":"10.4274/ejbh.galenos.2024.2024-10-6","DOIUrl":"10.4274/ejbh.galenos.2024.2024-10-6","url":null,"abstract":"<p><p>Tuberculosis (TB) of the rib is an uncommon manifestation of extrapulmonary TB that can pose significant diagnostic challenges, especially when presenting as a breast mass. We report the case of a 74-year-old woman who presented with a left breast lump, initially suspected to be a plasmacytoma due to its imaging characteristics and clinical history. The mass was surgically excised, and histopathological analysis revealed granulomatous inflammation with caseous necrosis, suggesting TB. TB-polymerase chain reaction confirmed the diagnosis, despite negative Ziehl-Neelsen staining. The patient was treated with anti-tubercular therapy for twelve months, resulting in a favorable clinical outcome. This case highlights the importance of considering rib TB in the differential diagnosis of breast masses, particularly in endemic areas, and underscores the role of comprehensive diagnostic evaluations for timely and effective treatment.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"85-89"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy.","authors":"Özgen Arslan Solmaz, Nizamettin Kutluer, Mehmet Buğra Bozan","doi":"10.4274/ejbh.galenos.2024.2024-6-1","DOIUrl":"10.4274/ejbh.galenos.2024.2024-6-1","url":null,"abstract":"<p><strong>Objective: </strong>Triple negative breast carcinoma (TNBC) is characterized by the absence of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 receptor expression. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. The aim of this study was to investigate CA IX expression in TNBC and its relationship with treatment effect.</p><p><strong>Materials and methods: </strong>Immunohistochemical staining was performed on tru-cut biopsy materials with CA IX antibody. Positive staining was graded as low (<10%) and high (>10%). In addition, the relationship between tumor diameter, histological grade and the treatment effect on mastectomy materials performed after neoadjuvant treatment was evaluated.</p><p><strong>Results: </strong>TNBCs with positive staining for CA IX exhibited higher histological grade, and higher Ki-67 index compared to TNBCs with negative staining (<i>p</i> < 0.05). The response to treatment decreased as the degree of CA IX staining increased. There was no significant difference between the high staining group and low staining group in terms of patient age, tumor diameter and breast localisation.</p><p><strong>Conclusion: </strong>CA IX enzyme is a poor prognostic marker in TNBC cases. However, overexpression of CA IX was associated with reduced response to treatment.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"57-62"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation into Psychological Aspects of Patients Diagnosed with Breast Cancer: A Review Study of Postgraduate Theses Prepared in Turkey.","authors":"Umut Çıvgın","doi":"10.4274/ejbh.galenos.2024.2024-9-1","DOIUrl":"10.4274/ejbh.galenos.2024.2024-9-1","url":null,"abstract":"<p><p>A significant number of scientific data concerning breast cancer is generated in Turkey. The present research reviewed postgraduate theses examining the psychological evaluation of breast cancer patients conducted in Turkey. The objective of the review study was to ascertain the focal topics of the theses, identify commonly examined psychological variables, determine research gaps, compare the frequency of experimental and intervention studies with other kinds of research, and provide recommendations for literature. A retrospective descriptive study was designed by performing a search on the YÖK Thesis Center website with the keywords \"breast cancer\" and \"psychology\" (in Turkish and English) between 2000 and 2024. The criteria for inclusion in the review study required that the dissertation be a master's or doctoral thesis in psychology, involve breast cancer patients as participants, focus on patients who are not in remission, and be available as open access. Twenty-seven postgraduate theses were selected. Of the theses 88.9% were classified as master's theses, while 11.1% were categorized as doctoral theses. Although the variables included in the these studies were numerous, some were investigated more often. \"Post-traumatic growth\" was evaluated by 12 theses, \"perceived social support\" by 6, \"depression-anxiety-stress\" by 15, and \"coping\" by 8. more frequently observed factors include metacognition, ruminative thinking, schemas, body perception/image, and self-esteem. Most of the studies were relational and non-interventional. Only three studies used psychological intervention. It is suggested that thesis studies should include more participant characteristics, control for them in analyses, and be more experimental and effectiveness focused.