Bioscience, Biotechnology, and Biochemistry最新文献_第8页

Chemical and biological dynamics of natural pterins. 天然翼素的化学和生物动力学。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag094

Yuki Doi

引用次数: 0

Effect of Aronia melanocarpa extracts on allergic responses in mast cells. 黑桫椤提取物对肥大细胞过敏反应的影响。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag086

Ganbayar Ganbold, Anuu Zorig, Mika Suzuki, Shiman Qiu, Terigele Khereid, Mikako Takasugi, Hirofumi Arai

{"title":"Effect of Aronia melanocarpa extracts on allergic responses in mast cells.","authors":"Ganbayar Ganbold, Anuu Zorig, Mika Suzuki, Shiman Qiu, Terigele Khereid, Mikako Takasugi, Hirofumi Arai","doi":"10.1093/bbb/zbag086","DOIUrl":"10.1093/bbb/zbag086","url":null,"abstract":"Type I allergies, such as hay fever, are triggered when allergens cross-link IgE bound to the high-affinity IgE receptor on mast cells, leading to Ca2+ influx and the release of chemical mediators. Because conventional antiallergic drugs may cause adverse effects, natural food-derived bioactive compounds have attracted attention as safer alternatives for alleviating allergic symptoms. In this study, the antiallergic effects of Aronia melanocarpa (black chokeberry) fruit extract and its chromatographic fractions were evaluated using cultured mast cell lines. The 80% methanol-eluted fraction, rich in antioxidative polyphenols, significantly inhibited the release of histamine, β-hexosaminidase, and leukotriene B4 from stimulated cells. This effect was associated with reduced Ca2+ influx and decreased phosphorylation of spleen tyrosine kinase in the cell signaling pathway. Quercetin, identified as a major polyphenol in the active fraction, also suppressed chemical mediator release, suggesting that A. melanocarpa fruit may alleviate type I allergic responses by modulating mast cell activation.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1197-1208"},"PeriodicalIF":1.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of melanocortin-4 receptor (mc4r) genome editing on taste and odor components of red sea bream Pagrus major. 黑素皮质素-4受体（mc4r）基因组编辑对红鲷味觉和气味成分的影响

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag080

Hisako Fujiwara, Qiqi Wang, Tomoya Yoshino, Kasumi Kawanishi, Akane Matsumoto, Ayumi Furuta, Ryota Mabuchi, Youhei Washio, Keitaro Kato, Masato Kinoshita, Shota Tanimoto

{"title":"Influence of melanocortin-4 receptor (mc4r) genome editing on taste and odor components of red sea bream Pagrus major.","authors":"Hisako Fujiwara, Qiqi Wang, Tomoya Yoshino, Kasumi Kawanishi, Akane Matsumoto, Ayumi Furuta, Ryota Mabuchi, Youhei Washio, Keitaro Kato, Masato Kinoshita, Shota Tanimoto","doi":"10.1093/bbb/zbag080","DOIUrl":"10.1093/bbb/zbag080","url":null,"abstract":"To investigate the influence of genome editing on the taste and odor of fish meat, we conducted a comparative analysis of taste components, odor components, and lipid oxidation index in the dorsal muscle of mc4r-deficient red sea bream compared to the unedited control. In terms of taste components, only some free amino acids were significantly different in the mc4r-deficient group compared with the unedited control group. Differences were also noted in nonprotein nitrogen, equivalent umami concentration, and some taste-active value between the mc4r-deficient and unedited control groups. Regarding odor components, some volatile organic compounds were significantly different in the mc4r-deficient group. However, no differences were observed in other taste and odor components or the lipid oxidation index between these groups. These findings suggest that the effect of mc4r deficiency on taste and odor-related components and lipid oxidation in red sea bream muscle is minor.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1187-1196"},"PeriodicalIF":1.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TORC1 inactivation induces a noncanonical, separase-independent cohesin degradation. TORC1失活诱导非典型的、独立于分离的内聚蛋白降解。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag087

Chihiro Yamada, Honoka Goto, Ayana Futaguchi, Kohana Maeshima, Maho Morikawa, Kozo Tanaka, Takashi Ushimaru

引用次数: 0

Disease-specific gut microbial signatures generate model-derived cancer probability scores through targeted fecal qPCR profiling. 疾病特异性肠道微生物特征通过靶向粪便qPCR分析产生模型衍生的癌症概率评分。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag090

Tadashi Fujii, Eizaburo Ohno, Naoko Nakano, Kazunori Nakaoka, Hideaki Takahashi, Kohei Funasaka, Yohei Doi, Yoshiki Hirooka, Takumi Tochio

