Brain Circulation最新文献

{"title":"Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis.","authors":"Ziping Han, Tao Wang, Lingzhi Li, Junfen Fan, Rongliang Wang, Yangmin Zheng, Feng Yan, Haiping Zhao, Yumin Luo, Liqun Jiao","doi":"10.4103/bc.bc_16_24","DOIUrl":"10.4103/bc.bc_16_24","url":null,"abstract":"<p><strong>Background: </strong>Expression profiles and clinical significance of circular RNAs (circRNAs) in intracranial atherosclerotic stenosis (ICAS) patients have not been investigated yet.</p><p><strong>Materials and methods: </strong>A circRNA microarray was employed to identify differentially expressed circRNAs (DEcircRNAs) in peripheral neutrophils of ICAS patients. The levels of upregulated hsa-circRNA-087631/hsa-circRNA-101141 and downregulated hsa-circRNA-100914/hsa-circRNA-001082 were verified using quantitative real-time polymerase chain reaction (qRT-PCR). In addition, we compared the levels of those four DEcircRNAs before endovascular treatment (pre-E) and 24 h after endovascular treatment (post-E) and between patients with adverse event and severe adverse event (AE/SAE) and those without. Their area under the curve from the receiver operating characteristic (ROC) curve was calculated as well. Bioinformatic analyses of DEcircRNAs host genes and targeted genes in DEcircRNA-miRNA-mRNA regulatory network were further performed.</p><p><strong>Results: </strong>A total of 70 circRNAs were identified as differentially expressed in patients with ICAS; of these, 7 were upregulated and 63 were downregulated. qRT-PCR-based validation results of the four DEcircRNAs corresponded with the microarray data. The upregulated hsa-circRNA-087631 and hsa-circRNA-101141 were significantly downregulated 24 h post-E; moreover, they were significantly increased in patients with perioperative AE/SAE compared to those without AE/SAE. ROC analysis further supported their potential to be exploited as diagnostic biomarkers for ICAS. The validated DEcircRNA-miRNA-mRNA regulatory network and further bioinformatic analysis supported the core roles of hsa-circRNA-101141 in regulating target genes mainly related to actin or microtubule-based process.</p><p><strong>Conclusions: </strong>DEcircRNAs in peripheral neutrophils could serve as biomarkers for the diagnostic and AE prediction in ICAS patients receiving endovascular treatment. Moreover, these DEcircRNAs, especially hsa-circRNA-101141-hsa-miRNA-181d axis, might participate in the pathogenesis of ICAS by acting on actin or microtubule-based cytoskeleton organization processes in neutrophils.</p><p><strong>Trial registration: </strong>The CRTICAS study has been registered previously in the ClinicalTrial.gov database (NCT01994161).</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 3","pages":"200-211"},"PeriodicalIF":4.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic mental stress and ischemic injury: Mechanisms and implications - A mini review.","authors":"Yuequan Zhu, Leticia Simo, Xiaokun Geng, Fengwu Li, Yuchuan Ding","doi":"10.4103/bc.bc_88_24","DOIUrl":"10.4103/bc.bc_88_24","url":null,"abstract":"<p><p>Ischemic stroke is a leading cause of mortality and disability worldwide. Emerging evidence has highlighted a strong link between genetically predisposed risk factors, such as depression and chronic mental stress, and worsens stroke outcomes. This mini review explores the multifaceted role of mental stress in exacerbating ischemic injury. We discuss mechanisms at the cellular, subcellular, and epigenetic levels, including differential brain cell sensitivity, mitochondrial dysfunction, and novel epigenetic modifications like lactylation. This review provides a theoretical framework and scientific basis for understanding the clinical implications of mental stress in ischemic stroke management. The findings underscore the importance of further research to clarify these mechanisms and develop targeted interventions to mitigate the adverse effects of mental stress on stroke outcomes.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 3","pages":"171-177"},"PeriodicalIF":4.