Jonathan P Stange, Ellie P Xu, Sarah L Zapetis, Jiani Li, Lisanne Jenkins, Jagan Jimmy, Zihua Ye, Pia Sellery, Coralie S Phanord, Erika Forbes, Timothy J Trull, Robin J Mermelstein, Olusola Ajilore
{"title":"Neurophysiological Markers of Regulation Success in Everyday Life in Depression.","authors":"Jonathan P Stange, Ellie P Xu, Sarah L Zapetis, Jiani Li, Lisanne Jenkins, Jagan Jimmy, Zihua Ye, Pia Sellery, Coralie S Phanord, Erika Forbes, Timothy J Trull, Robin J Mermelstein, Olusola Ajilore","doi":"10.1016/j.bpsc.2025.01.004","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Self-regulation is often disrupted in depression and is characterized by negative affect and inflexible parasympathetic responses. However, our understanding of brain mechanisms of self-regulatory processes has largely been limited to laboratory contexts. Measuring individual differences in self-regulatory processes in everyday life-and their neural correlates-could inform our understanding of depression phenotypes and reveal novel intervention targets that impact everyday functioning.</p><p><strong>Methods: </strong>In individuals with remitted major depressive disorder and healthy comparison participants (N = 74), we measured 2 dimensions of regulation success in everyday life-perceived success with regulating affect and physiological success (parasympathetic augmentation following regulation attempts)-and their neural correlates using a functional magnetic resonance imaging emotion regulation task.</p><p><strong>Results: </strong>Perceptions of success were weakly associated with physiological success and had partially distinct neural correlates. Perceived success and physiological success in everyday life predicted reduced activity in brain regions involved in emotional salience while reacting to aversive stimuli in the scanner. During reappraisal in the scanner, greater perceived success in everyday life was dimensionally associated with more reappraisal-related activity in regions involved in cognitive control (including the dorsolateral and dorsomedial prefrontal cortices); in contrast, physiological success predicted enhanced downregulation of salience network activity (amygdala, insula).</p><p><strong>Conclusions: </strong>Results suggest that linking psychophysiology with behavior in everyday life can provide a window into dissociable dimensions of self-regulatory functioning. Integrating ambulatory and brain-based metrics may elucidate self-regulatory phenotypes with distinct neurophysiological mechanisms and targets for intervention to impact functioning in daily life.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological psychiatry. Cognitive neuroscience and neuroimaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.bpsc.2025.01.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Self-regulation is often disrupted in depression and is characterized by negative affect and inflexible parasympathetic responses. However, our understanding of brain mechanisms of self-regulatory processes has largely been limited to laboratory contexts. Measuring individual differences in self-regulatory processes in everyday life-and their neural correlates-could inform our understanding of depression phenotypes and reveal novel intervention targets that impact everyday functioning.
Methods: In individuals with remitted major depressive disorder and healthy comparison participants (N = 74), we measured 2 dimensions of regulation success in everyday life-perceived success with regulating affect and physiological success (parasympathetic augmentation following regulation attempts)-and their neural correlates using a functional magnetic resonance imaging emotion regulation task.
Results: Perceptions of success were weakly associated with physiological success and had partially distinct neural correlates. Perceived success and physiological success in everyday life predicted reduced activity in brain regions involved in emotional salience while reacting to aversive stimuli in the scanner. During reappraisal in the scanner, greater perceived success in everyday life was dimensionally associated with more reappraisal-related activity in regions involved in cognitive control (including the dorsolateral and dorsomedial prefrontal cortices); in contrast, physiological success predicted enhanced downregulation of salience network activity (amygdala, insula).
Conclusions: Results suggest that linking psychophysiology with behavior in everyday life can provide a window into dissociable dimensions of self-regulatory functioning. Integrating ambulatory and brain-based metrics may elucidate self-regulatory phenotypes with distinct neurophysiological mechanisms and targets for intervention to impact functioning in daily life.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
