BMC Microbiology最新文献

{"title":"Esketamine alleviates depressive-like behavior in mice via modulation of the microbiota-gut-brain axis and amino acid metabolism.","authors":"Xue Gong, ZengYan Lai, Lei Li, Li Fan, Yikun Ren, Qi Zhong, Qiang Mao","doi":"10.1186/s12866-025-04181-3","DOIUrl":"10.1186/s12866-025-04181-3","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"570"},"PeriodicalIF":4.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and comparative evaluation of LAMP, nested PCR and Real-time PCR assays for detecting Fusarium tricinctum, a fungal pathogen of Zanthoxylum bungeanum.","authors":"Yuqing Dong, Jing Song, Shuying Li, Jiasui Zhan, Tianhui Zhu","doi":"10.1186/s12866-025-04295-8","DOIUrl":"https://doi.org/10.1186/s12866-025-04295-8","url":null,"abstract":"<p><strong>Background: </strong>Zanthoxylum bungeanum is a highly valuable economic tree species in China, widely cultivated for its aromatic peel, medicinal properties, and industrial applications. In recent years, Fusarium tricinctum, a pathogen causing gummosis in Z. bungeanum, has severely impacted production in Sichuan and Gansu provinces. Early detection of this pathogen is challenging due to its prolonged incubation period and nonspecific symptoms, which often lead to significant crop losses and secondary infections by insects. Traditional methods of morphological identification are time-consuming and lack accuracy, necessitating the development of rapid molecular diagnostic tools.</p><p><strong>Results: </strong>In this study, we screened potential target sequences from F. tricinctum and developed three rapid detection methods-loop-mediated isothermal amplification (LAMP), nested PCR, and real-time fluorescent quantitative PCR (qPCR) based on the CYP51C gene. All three methods demonstrated high specificity and effectiveness for early diagnosis of gummosis in Z. bungeanum. qPCR exhibited the highest sensitivity, detecting DNA concentrations as low as 3.1 fg/µL, which was tenfold more sensitive than LAMP and nested PCR. Additionally, qPCR enabled absolute quantification of the pathogen. Nested PCR showed exceptional stability and reliability, while LAMP provided rapid, cost-effective, and visually interpretable results, making it ideal for field applications.</p><p><strong>Conclusions: </strong>These findings demonstrate the potential of molecular techniques to overcome traditional diagnostic limitations, providing practical solutions for early pathogen detection and sustainable disease management in Z. bungeanum. Among the methods, LAMP is optimal for field applications due to its simplicity, speed, and visual interpretation.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"568"},"PeriodicalIF":4.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomics and metabolomics to evaluate the potential role of gut microbiota and blood metabolites in patients with cerebral infarction.","authors":"Wei Huang, Yinghui Chai, Xiang Li, Qiuyue Zhang, Zengkui Yan, Yan Wang, Xiaoyong Tao, Jiatang Zhang, Feng Qiu","doi":"10.1186/s12866-025-04259-y","DOIUrl":"https://doi.org/10.1186/s12866-025-04259-y","url":null,"abstract":"<p><p>Cerebral infarction, a cerebrovascular disorder, is characterized by the sudden onset of neurological deficits and clinical symptoms. It ranks among the leading causes of death and severe disability worldwide. The etiology of cerebral infarction is multifaceted, with common risk factors including dietary patterns, smoking, hypertension, and diabetes mellitus. In recent years, the role of the gut microbiota in systemic immunity and tumorigenesis has been intensively explored, thrusting the research on the gut-brain axis into the spotlight. However, there is a lack of literature investigating the relationship between the gut microbiota and blood metabolites in cerebral infarction. In this study, we employed 16S rRNA analysis and ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) for a comprehensive metagenomic and metabolomic analysis of fecal samples from cerebral infarction patients and the general population. Our results revealed a significant correlation between the gut microbiome and serum metabolites, highlighting the impact of the microbiome on metabolic pathways. Specifically, we found that 35 gut microbiome taxa, such as Actinobacteriota and Peptostreptococcales-Tissierellales, were significantly enriched in the control group (N group). Through Linear Discriminant Analysis Effect Size (LEfSe) analysis, 72 taxa showed significant differences between cerebral infarction patients and healthy individuals. Among them, 22 key taxa were identified as microbial biomarkers for differentiating patients from healthy controls. These findings suggest that variations in the microbiome and metabolites could potentially serve as biomarkers for future diagnostic and therapeutic strategies in cerebral infarction.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"567"},"PeriodicalIF":4.