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved preoperative planning for endovascular therapy: High-resolution vessel wall magnetic resonance imaging shows promise in identifying proximal occlusion site and distal boundary of the occlusion of acute ischemic stroke.","authors":"Yuchao Dou, Qinghai Yao, Yongbo Xu, Leilei Luo, Sifei Wang, Bohao Zhang, Da Lu, Sihu Pan, Shuling Liu, Shuai Liu, Yuanyuan Xue, Kangjie Du, Chaowei Hao, Chen Cao, Ming Wei","doi":"10.4103/bc.bc_103_24","DOIUrl":"10.4103/bc.bc_103_24","url":null,"abstract":"<p><strong>Background and purpose: </strong>Detecting the proximal occlusion site (POS) and distal boundary of the occlusion (DBO) of arterial occlusion is very important for the prognosis of endovascular treatment. Recent studies have shown that magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) are also beneficial for preoperative patient selection for endovascular therapy. High-resolution vessel wall MRI (HRVW-MRI) for intraluminal detection of arterial largevessel occlusions (LVOs) is receiving increasing attention. The purpose of this study was to evaluate the diagnostic efficacy of HRVW-MRI for POS and DBO.</p><p><strong>Materials and methods: </strong>The data of 42 patients with acute anterior circulation cerebral infarction were retrospectively analyzed. By comparing with digital subtraction angiography (DSA), the POS and DBO were analyzed to determine the efficacy of HRVW-MRI for LVO location.</p><p><strong>Results: </strong>Good to excellent interobserver consistency was achieved in the analysis and evaluation of all image data (<i>k</i> > 0.70). There was better concordance for the POS between HRMRI and DSA than that between MRA and DSA (<i>k</i> = 0.834 vs. <i>k</i> = 0.309). Compared with DSA, HRVW-MRI showed an advantage over DSA in terms of clearly determining DBO (<i>χ</i>² = 9.389, <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>HRVW-MRI demonstrated a comparative advantage over Time-of-flight-MRA for differentiating the POS, with accuracy near-equivalent to that of DSA and a clear advantage over DSA for DBO detection. HRVW-MRI has the potential to improve preoperative planning for endovascular therapy.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 3","pages":"219-227"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pupillometry: A loupe to mirror intracranial status during recovery after neurosurgery.","authors":"Sangeetha R Palaniswamy, Rajeeb Mishra, Abhay Sikaria, Shivakeshava Murthy","doi":"10.4103/bc.bc_19_25","DOIUrl":"10.4103/bc.bc_19_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 3","pages":"247-249"},"PeriodicalIF":4.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of reperfusion therapy in acute ischemic stroke: Emerging advances, current challenges, and future directions.","authors":"Qiuting Wang, Na Liu, Leticia Simo, Qingfeng Ma, Chuanhui Li","doi":"10.4103/bc.bc_161_24","DOIUrl":"10.4103/bc.bc_161_24","url":null,"abstract":"<p><p>Significant advancements over the past decade have transformed reperfusion therapy for acute ischemic stroke. Standard treatments, including intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT), offer distinct benefits, with recent innovations expanding their efficacy and applicability. IVT, previously limited by a narrow therapeutic window, has seen enhancement with alternative agents such as tenecteplase, which may deliver comparable or superior outcomes to alteplase in selected cases. Expanding indications for EVT, particularly for large vessel occlusions and in extended time windows, have demonstrated promising results, underscoring its effectiveness beyond conventional time constraints. Recent trials further support the use of EVT for patients with large infarct cores in the anterior circulations, although mortality outcomes remain sensitive to treatment timing. In addition, mobile stroke units (MSUs) and prehospital management strategies have emerged as critical components for minimizing delays and improving clinical outcomes. Future research should focus on optimizing reperfusion therapies to individual patient profiles, investigating neuroprotective adjuncts, and expanding the global availability of MSUs to facilitate timely, accessible stroke care.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 3","pages":"187-199"},"PeriodicalIF":4.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular rehabilitation in patients with stroke: A comprehensive review of past and current evidence.","authors":"Huimin Fan, Yuchuan Ding, Ahmed Elmadhoun, Ruchi Mangal, Jing Feng, Xiaokun Geng","doi":"10.4103/bc.bc_16_23","DOIUrl":"10.4103/bc.bc_16_23","url":null,"abstract":"<p><p>In 2016, the American Physical Therapy Association Neurology Section published clinical practice guidelines titled \"Vestibular Rehabilitation (VR) for Peripheral Vestibular Hypofunction.