Brain Circulation最新文献

{"title":"Delayed destabilization and rupture of a giant anterior circulation aneurysm following flow-diverter placement: A case report.","authors":"Artur Eduardo Martio, Samuel Luís Scaravonatto Baldo Cunha, Luciano Bambini Manzato, Felipe Perini, José Ricardo Vanzin","doi":"10.4103/bc.bc_69_24","DOIUrl":"https://doi.org/10.4103/bc.bc_69_24","url":null,"abstract":"<p><p>Flow-diverting stents have been increasingly utilized for the treatment of intracranial aneurysms, especially when there are factors that go against coil embolization, such as wide neck and large aneurysm size. However, its use does not guarantee success, especially in giant lesions, and failure to obtain aneurysmal obliteration can result in long-term instability of the aneurysmal wall, leading to aneurysmal growth and late rupture. We present the case of a 65-year-old woman who suffered from a late aneurysmal dilation and rupture, 2 years and 4 months after flow-diverting treatment of a giant ophthalmic segment aneurysm. Although not fully understood, the pathophysiology of this phenomenon has one necessary factor: incomplete aneurysmal obliteration. When this scenario is present, two main factors take place: the augmentation of intrasaccular blood flow after stent delivery and the local inflammation caused by partial thrombus formation and the presence of the stent itself. To prevent this complication, complete aneurysmal obliteration must be assured, and the use of combined techniques is encouraged.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"89-93"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment of infectious intracranial aneurysms: A single-center experience.","authors":"Smit D Patel, Anvesh A Balabhadra, Ethan A Miller, Isha S Gandhi, Neel Patel, James Fowler, Ajay Tunguturi, Fadar Oliver Otite, Charles Bruno, Eric Sussman, Martin Ollenschleger, Tapan Mehta","doi":"10.4103/bc.bc_77_24","DOIUrl":"https://doi.org/10.4103/bc.bc_77_24","url":null,"abstract":"<p><strong>Introduction: </strong>Infectious intracranial aneurysms (IIAs), a notable complication of infective endocarditis (IE), pose significant clinical challenges. This study delineates the outcomes, management strategies, and clinical manifestations of IIAs, drawing from a single-center's experience.</p><p><strong>Methods: </strong>We conducted a retrospective observational analysis at our institution, focusing on patients diagnosed with IE between 2016 and 2022 who were also found to have IIAs. Data analysis was performed utilizing SAS statistical software alongside Microsoft Excel to execute descriptive statistical operations.</p><p><strong>Results: </strong>Among 862 IE patients, 25 (2.9%) were diagnosed with IIAs, totaling 41 mycotic aneurysms. Of these, 18 patients had a single aneurysm, while 7 had multiple. The cohort's median age was 45 years, with an interquartile range of 27-65 years, and a predominance of male patients (68.3%). Ischemic and hemorrhagic strokes were observed in 58.6% and 87.8% of the cases, respectively. Ruptured IIAs were noted in 58.5% of instances, with the remainder unruptured. The average diameter of ruptured IIAs was 3.3 mm, compared to 2.1 mm for unruptured aneurysms, although this difference was not statistically significant (<i>P</i> = 0.324). The most frequent IIA locations were the distal segments of the posterior and middle cerebral arteries. Patients with ruptured IIAs experienced higher in-hospital mortality rates (29.1%) relative to those with unruptured IIAs (11.7%). Treatment was administered to 58.3% of ruptured IIAs, with no interventions for unruptured aneurysms (<i>P</i> = 0.001). Treatment modalities included surgical resection, n-butyl cyanoacrylate, coils, and Onyx embolization. The treated ruptured IIAs had an average size of 4.4 mm, versus 2.0 mm for untreated aneurysms. Among those treated, the majority were either discharged home (21.4%) or to other facilities (78.6%), with no in-hospital mortalities reported in this group.</p><p><strong>Conclusion: </strong>The findings suggest that endovascular treatment is a viable and effective option for managing ruptured IIAs, with decisions tailored to individual patient comorbidities. Further multicenter studies are recommended to corroborate these findings and refine treatment strategies for IIAs associated with infective endocarditis.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"24-29"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congestive heart failure and its associations with cognition and cerebral blood flow.","authors":"Sandra Kong, Emma Gootee, Nicole Williams, Rebecca F Gottesman, Michelle C Johansen","doi":"10.4103/bc.bc_86_24","DOIUrl":"https://doi.org/10.4103/bc.bc_86_24","url":null,"abstract":"<p><strong>Background: </strong>Congestive heart failure (CHF) has been linked to dementia but for reasons not well understood. Our retrospective cohort study aims to determine if specific measures of CHF severity are associated with cognitive performance or cerebral blood flow velocity (CBFV) among decompensated CHF outpatients.