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of P38 lipoprotein in Mycoplasma penetrans adhesion to human urothelial cells.","authors":"Kaihua Zhang, Weilu Zou, Yanming Chen","doi":"10.1186/s12866-025-04215-w","DOIUrl":"https://doi.org/10.1186/s12866-025-04215-w","url":null,"abstract":"<p><p>Mycoplasma penetrans, a bacterium detected in individuals seropositive for HIV and phylogenetically clustered with M. muris, may contribute to the progression of Acquired Immune Deficiency Syndrome (AIDS). Cellular adhesion is essential for Mycoplasma infection of host cells. M. penetrans exhibits the capacity to adhere to and invade human cells, precipitating diseases of the genital and urinary tracts. However, the proteinaceous mediators of its adhesion remain largely elusive. The P35 family lipoprotein, encoded by the mpl gene, is a prominent surface lipoprotein of M. penetrans. Here, we investigated the role of P38, a member of the P35 family, in the adhesion of M. penetrans to human urothelial cells (SV-HUC-1). We expressed and purified recombinant P38 (rP38) and confirmed its localization using Western blot. Adhesion assays, adhesion inhibition assays, and adhesion competition assays were performed to evaluate the adhesive properties of rP38 and M. penetrans. Our findings indicated that P38 localizes to the cell membrane of M. penetrans. Both rP38 and M. penetrans adhered to SV-HUC-1 cells, with optimal adhesion observed at 60 μg/mL for rP38 and 1 × 10⁷ CCU (Colony-Changing Units)/mL for M. penetrans. Anti-rP38 serum partially inhibited M. penetrans adhesion to SV-HUC-1 cells, and rP38 competed with M. penetrans for binding to SV-HUC-1 cells. These results suggest that P38 may function as an adhesin of M. penetrans, providing insights into its pathogenic mechanisms.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"566"},"PeriodicalIF":4.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and antimicrobial susceptibility of E. coli O157:H7 in the milk supply chain, milking environments and humans in Woliata Sodo, Ethiopia.","authors":"Seblewengel Ayichew, Ashagrie Zewdu, Bekele Megersa, Teshale Sori, Fanta D Gutema","doi":"10.1186/s12866-025-04289-6","DOIUrl":"https://doi.org/10.1186/s12866-025-04289-6","url":null,"abstract":"<p><strong>Background: </strong>Escherichia coli O157:H7 is a strain that produces Shiga toxin, which can cause infections ranging from mild to severe in humans. Cattle are a primary reservoir for the bacteria, and the contaminated milk and milk products can transmit these bacteria to humans, posing a risk of infection. The present study aimed to evaluate the occurrence of E. coli O157:H7 and determine its antimicrobial susceptibility profile across the milk supply chain, milking environments, and humans in Woliata Sodo, Southern Ethiopia.</p><p><strong>Methodology: </strong>A total of 644 samples, including raw milk, hand swabs, teat swabs, equipment swabs, floor swabs, and human stool, were collected through a cross sectional study. Bacterial detection was performed according to the ISO 16,654 standard method, and the antimicrobial susceptibility of the isolates was evaluated using the Kirby-Bauer disk diffusion method against 14 antimicrobials representing ten different classes.</p><p><strong>Results: </strong>The overall detection rate of E. coli O157:H7 was 3.1% (20/644). The highest detection rate was observed in milk samples collected at milk collecting centers, at 10% (5/50). In comparison, detection rates were 6.8% (4/59) in samples from milkers' hands, 5.4% (2/37) in farm floor swabs, and 2.9% among outpatients presenting with diarrhea. All the isolates showed resistance to doxycycline, erythromycin, tetracycline, clindamycin, and vancomycin. Additionally, 95%, 90%, and 90% of isolates were resistant to amoxicillin, ampicillin, and streptomycin, respectively. Resistance was lower for ceftriaxone (20%) and chloramphenicol (15%). A significant proportion (100%) of the isolates exhibited multidrug resistance.</p><p><strong>Conclusion: </strong>This study confirmed the presence of multidrug resistant E. coli O157:H7 in the tested sample. Notably, the highest prevalence was detected in milk samples from collection centers, underscoring post harvest contamination as a critical point of intervention. Identification of the pathogen on milkers' hands, farm floors, and human stool samples highlights potential transmission pathways and suggests a tangible risk of foodborne infections. These findings emphasize the critical need for targeted public health strategies, including comprehensive education on hygienic practices and the implementation of effective contamination control measures, to reduce the risk of infection and protect consumer health.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"565"},"PeriodicalIF":4.