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Screening of novel lactic acid bacteria with high induction of IgA production, dendritic cell activation, and IL-12 production. 具有高诱导IgA生成、树突状细胞激活和IL-12生成的新型乳酸菌的筛选。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-13 DOI: 10.1093/bbb/zbae196
Keigo Tsuruno, Takashi Mawatari, Yukimasa Tanaka-Azuma, Atsushi Yamatsu, Soichi Tanabe
{"title":"Screening of novel lactic acid bacteria with high induction of IgA production, dendritic cell activation, and IL-12 production.","authors":"Keigo Tsuruno, Takashi Mawatari, Yukimasa Tanaka-Azuma, Atsushi Yamatsu, Soichi Tanabe","doi":"10.1093/bbb/zbae196","DOIUrl":"https://doi.org/10.1093/bbb/zbae196","url":null,"abstract":"<p><p>In this study, we screened 308 lactic acid bacteria strains for high immunoglobulin A (IgA) production, dendritic cell activation, and IL-12 production using human derived cells. Among them, Lactobacillus helveticus GCL1815 demonstrated superior performance in all aspects, indicating its remarkable potential for immunomodulatory functions in both innate and adaptive immunity.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Bacillus subtilis genome vector system that can transmit synthesized genomes. 可传播合成基因组的枯草芽孢杆菌基因组载体系统的研制。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-11 DOI: 10.1093/bbb/zbae194
Mitsuhiro Itaya
{"title":"Development of a Bacillus subtilis genome vector system that can transmit synthesized genomes.","authors":"Mitsuhiro Itaya","doi":"10.1093/bbb/zbae194","DOIUrl":"https://doi.org/10.1093/bbb/zbae194","url":null,"abstract":"<p><p>Cloning of small DNA segments has been established using Escherichia coli plasmids. The cloned DNA can be transferred to various cells using transformation. In contrast, cloning of large DNA segments of more than several hundred kilobase pairs has been limited to the Bacillus subtilis genome cloning system. The advantage of giant DNA cloned by B. subtilis is that all kinds of gene editing can be implemented by the high and strict natural transformation ability of the host. However, the following transfer step of giant synthesized and edited genomes to different cell systems require a special system by avoiding exposure in liquid. The use of a conjugational plasmid pLS20 that was developed for 20 years improves the B. subtilis genome vector establishment process from scratch. The use of the unique B. subtilis genome vector system from synthesis to transmit genomes is now being manipulated and summarized for the first time.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adapting Caenorhabditis elegans to evaluating functional foods and ingredients for cholesterol absorption. 使秀丽隐杆线虫适应于评价功能食品和成分对胆固醇的吸收。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-11 DOI: 10.1093/bbb/zbae193
Kanato Sakamoto, Tsuyoshi Kawano
{"title":"Adapting Caenorhabditis elegans to evaluating functional foods and ingredients for cholesterol absorption.","authors":"Kanato Sakamoto, Tsuyoshi Kawano","doi":"10.1093/bbb/zbae193","DOIUrl":"https://doi.org/10.1093/bbb/zbae193","url":null,"abstract":"<p><p>The nematode Caenorhabditis elegans is an excellent model organism for elucidating higher life phenomena. C. elegans and humans are common in many aspects. During our research on development and life span regulation, we identified RAB-18, a small GTPase involved in the membrane trafficking of NCR-1, a cholesterol transporter mainly expressed in the intestine. We expressed the human NPC1L1, an intestinal cholesterol transporter, in mutant C. elegans lacking NCR-1. NPC1L1-expressing animals revealed almost the same larval diapause in the presence of a diapause-inducing pheromone and lipid droplets containing cholesterol as in wild-type C. elegans. This result indicates that C. elegans NCR-1 and human NPC1L1 are exchangeable and that C. elegans RAB-18 transports human NPC1L1 to the apical membrane in the C. elegans intestine. This transgenic C. elegans could be adapted to evaluate functional foods and ingredients regarding cholesterol absorption.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secretory expression in Bacillus subtilis, purification and characterization of a persistent protein-degrading enzyme from Nocardiopsis sp. TOA-1. 枯草芽孢杆菌分泌表达、Nocardiopsis sp. TOA-1持久性蛋白降解酶的纯化和特性研究。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-10 DOI: 10.1093/bbb/zbae191
