Brain Circulation最新文献

{"title":"Outcomes of early targeted embolization for ruptured arteriovenous malformation-associated aneurysms: A single-center study.","authors":"Koki Onodera, Kuya Azekami, Masataka Yoshimura, Hiroki Kurita, Shinya Kohyama","doi":"10.4103/bc.bc_89_25","DOIUrl":"10.4103/bc.bc_89_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 4","pages":"339-344"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There is currently no evidence that long-COVID-19 leads to neurodegenerative diseases such as SDAT, amyotrophic lateral sclerosis, or Parkinson's disease.","authors":"Josef Finsterer","doi":"10.4103/bc.bc_81_25","DOIUrl":"10.4103/bc.bc_81_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 4","pages":"354-355"},"PeriodicalIF":4.8,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial dural arteriovenous fistula and arteriovenous malformation discovered incidentally after stroke.","authors":"Marialuisa Zedde, Rosario Pascarella","doi":"10.4103/bc.bc_158_25","DOIUrl":"https://doi.org/10.4103/bc.bc_158_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"90-94"},"PeriodicalIF":4.8,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous air embolism through occipital emissary venous breach.","authors":"Sangeetha R Palaniswamy, K Yaseen Taj","doi":"10.4103/bc.bc_134_25","DOIUrl":"10.4103/bc.bc_134_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 4","pages":"356-357"},"PeriodicalIF":4.8,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale and design of Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY): A multicenter randomized trial.","authors":"Anxin Wang, Jing Li, Xiaoli Zhang, Xue Xia, Yilong Wang","doi":"10.4103/bc.bc_65_25","DOIUrl":"https://doi.org/10.4103/bc.bc_65_25","url":null,"abstract":"<p><strong>Background: </strong>Shuxuening injection (SXNI), a multi-target cerebroprotectant, holds promise as adjuvant therapy to intravenous thrombolysis (IVT) in acute ischemic stroke (AIS), but its efficacy has not yet been established.</p><p><strong>Aim: </strong>The aim of this study was to present the rationale and design of the Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY) trial.</p><p><strong>Design: </strong>This multicenter, randomized, double-blind, placebo-controlled trial sought to evaluate the efficacy and safety of SXNI in AIS patients undergoing IVT. The estimated sample size is 1380 patients. Eligible participants aged ≥ 18 years with symptom onset within 6 h, who are receiving or planned for IVT and have a baseline National Institutes of Health Stroke Scale score of 4-25, will be randomly assigned (1:1) to receive either SXNI or placebo for 10-14 days.</p><p><strong>Study outcomes: </strong>The primary efficacy outcome is the proportion of patients with favorable functional outcome (modified Rankin Scale score of 0-1) at 90 days. The primary safety outcome is the adverse events within 90 days.</p><p><strong>Discussion: </strong>The SHINY trial will provide evidence on whether SXNI exerts cerebroprotective effect in IVT-treated AIS patients.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (identifier: NCT06157502).</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"1-6"},"PeriodicalIF":4.8,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of therapeutic hypothermia by CiteSpace-based bibliometric analysis.","authors":"Xiaole Jia, Xuehong Chu, Xiao Dong, Yuanyuan Liu, Erlan Yu, Xunming Ji, Di Wu, Chuanjie Wu","doi":"10.4103/bc.bc_47_24","DOIUrl":"https://doi.org/10.4103/bc.bc_47_24","url":null,"abstract":"<p><strong>Background: </strong>In recent years, neuroprotective techniques have become increasingly common in neurology. Therapeutic hypothermia, as one of the classic neuroprotective techniques, has attracted the great attention of many researchers.</p><p><strong>Data and methods: </strong>CiteSpace is a software that allows for the interactive visualizations of structural and temporal patterns and trends in the scientific domain. It is widely used for the visual exploration of scientific literature. This study analyses the literature on therapeutic hypothermia and its neuroprotective use from 1992 to 2023 using CiteSpace, with data sourced from Web of Science Core Collection.</p><p><strong>Results: </strong>A quantitative analysis of the annual number of publications revealed a consistent upward trend since 1992, reaching a peak in 2012. Since then, the number of publications has remained at over 50 per year. In the analysis of collaborative countries/regions and institutions, we discovered that the United States has the highest number of publications among all countries, while the University of California System leads in terms of publications among all institutions. In the authors, co-cited authors analysis, and co-cited references analysis, we ranked authors and references by number of publications and citations. In the keyword and cluster analysis, it showed that the most frequently occurring keywords were mild hypothermia, moderate hypothermia, and therapeutic hypothermia. In terms of disease, hypothermia was most frequently applied to traumatic brain injury, hypoxic-ischemic encephalopathy, and ischemic stroke.