Biological psychiatry. Cognitive neuroscience and neuroimaging最新文献

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Longitudinal changes in infant attention-related brain networks and fearful temperament. 婴儿注意力相关大脑网络与恐惧气质的纵向变化。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-07-18 DOI: 10.1016/j.bpsc.2025.07.003
Courtney A Filippi, Alice Massera, Jiayin Xing, Hyung G Park, Emilio Valadez, Jed Elison, Dana Kanel, Daniel S Pine, Nathan A Fox, Anderson Winkler
{"title":"Longitudinal changes in infant attention-related brain networks and fearful temperament.","authors":"Courtney A Filippi, Alice Massera, Jiayin Xing, Hyung G Park, Emilio Valadez, Jed Elison, Dana Kanel, Daniel S Pine, Nathan A Fox, Anderson Winkler","doi":"10.1016/j.bpsc.2025.07.003","DOIUrl":"10.1016/j.bpsc.2025.07.003","url":null,"abstract":"<p><strong>Background: </strong>Anxiety disorders may partly stem from altered neurodevelopment of attention-related networks. Neonatal alterations in resting-state functional connectivity (rsFC) among the dorsal attention (DAN); frontal parietal (FPN); salience (SN); and default mode networks (DMN)) relate to fearful temperament, a risk marker for anxiety. Nevertheless, little research examines development of these networks beyond the first months of life, particularly in fearful infants. This study examines how changes in these networks in the first two years of life relate to fearful temperament.</p><p><strong>Methods: </strong>Using data from the Baby Connectome Project (from 180 infants across 396 sessions), we conducted independent components analysis to extract rsFC among the DMN, SN, DAN, and FPN. Longitudinal modeling characterized 1) age-related changes (slope) in rsFC through age two; 2) relations between rsFC change (slope) and fearfulness at age 2; 3) relations between rsFC and fearfulness trajectories (slope and intercept) over the first two years of life.</p><p><strong>Results: </strong>Age-related decreases occurred in rsFC in DAN - FPN and DMN - SN. Smaller decreases in DAN - FPN rsFC over time related to greater fear at age 2, and to increases in fearfulness over time. High initial DAN-FPN rsFC and low initial DAN - SN rsFC also related to increasing fearfulness over time.</p><p><strong>Conclusion: </strong>This study provides the first evidence that changes in attention-related brain networks are related to early-life fearfulness, a robust early-life risk marker of anxiety.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12340726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parsing Autism Heterogeneity: Transcriptomic Subgrouping of Imaging-Derived Phenotypes in Autism. 解析自闭症异质性:自闭症中成像衍生表型的转录组亚组。
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-07-10 DOI: 10.1016/j.bpsc.2025.07.001
Johanna Leyhausen, Caroline Gurr, Lisa M Berg, Hanna Seelemeyer, Bassem Hermila, Tim Schäfer, Andreas G Chiocchetti, Charlotte M Pretzsch, Eva Loth, Bethany Oakley, Jan K Buitelaar, Christian F Beckmann, Tony Charman, Thomas Bourgeron, Eli Barthome, Tobias Banaschewski, Emily Jh Jones, Declan Murphy, Christine Ecker
{"title":"Parsing Autism Heterogeneity: Transcriptomic Subgrouping of Imaging-Derived Phenotypes in Autism.","authors":"Johanna Leyhausen, Caroline Gurr, Lisa M Berg, Hanna Seelemeyer, Bassem Hermila, Tim Schäfer, Andreas G Chiocchetti, Charlotte M Pretzsch, Eva Loth, Bethany Oakley, Jan K Buitelaar, Christian F Beckmann, Tony Charman, Thomas Bourgeron, Eli Barthome, Tobias Banaschewski, Emily Jh Jones, Declan Murphy, Christine Ecker","doi":"10.1016/j.bpsc.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.bpsc.2025.07.001","url":null,"abstract":"<p><strong>Background: </strong>Neurodevelopmental conditions, such as autism, are highly heterogeneous both at the mechanistic and phenotypic level. Parsing heterogeneity is therefore vital for uncovering underlying processes that could inform the development of targeted, personalized support. The study aimed to parse heterogeneity in autism by identifying subgroups that converge at both phenotypic and molecular levels.