Bioscience, Biotechnology, and Biochemistry最新文献_第8页

Microbial production of aromatic compounds and synthesis of high-performance bioplastics. 微生物生产芳香族化合物和合成高性能生物塑料。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-22 DOI: 10.1093/bbb/zbae111

Shunsuke Masuo

引用次数: 0

Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils. 枪叶桉提取物对α-突触核蛋白淀粉样纤维的抑制作用

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-22 DOI: 10.1093/bbb/zbae114

Masatomo So, Misaki Ono, Shigeki Oogai, Minako Kondo, Kaede Yamazaki, Charlotte Nachtegael, Hiroshi Hamajima, Risa Mutoh, Masaki Kato, Hisaya Kawate, Tomoyuki Oki, Yasushi Kawata, Shiho Kumamoto, Noritaka Tokui, Toshiki Takei, Kuniyoshi Shimizu, Akio Inoue, Naoki Yamamoto, Motoko Unoki, Kenichi Tanabe, Kinichi Nakashima, Hiroyuki Sasaki, Hironobu Hojo, Yasuo Nagata, Isao Suetake

{"title":"Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils.","authors":"Masatomo So, Misaki Ono, Shigeki Oogai, Minako Kondo, Kaede Yamazaki, Charlotte Nachtegael, Hiroshi Hamajima, Risa Mutoh, Masaki Kato, Hisaya Kawate, Tomoyuki Oki, Yasushi Kawata, Shiho Kumamoto, Noritaka Tokui, Toshiki Takei, Kuniyoshi Shimizu, Akio Inoue, Naoki Yamamoto, Motoko Unoki, Kenichi Tanabe, Kinichi Nakashima, Hiroyuki Sasaki, Hironobu Hojo, Yasuo Nagata, Isao Suetake","doi":"10.1093/bbb/zbae114","DOIUrl":"10.1093/bbb/zbae114","url":null,"abstract":"Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1289-1298"},"PeriodicalIF":1.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular modification of chlorogenic acid via radiolysis with inhibitory effects on NO production. 通过辐射分解对绿原酸进行分子修饰，从而抑制 NO 的产生。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-22 DOI: 10.1093/bbb/zbae123

Gyeong Han Jeong, Hanui Lee, Kyung-Bon Lee, Byung Yeoup Chung, Hyoung-Woo Bai

{"title":"Molecular modification of chlorogenic acid via radiolysis with inhibitory effects on NO production.","authors":"Gyeong Han Jeong, Hanui Lee, Kyung-Bon Lee, Byung Yeoup Chung, Hyoung-Woo Bai","doi":"10.1093/bbb/zbae123","DOIUrl":"10.1093/bbb/zbae123","url":null,"abstract":"The molecular modification of chlorogenic acid (1) through γ-irradiation resulted in the formation of five new products: chlorogenosins A (2), B (3), C (4), D (5), and E (6) along with known compounds rosmarinosin B (7), protocatechuic acid (8), and protocatechuic aldehyde (9). The structures of the new compounds were elucidated using spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectroscopy, and circular dichroism spectroscopy. The potential anti-inflammatory activities of all the isolated compounds were determined by evaluating their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide-induced RAW 264.7 macrophages. Notably, compounds 2 and 3, which contained two hydroxymethyl functionalities instead of the trans-olefinic moiety present in the original chlorogenic acid, exhibited stronger inhibitory effects on NO production than that of the original compound. These findings suggest that the predominant chemical changes induced in chlorogenic acid by γ-irradiation may enhance its anti-inflammatory properties.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1261-1269"},"PeriodicalIF":1.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacillus subtilis grown in a "breathing" vessel without sparger aeration. 枯草芽孢杆菌在 "会呼吸 "的容器中生长，不使用喷射器通气。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-22 DOI: 10.1093/bbb/zbae120

Ken-Ichi Yoshida, Kyosuke Yokoyama, Ayşegül Öktem, Shu Ishikawa, Jan Maarten van Dijl, Masato Yotsuya, Ryosuke Sato

引用次数: 0

Soymilk yogurt fermented using Pediococcus pentosaceus TOKAI 759 m improves mice gut microbiota and reduces pro-inflammatory cytokine production. 使用五胜肽球菌 TOKAI 759 m 发酵的豆奶酸奶可改善小鼠肠道微生物群并减少促炎细胞因子的产生。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-22 DOI: 10.1093/bbb/zbae112

Yuki Nakashima, Kotone Onuki, Tomoyuki Hibi, Rei-Ichi Ohno, Hikari Sugawa, Yuki Tominaga, Shin Yasuda, Hideki Kinoshita