</p><p><strong>Conclusions: </strong>Therapeutic hypothermia technology has great research heat in the fields of the mechanism of action, conditions and limitations of application, treatment of certain brain diseases, etc., and our study provides insights that can inform future research on therapeutic hypothermia and its neuroprotective effects.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"67-75"},"PeriodicalIF":4.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mucosa-associated lymphoid tissue translocation gene 1-related immune prognostic signature and targeted drug screening for glioblastoma.","authors":"Hui Li, Zhishan Du, Han Lu, Jianxin Xi, Hong Hu","doi":"10.4103/bc.bc_65_24","DOIUrl":"https://doi.org/10.4103/bc.bc_65_24","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma (GBM) is the most common intracranial malignancy in adults, and traditional treatments such as surgery, chemotherapy, and radiotherapy have shown limited improvements in patient prognosis. While immunotherapy has transformed treatment outcomes for many cancers, GBM patients often exhibit resistance due to the tumor's unique immunosuppressive microenvironment, resulting in poor prognosis. The mucosa-associated lymphoid tissue translocation gene 1 (MALT1) has been implicated in the activation of nuclear factor kappa-B and the promotion of cancer cell proliferation and migration. Inhibiting MALT1 has been shown to reduce the mesenchymal phenotype of GBM. Thus, understanding the role of MALT1 in GBM's immunosuppressive microenvironment is crucial.</p><p><strong>Materials and methods: </strong>In this study, we analyzed RNA-seq data from 169 GBM patients obtained from The Cancer Genome Atlas database, categorizing them into MALT1_High and MALT1_Low groups based on MALT1 expression levels. We quantified the enrichment levels of 29 immune signatures for each patient in both the groups. We then identified differentially expressed immune genes and used these to develop an immune prognostic signature (IPS) through Least Absolute Shrinkage and Selection Operator Cox regression analysis. Furthermore, we validated the role of MALT1 in GBM through MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), scratch assays, and small interfering RNA knockdown experiments. In addition, we tested the effects of promising MALT1 inhibitors identified through computer-aided technologies.</p><p><strong>Results: </strong>Our analysis revealed that PDYN, a gene not previously associated with GBM prognosis, could serve as a potential target. Using a three-gene IPS, we created a predictive nomogram model to assess the prognosis of GBM patients. The validation experiments confirmed that MALT1 plays a significant role in promoting GBM cell proliferation, migration, and invasion. In addition, the computer-aided identification of MALT1 inhibitors demonstrated their potential to inhibit GBM progression.</p><p><strong>Conclusion: </strong>This study explored the role of MALT1 in GBM's immunosuppressive microenvironment, developed a novel MALT1-related prognostic model, and identified potential targeted therapies for GBM, providing new avenues for therapeutic intervention.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"12 1","pages":"42-57"},"PeriodicalIF":4.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of selective cerebral venous sinus cooling as a novel neuroprotective therapy following mechanical thrombectomy.","authors":"Zhenjian Ma, Yongbo Xu, Miaowen Jiang, Sifei Wang, Fanlei Meng, Wenjun Wu, Ming Li, Ming Wei","doi":"10.4103/bc.bc_14_24","DOIUrl":"10.4103/bc.bc_14_24","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 4","pages":"345-348"},"PeriodicalIF":4.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link trend in the field of coronaviruses and cognitive impairment: A bibliometric analysis based on bibliometrix.","authors":"Wangxinjun Cheng, Moyu Wang, Chufan Zhou, Moyi Li","doi":"10.4103/bc.bc_107_24","DOIUrl":"10.4103/bc.bc_107_24","url":null,"abstract":"<p><strong>Background: </strong>Coronaviruses (CoVs) significantly impact human health, targeting the respiratory and nervous systems and causing long-term complications such as cognitive impairment. While the cognitive effects of CoVs, including severe acute respiratory syndrome CoV, are well-documented, a comprehensive analysis of the evolving research landscape remains unexplored.