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"16-32"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: <i>RECQL4/FAM13C</i> Genes Address Common Hub Genes and Drugs.","authors":"Gizem Ayna Duran","doi":"10.4274/ejbh.galenos.2024.2024-11-2","DOIUrl":"10.4274/ejbh.galenos.2024.2024-11-2","url":null,"abstract":"<p><strong>Objective: </strong>The prevalence of breast cancer and gynaecological cancers is high, and these cancer types can occur consecutively as secondary cancers. The aim of our study is to determine the genes commonly expressed in these cancers and to identify the common hub genes and drug components.</p><p><strong>Materials and methods: </strong>Gene intensity values of breast cancer, gynaecological cancers such as cervical, ovarian and endometrial cancers were used from the Gene Expression Omnibus database Affymetrix Human Genome U133 Plus 2.0 Array project. Using the linear modelling method included in the R LIMMA package, genes that differ between healthy individuals and cancer patients were identified. Hub genes were determined using cytoHubba in Cytoscape program. \"ShinyGo 0.80\" tool was used to determine the disease-specific biological KEGG pathways. Drug.MATADOR from the ShinyGo 0.80 tool was used to predict drug-target relationships.</p><p><strong>Results: </strong>The RecQ Like Helicase 4 and <i>Family with Sequence Similarity 13 Member C</i> genes were found to be similarly expressed in breast cancer and gynaecological cancers. Upon KEGG pathway analyses with hub genes, Drug.MATADOR analysis with hub genes related to cancer related pathways was performed. We have determined these gene/drug interactions: NBN (targeted by Hydroxyurea), EP300 (targeted by Acetylcarnitine) and MAPK14 (targeted by Salicylate and Dibutyryl cyclic AMP).</p><p><strong>Conclusion: </strong>The drugs associated with hub genes determined in our study are not routinely used in cancer treatment. Our study offers the opportunity to identify the target genes of drugs used in breast and gynaecological cancers with the drug repurposing approach.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"63-73"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance.","authors":"Zeynep Erdoğan İyigün, Tolga Ozmen, Serkan İlgün, Cansu Nakipoğlu, Enver Özkurt, Filiz Çelebi, Çağlar Ünal, Alper Öztürk, Gül Alço, Çetin Ordu, Gürsel Soybir","doi":"10.4274/ejbh.galenos.2024.2024-9-5","DOIUrl":"10.4274/ejbh.galenos.2024.2024-9-5","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the relationship between subclinical lymphedema identified prior to surgical intervention and clinical lymphedema observed in the late period, the incidence of lymphedema in our cohort, and the associated risk factors.</p><p><strong>Materials and methods: </strong>This prospective study was conducted with early-stage breast cancer patients who had been enrolled in a previous study. For diagnosing lymphedema, physical examination, L-Dex® score, and circumferential measurement was used. The L-Dex^® score was used as a screening test for preoperative, subclinical lymphedema since there were no clinical findings. Patients with subclinical lymphedema were provided with education and followed up more frequently with regular monitoring.</p><p><strong>Results: </strong>The mean age of the 217 participants was 56.7±12.7 years (range 29-90), and the mean body mass index was 27.7±3.3 kg/m² (range 19.3-36.9). Among the 217 patients, lymphedema was detected in 31 (14.7%) at a median follow-up period of 89 months (range 73-108 months). Multivariable analysis of factors associated with late-stage lymphedema revealed positive lymph node count and capsular invasion as significant factors (<i>p</i> = 0.001 for both). Forty (18.4%) had preoperative subclinical lymphedema. At the end of the follow-up period, lymphedema persisted in 11 patients (27.5%) and resolved in 29 patients (72.5%). In multivariable analysis, the positive lymph node count was identified as an independent variable in these patients.</p><p><strong>Conclusion: </strong>Identifying high-risk patients, regular monitoring, and early intervention can significantly reduce the risk of clinical lymphedema through timely treatment.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"40-45"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosai-Dorfman Disease Presenting With FDG-Avid Breast Masses and Axillary Lymph Nodes on PET-CT in a Patient With Recent Diagnosis of Endometrial Carcinoma: A Diagnostic Dilemma.","authors":"Jennifer Kudja-Rennick, Pai Raghav, Cedric Pluguez-Turull, Katherine Drews-Elger, Cristina Hoyos","doi":"10.4274/ejbh.galenos.2024.2024-9-2","DOIUrl":"10.4274/ejbh.galenos.2024.2024-9-2","url":null,"abstract":"<p><p>Rosai-Dorfman disease (RDD) is a self-limited, idiopathic, non-neoplastic disorder characterized by the proliferation of phagocytic histiocytes, which can mimic malignant lymphoproliferative disease. Cases of RDD most commonly present as bilateral painless cervical lymphadenopathy, with lesser involvement of the axilla, inguinal, and mediastinal lymph nodes. We present the case of a 62-year-old woman with a history of endometrial serous carcinoma who underwent evaluation at a dedicated breast imaging department after positron emission tomography/computed tomography (PET/CT) revealed breast masses and axillary nodes with increased uptake of fluorodeoxyglucose (FDG). Upon clinical examination, she had bilateral palpable lumps in both breasts and axillae. Subsequent dedicated breast imaging with bilateral diagnostic mammography with tomosynthesis and bilateral complete breast ultrasound were suspicious for malignancy detecting bilateral breast masses and axillary lymphadenopathy corresponding to the FDG-avid findings on PET/CT. Ultrasound-guided core needle biopsies, however, revealed a diagnosis of RDD. This case highlights the unique characteristics of RDD with an atypical clinical presentation suspicious for breast cancer both clinically and radiologically.