</p><p><strong>Methods: </strong>An imaging-transcriptomics approach was used to link neuroanatomical imaging-derived phenotypes in autism to whole-brain gene expression signatures provided by the Allen Human Brain Atlas. Neuroimaging and clinical data of N=359 autistic participants aged 6-30 years were provided by the EU-AIMS Longitudinal European Autism Project. Individuals were stratified using data-driven clustering techniques based on the correlation between brain phenotypes and transcriptomic profiles. The resulting subgroups were characterized on the clinical, neuroanatomical, and molecular level.</p><p><strong>Results: </strong>We identified three subgroups of autistic individuals based on the correlation between imaging-derived phenotypes and transcriptomic profiles which showed different clinical phenotypes. The individuals with the strongest transcriptomic associations to imaging-derived phenotypes showed the lowest level of symptom severity. The genesets most characteristic for each subgroup were significantly enriched for genes previously implicated in autism etiology, including processes like synaptic transmission and neuronal communication, and mapped onto different gene ontology categories.</p><p><strong>Conclusion: </strong>Autistic individuals can be sub-grouped based on the transcriptomic signatures associated with their neuroanatomical fingerprints, revealing subgroups that show differences in clinical measures. The study presents an analytical framework for linking neurodevelopmental and clinical diversity in autism to underlying molecular mechanisms, thus highlighting the need for personalized support strategies.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Deep Brain Stimulation and Dopaminergic Therapy on Intrinsic Preference for Free Choice in Patients With Parkinson's Disease. 脑深部刺激和多巴胺能治疗对帕金森病患者自由选择内在偏好的影响。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-07-07 DOI: 10.1016/j.bpsc.2025.06.008
David Bendetowicz, Gizem Temiz, Nicolas Tempier, Elodie Hainque, Marie-Laure Welter, Virginie Czernecki, Brian Lau, Carine Karachi, Jérôme Munuera
{"title":"Influence of Deep Brain Stimulation and Dopaminergic Therapy on Intrinsic Preference for Free Choice in Patients With Parkinson's Disease.","authors":"David Bendetowicz, Gizem Temiz, Nicolas Tempier, Elodie Hainque, Marie-Laure Welter, Virginie Czernecki, Brian Lau, Carine Karachi, Jérôme Munuera","doi":"10.1016/j.bpsc.2025.06.008","DOIUrl":"10.1016/j.bpsc.2025.06.008","url":null,"abstract":"<p><strong>Background: </strong>Humans prefer to make choices freely, even when doing so does not maximize future outcomes, which suggests that free choice is intrinsically rewarding. While value-based decision impairments are well documented in Parkinson's disease (PD), the mechanisms that underlie intrinsically motivated behavior remain unclear. In this study, we investigated how the dopaminergic (DAergic) and basal ganglia systems contribute to intrinsic reward in PD.</p><p><strong>Methods: </strong>We designed a decision-making task to dissociate the intrinsic value of free choice from extrinsic reward. Twenty PD patients with subthalamic nucleus deep brain stimulation (STN-DBS) and 25 on DA therapy completed the task both while ON and OFF treatment. Performance was compared with 20 age-matched healthy control participants. We analyzed DBS electrode contacts, modeled activated tissue volumes, and examined cortico-subthalamic connectivity using high-resolution diffusion magnetic resonance imaging.</p><p><strong>Results: </strong>PD patients OFF STN-DBS showed reduced preference for free choice, which increased when STN-DBS was ON. This effect was associated with recruitment of the right medial prefrontal cortex (mPFC). Acute ON/OFF DA therapy did not alter free-choice preference. However, patients with lower chronic DA doses-comparable to those in the DBS group-exhibited reduced free-choice preference compared with patients with higher chronic intake.</p><p><strong>Conclusions: </strong>STN-DBS enhances free-choice preference by modulating the right mPFC-STN network, suggesting that this hyperdirect pathway influences intrinsic valuation of choice. These results indicate that STN-DBS promotes self-determined behavior even in risky contexts. Furthermore, chronic DAergic therapy may influence sensitivity to intrinsic reward.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mild Behavioral Impairment and Cortical Thinning: Biomarkers of Early Neurodegeneration. 轻度行为障碍和皮层变薄:早期神经变性的生物标志物。