\" These guidelines recommend that physicians should provide VR to individuals with peripheral vestibular hypofunction, emphasizing its importance in managing dysfunctions of the vestibular system. Previous systematic reviews or studies on vestibular function have concluded that VR has positive effects on central vestibular disorders. More recently, a systematic review has found that there are positive effects of VR on ambulatory performance in stroke patients. Evidence is consistently being added regarding the positive impact of VR in patients with a history of stroke who are currently living with dizziness, balance, and gait impairments. However, there are still many unanswered questions in this area. Most studies lack complementary quantitative vestibular function testing and uniform standards for the timing and frequency of the VR. Furthermore, the methods of VR are carried out in a general fashion without catering to the individual, resulting in a lack of understanding of the mechanisms of various VR approaches. In future, much work needs to be done to solve these questions. The objective of this review is to investigate and validate the impact of VR on stroke patients while assessing the associated methodologies for determining its effectiveness. In particular, this review aims to offer a thorough evaluation of the advantages and drawbacks of employing VR in stroke rehabilitation.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"107-112"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral arteritis in bacterial meningitis: Structural adaptations of the vascular wall in response to an infectious nidus - A narrative review.","authors":"Vivig Shantha Kumar, Vignarth Shantha Kumar","doi":"10.4103/bc.bc_4_23","DOIUrl":"10.4103/bc.bc_4_23","url":null,"abstract":"<p><p>Despite dramatic improvements in diagnosis and antimicrobial treatment of bacterial meningitis over the last few decades, adverse postinfective sequelae and mortality remain exceedingly high in adults. Of note, the unfavorable clinical outcome is usually attributable to the presence of intracranial complications during the acute phase of infection, such as cerebral edema and increases in intracranial pressure and cerebral blood flow disturbances. Involvement of the cerebral vasculature during bacterial meningitis is overwhelmingly clear from clinical and laboratory evidence highlighting cerebral blood flow alterations with the use of Doppler blood flow analysis, angiographic studies of cerebral vessel wall structural irregularities and computed tomography/magnetic resonance imaging recording of cerebral infarctions. With the widespread agreement of cerebrovascular involvement in bacterial meningitis, very few studies have documented histopathological observations of cerebral vessel irregularities affecting the various layers of the vascular wall. In an attempt to understand the arterial wall changes that take place before the occurrence of cerebral ischemic consequences in bacterial meningitis, we have investigated the sequential changes affecting the arterial vasculature, beginning with early reflexive modifications of the adventitia and culminating in late proliferative lesions of the intima.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"97-106"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine treatment amid intravenous fluid shortages.","authors":"Wayne Zhong, Adeel Zubair","doi":"10.4103/bc.bc_6_25","DOIUrl":"10.4103/bc.bc_6_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"159-161"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant M1 segment aneurysm: Illustration of the importance of cross-sectional ratio of aneurysmal neck and the parent artery.","authors":"Soumen Kanjilal, Preetham S Dange, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Awadhesh Kumar Jaiswal","doi":"10.4103/bc.bc_85_24","DOIUrl":"10.4103/bc.bc_85_24","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"148-152"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis comparing AIDoc and RAPIDAI in the detection of large vessel occlusions.","authors":"Mary Bankston, Christopher Stevens, Muhammad Abubakar Ayub, Joshua Strobel, Octavio Arevalo, Hugo Cuellar, Himanshu Chokhawala","doi":"10.4103/bc.bc_5_25","DOIUrl":"10.4103/bc.bc_5_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"143-147"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}