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"74-79"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Tumor Response to Neoadjuvant Chemotherapy in Breast Cancer Using MRI and ¹⁸F-FDG PET/CT.","authors":"Reem Yusuf AlBuainain, Fatema Yusuf Bunajem, Hussain Adnan Abdulla","doi":"10.4274/ejbh.galenos.2024.2024-8-2","DOIUrl":"10.4274/ejbh.galenos.2024.2024-8-2","url":null,"abstract":"<p><strong>Objective: </strong>Neoadjuvant chemotherapy (NACT) has been the primary treatment method for patients with local advanced breast cancer. A pathological complete response (pCR) to therapy correlates with better overall disease prognosis. Magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) have been widely used to monitor the response to NACT in breast cancer. The aim of this study was to assess tumor response to NACT by MRI and PET/CT, to determine which imaging modality is more accurate in detecting tumor response post NACT in breast cancer.</p><p><strong>Materials and methods: </strong>A retrospective review of our database revealed 34 women with breast cancer that had MRI and PET/CT performed prior to and after NACT, followed by definitive surgery. For response assessment, we calculated the difference in maximum diameter of the tumor in MRI and difference in standard uptake values in PET/CT. The correspondence rate between the imaging modalities and pCR were calculated. For the prediction of pCR, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy where analyzed.</p><p><strong>Results: </strong>The assessment of tumor response to NACT showed 11 cases with pCR (32%), 15 pathological partial response (44%) and eight pathological no response (24%). The correspondence rate between MRI and pathological response was 50% (17/34), compared to 65% (22/34) for PET/CT. For prediction of pCR, MRI showed higher specificity compared to PET/CT (78.2% <i>vs.</i> 73.9%, <i>p</i> = 0.024), while the accuracy of PET/CT was significantly higher (79.4% <i>vs.</i> 70.5%, <i>p</i> = 0.004). PET/CT also had a higher NPV compared to MRI (94.4% <i>vs.</i> 78.2%, <i>p</i> = 0.002). There were no differences in terms of sensitivity and PPV between MRI and PET/CT.</p><p><strong>Conclusion: </strong>Compared to MRI, PET/CT was more likely to correlate with the pathological response after NACT. For the prediction of pCR, PET/CT proved to be a more accurate imaging modality to monitor response after NACT than MRI.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"46-51"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of Awareness, Screening Practices, and Self-Detection Among Breast Cancer Patients.","authors":"Ahmed Nawzad Hassan, Mustafa Saber Al-Attar","doi":"10.4274/ejbh.galenos.2024.2024-5-6","DOIUrl":"10.4274/ejbh.galenos.2024.2024-5-6","url":null,"abstract":"<p><strong>Objective: </strong>Having good knowledge and performing regular pre-tests under physician supervision play a crucial role in the early detection of breast cancer. The aim of this study was to investigate the level of awareness, frequency of performing routine screening, types of screening methods prior to detection, and who detected the case, among women diagnosed with breast cancer.</p><p><strong>Materials and methods: </strong>A cross-sectional study that used a designed questionnaire applied to investigate demographic data and four other aspects: level of awareness, screening practices, type of screening methods used, and who detected the case for the first time. Women who were diagnosed with breast cancer and registered at Nanakali Hospital were included.</p><p><strong>Results: </strong>A total of 150 women participated. Most of the participants (80%) had no previous knowledge regarding causes, signs and symptoms, or detection methods, while only 20% had little information. Among the participants, most (87.3%) did not undergo any pre-tests before the time of diagnosis, while only 12.7% did pre-test at least once. The screening methods used prior to the diagnosis were: breast self-exam (n=9); ultrasonography (n=8), and only two had mammography. Detecting the case for the first time, 68.7% of the cases were detected by chance or accidentally, and 31.3% were detected by physicians.