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-07-07 DOI: 10.1016/j.bpsc.2025.06.010
Yi Jin Leow, Seyed Ehsan Saffari, Ashwati Vipin, Pricilia Tanoto, Rasyiqah Binte Shaik Mohamed Salim, Bocheng Qiu, Zahinoor Ismail, Nagaendran Kandiah
{"title":"Mild Behavioral Impairment and Cortical Thinning: Biomarkers of Early Neurodegeneration.","authors":"Yi Jin Leow, Seyed Ehsan Saffari, Ashwati Vipin, Pricilia Tanoto, Rasyiqah Binte Shaik Mohamed Salim, Bocheng Qiu, Zahinoor Ismail, Nagaendran Kandiah","doi":"10.1016/j.bpsc.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.bpsc.2025.06.010","url":null,"abstract":"<p><strong>Background: </strong>Mild Behavioral Impairment(MBI) is increasingly recognized as an early phenotypic marker of neurodegeneration, characterized by neuropsychiatric symptoms(NPS) emerging prior to overt cognitive decline. While structural neuroimaging studies link cortical thinning with NPS, the relationship between MBI and cortical morphology remains underexplored in diverse, community-based cohorts. This study investigated whether early behavioral alterations, assessed via the Mild Behavioral Impairment Checklist(MBI-C), correlate with region-specific cortical thinning in a Southeast Asian cohort.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted on 969 participants (mean age 61.99±10.19years;39.6% male;87.2%Chinese) from the Biomarkers and Cognition Study in Singapore(BIOCIS), spanning cognitively normal, subjective cognitive decline(SCD), and mild cognitive impairment(MCI). MBI was assessed using self-reported MBI-C. Cortical thickness was measured using T1-weighted MRI scans processed with FreeSurfer. Associations between cortical thinning and MBI-C total and subdomain scores were evaluated.</p><p><strong>Results: </strong>Higher scores on the MBI-C Belief subdomain were significantly associated with cortical thinning in the right hemisphere(β=-0.0177;95%CI:-0.0342to-0.0012;P=0.035). Region-specific analyses showed temporal lobe thinning in the posterior superior temporal sulcus, fusiform gyrus, superior temporal gyrus, temporal pole, and transverse temporal gyrus, and associations remained significant after false discovery rate(FDR) correction(P=0.042-0.045). Additional cortical thinning was observed in the right postcentral gyrus, supramarginal gyrus, and insula(FDR P≤0.039).</p><p><strong>Conclusions: </strong>Elevated MBI, particularly abnormal beliefs, is linked to cortical thinning in regions subserving memory, sensory integration, and emotional regulation predominantly in the right hemisphere. These findings highlight the potential of MBI-C as an early neurodegenerative marker. Further longitudinal studies are needed to clarify temporal dynamics and mechanisms underlying behavioral symptoms and neurodegenerative processes.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketosis Elevates Antioxidants and Markers of Energy Metabolism: A Proton Magnetic Resonance Spectroscopy Study. 酮症提高抗氧化剂和能量代谢标志物:1H磁共振光谱研究。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-07-07 DOI: 10.1016/j.bpsc.2025.06.009
Helena van Nieuwenhuizen, Botond B Antal, Antoine Hone-Blanchet, Andrew Lithen, Liam McMahon, Sofia Nikolaidou, Zeming Kuang, Kieran Clarke, Bruce G Jenkins, Douglas L Rothman, Lilianne R Mujica-Parodi, Eva-Maria Ratai
