Brain Circulation最新文献

{"title":"Management dilemma in dural arteriovenous fistulas with pial arterial supply: To embolize the pial artery or not?","authors":"Xin Su, Yongjie Ma, Peng Zhang, Hongqi Zhang","doi":"10.4103/bc.bc_105_25","DOIUrl":"10.4103/bc.bc_105_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 2","pages":"193-194"},"PeriodicalIF":5.2,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress on the mechanism of pathological injury secondary to venous stroke and their therapeutic strategies: A narrative review.","authors":"Shanshan Wei, Yan Li, Xiaohong Yu, Rui Ding, Guangrong Meng","doi":"10.4103/bc.bc_180_24","DOIUrl":"10.4103/bc.bc_180_24","url":null,"abstract":"<p><p>Cerebral venous thrombosis (CVT) is a subset of stroke with a rising trend over the recent years, namely, venous stroke. Its pathogenesis is distinctly heterogeneous from that of arterial ischemic stroke. Severe CVT often results in irreversible brain damage due to concomitant cerebral venous infarction and/or hemorrhage, and the prognosis is extremely poor. Currently, venous stroke has received increasing attention and focus from the scientific community. It has been identified that blood-brain barrier disruption, impaired lymphatic drainage, immune inflammatory response, endoplasmic reticulum stress, oxidative/nitrative stress, and excitotoxicity are intimately tied to the pathophysiology secondary to CVT; however, the specific pathological molecular mechanisms remain to be elaborated in detail. Based on the latest research, combined with the current transcriptomics data, this study reviews the potential pathomechanisms linked with secondary brain injury post-CVT and summarizes the relevant therapeutic strategies, which will contribute to the grasp of the pathology of venous stroke for early clinical recognition and intervention.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 2","pages":"103-111"},"PeriodicalIF":5.2,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial dural arteriovenous fistula and arteriovenous malformation discovered incidentally after stroke.","authors":"Marialuisa Zedde, Rosario Pascarella","doi":"10.4103/bc.bc_158_25","DOIUrl":"10.4103/bc.bc_158_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"90-94"},"PeriodicalIF":5.2,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous air embolism through occipital emissary venous breach.","authors":"Sangeetha R Palaniswamy, K Yaseen Taj","doi":"10.4103/bc.bc_134_25","DOIUrl":"10.4103/bc.bc_134_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 4","pages":"356-357"},"PeriodicalIF":4.8,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale and design of Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY): A multicenter randomized trial.","authors":"Anxin Wang, Jing Li, Xiaoli Zhang, Xue Xia, Yilong Wang","doi":"10.4103/bc.bc_65_25","DOIUrl":"10.4103/bc.bc_65_25","url":null,"abstract":"<p><strong>Background: </strong>Shuxuening injection (SXNI), a multi-target cerebroprotectant, holds promise as adjuvant therapy to intravenous thrombolysis (IVT) in acute ischemic stroke (AIS), but its efficacy has not yet been established.</p><p><strong>Aim: </strong>The aim of this study was to present the rationale and design of the Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY) trial.</p><p><strong>Design: </strong>This multicenter, randomized, double-blind, placebo-controlled trial sought to evaluate the efficacy and safety of SXNI in AIS patients undergoing IVT. The estimated sample size is 1380 patients. Eligible participants aged ≥ 18 years with symptom onset within 6 h, who are receiving or planned for IVT and have a baseline National Institutes of Health Stroke Scale score of 4-25, will be randomly assigned (1:1) to receive either SXNI or placebo for 10-14 days.</p><p><strong>Study outcomes: </strong>The primary efficacy outcome is the proportion of patients with favorable functional outcome (modified Rankin Scale score of 0-1) at 90 days. The primary safety outcome is the adverse events within 90 days.</p><p><strong>Discussion: </strong>The SHINY trial will provide evidence on whether SXNI exerts cerebroprotective effect in IVT-treated AIS patients.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (identifier: NCT06157502).</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"1-6"},"PeriodicalIF":5.2,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis and management of idiopathic intracranial hypertension: A narrative review.","authors":"Yuanyuan Liu, Xiao Dong, Xi Chen, Simiao Zhang, Xuehong Chu, Wanwan Zhang, Erlan Yu, Xiaole Jia, Chuanjie Wu, Xunming Ji","doi":"10.4103/bc.bc_13_25","DOIUrl":"10.4103/bc.bc_13_25","url":null,"abstract":"<p><p>Idiopathic intracranial hypertension (IIH) is a disease that predominantly affects obese women of reproductive age. As obesity rates increase globally, the incidence of this disease is also on the rise. Elevated intracranial pressure without secondary etiology is the main diagnostic feature of this disorder; however, little is known about its underlying pathophysiologic mechanisms. Headache, blurred vision, and pulsatile tinnitus are its main clinical features. With increasing evidence that IIH is a systemic metabolic disorder, many studies targeting the metabolism of patients with IIH continue to emerge, aiming to provide more therapeutic options for patients with IIH. In this review, we highlight recent advances regarding the pathogenesis and treatment of IIH in adults. Finally, we briefly discuss future research directions.