Aoto Takano, Mamiko Yano, Tomoka Nakamura, Kazufumi Takano, Shun-Ichi Tanaka
{"title":"Secretory expression in Bacillus subtilis, purification and characterization of a persistent protein-degrading enzyme from Nocardiopsis sp. TOA-1.","authors":"Aoto Takano, Mamiko Yano, Tomoka Nakamura, Kazufumi Takano, Shun-Ichi Tanaka","doi":"10.1093/bbb/zbae191","DOIUrl":"https://doi.org/10.1093/bbb/zbae191","url":null,"abstract":"<p><p>Keratinase from Nocardiopsis sp. TOA-1 (NAPase) holds significant potential for industrial and medical applications. Here, we developed a heterologous secretory expression system for NAPase in Bacillus subtilis. The recombinant enzyme exhibited catalytic properties comparable to the native enzyme, demonstrating its suitability for further protein engineering. This work provides a foundation for enhancing NAPase activity and stability, expediting its biotechnological applications.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic mechanisms underlying diverse panicle architecture in rice. 水稻穗型结构多样性的遗传机制。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-10 DOI: 10.1093/bbb/zbae189
Ayumi Agata
{"title":"Genetic mechanisms underlying diverse panicle architecture in rice.","authors":"Ayumi Agata","doi":"10.1093/bbb/zbae189","DOIUrl":"https://doi.org/10.1093/bbb/zbae189","url":null,"abstract":"<p><p>Rice panicle architecture exhibits remarkable diversity and is crucial in determining grain production. Recent advances in the understanding of the genetic mechanisms underlying panicle morphogenesis offer promising avenues for improving rice productivity. Here, I reviewed recent studies on the developmental regulatory genes responsible for panicle architecture and explored how these findings can be applied to crop breeding. I also discuss the potential of using wild Oryza genetic resources, highlighting their value not only for scientific exploration but also for breeding innovation. Isolating novel genes related to panicle development and understanding their function are essential for designing diverse panicle architectures by quantitative trait locus pyramiding or genome editing technology. The use of these genetic resources offers a sustainable means to improve rice plant architecture and their resilience to climate change.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiogenin-catalyzed cleavage within tRNA anticodon-loops identified by cP-RNA-seq. 通过cP-RNA-seq鉴定的tRNA反密码子环中血管生成素催化的切割。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-10 DOI: 10.1093/bbb/zbae192
Megumi Shigematsu, Ryuma Matsubara, Justin Gumas, Takuya Kawamura, Yohei Kirino
{"title":"Angiogenin-catalyzed cleavage within tRNA anticodon-loops identified by cP-RNA-seq.","authors":"Megumi Shigematsu, Ryuma Matsubara, Justin Gumas, Takuya Kawamura, Yohei Kirino","doi":"10.1093/bbb/zbae192","DOIUrl":"https://doi.org/10.1093/bbb/zbae192","url":null,"abstract":"<p><p>Angiogenin (Ang), an endoribonuclease belonging to the RNase A superfamily, cleaves the anticodon-loops of tRNAs to produce tRNA half molecules. Although previous studies have demonstrated the involvement of Ang in the pathobiology of neurodegenerative disorders, the characterization of Ang-generated tRNA halves in neuronal cells remains limited. This is partly due to the technical