</p><p><strong>Conclusion: </strong>The level of awareness and performance of routine screening differ greatly among different populations and countries. Women in Erbil, generally have a low level of awareness and insufficient knowledge regarding breast cancer; most women do not undertake any regular screening for early detection of this cancer compared to Western countries. Having previous knowledge and doing pre-tests regularly play a key role in the early detection of this cancer, which minimizes the consequences.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"52-56"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Diagnostic Breast Ultrasound: A Comparative Analysis of Decision Support Among Radiologists With Various Levels of Expertise.","authors":"Filiz Çelebi, Onur Tuncer, Müge Oral, Tomris Duymaz, Tolga Orhan, Gökhan Ertaş","doi":"10.4274/ejbh.galenos.2024.2024-9-7","DOIUrl":"10.4274/ejbh.galenos.2024.2024-9-7","url":null,"abstract":"<p><strong>Objective: </strong>To investigate integrating an artificial intelligence (AI) system into diagnostic breast ultrasound (US) for improved performance.</p><p><strong>Materials and methods: </strong>Seventy suspicious breast mass lesions (53 malignant and 17 benign) from seventy women who underwent diagnostic breast US complemented with shear wave elastography, US-guided core needle biopsy and verified histopathology were enrolled. Two radiologists, one with 15 years of experience and the other with one year of experience, evaluated the images for breast imaging-reporting and data system (BI-RADS) scoring. The less-experienced radiologist re-evaluated the images with the guidance of a commercial AI system and the maximum elasticity from shear wave elastography. The BI-RADS scorings were processed to determine diagnostic performance and malignancy detections.</p><p><strong>Results: </strong>The experienced reader demonstrated superior performance with an area under the curve (AUC) of 0.888 [95% confidence interval (CI): 0.793-0.983], indicating high diagnostic accuracy. In contrast, the Koios decision support (DS) system achieved an AUC of 0.693 (95% CI: 0.562-0.824). The less-experienced reader, guided by both Koios and elasticity, showed an AUC of 0.679 (95% CI: 0.534-0.823), while Koios alone resulted in an AUC of 0.655 (95% CI: 0.512-0.799). Without any guidance, the less-experienced reader exhibited the lowest performance, with an AUC of 0.512 (95% CI: 0.352-0.672). The experienced reader had a sensitivity of 98.1%, specificity of 58.8%, positive predictive value of 88.1%, negative predictive value of 90.9%, and overall accuracy of 88.6%. The Koios DS showed a sensitivity of 92.5%, specificity of 35.3%, and an accuracy of 78.6%. The less-experienced reader, when guided by both Koios and elasticity, achieved a sensitivity of 92.5%, specificity of 23.5%, and an accuracy of 75.7%. When guided by Koios alone, the less-experienced reader had a sensitivity of 90.6%, specificity of 17.6%, and an accuracy of 72.9%. Lastly, the less-experienced reader without any guidance showed a sensitivity of 84.9%, specificity of 17.6%, and an accuracy of 68.6%.</p><p><strong>Conclusion: </strong>Diagnostic evaluation of the suspicious masses on breast US images largely depends on experience, with experienced readers showing good performances. AI-based guidance can help improve lower performances, and using the elasticity metric may further improve the performances of less experienced readers. This type of guidance may reduce unnecessary biopsies by increasing the detection rate for malignant lesions and deliver significant benefits for routine clinical practice in underserved areas where experienced readers may not be available.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"33-39"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyoderma Gangrenosum: A Nightmare for Breast Surgery-Two Case Reports.","authors":"Gülşen Akoğlu, Murat Demiriz, Kerim Bora Yılmaz","doi":"10.4274/ejbh.galenos.2024.2024-7-5","DOIUrl":"10.4274/ejbh.galenos.2024.2024-7-5","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) is a rare, chronic, neutrophilic dermatosis characterized by painful ulcers that are often misdiagnosed as wound infections. We report two cases of postsurgical PG following breast surgery: A 46-year-old woman with a non-healing ulcer after a breast biopsy and a 37-year-old woman with wound dehiscence after bilateral reduction mammoplasty. Both cases were initially managed with repeated debridements, antibiotics, and wound care without improvement. The diagnosis of PG was made based on the increase in wound size and irregularity. Treatment with oral doxycycline and topical tacrolimus led to favorable healing within four months. Breast surgical tehniques, which aim to achieve aesthetic results using intraglandular flaps, have become an important part of clinical practice in breast surgery. Early diagnosis and appropriate management are crucial in postsurgical PG to avoid misdiagnosis and ineffective treatments that cause patient disfigurement.</p>","PeriodicalId":93996,"journal":{"name":"European journal of breast health","volume":"21 1","pages":"80-84"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}