Brain Circulation最新文献_第4页

Evaluation of markers of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under total intravenous anesthesia versus inhalational anesthesia: A prospective randomized trial (COM-IVIN trial) 评估在全静脉麻醉与吸入麻醉下进行脑动脉瘤夹闭术的患者的脑氧合和新陈代谢指标：前瞻性随机试验（COM-IVIN 试验）

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_66_23

Ashitha Arumadi, A. Hrishi, Unnikrishnan Prathapadas, M. Sethuraman, Easwer Hari Venket

{"title":"Evaluation of markers of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under total intravenous anesthesia versus inhalational anesthesia: A prospective randomized trial (COM-IVIN trial)","authors":"Ashitha Arumadi, A. Hrishi, Unnikrishnan Prathapadas, M. Sethuraman, Easwer Hari Venket","doi":"10.4103/bc.bc_66_23","DOIUrl":"https://doi.org/10.4103/bc.bc_66_23","url":null,"abstract":"INTRODUCTION: Anesthetic goals in patients undergoing clipping of cerebral aneurysm include maintenance of cerebral blood flow, oxygenation, and metabolism to avoid cerebral ischemia and maintenance of hemodynamic stability. We intend to study the influence of anesthetic agents on the outcome of aneurysmal subarachnoid hemorrhage (SAH). MATERIALS AND METHODS: This is a prospective, randomized, parallel, single-center pilot trial approved by the Institutional Ethics Committee and is prospectively registered with the Clinical Trial Registry of India. Patients with aneurysmal SAH (aSAH) admitted to our institution for surgical clipping, fulfilling the trial inclusion criteria, will be randomized in a 1:1 allocation ratio utilizing a computerized random allocation sequence to receive either total intravenous anesthesia (n = 25) or inhalational anesthesia (n = 25). Our primary objective is to study the effects of these anesthetic techniques on cerebral oxygenation and metabolism in patients with aSAH. Our secondary objective is to evaluate the impact of these anesthetic techniques on the incidence of delayed cerebral ischemia and long-term patient outcomes in patients with aSAH. The Modified Rankin Score and Glasgow Outcome Scale (GOS) at discharge and 3 months following hospital discharge will be evaluated. An observer blinded to the study intervention will assess the outcome measures. DISCUSSION: This study will provide more insight as to which is the ideal anesthetic agent that offers a better neurophysiological profile regarding intraoperative cerebral oxygenation and metabolism, thereby contributing to better postoperative outcomes in aSAH patients.","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probucol will become a new model for treating cerebral infarction with a high risk of hemorrhage: A narrative review 普罗布考将成为治疗出血风险高的脑梗塞的新模式：叙述性综述

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_44_23

Liguo Lang, Jianying Zhang, Dongju Zheng, Huanmin Gao

{"title":"Probucol will become a new model for treating cerebral infarction with a high risk of hemorrhage: A narrative review","authors":"Liguo Lang, Jianying Zhang, Dongju Zheng, Huanmin Gao","doi":"10.4103/bc.bc_44_23","DOIUrl":"https://doi.org/10.4103/bc.bc_44_23","url":null,"abstract":"Lipid-lowering agents are relevant in stroke prevention. Probucol (PU) is an antioxidative and lipid-lowering drug that has been used to treat atherosclerotic cardiovascular diseases and xanthomas. The drug penetrates the core of low-density lipoprotein cholesterol (LDL-C) particles, enhancing the activity of plasma cholesterol l ester transfer protein (CETP) and strengthening the liver scavenger receptor type I, resulting in reducing LDL-C; by increasing the activity of paraoxonase 1, upregulating the antioxidant function of high-density lipoprotein (HDL), and it decreases the serum HDL-cholesterol (HDL-C) level. This drug has been retired from the Western markets for lowering HDL-C levels and Q-interval prolongation. The latter side effect has been rarely reported and may be transient. Recent clinical evidence supports the effectiveness of PU in preventing cardiovascular events and in reducing mortality, irrespective of the reduction of HDL-C. Based on basic research and clinical studies, it appears that PU might be a valuable alternative when statins are ineffective or contraindicated, in patients at high risk of recurrence of cerebral ischemia and hemorrhage.","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils 探索长非编码 RNA 和 mRNA 在颅内动脉粥样硬化性狭窄中的作用：从中性粒细胞的角度

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_63_23

Yilin Wang, Tao Wang, Z. Han, Rongliang Wang, Yue Hu, Zhenhong Yang, Tong Shen, Yangmin Zheng, Jichang Luo, Yan Ma, Yumin Luo, Liqun Jiao