limitations of standard RNA-seq methods, which cannot capture Ang-generated RNAs containing a 2',3'-cyclic phosphate (cP). In this report, we established an Ang treatment model using SH-SY5Y, a human neuroblastoma cell line, and demonstrated Ang-dependent accumulation of tRNA halves. By performing cP-RNA-seq, which selectively captures cP-containing RNAs, we identified Ang-generated tRNA halves and the specific cleavage positions within tRNA anticodon-loops responsible for their generation. Our results provide insights into the anticodon-loop cleavage and the selective production of a specific subset of tRNA halves by Ang.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDZK1 gene transfer ameliorates lipopolysaccharide-induced cholestasis in rats by rescuing hepatic ABC transporters. PDZK1基因转移通过挽救肝ABC转运体改善脂多糖诱导的大鼠胆汁淤积。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-10 DOI: 10.1093/bbb/zbae190
Tao Wu, Ji Wu, Li Liu, Hongping Song
{"title":"PDZK1 gene transfer ameliorates lipopolysaccharide-induced cholestasis in rats by rescuing hepatic ABC transporters.","authors":"Tao Wu, Ji Wu, Li Liu, Hongping Song","doi":"10.1093/bbb/zbae190","DOIUrl":"https://doi.org/10.1093/bbb/zbae190","url":null,"abstract":"<p><p>Lipopolysaccharide (LPS) causes inflammatory cholestasis in sepsis. We investigated the role of PDZK1 in the repression of ABC transporters in LPS-induced cholestasis. Lentiviral gene transfer of PDZK1 to rats was conducted to explore its influence on cholestasis induced by LPS. And the effect of lentivirus-mediated shRNA targeting PDZK1 on ABC transporters in rat liver BRL-3A cells was evaluated. Lentiviral vector encoding rat PDZK1 was administered to rats by tail intravenous injection. Obviously elevated serum total bile acid (TBA) level and liver biochemical markers in cholestatic rats were decreased by the Lv-PDZK1 delivery. Also Lv-PDZK1 delivery stimulated the suppressed hepatic ABC transporters expression. In vitro, after the lentiviral vector LV3/PDZK1 shRNA transfection, no expression of PDZK1 and mild expression of ABC transporters were detected in BRL-3A cells by Western blotting. Our results indicate that the lentiviral-mediated hepatocyte PDZK1 expression ameliorates LPS-induced cholestasis in rats by rescuing hepatic ABC transporters expression.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nitrogen deficiency influences strigolactone levels in basal parts of shoots and shoot branching phenotype in Arabidopsis thaliana. 缺氮对拟南芥芽基部独角麦内酯水平和芽分枝表型的影响。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-09 DOI: 10.1093/bbb/zbae185
Riko Sakioka, Kaori Yoneyama
{"title":"Nitrogen deficiency influences strigolactone levels in basal parts of shoots and shoot branching phenotype in Arabidopsis thaliana.","authors":"Riko Sakioka, Kaori Yoneyama","doi":"10.1093/bbb/zbae185","DOIUrl":"https://doi.org/10.1093/bbb/zbae185","url":null,"abstract":"<p><p>Strigolactones (SLs) are allelochemicals attracting both symbiotic arbuscular mycorrhizal (AM) fungi and root parasitic plants and a novel class of phytohormones inhibiting lateral shoot branching. In general, nutrient deficiency significantly promotes SL production in roots and exudation into the rhizosphere, and also induces suppressed shoot branching phenotype in host plants of AM fungi including rice, tomato, maize, etc. Nutrient deficiencies also inhibit the shoot branching in Arabidopsis thaliana (hereafter Arabidopsis), a non-host of AM fungi, while the level of carlactone, a non-canonical SL and the SL precursor for the other SLs, was reported to be unaffected. Because Arabidopsis SLs including CL and methyl carlactonoate,, are highly unstable, relationships between SL levels and shoot branching in Arabidopsis remain elusive. Herein, we demonstrate that nitrogen deficiency increases SL levels in the basal part of shoots in Arabidopsis and lateral shoot branching appears to be strongly regulated by these SLs.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isomaltodextrin inhibits kidney enlargement induced by a high-protein diet through its metabolism by gut microbiota. 异麦芽糖糊精通过肠道菌群代谢抑制高蛋白饮食引起的肾肿大。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-06 DOI: 10.1093/bbb/zbae188