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 3","pages":"246-256"},"PeriodicalIF":5.2,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early antiplatelet therapy was associated with reduced neurological deterioration in stroke patients treated with intravenous thrombolysis.","authors":"Jing Wang, Min Zhao, Haijuan Kang, Sijie Li, Di Wu, Hongrui Ma, Longfei Wu, Guiyou Liu, Haiqing Song, Qingfeng Ma, Xunming Ji, Wenbo Zhao","doi":"10.4103/bc.bc_9_25","DOIUrl":"10.4103/bc.bc_9_25","url":null,"abstract":"<p><strong>Background: </strong>Patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) are at high risk of early neurological deterioration (END) due to increased platelet activation.</p><p><strong>Objectives: </strong>The objective of the study was to investigate the safety and efficacy of early antiplatelet therapy in reducing END postthrombolysis, and identify patients who may benefit.</p><p><strong>Methods: </strong>In this observational study, AIS patients receiving IVT were stratified into the early tirofiban group and the control group according to antiplatelet therapy during the first 24 h following IVT. The primary endpoint was END₄ (the National Institutes of Health Stroke Scale score increase ≥ 4 points) within 72 h following IVT. Binary logistic regression with propensity-score-matching was applied to analyze outcomes between the groups.</p><p><strong>Results: </strong>Of the 319 patients enrolled, 66 in the early tirofiban group and 120 matched controls were analyzed. END₄ occurred in four patients (6.1%) with early tirofiban and 15 patients (12.5%) in the control group. Early tirofiban administration was associated with lower odds of END₄ (adjusted odd ratio, 0.2; 95% confidence interval, 0.1-0.8). Intracranial hemorrhage occurred in 2 (3.0%, none symptomatic) and 3 (2.5%, 2 symptomatic) patients, respectively, with no significant association between early tirofiban and major bleeding or mortality. Early tirofiban was significantly correlated with reduced END₄ among patients aged 66-80 years, those without prestroke antiplatelet therapy, and those with neutral response to IVT (adjusted <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Early tirofiban therapy following IVT was associated with reduced END without increased bleeding risk. Specific patient subgroups may potentially benefit from early antiplatelet therapy, further confirmation is needed.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 3","pages":"279-287"},"PeriodicalIF":5.2,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulation of microglia/macrophages and neutrophils as immunotherapeutic targets in ischemic stroke: A narrative review.","authors":"Evren Ekingen, Rasit Dinc","doi":"10.4103/bc.bc_41_25","DOIUrl":"10.4103/bc.bc_41_25","url":null,"abstract":"<p><p>Ischemic stroke (IS) remains a critical global issue characterized by high mortality and morbidity rates, primarily caused by neuronal death and brain dysfunction resulting from vascular occlusion. In secondary injuries following IS, inflammation plays a vital role, leading to increased neuronal damage and a poorer prognosis in the early stages. However, inflammation serves a dual purpose in stroke pathophysiology, promoting tissue repair and healing, especially in the later stages of stroke. Mechanical thrombectomy and intravenous thrombolysis are the primary therapeutic choices for IS. However, their narrow therapeutic windows and increased bleeding risks remain problematic. Recent research highlights the therapeutic potential of regulating immune cells, focusing on microglia, macrophages, and neutrophils, due to their dual roles in IS. Current preclinical and clinical studies have shown that this strategy holds promise in the prevention and management of IS. The aim of this review to assess the evolving landscape of immune modulation as therapeutic avenue in ischemic stroke.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 3","pages":"215-225"},"PeriodicalIF":5.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of therapeutic hypothermia by CiteSpace-based bibliometric analysis.","authors":"Xiaole Jia, Xuehong Chu, Xiao Dong, Yuanyuan Liu, Erlan Yu, Xunming Ji, Di Wu, Chuanjie Wu","doi":"10.4103/bc.bc_47_24","DOIUrl":"10.4103/bc.bc_47_24","url":null,"abstract":"<p><strong>Background: </strong>In recent years, neuroprotective techniques have become increasingly common in neurology. Therapeutic hypothermia, as one of the classic neuroprotective techniques, has attracted the great attention of many researchers.