{"title":"Vestibular rehabilitation in patients with stroke: A comprehensive review of past and current evidence.","authors":"Huimin Fan, Yuchuan Ding, Ahmed Elmadhoun, Ruchi Mangal, Jing Feng, Xiaokun Geng","doi":"10.4103/bc.bc_16_23","DOIUrl":"10.4103/bc.bc_16_23","url":null,"abstract":"<p><p>In 2016, the American Physical Therapy Association Neurology Section published clinical practice guidelines titled \"Vestibular Rehabilitation (VR) for Peripheral Vestibular Hypofunction.\" These guidelines recommend that physicians should provide VR to individuals with peripheral vestibular hypofunction, emphasizing its importance in managing dysfunctions of the vestibular system. Previous systematic reviews or studies on vestibular function have concluded that VR has positive effects on central vestibular disorders. More recently, a systematic review has found that there are positive effects of VR on ambulatory performance in stroke patients. Evidence is consistently being added regarding the positive impact of VR in patients with a history of stroke who are currently living with dizziness, balance, and gait impairments. However, there are still many unanswered questions in this area. Most studies lack complementary quantitative vestibular function testing and uniform standards for the timing and frequency of the VR. Furthermore, the methods of VR are carried out in a general fashion without catering to the individual, resulting in a lack of understanding of the mechanisms of various VR approaches. In future, much work needs to be done to solve these questions. The objective of this review is to investigate and validate the impact of VR on stroke patients while assessing the associated methodologies for determining its effectiveness. In particular, this review aims to offer a thorough evaluation of the advantages and drawbacks of employing VR in stroke rehabilitation.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"107-112"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain CirculationPub Date : 2025-05-31eCollection Date: 2025-04-01DOI: 10.4103/bc.bc_4_23
Vivig Shantha Kumar, Vignarth Shantha Kumar
{"title":"Cerebral arteritis in bacterial meningitis: Structural adaptations of the vascular wall in response to an infectious nidus - A narrative review.","authors":"Vivig Shantha Kumar, Vignarth Shantha Kumar","doi":"10.4103/bc.bc_4_23","DOIUrl":"10.4103/bc.bc_4_23","url":null,"abstract":"<p><p>Despite dramatic improvements in diagnosis and antimicrobial treatment of bacterial meningitis over the last few decades, adverse postinfective sequelae and mortality remain exceedingly high in adults. Of note, the unfavorable clinical outcome is usually attributable to the presence of intracranial complications during the acute phase of infection, such as cerebral edema and increases in intracranial pressure and cerebral blood flow disturbances. Involvement of the cerebral vasculature during bacterial meningitis is overwhelmingly clear from clinical and laboratory evidence highlighting cerebral blood flow alterations with the use of Doppler blood flow analysis, angiographic studies of cerebral vessel wall structural irregularities and computed tomography/magnetic resonance imaging recording of cerebral infarctions. With the widespread agreement of cerebrovascular involvement in bacterial meningitis, very few studies have documented histopathological observations of cerebral vessel irregularities affecting the various layers of the vascular wall. In an attempt to understand the arterial wall changes that take place before the occurrence of cerebral ischemic consequences in bacterial meningitis, we have investigated the sequential changes affecting the arterial vasculature, beginning with early reflexive modifications of the adventitia and culminating in late proliferative lesions of the intima.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"97-106"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain CirculationPub Date : 2025-05-31eCollection Date: 2025-04-01DOI: 10.4103/bc.bc_85_24
Soumen Kanjilal, Preetham S Dange, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Awadhesh Kumar Jaiswal
{"title":"Giant M1 segment aneurysm: Illustration of the importance of cross-sectional ratio of aneurysmal neck and the parent artery.","authors":"Soumen Kanjilal, Preetham S Dange, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Awadhesh Kumar Jaiswal","doi":"10.4103/bc.bc_85_24","DOIUrl":"10.4103/bc.bc_85_24","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"148-152"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain CirculationPub Date : 2025-05-31eCollection Date: 2025-04-01DOI: 10.4103/bc.bc_5_25
Mary Bankston, Christopher Stevens, Muhammad Abubakar Ayub, Joshua Strobel, Octavio Arevalo, Hugo Cuellar, Himanshu Chokhawala
{"title":"A retrospective analysis comparing AIDoc and RAPIDAI in the detection of large vessel occlusions.","authors":"Mary Bankston, Christopher Stevens, Muhammad Abubakar Ayub, Joshua Strobel, Octavio Arevalo, Hugo Cuellar, Himanshu Chokhawala","doi":"10.4103/bc.bc_5_25","DOIUrl":"10.4103/bc.bc_5_25","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"143-147"},"PeriodicalIF":2.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent treatment of motor deficits, cognitive deficits, and depression using transcranial direct current stimulation in a patient with stroke: A case study.","authors":"Sujita Kumar Kar, Rahul Prajapati, Babli Kumari, Priyanshi Chaudhary, Mohita Joshi","doi":"10.4103/bc.bc_73_24","DOIUrl":"10.4103/bc.bc_73_24","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"166-168"},"PeriodicalIF":2.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain CirculationPub Date : 2025-04-16eCollection Date: 2025-04-01DOI: 10.4103/bc.bc_72_24
