Association of baseline plasma fibrinogen levels with cognitive and affective status at 30 and 90 days in individuals with ischemic stroke: A prospective study from Nigeria.

IF 2.3 4区 医学 Q3 CLINICAL NEUROLOGY
Brain Circulation Pub Date : 2024-12-28 eCollection Date: 2024-10-01 DOI:10.4103/bc.bc_52_24
Adekola B Ademoyegun, Taofeek O Awotidebe, Marufat O Odetunde, Samuel O Inaolaji, Serifat O Bakare, Funmilola W Azeez, Olanrewaju Olayemi
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引用次数: 0

Abstract

Background: The influence of fibrinogen as a risk factor in developing poststroke neuropsychological and cognitive problems is underreported. This study aimed to evaluate the relationship between baseline fibrinogen levels and depression, anxiety, and cognition 30- and 90-day after stroke.

Methods: This prospective study involved 48 patients with first-ever mild-to-moderate ischemic stroke, whose plasma fibrinogen levels were assessed within 24 h of stroke onset. Clinical depression, anxiety, and cognitive impairment were evaluated by the Hospital Anxiety and Depression Scale and Montreal Cognitive Assessment at 30- and 90-day after stroke.

Results: After adjusting for important covariates, the multiple linear regression models showed that baseline plasma fibrinogen was associated with the symptoms of depression, anxiety, and cognitive decline at both 30- and 90-day follow-up (P < 0.05). The receiver operating characteristic curve showed that baseline fibrinogen threshold > 409.0 mg/dl (82.4% sensitivity and 71.0% specificity), >405.0 mg/dl (80.0% sensitivity and 71.4% specificity), and > 400.0 mg/dl (80.6% sensitivity and 76.5% specificity) could respectively predict the presence of depression, anxiety, and cognitive impairment 90 days after stroke.

Conclusions: High levels of baseline plasma fibrinogen are associated with the onset and severity of symptoms of depression, anxiety, and cognitive decline at 30 and 90 days after stroke. This study shows that fibrinogen may be a viable target for monitoring and intervention in the management of poststroke neuropsychological and cognitive disorders. Future clinical trials are needed to clarify whether defibrinogenation will prevent or reduce the rate and severity of symptoms of depression, anxiety, and cognitive decline among patients with ischemic stroke.

Trial registration: Pan African Clinical Trial Registry (registration number: PACTR202406755848901).

基线血浆纤维蛋白原水平与缺血性卒中患者30天和90天认知和情感状态的关系:尼日利亚的一项前瞻性研究
背景:纤维蛋白原作为卒中后神经心理和认知问题的危险因素的影响被低估。本研究旨在评估基线纤维蛋白原水平与中风后30天和90天的抑郁、焦虑和认知之间的关系。方法:这项前瞻性研究纳入48例首次轻度至中度缺血性卒中患者,在卒中发作24小时内评估其血浆纤维蛋白原水平。临床抑郁、焦虑和认知障碍在卒中后30天和90天通过医院焦虑和抑郁量表和蒙特利尔认知评估进行评估。结果:在调整重要协变量后,多元线性回归模型显示,基线血浆纤维蛋白原与30天和90天随访时抑郁、焦虑和认知能力下降的症状相关(P < 0.05)。受试者工作特征曲线显示,基线纤维蛋白原阈值> 409.0 mg/dl(敏感性82.4%,特异性71.0%)、>405.0 mg/dl(敏感性80.0%,特异性71.4%)和> 400.0 mg/dl(敏感性80.6%,特异性76.5%)可分别预测卒中后90天是否存在抑郁、焦虑和认知障碍。结论:高水平的基线血浆纤维蛋白原与卒中后30和90天抑郁、焦虑和认知能力下降症状的发生和严重程度有关。本研究表明,纤维蛋白原可能是监测和干预脑卒中后神经心理和认知障碍管理的可行目标。未来的临床试验需要明确去纤维蛋白原化是否会预防或降低缺血性卒中患者抑郁、焦虑和认知能力下降症状的发生率和严重程度。试验注册:Pan African Clinical Trial Registry(注册号:PACTR202406755848901)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain Circulation
Brain Circulation Multiple-
自引率
5.30%
发文量
31
审稿时长
16 weeks
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