{"title":"Disease-specific gut microbial signatures generate model-derived cancer probability scores through targeted fecal qPCR profiling.","authors":"Tadashi Fujii, Eizaburo Ohno, Naoko Nakano, Kazunori Nakaoka, Hideaki Takahashi, Kohei Funasaka, Yohei Doi, Yoshiki Hirooka, Takumi Tochio","doi":"10.1093/bbb/zbag090","DOIUrl":"10.1093/bbb/zbag090","url":null,"abstract":"The gut microbiome is a potential source of noninvasive cancer biomarkers. We evaluated six fecal microbial markers and developed targeted quantitative PCR (qPCR)-based logistic models for colorectal cancer (CRC) and pancreatic cancer (PC). Using LASSO with the 1-standard-error rule, four markers were selected for CRC (afb, nan, fsr, and 5ar) and three for PC (but, fsr, and saa). In postselection leave-one-out cross-validation of fixed model structures, the CRC and PC models yielded area under the curve (AUCs) of 0.824 and 0.780, respectively. Fixed-model application yielded AUCs of 0.716 for colorectal adenoma and 0.540 for the pancreatic high-risk group. In an exploratory early PC versus high-risk comparison, the fecal qPCR score yielded an AUC of 0.739, compared with 0.543 for CA19-9, although the difference was not statistically significant. Overall, the disease-specific model performance and fixed-model behavior across clinically related groups support further evaluation of model-derived cancer probability scores as exploratory cancer-assessment tools.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1273-1282"},"PeriodicalIF":1.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary metabolites associated with exosome-like nanovesicles from green tea (Camellia sinensis) infusion and the origin of these nanovesicles. 绿茶（Camellia sinensis）输注中与外泌体样纳米囊泡相关的次生代谢物及其起源

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag083

Manami Monobe, Kaori Ema, Hideki Horie

引用次数: 0

Physicochemical and functional properties of albumin fractions from barley and rye seed protein isolate. 大麦和黑麦种子分离蛋白白蛋白组分的理化性质和功能特性。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag089

Kazumi Ninomiya, Miho Otsuka, Norikazu Ogino, Yutaka Aoyama, Yusuke Yamaguchi, Hitomi Kumagai, Hitoshi Kumagai, Yusuke Inoue

{"title":"Physicochemical and functional properties of albumin fractions from barley and rye seed protein isolate.","authors":"Kazumi Ninomiya, Miho Otsuka, Norikazu Ogino, Yutaka Aoyama, Yusuke Yamaguchi, Hitomi Kumagai, Hitoshi Kumagai, Yusuke Inoue","doi":"10.1093/bbb/zbag089","DOIUrl":"10.1093/bbb/zbag089","url":null,"abstract":"Barley and rye are major cereals worldwide and contain proteinaceous α-amylase inhibitors for biological defence against insects. Inhibiting mammalian α-amylase could potentially be a promising functional food characteristic for suppressing postprandial blood glucose levels. This study examined in vitro mammalian α-amylase inhibitory effects and the physicochemical and functional properties of barley and rye albumins, including thermal stability, solubility, emulsifying, and foaming properties, to evaluate their potential applications in various foods. Both barley and rye albumins inhibited mammalian α-amylase and maintained their activity even after heating. High solubility was observed at pH 3.0-6.0, which was maintained after heating at 80 °C for 20 min. Furthermore, barley and rye albumins exhibited high emulsifying and foaming properties at pH 3.0-6.0. These findings suggest that barley and rye albumins are promising materials for suppressing postprandial blood glucose elevation and can be used in various functional foods.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1218-1227"},"PeriodicalIF":1.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms underlying glucose-induced increase in β-glucosidase activity in Bacillus subtilis strains 168 and Miyagino and sugar-independent activation by soybean broth medium. 葡萄糖诱导枯草芽孢杆菌菌株168和Miyagino β-葡萄糖苷酶活性升高的机制以及大豆肉汤培养基对糖的非依赖性激活。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag088

Shyuichiro Inagaki

引用次数: 0

Anti-inflammatory effect of Curcuma zedoaria ethanol extract on high-fat diet-induced obesity in mice. 莪术乙醇提取物对小鼠高脂饮食性肥胖的抗炎作用。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag093

Kazuaki Yamasaki, Isoko Kuriyama

引用次数: 0

β-catenin does not co-activate vitamin D receptor-mediated transcription in osteoblastic and nonosteoblastic cells. β-连环蛋白不能共同激活成骨细胞和非成骨细胞中维生素D受体介导的转录。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag084

Tram Thi-Ngoc Nguyen, Yoshiaki Kanemoto, Takahiro Sawada, Jingyun Zhang, Tomohiro Kurokawa, Shigeaki Kato

引用次数: 0