</p><p><strong>Materials and methods: </strong>One hundred and thirty-eight patients with transthoracic echocardiogram ≤1-year preceding consent were included. Forty-nine patients had concurrent transcranial Doppler ultrasonography administered by a trained technician assessing anterior cerebral artery, middle cerebral artery, and internal carotid artery (ICA) CBFV. CHF characteristics considered were NYHA classification, CHF type (heart failure with preserved ejection fraction vs. heart failure with mildly reduced/reduced ejection fraction), and left ventricular ejection fraction (LVEF; continuous [per 5%] or categorized [≤40%, 40%-55%, and ≥55%]). A trained psychometrist administered a standardized cognitive battery including Rey Auditory Verbal Learning Test, Rey Complex Figure Copy and Immediate Recall test, Letter-Number Sequencing (LNS) test, and Trail Making Tests. Adjusted multivariable linear regression models determined the association between CHF characteristics and standardized cognitive tests as well as between CHF characteristics and standardized CBFV, in distinct models.</p><p><strong>Results: </strong>On average, NYHA Class 1-2 patients had better LNS scores than NYHA Class 3-4 patients (β: 0.47; 95% CI: 0.09, 0.84). Patients with LVEF 40%-55% had higher ICA CBFVs than those with LVEF ≤40% (β: 13.7; 95% CI: 1.01, 26.39). No associations between other CHF characteristics and either cognitive performance or CBFV were found.</p><p><strong>Conclusion: </strong>Blood flow may be an important mechanism behind CHF-related cognitive decline, but studies with larger sample sizes and a control group without CHF are needed.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"30-38"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes and prognostic factors after surgery alone for brain arteriovenous malformation.","authors":"Zhao-Ying Zhu, Wei Zhang, Li-Chuan Gao, Gui-Jun Zhang, Jing Chen","doi":"10.4103/bc.bc_95_24","DOIUrl":"https://doi.org/10.4103/bc.bc_95_24","url":null,"abstract":"<p><strong>Objectives: </strong>There is a paucity of data regarding the long-term hemorrhage/progression outcomes of brain arteriovenous malformation (BAVM). The purpose of this study was to examine the outcomes of surgical treatment alone over a long follow-up period.</p><p><strong>Materials and methods: </strong>All patients (<i>n</i> = 356) harboring Grade I-III BAVMs who had been surgically treated alone between January 2010 and December 2019 were included. Univariate analysis and multivariate analysis with proportional hazard models were implemented to identify the predictors of hemorrhage-free survival (HFS) (<i>n</i> = 356) and progression-free survival (PFS) (<i>n</i> = 334).</p><p><strong>Results: </strong>Of the 356 BAVM patients, 233 were male and 123 were female (male-to-female ratio of 1.89:1). Rehemorrhage was observed in 22 (6.2%) patients. The overall HFS rates at 5, 10, and 15 years in the entire cohort were 96.0%, 92.4%, and 91.1%, respectively. A 1 cm³ increase in lesion volume (hazard ratio [HR] = 1.049, 95% confidence interval [CI] = 1.013-1.085; <i>P</i> = 0.007) was a significant adverse factor for HFS. The probabilities of PFS at 5, 10, and 15 years were 94.9%, 90.6%, and 85.5%, respectively. With respect to clinical predictors of PFS, only male sex (HR = 3.146, 95% CI = 1.088-9.098; <i>P</i> = 0.034) was a significant predictor of PFS after surgical treatment in the univariate analysis.</p><p><strong>Conclusions: </strong>For the majority of patients, surgery remains the first-line treatment for BAVMs. Our study included a significant subset of patients who were successfully managed by surgery alone.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"57-63"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Systemic Inflammatory Response Index with the cardiometabolic multimorbidity among US adults: A population-based study.","authors":"Jing Li, Songfeng Zhao, Xiaowen Zhang, Mengyan Fan, Jiaxin Wan, Rijin Lin, Feng Fan, Guo Liu, Sheng Guan, Aihua Liu","doi":"10.4103/bc.bc_32_24","DOIUrl":"https://doi.org/10.4103/bc.bc_32_24","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation plays an essential role in the occurrence and progression of cardiometabolic diseases (CMDs). We aim to examine the association between a novel inflammatory biomarker Systemic Inflammatory Response Index (SIRI) and different cardiometabolic multimorbidity (CMM) statuses.</p><p><strong>Methods: </strong>This was a cross-sectional study that includes general participants of the National Health and Nutrition Examination Survey database from 1999 to 2018. SIRI was calculated as neutrophil count × lymphocyte count/monocyte count. The CMDs were defined as a series of diseases including diabetes mellitus (DM), heart disease (HD), and stroke. We explored the association of SIRI with outcomes with weighted multivariable logistic regression models weighted restricted cubic spline. The diagnostic value of SIRI was evaluated using weighted receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>A total of 43,345 participants were enrolled with a mean age of 45.86 years. The weighted prevalence of CMD and CMM was 17.14% and 2.94%, respectively. Compared to those without CMD, the adjusted odds ratios (95% confidence interval) for each unit increase in SIRI were 1.14 (1.09-1.19) for DM, 1.13 (1.07-1.19) for HD, 1.11 (1.04-1.19) for stroke, 1.17 (1.12-1.22) for CMD, and 1.16 (1.10-1.23) for CMM, according to the weighted multivariable logistic regression. Elevated SIRI level was independently associated with increased CMM. There was no interaction found in subgroup analysis. According to the ROC analysis, SIRI had a superior diagnostic ability to neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio for CMD (area under the curve [AUC] =0.581) and CMM (AUC = 0.633).