</p><p><strong>Methods: </strong>We performed a bibliometric analysis of CoV-related cognitive research from 1998 to 2025 using data from the Web of Science Core Collection. Bibliometrix software was employed to examine publication trends, geographical contributions, institutional output, author collaborations, and research hotspots.</p><p><strong>Results: </strong>Among 4,076 publications analyzed, a dramatic rise in research output was observed post-2020, correlating with the COVID-19 pandemic. The United States led in publication count (24.63%) and citations, followed by Italy and China. The University of Toronto is ranked as the most prolific institution. The most highly cited articles are from Alzheimer's and Dementia, The Lancet Infectious Diseases, and eClinicalMedicine. Cao Bing, Mazza, Mario Gennaro, and Wang Yi had the most influence on CoV impact on cognitive impairment. Keyword analysis revealed emerging research themes such as \"depression,\" \"anxiety,\" and \"health,\" reflecting the psychological and cognitive effects of the pandemic. Highly cited articles identified neuroinflammatory and neuroimmune pathways, emphasizing the role of viral invasion in cognitive dysfunction.</p><p><strong>Conclusion: </strong>The COVID-19 pandemic has driven a surge in studies linking CoV infections to cognitive impairment. This research highlights mechanisms such as blood-brain barrier disruption, neuronal damage, and altered cerebral glucose metabolism. Future studies should focus on standardized diagnostic criteria and therapeutic strategies to mitigate long-term cognitive sequelae.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 4","pages":"322-332"},"PeriodicalIF":4.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis.","authors":"Ziping Han, Tao Wang, Lingzhi Li, Junfen Fan, Rongliang Wang, Yangmin Zheng, Feng Yan, Haiping Zhao, Yumin Luo, Liqun Jiao","doi":"10.4103/bc.bc_16_24","DOIUrl":"10.4103/bc.bc_16_24","url":null,"abstract":"<p><strong>Background: </strong>Expression profiles and clinical significance of circular RNAs (circRNAs) in intracranial atherosclerotic stenosis (ICAS) patients have not been investigated yet.</p><p><strong>Materials and methods: </strong>A circRNA microarray was employed to identify differentially expressed circRNAs (DEcircRNAs) in peripheral neutrophils of ICAS patients. The levels of upregulated hsa-circRNA-087631/hsa-circRNA-101141 and downregulated hsa-circRNA-100914/hsa-circRNA-001082 were verified using quantitative real-time polymerase chain reaction (qRT-PCR). In addition, we compared the levels of those four DEcircRNAs before endovascular treatment (pre-E) and 24 h after endovascular treatment (post-E) and between patients with adverse event and severe adverse event (AE/SAE) and those without. Their area under the curve from the receiver operating characteristic (ROC) curve was calculated as well. Bioinformatic analyses of DEcircRNAs host genes and targeted genes in DEcircRNA-miRNA-mRNA regulatory network were further performed.</p><p><strong>Results: </strong>A total of 70 circRNAs were identified as differentially expressed in patients with ICAS; of these, 7 were upregulated and 63 were downregulated. qRT-PCR-based validation results of the four DEcircRNAs corresponded with the microarray data. The upregulated hsa-circRNA-087631 and hsa-circRNA-101141 were significantly downregulated 24 h post-E; moreover, they were significantly increased in patients with perioperative AE/SAE compared to those without AE/SAE. ROC analysis further supported their potential to be exploited as diagnostic biomarkers for ICAS. The validated DEcircRNA-miRNA-mRNA regulatory network and further bioinformatic analysis supported the core roles of hsa-circRNA-101141 in regulating target genes mainly related to actin or microtubule-based process.</p><p><strong>Conclusions: </strong>DEcircRNAs in peripheral neutrophils could serve as biomarkers for the diagnostic and AE prediction in ICAS patients receiving endovascular treatment. Moreover, these DEcircRNAs, especially hsa-circRNA-101141-hsa-miRNA-181d axis, might participate in the pathogenesis of ICAS by acting on actin or microtubule-based cytoskeleton organization processes in neutrophils.</p><p><strong>Trial registration: </strong>The CRTICAS study has been registered previously in the ClinicalTrial.gov database (NCT01994161).</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 3","pages":"200-211"},"PeriodicalIF":4.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}