{"title":"Ketosis Elevates Antioxidants and Markers of Energy Metabolism: A Proton Magnetic Resonance Spectroscopy Study.","authors":"Helena van Nieuwenhuizen, Botond B Antal, Antoine Hone-Blanchet, Andrew Lithen, Liam McMahon, Sofia Nikolaidou, Zeming Kuang, Kieran Clarke, Bruce G Jenkins, Douglas L Rothman, Lilianne R Mujica-Parodi, Eva-Maria Ratai","doi":"10.1016/j.bpsc.2025.06.009","DOIUrl":"10.1016/j.bpsc.2025.06.009","url":null,"abstract":"<p><strong>Background: </strong>Ketosis is known to alter the balance of neuroactive amino acids and enhance neural function compared with a glycolytic condition. However, its influence on other metabolites, such as antioxidants and neural energy markers, and the mechanisms by which ketosis improves neural function remain unclear.</p><p><strong>Methods: </strong>Here, we measured the neurochemical effects of acute ketosis on key brain metabolites (neurotransmitters, antioxidants, and energy markers) in the human brain using ultra-high-field proton magnetic resonance spectroscopy (<sup>1</sup>H-MRS) and investigated the subsequent impact on neural function, measured via dynamic functional connectivity, using resting-state functional magnetic resonance imaging (rs-fMRI). In a within-subjects design, 63 healthy adults (30 female) from across the lifespan underwent <sup>1</sup>H-MRS and rs-fMRI scans before and after consuming individually weight-dosed and calorically matched ketone monoester or glucose drinks.</p><p><strong>Results: </strong>Ketone monoester administration, but not glucose, significantly elevated cerebral antioxidants and energy markers while decreasing GABA (gamma-aminobutyric acid), glutamate, and glutamine levels in the posterior cingulate cortex. Notably, increased energy markers, specifically an increase in total creatine, correlated with greater improvements in neural function measured using rs-fMRI.</p><p><strong>Conclusions: </strong>Our results integrate metabolic and functional neuroimaging findings, offering a comprehensive understanding of ketosis-induced changes in brain chemistry and functional network dynamics. These insights clarify potential mechanisms by which ketosis imparts its neural benefits and provide valuable information to assist the development of novel treatment strategies for a variety of psychiatric and neurodegenerative disorders.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain Functional Connectivity Mediates the Association Between Adverse Childhood Experiences and Conduct Problems. 脑功能连通性在不良童年经历与行为问题之间的关联中起中介作用。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-07-05 DOI: 10.1016/j.bpsc.2025.06.007
Panshi Liu, Donghui Song, Ying Guo, Hui Zhang
{"title":"Brain Functional Connectivity Mediates the Association Between Adverse Childhood Experiences and Conduct Problems.","authors":"Panshi Liu, Donghui Song, Ying Guo, Hui Zhang","doi":"10.1016/j.bpsc.2025.06.007","DOIUrl":"10.1016/j.bpsc.2025.06.007","url":null,"abstract":"<p><strong>Background: </strong>Adverse childhood experiences (ACEs) are key risk factors for adolescent mental health problems, including conduct problems (CPs). While ACEs may impact CPs through neurobiological pathways, it is unclear whether brain functional connectivity (FC) acts as the neurobiological link.</p><p><strong>Methods: </strong>We included 11,868 children from the baseline sample of the Adolescent Brain Cognitive Development (ABCD) Study. First, the continuous association between ACEs and CP severity was analyzed using linear mixed-effects (LME) modeling. Next, connectome-based predictive modeling (CPM) was used to predict CP scores and identify the CP-related connections, which were validated in 174 Healthy Brain Network (HBN) clinical participants. Finally, mediation analyses assessed whether the strength of CP-related connections mediated the association between ACEs and CP scores collected at baseline, 2 years, and 4 years after the ACEs report in the ABCD sample.