</p><p><strong>Data and methods: </strong>CiteSpace is a software that allows for the interactive visualizations of structural and temporal patterns and trends in the scientific domain. It is widely used for the visual exploration of scientific literature. This study analyses the literature on therapeutic hypothermia and its neuroprotective use from 1992 to 2023 using CiteSpace, with data sourced from Web of Science Core Collection.</p><p><strong>Results: </strong>A quantitative analysis of the annual number of publications revealed a consistent upward trend since 1992, reaching a peak in 2012. Since then, the number of publications has remained at over 50 per year. In the analysis of collaborative countries/regions and institutions, we discovered that the United States has the highest number of publications among all countries, while the University of California System leads in terms of publications among all institutions. In the authors, co-cited authors analysis, and co-cited references analysis, we ranked authors and references by number of publications and citations. In the keyword and cluster analysis, it showed that the most frequently occurring keywords were mild hypothermia, moderate hypothermia, and therapeutic hypothermia. In terms of disease, hypothermia was most frequently applied to traumatic brain injury, hypoxic-ischemic encephalopathy, and ischemic stroke.</p><p><strong>Conclusions: </strong>Therapeutic hypothermia technology has great research heat in the fields of the mechanism of action, conditions and limitations of application, treatment of certain brain diseases, etc., and our study provides insights that can inform future research on therapeutic hypothermia and its neuroprotective effects.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"67-75"},"PeriodicalIF":5.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in the management of carotid artery stenosis: A bibliometric analysis from 2012 to 2022.","authors":"Siddhant Kumarapuram, Allen Ye Fu, Arevik Abramyan, Sanjeev Ariyandath Sreenivasan, Jay Kavia, Arsala Khan, Sanya Ravoori, Smriti Mumudi, Sudipta Roychowdhury, Gaurav Gupta","doi":"10.4103/bc.bc_20_25","DOIUrl":"10.4103/bc.bc_20_25","url":null,"abstract":"<p><strong>Introduction: </strong>Carotid stenosis causes about 10%-20% of ischemic stroke cases. Landmark clinical trials revealed the utility of endarterectomy for symptomatic patients with > 50% stenosis or asymptomatic patients with > 70% stenosis. Then, trials on stenting exhibited alternative, safer approach in patients younger than 70 years old, and at higher risk of myocardial infarction. Our bibliometrics study explores how carotid stenosis literature has changed between 2012 and 2022 to reflect novel treatment options and research.</p><p><strong>Methods: </strong>The Web of Science database was investigated for 6,639 publication items between 2012 and 2022 pertaining to carotid stenosis in neurosurgery. Networks were built to analyze keywords, key terms, countries of publication, and popular journals for submission. Subsequently, items within each network were organized into clusters and evaluated for publication date. Items were ranked for their interconnectedness to other items and prevalence within the literature. The most relevant items were tracked over time. In addition, relevant terms and connections were isolated from the network.</p><p><strong>Results: </strong>Terms were arranged into six major clusters (treatments, imaging, risk factors, prognostic markers, plaque characteristics, and basic science research). The treatment and basic science clusters contained terms with more recent popularity. The phrase \"carotid endarterectomy\" was more prevalent than \"carotid stenosis\" across all years except 2018. In addition, the term \"mouse\" in the basic science cluster was connected to all other clusters revealing the increased translational research. The United States was the largest publisher overall and China published the most recent articles.</p><p><strong>Conclusions: </strong>Modern research on carotid stenosis is characterized by advancements in basic science and preference for carotid endarterectomy. Past reports suggest that endarterectomy provides better outcomes than stenting. As treatment options continue to expand into modern scientific enterprise, developing nations will continue to impact the future of carotid stenosis research and top-tier journals will remain the largest outlet of such research.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 3","pages":"288-295"},"PeriodicalIF":5.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}