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic farming significantly improves microbial community structure, network complexity, and functional diversity in the Gannan navel orange orchard.","authors":"Lianlian Liu, Muhammad Atif Muneer, Yanting Zhong, Boyi He, Xuexian Li","doi":"10.1186/s12866-025-04271-2","DOIUrl":"https://doi.org/10.1186/s12866-025-04271-2","url":null,"abstract":"<p><strong>Background: </strong>In recent years, improper agricultural management practices have led to the loss of biodiversity and poor fruit quality in orchards. Converting conventional farming to organic farming is an environmentally responsible approach to improving sustainable fruit production. However, questions remain regarding how the microbial community responds to different farming practices in citrus trees. Specifically, this study aims to investigate how organic and conventional farming affect the microbial community structure and functional diversity in the Gannan navel orange orchard using 16S rRNA gene sequencing and Biolog Eco-Plate analysis.</p><p><strong>Results: </strong>The results showed that the soil bacterial diversity (α-diversity index) under organic farming was higher than that under conventional farming. Actinobacteria, Bacteroidetes, and Firmicutes were more abundant in root and fruit compartments under organic farming, indicating that organic farming promotes the enrichment of copiotrophic bacteria (r-strategists). Furthermore, organic farming resulted in a considerable increase in the relative abundance of Burkholderia and Streptomyces in root tissues. Interestingly, organic farming exhibited a more complex bacterial network. Biolog analysis further revealed higher functional diversity of the soil microbial community under organic farming when compared with that under conventional farming.</p><p><strong>Conclusions: </strong>These findings provide evidence that organic farming improves the bacterial community structure and promotes microbial functional diversity in the citrus orchards, contributing to the overall health and production of the citrus crop. Synthetic microbial communities of the organic citrus orchards hold great promise for more efficient environment-friendly orchard management towards sustainable agriculture.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"561"},"PeriodicalIF":4.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillus cereus-derived α-amylase disrupts biofilm formation and quorum sensing in multidrug-resistant Klebsiella pneumoniae.","authors":"Abd-El-Rahman A Mustafa, Amal M Abo-Kamer, Lamiaa A Al-Madboly","doi":"10.1186/s12866-025-04301-z","DOIUrl":"https://doi.org/10.1186/s12866-025-04301-z","url":null,"abstract":"<p><strong>Background and objectives: </strong>Klebsiella pneumoniae is a multidrug-resistant pathogen implicated in severe community- and hospital-acquired infections such as bacteremia, urinary tract infections, sepsis, and pneumonia. Biofilm formation, driven by extracellular polymeric substances (EPS), enhances its persistence and resistance to antibiotics. This study evaluated the anti-biofilm, antibacterial, and quorum-quenching activities of a novel α-amylase B. cereus-derived α-amylase against clinical isolates of K. pneumoniae.</p><p><strong>Methods: </strong>The anti-biofilm activity of the enzyme was assessed via minimum biofilm inhibitory concentration (MBIC) and minimum biofilm eradication concentration (MBEC) assays. Biofilm architecture and viability were analyzed using confocal laser scanning microscopy (CLSM) with live/dead staining. Antibacterial efficacy was determined through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. Quorum-quenching effects were evaluated using qRT-PCR to assess the expression of biofilm-associated genes (fimH and mrkD), normalized to rpoB.</p><p><strong>Results: </strong>B. cereus-derived α-amylase exhibited MBIC and MBEC values of 64 µg/ml and 128 µg/ml, respectively; MIC and MBC ranged from 32 to 128 µg/ml. The B. cereus-derived α-amylase enzyme inhibited biofilm formation by approximately 79% ± 0.69, compared to 58% ± 2.06 by commercial α-amylase. Biofilm thickness was reduced from 179 μm to ~ 39 μm and ~ 73 μm following treatment with B. cereus-derived and commercial α-amylase, respectively. Live/dead ratios shifted significantly from 97/3% (untreated) to ~ 54/46% and 73/27% after treatment with B. cereus-derived and commercial α-amylase enzymes, respectively. Quorum-sensing gene expression was markedly downregulated following treatment with ½ MIC of B. cereus-derived α-amylase: fimH to 0.247 ± 0.045 (75.3% reduction) and mrkD to 0.187 ± 0.035 (81.3% reduction).</p><p><strong>Conclusion: </strong>B. cereus-derived α-amylase exhibited potent anti-biofilm, antibacterial, and quorum-quenching activities against K. pneumoniae clinical isolates. These findings highlight its potential as a novel therapeutic agent for managing biofilm-associated infections, either alone or as an adjunct to conventional treatments.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"563"},"PeriodicalIF":4.