</p><p><strong>Results: </strong>LME modeling showed total ACEs and all 10 ACE categories were associated with increased CP scores (d = 0.056-0.465, false discovery rate-corrected p < .01). CPM significantly predicted CP scores (ρ = 0.128, p < .001), validated in the HBN dataset (ρ = 0.148, p = .048). The identified CP-related connections are involved in sensorimotor processing, emotional cognition, and impulsivity. Mediation analysis revealed that the strength of CP-related connections partially mediated the association between ACEs and CP scores at baseline, 2-year follow-up, and 4-year follow-up (β = 0.0086-0.015, p < .01).</p><p><strong>Conclusions: </strong>This is the first study to our knowledge to suggest that FC provides a biological link between ACEs and subsequent CPs. ACEs may impact the strength of CP-related connections, in turn increasing risk of CPs. These findings highlight the importance of early assessment of ACEs and suggest CP-related connections as potential biomarkers.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder. 在一项随机试验中,COMT抑制对酒精使用障碍患者抑制性加工神经相关的影响
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-06-13 DOI: 10.1016/j.bpsc.2025.06.003
Drew E Winters, Joseph P Schacht
{"title":"Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder.","authors":"Drew E Winters, Joseph P Schacht","doi":"10.1016/j.bpsc.2025.06.003","DOIUrl":"10.1016/j.bpsc.2025.06.003","url":null,"abstract":"<p><strong>Background: </strong>Dysregulation of inhibitory control is a core feature of alcohol use disorder (AUD) and is mediated, in part, by catechol-O-methyltransferase (COMT) regulation of cortical dopaminergic neurotransmission. Tolcapone, a brain-penetrant COMT inhibitor, potentiates evoked dopamine release and may improve inhibitory control in AUD.</p><p><strong>Methods: </strong>Non-treatment-seeking participants with AUD (N = 64) were randomized to tolcapone (titrated to 200 mg three times a day) or placebo for 8 days and completed a functional magnetic resonance imaging stop signal task on study days 1 (prior to medication ingestion) and 7. Brain areas in which activation for the contrast of successful versus unsuccessful stop trials (stop success [SS]>stop error [SE]) differed between medication groups on day 7 relative to day 1 were identified. Activation of these areas and their functional connectivity with other areas were tested for association with changes in drinking during the medication period and with changes in stop signal reaction time, a behavioral index of inhibitory control.</p><p><strong>Results: </strong>The tolcapone group demonstrated greater SS>SE activation in the right dorsolateral prefrontal cortex and inferior frontal gyrus (iFG). In the tolcapone group, greater activation of both areas was associated with improved inhibitory control, and greater iFG activation was associated with reduced drinking. Increased connectivity between the iFG and right anterior insula was associated with reduced drinking, and increased connectivity between the iFG and anterior cingulate cortex was associated with improved inhibitory control.</p><p><strong>Conclusions: </strong>Tolcapone increased activation of cortical areas implicated in inhibitory control. The associations between increased iFG activation and connectivity, improved inhibitory control, and reduced drinking suggest that pharmacological interventions that increase cortical dopamine may rescue dysregulated inhibitory control among people with AUD.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurite Density and Kurtosis in the Gray Matter of People With Early Schizophrenia. 早期精神分裂症患者脑灰质中的神经突密度和峰度。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-06-10 DOI: 10.1016/j.bpsc.2025.06.001
Peter C Van Dyken, Ali R Khan, Lena Palaniyappan