</p><p><strong>Conclusions: </strong>Elevated level of SIRI was positively associated with the prevalence of DM, coronary artery disease, stroke, CMD, and CMM, suggesting that SIRI could be a potential noninvasive biomarker for CMD and CMM.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"39-47"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From long COVID to neurodegeneration.","authors":"Luis Del Carpio-Orantes","doi":"10.4103/bc.bc_144_24","DOIUrl":"https://doi.org/10.4103/bc.bc_144_24","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"94-95"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an endovascular aneurysm model in pigs for chronic experiments.","authors":"Lara Bender, Thorsten Sichtermann, Jan Minkenberg, Christoph Dorn, Rebecca May, Charlotte S Weyland, Dimah Hasan, Andrea Stockero, Hani Ridwan, Martin Wiesmann, Omid Nikoubashman, Christiane Franz","doi":"10.4103/bc.bc_112_24","DOIUrl":"https://doi.org/10.4103/bc.bc_112_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Cerebral aneurysms are a potentially life-threatening condition for humans. Due to the anatomical variability of different aneurysm types in human patients, animal models are indispensable for endovascular research. The aim of our study was to evaluate an endovascular aneurysm model in chronical experiments using 12 female Aachen minipigs.</p><p><strong>Materials and methods: </strong>For aneurysm creation in external carotid and subclavian arteries, Amplatzer vascular plugs were used as occlusion devices, leaving simple stumps that serve as surrogate aneurysms. If necessary and anatomically possible, additional embolic materials, such as coils and liquid embolic agents were used.</p><p><strong>Results: </strong>We created 42 aneurysms. Aneurysm creation was possible without complications in all cases. There was no spontaneous thrombosis of fabricated aneurysms. Complete perfusion arrest behind the fabricated aneurysm was challenging but achieved in 45% of cases. We were not able to identify significant factors that have an impact on the persisting perfusion of fabricated aneurysms on final imaging, particularly not the presence of side branches in the aneurysm lumen (<i>P</i> = 0.734) or volumes of the fabricated aneurysms (<i>P</i> = 0.620). Albeit not significant, the use of additional occlusive measures (coils, liquid embolic agents) and antithrombotic drugs (ASA, heparin and tirofiban) may be factors for persisting perfusion: Perfusion arrest behind the fabricated aneurysm was twice as high in animals treated with ASA and heparin compared to animals treated with ASA, heparin, and tirofiban (48% vs. 22%; <i>P</i> = 0.149).</p><p><strong>Conclusion: </strong>Despite its limitations, including persistent perfusion and impaired predictability for long-term experiments, the endovascular aneurysm model shows potential to replace certain surgical models and offers broad applications in biomedical research and aneurysm therapy.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"77-85"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Movement disorders associated with acetylcholinesterase inhibitors in Alzheimer's dementia: A systematic review.","authors":"Jamir Pitton Rissardo, Ana Letícia Fornari Caprara","doi":"10.4103/bc.bc_134_24","DOIUrl":"https://doi.org/10.4103/bc.bc_134_24","url":null,"abstract":"<p><strong>Background: </strong>Acetylcholinesterase inhibitors (AChEIs) are widely used in Alzheimer's disease (AD). This study aims to systematically review the literature about movement disorders (MDs) associated with AChEIs for AD, which include donepezil, galantamine, rivastigmine, tacrine, and ipidacrine.</p><p><strong>Methodology: </strong>Two reviewers conducted a comprehensive review of relevant studies across six databases, without language restrictions, covering publications from 1992 to 2024.</p><p><strong>Results: </strong>Overall, 74 studies containing 92 cases were found of MDs related to ACHEIs. The MDs found were Pisa syndrome in 33 patients, parkinsonism in 31, myoclonus in 11, dystonia in 10, dyskinesia in 6, and extrapyramidal symptoms in 1. Regarding the medications, the abnormal movements were associated with donepezil in 62 cases, rivastigmine in 15, galantamine in 10, and tacrine in 5. No case of ipidacrine-induced MD was found. Overall, the most commonly affected sex was the female, accounting for 61.9% of the cases. The mean and median age was 74.1 (standard deviation: 8.9) and 75 years (range: 49-93 years). The MD occurred within 6 months of the starting of AChEI in approximately 70% of the patients. Furthermore, the full recovery of the MD after the main management was noticed within 6 months in about 80% of the patients. About 86.3% of the individuals fully recovered after treatment, which included AChEI discontinuation, dose adjustment, and prescription of additional therapy.