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three bacterial strains efficiently reduce selenite to selenium nanoparticles in cell membranes.","authors":"Ruixia Li, Wenqiang Chen, Siyuan Huang, Daihua Jiang, Zhengjie Zhu, Chong Li, Xuejiao Huang","doi":"10.1186/s12866-025-04304-w","DOIUrl":"https://doi.org/10.1186/s12866-025-04304-w","url":null,"abstract":"<p><p>Microbial synthesis of selenium nanoparticles (SeNPs) as a fertilizer can promote the development of selenium-rich agricultural products. However, most known selenium-reduction strains exhibit a tolerance to selenite of ≤ 100 mmol/L and possess relatively low reduction efficiency. In this study, three strains capable of tolerating selenite concentrations of > 300 mmol/L were screened from selenium-rich soil in Bama, Guangxi, China. Based on 16 S rRNA gene sequence analysis, the three strains were identified as Citrobacter sp.BM-1, Providencia sp.BM-2, and Brucella sp.BM-3. Notably, Brucella sp.BM-3 represents a novel selenium-reducing bacteria. All three strains reduced SeO₃^2- to SeNPs on the cell membrane and subsequently released these nanoparticles outside the cells, forming spherical SeNPs with a particle size of 210-221 nm. Furthermore, qPCR analysis revealed that the selenium-reduction mechanisms in these strains primarily involve the glutathione pathway, which is catalyzed by nitrate reductase and sulfate reductase. These findings suggest that Citrobacter sp.BM-1, Providencia sp.BM-2, and Brucella sp.BM-3 are promising candidates for the synthesis of SeNPs.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"564"},"PeriodicalIF":4.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of bisphenol A on root traits and rhizosphere bacteria: exploring the link between rhizosphere bacterial and root growth.","authors":"Manli Yang, Shanningmei Zuo, Ahui Liu, Nana Zhong, Xueping Lu, Xun Liu, Xiasen Jiang, Tao Hu, Yuntong Liu, Xiaogang Ren, Kang Zhou, Chuansheng Wu","doi":"10.1186/s12866-025-04306-8","DOIUrl":"https://doi.org/10.1186/s12866-025-04306-8","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA), a widespread environmental pollutant, has been extensively studied for its effects on bacteria and plant, but its impact on rhizosphere bacterial communities and plant root traits is less understood. At the same time, the role of bacteria in helping plants resist adversity is widely recognized, but the relationship between BPA-induced with rhizosphere bacterial changes and root development is still unclear. Therefore, this study investigated the effects of varying BPA concentrations (1.5, 17.2, and 50 mg/L) on soybean root traits and rhizosphere bacterial communities, as well as the relationship between them.</p><p><strong>Result: </strong>The results revealed that BPA exposure significantly altered root traits, with root length, surface area, volume, and tip numbers being suppressed at 50 mg/L, while lower concentrations (1.5 and 17.2 mg/L) promoted root elongation and thickening. Bacterial community composition shifted notably, with Bacillota increasing and Pseudomonadota decreasing in relative abundance across all BPA treatments. Alpha diversity, measured by richness and Shannon_e indices, increased slightly at lower BPA concentrations, while beta diversity (Bray_Curtis and UniFrac) analysis showed significant differences, particularly at 50 mg/L. Community assembly processes (βNRI and βNTI) were dominated by deterministic mechanisms at lower BPA concentrations but shifted toward stochastic processes at 50 mg/L. Correlation analysis revealed significant relationships between bacterial community dynamics and root traits (Principal component PC1 and PC2), with alpha diversity indices influencing root traits represented by PC2 and beta diversity indices showing a negative correlation with PC1.</p><p><strong>Conclusions: </strong>BPA exposure not only alters root morphology and bacterial community structure but also highlights the intricate interplay between rhizosphere bacteria and plant roots under BPA stress. This study contributes to the theoretical understanding of plant-microbe interactions in contaminated environments and may inform future research on microbial involvement in plant stress responses.</p>","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"560"},"PeriodicalIF":4.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, culture, and in vitro functional validation of intratumor bacteria from lung cancer patients.","authors":"Yifan Sun, Jianghui Tong, Yafang Tan, Yuejiao Liu, Dong Li, Huan Yu, Yuling He, Jianjie Li, Bo Jia, Hongchao Xiong, Yujia Chi, Ruifu Yang, Ziping Wang, Yujing Bi","doi":"10.1186/s12866-025-04237-4","DOIUrl":"https://doi.org/10.1186/s12866-025-04237-4","url":null,"abstract":"","PeriodicalId":9233,"journal":{"name":"BMC Microbiology","volume":"25 1","pages":"558"},"PeriodicalIF":4.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}