{"title":"Neurite Density and Kurtosis in the Gray Matter of People With Early Schizophrenia.","authors":"Peter C Van Dyken, Ali R Khan, Lena Palaniyappan","doi":"10.1016/j.bpsc.2025.06.001","DOIUrl":"10.1016/j.bpsc.2025.06.001","url":null,"abstract":"<p><strong>Background: </strong>Classic models of diffusion-weighted imaging, especially diffusion tensor imaging, are unsuitable for application to the cortical gray matter given its high microstructural complexity. As such, most neuroimaging studies have focused on gross structural effects of schizophrenia, such as cortical thickness differences. More recently developed models, such as neurite orientation dispersion and density imaging (NODDI) and diffusion kurtosis imaging (DKI), incorporate higher-resolution data and may provide more sensitive descriptions of schizophrenia pathology with more specific interpretations.</p><p><strong>Methods: </strong>We applied the NODDI and DKI models to the cortical gray matter of people with early schizophrenia (n = 54) and healthy control participants (n = 51) from the Human Connectome Project for Early Psychosis dataset. Comparisons between groups were made using region-of-interest and clustering approaches. The effect sizes of these approaches were compared with those of cortical thickness differences. We also investigated the relationship between these parameters and lifetime antipsychotic usage.</p><p><strong>Results: </strong>Cortical thickness differences were most prominent between groups in terms of global effect size and spatial extent. We also observed a diffuse, right hemisphere-dominant increase in mean kurtosis and isotropic diffusion fraction throughout the gray matter, which was not fully explained by partial volume effects. Additionally, a lower neurite density index (NDI) correlated with greater lifetime antipsychotic usage.</p><p><strong>Conclusions: </strong>Increases in mean kurtosis and isotropic diffusion fraction are both markers of schizophrenia, consistent with inflammation models of the gray matter in schizophrenia. NDI reduction, reflecting intraneurite pathology, becomes prominent only in individuals with greater disease burden.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebello-Thalamo-Cortical Dysconnectivity in Schizophrenia Spectrum Disorders: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis. 精神分裂症谱系障碍的小脑-丘脑-皮质连接障碍:静息状态fMRI荟萃分析。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-06-09 DOI: 10.1016/j.bpsc.2025.05.017
Orsolya Lányi, Daniel Zahemszky, Alexander Schulze Wenning, Marie Anne Engh, Zsolt Molnár, András Attila Horváth, Péter Hegyi, Gábor Csukly
{"title":"Cerebello-Thalamo-Cortical Dysconnectivity in Schizophrenia Spectrum Disorders: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis.","authors":"Orsolya Lányi, Daniel Zahemszky, Alexander Schulze Wenning, Marie Anne Engh, Zsolt Molnár, András Attila Horváth, Péter Hegyi, Gábor Csukly","doi":"10.1016/j.bpsc.2025.05.017","DOIUrl":"10.1016/j.bpsc.2025.05.017","url":null,"abstract":"<p><strong>Background: </strong>Cerebello-thalamo-cortical (CTC) network dysfunctions are well documented in schizophrenia spectrum disorders (SSDs) and preclinical states. However, small samples and methodological heterogeneity often limit individual neuroimaging studies. To overcome these challenges, we conducted a coordinate-based meta-analysis to characterize CTC alterations across illness stages and examine associations with symptom dimensions.</p><p><strong>Methods: </strong>Our meta-analysis was preregistered and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the recommendations of the Cochrane Handbook. A systematic search was conducted in 3 databases in September 2023. Included articles used seed-based resting-state functional magnetic resonance imaging in patients with SSDs, patients with first-episode psychosis, participants at clinical high risk for psychosis, and healthy control participants. Seeds were defined in the thalamus and the cerebellum. Two coordinate-based meta-analytic methods, activation likelihood estimation and seed-based d mapping, were used. Risk of bias was evaluated per the Organization for Human Brain Mapping recommendations.</p><p><strong>Results: </strong>In SSDs thalamic hypoconnectivity was found in the prefrontal cortex, limbic lobe, thalamus, and cerebellum, whereas hyperconnectivity was observed in the somatomotor and visual association areas (29 studies, 2768 patients). Dysconnectivity was linked to disease progression and symptoms. Cerebellar analysis indicated hypoconnectivity in the prefrontal cortex, cerebellum, and thalamus, with hyperconnectivity in the motor cortex, somatosensory cortex, and orbitofrontal cortex (19 studies, 1159 patients). Cerebellar clusters did not survive multiple comparison correction.