{"title":"Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils","authors":"Yilin Wang, Tao Wang, Z. Han, Rongliang Wang, Yue Hu, Zhenhong Yang, Tong Shen, Yangmin Zheng, Jichang Luo, Yan Ma, Yumin Luo, Liqun Jiao","doi":"10.4103/bc.bc_63_23","DOIUrl":"https://doi.org/10.4103/bc.bc_63_23","url":null,"abstract":"CONTEXT: Circulating neutrophils and long noncoding RNAs (lncRNAs) play various roles in intracranial atherosclerotic stenosis (ICAS). OBJECTIVE: Our study aimed to detect differentially expressed (DE) lncRNAs and mRNAs in circulating neutrophils and explore the pathogenesis of atherosclerosis from the perspective of neutrophils. METHODS: Nineteen patients with ICAS and 15 healthy controls were enrolled. The peripheral blood of the participants was collected, and neutrophils were separated. The expression profiles of lncRNAs and mRNAs in neutrophils from five patients and five healthy controls were obtained, and DE lncRNAs and mRNAs were selected. Six lncRNAs were selected and validated using quantitative reverse transcription–polymerase chain reaction (qRT-PCR), and ceRNA and lncRNA-RNA binding protein (RBP)-mRNA networks were constructed. Correlation analysis between lncRNAs and mRNAs was performed. Functional enrichment annotations were also performed. RESULTS: Volcano plots and heat maps displayed the expression profiles and DE lncRNAs and mRNAs, respectively. The qRT-PCR results revealed that the four lncRNAs showed a tendency consistent with the expression profile, with statistical significance. The ceRNA network revealed three pairs of regulatory networks: lncRNA RP3-406A7.3-NAGLU, lncRNA HOTAIRM1-MVK/IL-25/GBF1/CNOT4/ANKK1/PLEKHG6, and lncRNA RP11-701H16.4-ZNF416. The lncRNA-RBP-mRNA network showed five pairs of regulatory networks: lncRNA RP11-701H16.4-TEK, lncRNA RP11-701H16.4-MED17, lncRNA SNHG19-NADH-ubiquinone oxidoreductase core subunit V1, lncRNA RP3-406A7.3-Angel1, and lncRNA HOTAIRM1-CARD16. CONCLUSIONS: Our study identified and verified four lncRNAs in neutrophils derived from peripheral blood, which may explain the transcriptional alteration of neutrophils during the pathophysiological process of ICAS. Our results provide insights for research related to the pathogenic mechanisms and drug design of ICAS.","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localization of cerebral vasculopathy following bacterial meningitis: What can we learn about postinfective ischemic sequelae? 细菌性脑膜炎后脑血管病的定位：我们能从感染后缺血性后遗症中学到什么？

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_97_22

V. Kumar, V. Kumar

引用次数: 0

Optimal rehabilitation strategies for early postacute stroke recovery: An ongoing inquiry 脑卒中急性期后早期恢复的最佳康复策略：持续探索

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_33_23

Yanna Tong, Yuchuan Ding, Zhenzhen Han, Honglian Duan, Xiaokun Geng

{"title":"Optimal rehabilitation strategies for early postacute stroke recovery: An ongoing inquiry","authors":"Yanna Tong, Yuchuan Ding, Zhenzhen Han, Honglian Duan, Xiaokun Geng","doi":"10.4103/bc.bc_33_23","DOIUrl":"https://doi.org/10.4103/bc.bc_33_23","url":null,"abstract":"Early rehabilitation is crucial in reducing stroke-related disability, but the optimal training model remains unclear. We conducted a trial comparing different initiation timings and intensities of mobilization strategies after stroke. Results showed that early intensive mobilization had favorable outcomes at 3 months post-stroke, while very early intensive mobilization had poorer chances of favorable outcomes. Our investigation into brain injury mechanisms induced by very early exercise within 24 hours of stroke onset aligned with guidelines advising against high-dose very early mobilization. Additionally, we are studying the effects of various exercise intensities and frequencies on early stroke rehabilitation. Integrated rehabilitation models, such as combining remote ischemic conditioning (RIC) with exercise (RICE), hold promise. Our study found RICE to be safe and feasible for early rehabilitation of acute ischemic stroke patients, and further research is underway to determine its efficacy in a larger sample size. Despite extensive research, identifying the most effective early recovery strategies remains a complex challenge, necessitating ongoing work in the field of early rehabilitation after stroke.","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent ischemic stroke from reversible extracranial internal carotid artery and middle cerebral artery vasospasm: A case report 可逆性颅外颈内动脉和大脑中动脉血管痉挛导致的复发性缺血性中风：病例报告

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_47_23

Aini He, K. Dong, Wenbo Zhao, Benke Zhao, Wei Sun, Xiao Wu, Xia Lu, Yanfei Chen, Haiqing Song

引用次数: 0

The microbiome and neurosurgery 微生物组与神经外科

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_59_23

James Kelbert, Thomas C. Varkey

引用次数: 0

Rule out alternative causes before attributing polyradiculitis to influenza or severe acute respiratory syndrome coronavirus 2 vaccination 在将多发性神经炎归咎于流感或严重急性呼吸道综合征冠状病毒 2 疫苗接种之前，应排除其他原因

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-10-01 DOI: 10.4103/bc.bc_14_23

J. Finsterer

引用次数: 0

Recurrent paraneoplastic cerebral hemorrhage in lung cancer: A case report. 肺癌复发性副肿瘤脑出血1例。

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-04-01 DOI: 10.4103/bc.bc_78_22

Michele Alessiani, Adriano Bonura, Gianmarco Iaccarino, Marilena Mangiardi, Francesca Romana Pezzella, Maria Cristina Bravi, Domenica Crupi, Michele Galluzzo, Sabrina Anticoli

引用次数: 0

Basilar artery recanalization by proximal balloon occlusion and aspiration in a single vessel vertebrobasilar system: A case report. 单血管椎基底动脉系统近端球囊闭塞与抽吸再通1例。

IF 1.9 4区医学

Brain Circulation Pub Date : 2023-04-01 DOI: 10.4103/bc.bc_79_22

Matthew Gusler, Seyed-Mostafa Razavi, Aaron Grossman, Charles Prestigiacomo, Ashkan Mowla, Peyman Shirani

引用次数: 0