Ryodai Takagaki, Jun Takahashi, Shin Endo, Ryota Kujirai, Mizuki Abe, Koichi Kikuchi, Chitose Suzuki, Yotaro Matsumoto, Yoshihisa Tomioka, Takaaki Abe, Hidetoshi Morita
{"title":"Isomaltodextrin inhibits kidney enlargement induced by a high-protein diet through its metabolism by gut microbiota.","authors":"Ryodai Takagaki, Jun Takahashi, Shin Endo, Ryota Kujirai, Mizuki Abe, Koichi Kikuchi, Chitose Suzuki, Yotaro Matsumoto, Yoshihisa Tomioka, Takaaki Abe, Hidetoshi Morita","doi":"10.1093/bbb/zbae188","DOIUrl":"https://doi.org/10.1093/bbb/zbae188","url":null,"abstract":"<p><p>To evaluate the effects of the soluble fiber isomaltodextrin in a protein-biased diet, a 21-day protein diet trial was conducted in rats, with 60% of the calories derived from protein. The results revealed that the high-protein diet alone led to a significant increase in kidney weight. In contrast, the consumption of water with 5% isomaltodextrin dissolved in it, along with a high-protein diet, suppressed this weight gain. To elucidate this mechanism, an analysis of serum urea toxins confirmed that the concentrations of phenyl sulfate were significantly higher with high protein, and significantly lower with isomaltodextrin. The impact of a high-protein on increased phenol in cecal contents, an increased that was mitigated by the isomaltodextrin. This suggests that the inhibitory effect of isomaltodextrin on renal hypertrophy was due to the suppression of urea toxin precursor production by the gut microbiota.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new phthalide derivative from the mushroom Cyclocybe cf. erebia culture filtrate affects the phase of circadian rhythms in mouse fibroblasts. 一种来自蘑菇 Cyclocybe cf. erebia 培养滤液的新邻苯二甲酸酯衍生物会影响小鼠成纤维细胞的昼夜节律相位。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-05 DOI: 10.1093/bbb/zbae187
Yusei Kobayashi, Yuanyuan Lu, Nan Li, Naoki Endo, Kozue Sotome, Kotomi Ueno, Yu Tahara, Atsushi Ishihara
{"title":"A new phthalide derivative from the mushroom Cyclocybe cf. erebia culture filtrate affects the phase of circadian rhythms in mouse fibroblasts.","authors":"Yusei Kobayashi, Yuanyuan Lu, Nan Li, Naoki Endo, Kozue Sotome, Kotomi Ueno, Yu Tahara, Atsushi Ishihara","doi":"10.1093/bbb/zbae187","DOIUrl":"https://doi.org/10.1093/bbb/zbae187","url":null,"abstract":"<p><p>Circadian rhythms are biological systems that provide approximately 24-hour cycles for the behavior and physiological functions of organisms. As diverse modern lifestyles often cause disturbances in circadian rhythms, new approaches to their regulation are required. Therefore, new compounds that affect circadian rhythms have been explored in edible mushrooms. The extract from the culture filtrate of Cyclocybe cf. erebia showed activity that advanced the circadian rhythm in a bioassay with mouse fibroblasts expressing the LUCIFERASE protein under the control of the Period2 promoter. Bioassay-guided fractionation of the extract resulted in the isolation of the compound. Spectroscopic analyses identified the compound as a phthalide derivative, and the compound was named cyclocybelide. Treatment of mouse fibroblasts with the compound shifted the circadian rhythm forward, irrespective of the timing of treatment. In addition, some phthalide derivatives with hydroxy and methoxy groups showed similar effects on circadian rhythms.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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