</p><p><strong>Conclusions: </strong>Our findings provide robust meta-analytic evidence of CTC dysconnectivity in SSDs, suggesting that this network captures a core neurobiological feature of psychotic disorders. Consistent patterns of altered CTC connectivity underscore the importance of future clinical investigations of this network as a potential target for therapeutic interventions.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auditory and Visual Thalamocortical Connectivity Alterations in Unmedicated People With Schizophrenia: An Individualized Sensory Thalamic Localization and Resting-State Functional Connectivity Study. 未服药的精神分裂症患者的听觉和视觉丘脑皮质连通性改变:一项个性化的感觉丘脑定位和静息状态功能连通性研究。
IF 4.8
Biological psychiatry. Cognitive neuroscience and neuroimaging Pub Date : 2025-06-06 DOI: 10.1016/j.bpsc.2025.05.016
John C Williams, Philip N Tubiolo, Roberto B Gil, Zu Jie Zheng, Eilon B Silver-Frankel, Natalka K Haubold, Sameera K Abeykoon, Dathy T Pham, Najate Ojeil, Kelly Bobchin, Mark Slifstein, Jodi J Weinstein, Greg Perlman, Guillermo Horga, Anissa Abi-Dargham, Jared X Van Snellenberg
{"title":"Auditory and Visual Thalamocortical Connectivity Alterations in Unmedicated People With Schizophrenia: An Individualized Sensory Thalamic Localization and Resting-State Functional Connectivity Study.","authors":"John C Williams, Philip N Tubiolo, Roberto B Gil, Zu Jie Zheng, Eilon B Silver-Frankel, Natalka K Haubold, Sameera K Abeykoon, Dathy T Pham, Najate Ojeil, Kelly Bobchin, Mark Slifstein, Jodi J Weinstein, Greg Perlman, Guillermo Horga, Anissa Abi-Dargham, Jared X Van Snellenberg","doi":"10.1016/j.bpsc.2025.05.016","DOIUrl":"10.1016/j.bpsc.2025.05.016","url":null,"abstract":"<p><strong>Background: </strong>Converging evidence from clinical neuroimaging and animal models has strongly implicated dysfunction of thalamocortical circuits in the pathophysiology of schizophrenia (SZ). Preclinical models of genetic risk for SZ have shown reduced synaptic transmission from the auditory thalamus to the primary auditory cortex, which may represent a correlate of auditory disturbances such as hallucinations. However, human neuroimaging studies have found a generalized increase in resting-state functional connectivity (RSFC) between whole thalamus and sensorimotor cortex in people with SZ (PSZ). We aimed to more directly translate preclinical findings by specifically localizing auditory and visual thalamic nuclei in unmedicated PSZ and measuring RSFC to primary sensory cortices.</p><p><strong>Methods: </strong>In this case-control study, 82 unmedicated PSZ and 55 matched healthy control participants (HCs) completed RSFC functional magnetic resonance imaging (fMRI) (N = 137). Auditory and visual thalamic nuclei were localized for 55 unmedicated PSZ and 46 HCs who also completed a sensory thalamic nuclei localizer fMRI task (n = 101). Using localized nuclei as RSFC seeds, we assessed group differences in auditory and visual thalamocortical connectivity and associations with positive symptom severity.</p><p><strong>Results: </strong>Auditory thalamocortical connectivity was not significantly different between PSZ and HCs, but hyperconnectivity was associated with greater positive symptom severity in the bilateral superior temporal gyrus. Visual thalamocortical connectivity was significantly greater in PSZ relative to HCs in the secondary and higher-order visual cortex but was not predictive of positive symptom severity.</p><p><strong>Conclusions: </strong>These results indicate that visual thalamocortical hyperconnectivity is a generalized marker of SZ, while hyperconnectivity in auditory thalamocortical circuits relates more specifically to positive symptom severity.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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