</p><p><strong>Conclusions: </strong>The occurrence of tacrine-induced tremor indicated a potential predisposition to movement disorders associated with AChEI therapy. Based on the drug class side effect profile, it is possible that future studies may observe abnormal movements with other AChEIs.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"9-23"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01492 is associated with susceptibility to large atherosclerotic stroke and levels of inflammatory factors.","authors":"Jianyu Liu, Da Liu, Xing Guo, Li Zhou, Zhiyao Xu, Hua Liu","doi":"10.4103/bc.bc_42_24","DOIUrl":"https://doi.org/10.4103/bc.bc_42_24","url":null,"abstract":"<p><strong>Background: </strong>LINC01492 polymorphism has been implicated in the susceptibility of large artery atherosclerotic (LAA) stroke; however, a dearth of systematic research exists regarding this association in the Asian population at present.</p><p><strong>Subjects and methods: </strong>This study enrolled Han Chinese patients with LAA stroke (n = 428) and age- and sex-matched controls (n = 434). We employed dominant, recessive, and codominant genetic models to analyze the distribution of alleles and genotypes for 14 tag single nucleotide polymorphisms (SNPs) in LINC01492. Furthermore, we quantified the transcript levels of LINC01492 as well as concentrations of inflammatory factors (interleukin [IL]-1β, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor alpha, and CCL18). In addition, we explored the association between these SNPs and levels of inflammatory factors.</p><p><strong>Results: </strong>The rs10990654 AA genotype of LINC01492 was markedly associated with a heightened risk of LAA stroke (odds ratio [OR] = 6.403, 95% confidence interval [CI] = 1.180-34.734, <i>P</i> = 0.031). Conversely, both the GG genotype of rs10990654 (OR = 0.614, 95% CI = 0.384-0.980, <i>P</i> = 0.041) and the GG genotype of rs16922693 (OR = 0.518, 95% CI = 0.313-0.857, <i>P</i> = 0.010) were identified as being linked to a reduced risk in this study population. In addition, the transcription level of LINC01492 was markedly reduced in patients compared to controls. Furthermore, significant variations were observed in IL-10 and IL-18 levels across genotypes at LINC01492 polymorphism loci among patients.</p><p><strong>Conclusions: </strong>The genetic polymorphisms and transcript levels of LINC01492 exhibit an association with susceptibility to LAA stroke, and the available evidence suggests that this association may be mediated through IL-10 and IL-18.</p><p><strong>Trial registration: </strong>The trial was registered with the Chinese Clinical Trial Registry (www.chictr.org.cn) under trial registration number ChiCTR2000032684.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"48-56"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between sleep duration and stroke risk.","authors":"Yu Cheng, Yuchuan Ding, Ahmed Elmadhoun, Xunming Ji, Xiaokun Geng","doi":"10.4103/bc.bc_7_24","DOIUrl":"https://doi.org/10.4103/bc.bc_7_24","url":null,"abstract":"<p><p>In this review paper, we explore the complex relationship between sleep duration and stroke risk, outlining the association of both insufficient sleep and excessive sleep with an increased risk of cerebrovascular diseases. We explore a U-shaped relationship between sleep duration and cardiovascular outcomes, including stroke. Our review explores findings from cohort studies, meta-analyses, and Mendelian randomization studies, highlighting the nuanced findings and identifying gaps in the current literature. We discussed the direct and indirect effects of sleep duration on stroke risk, considering factors such as atherosclerosis, atrial fibrillation, hypertension, and hyperlipidemia. We also discuss the methodological challenges inherent in current studies, such as the reliance on self-reported sleep measures and the need for more objective and comprehensive assessments. The paper emphasizes the importance of recognizing individual variations in optimal sleep duration and the potential confounding effects of sleep quality and other sleep-related disorders on stroke risk. Furthermore, we explore the potential mechanisms by which sleep duration may influence endothelial function, oxidative stress, and vascular compliance, suggesting areas for future investigation. The paper makes a compelling case for the inclusion of sleep duration as a key factor in stroke prevention strategies, recommending that healthcare professionals proactively assess and manage sleep patterns to mitigate stroke risk.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 1","pages":"1-8"},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}