Zikai Xu, Zhen Li, Ying Dong, Yao Chen, Ming Li, Baoying Song, Yang Zhang, Miaowen Jiang, Xuxiang Zhang
{"title":"The role of antioxidant therapy in modulating neuropathic pain: A systematic review of mechanistic insights and research trends (2003-2024).","authors":"Zikai Xu, Zhen Li, Ying Dong, Yao Chen, Ming Li, Baoying Song, Yang Zhang, Miaowen Jiang, Xuxiang Zhang","doi":"10.4103/bc.bc_72_24","DOIUrl":"10.4103/bc.bc_72_24","url":null,"abstract":"<p><p>This bibliometric analysis investigates the role of antioxidant therapy in addressing neuropathic pain, emphasizing mechanistic insights and research trends from 2003 to 2024. Neuropathic pain, often unresponsive to standard treatments, is closely associated with oxidative stress as a key factor in its pathophysiology. This study utilizes the Web of Science Core Collection to analyze 699 articles related to \"antioxidants\" and \"neuropathic pain.\" CiteSpace software was employed to examine publication trends, global collaborations, co-citation networks, and research hotspots. Results indicate a consistent rise in research activity, peaking in 2022, with China, India, and Italy as leading contributors. The University of Florence and Universidade Federal de Santa Maria emerged as prominent institutions, while influential authors included Pol Olga and Trevisan Gabriela. Key studies highlighted oxidative stress and neuropathic pain mechanisms, with neuroinflammation and specific molecular pathways gaining attention as emerging research foci. The findings underscore the growing interest in antioxidant therapies as potential interventions for neuropathic pain. Despite significant advances in understanding underlying mechanisms, there is a need for further exploration of novel antioxidants and their clinical applications. Enhanced international collaboration and the use of advanced molecular techniques are essential to drive future progress in this field.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"113-126"},"PeriodicalIF":2.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain CirculationPub Date : 2025-04-09eCollection Date: 2025-04-01DOI: 10.4103/bc.bc_132_24
Arevik Abramyan, Mena Samaan, Kaustav Chattopadhyay, Siddhant Kumarapuram, Srihari Sundararajan, Hai Sun, Emad Nourollah-Zadeh, Sudipta Roychowdhury, Gaurav Gupta
{"title":"Flow diversion for acutely ruptured intracranial aneurysms: A single-center retrospective analysis of 30 consecutive cases.","authors":"Arevik Abramyan, Mena Samaan, Kaustav Chattopadhyay, Siddhant Kumarapuram, Srihari Sundararajan, Hai Sun, Emad Nourollah-Zadeh, Sudipta Roychowdhury, Gaurav Gupta","doi":"10.4103/bc.bc_132_24","DOIUrl":"10.4103/bc.bc_132_24","url":null,"abstract":"<p><strong>Objectives: </strong>When presented with acutely ruptured aneurysms, neurosurgeons may elect to use flow diverters (FDs). However, with the limited evidence concerning their safety and the potential thromboembolic and hemorrhagic complications, their use is extremely infrequent and often quite limited. In this study, we evaluated treatment-related complications, as well as clinical and radiological outcomes, in patients treated with FD stents for acutely ruptured intracranial aneurysms.</p><p><strong>Materials and methods: </strong>We conducted a retrospective review of patients treated with FDs within 15 days postsubarachnoid hemorrhage from 2012 to 2024. Patient demographics, aneurysm characteristics, procedural specifics, along with clinical and imaging follow-ups were assessed.</p><p><strong>Results: </strong>The study included 30 patients with a mean age of 55.6 years. Most aneurysms were located within the anterior circulation and were either small or medium-sized. Morphologically, aneurysms were saccular (43.3%), blister-like (40%), and fusiform/dissecting (16.7%). The mean time from rupture onset to treatment was 4.4 days. FD release was successfully achieved in all cases. Posttreatment rebleeding occurred in 10% of patients, ischemic complications in 6.7%, and treatment-related mortality was 6.6%, with an overall mortality of 13.3%. At discharge, 70% of patients achieved a favorable functional outcome. The mean available radiological follow-up period was 26 months, with complete aneurysm occlusion observed in 57.1% of patients at 1 month and in 100% of those available (40%) for follow-up after 1 year.</p><p><strong>Conclusions: </strong>Flow diversion for acutely ruptured aneurysms demonstrates promising outcomes, although careful patient selection and alternative treatment consideration are essential. Future prospective, multicenter studies are needed to validate preliminary findings and optimize treatment protocols for this high-risk patient population.</p>","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"135-142"},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moyamoya disease in early infancy: Report of youngest Indian infant.","authors":"Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Vivek Gupta","doi":"10.4103/bc.bc_115_24","DOIUrl":"10.4103/bc.bc_115_24","url":null,"abstract":"","PeriodicalId":9288,"journal":{"name":"Brain Circulation","volume":"11 2","pages":"169-170"},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}