{"title":"Soymilk yogurt fermented using Pediococcus pentosaceus TOKAI 759 m improves mice gut microbiota and reduces pro-inflammatory cytokine production.","authors":"Yuki Nakashima, Kotone Onuki, Tomoyuki Hibi, Rei-Ichi Ohno, Hikari Sugawa, Yuki Tominaga, Shin Yasuda, Hideki Kinoshita","doi":"10.1093/bbb/zbae112","DOIUrl":"10.1093/bbb/zbae112","url":null,"abstract":"This study aimed to determine the anti-inflammatory activities and bioactive compounds of soymilk yogurt prepared using Lactiplantibacillus plantarum TOKAI 17 or Pediococcus pentosaceus TOKAI 759 m. Mice were divided into five groups: normal diet (ND), soymilk, soymilk yogurt using L. plantarum TOKAI 17 (SY 17) or P. pentosaceus TOKAI 759 m (SY 759 m), and 0.5 × 109 cells of each starter strain (BC 17 or BC759m). In the SY 759 m group, the serum pro-inflammatory cytokine levels and the cytotoxicity of natural killer cells were attenuated compared to the ND group. In the cecum microbiota, the abundances of butyrate-producing bacteria increased in the SY 759 m and BC 17 groups. Furthermore, SY 759 m metabolites contained high levels of aglycone isoflavone, adenine and showed a significant decrease in CCL-2 and interleukin-6 production in lipopolysaccharide-induced macrophage. In conclusion, soymilk yogurt produced using P. pentosaceus TOKAI 759 m modulates the gut microbiota and can potentially prevent pro-inflammatory cytokine production.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1349-1361"},"PeriodicalIF":1.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation and determination of CoQ10(H2) and CoQ10(H4) species from black yeast-like fungi and filamentous fungi. 黑酵母样真菌和丝状真菌中 CoQ10(H2) 和 CoQ10(H4) 种类的调查和测定。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-21 DOI: 10.1093/bbb/zbae149

Jomkwan Jumpathong, Ikuhisa Nishida, Yasuhiro Matsuo, Tomohiro Kaino, Makoto Kawamukai

{"title":"Investigation and determination of CoQ10(H2) and CoQ10(H4) species from black yeast-like fungi and filamentous fungi.","authors":"Jomkwan Jumpathong, Ikuhisa Nishida, Yasuhiro Matsuo, Tomohiro Kaino, Makoto Kawamukai","doi":"10.1093/bbb/zbae149","DOIUrl":"https://doi.org/10.1093/bbb/zbae149","url":null,"abstract":"Coenzyme Q (CoQ) or ubiquinone functions as an electron transporter in the electron transport system in both prokaryotes and eukaryotes. The isoprenyl side chain of CoQ is modified in some organisms, especially in fungi, for optimal electron transport performance under various conditions. In this study, we investigated the side chain saturated dihydro CoQ (CoQ10(H2)) in Aureobasidium pullulans EXF-150, Sydowia polyspora NBRC 30562, and naturally isolated Plowrightia sp. A37, all of which are melanized Dothideomycetes species within the Ascomycota, and also in filamentous fungi Aspergillus oryzae and Aspergillus terreus. Plowrightia sp. A37 produced the rarely synthesized tetrahydro type CoQ10(H4), especially in glucose-rich medium, during extended cultivation in contrast to CoQ10(H2) in time-limited cultivation. Using liquid chromatography-mass spectrometry, we identified demethoxyubiquinone-H2 (DMQ(H2)) as an indicative intermediate that suggests that the side chain-saturation of CoQ occurs after the formation of DMQ and not always in the last step as previously considered.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative analysis of sodium concentration in condiments, soft drinks and mineral water by external standard 23Na-qNMR. 利用外部标准 23Na-qNMR 对调味品、软饮料和矿泉水中的钠浓度进行定量分析。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-21 DOI: 10.1093/bbb/zbae150

Kenji Ogura

引用次数: 0

Novel compound, pleuropyronine, and other polyketides isolated from the edible mushroom Pleurotus ostreatus suppress bacterial biofilm formation. 从食用菌褶菇中分离出的新型化合物褶菇碱和其他多酮类化合物可抑制细菌生物膜的形成。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-18 DOI: 10.1093/bbb/zbae148

Jewel C De Padua, Takashi Kikuchi, Futa Sakakibara, Angeles M De Leon, Melfei E Bungihan, Kotomi Ueno, Thomas Edison E Dela Cruz, Atsushi Ishihara

{"title":"Novel compound, pleuropyronine, and other polyketides isolated from the edible mushroom Pleurotus ostreatus suppress bacterial biofilm formation.","authors":"Jewel C De Padua, Takashi Kikuchi, Futa Sakakibara, Angeles M De Leon, Melfei E Bungihan, Kotomi Ueno, Thomas Edison E Dela Cruz, Atsushi Ishihara","doi":"10.1093/bbb/zbae148","DOIUrl":"https://doi.org/10.1093/bbb/zbae148","url":null,"abstract":"An increase in the number of drug-resistant microbes is a major threat to human health. Bacterial drug resistance is mostly mediated by biofilm formation. In this study, the culture filtrate from the edible mushroom, Pleurotus ostreatus, was fractionated to isolate compounds that inhibit the biofilm formation of six pathogenic bacteria. Notably, we isolated compounds 16 using bioassay-guided chromatographic separations. Spectroscopic and X-ray diffraction analyses identified 1 as a novel fused bicyclic pyrone-furan, named pleuropyronine, whereas 2-6 were known polyketides. Pleuropyronine inhibited biofilm formation in four gram-negative bacteria, with IC50 values ranging from 5.4 to 8.7 µg/mL, whereas 2-6 exhibited IC50 values between 1.0 and 5.3 µg/mL against five bacteria. Additionally, pleuropyronine bioactivity was confirmed by the inhibition of exopolysaccharide and biofilm formation induced by C6-homoserine lactone. Thus, this may serve as a pioneering study on the pharmacological potential of isolated compounds, offering valuable insights for future research.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A type II toxin-antitoxin system, ECs3274-ECs3275, in enterohemorrhagic Escherichia coli O157. 肠出血性大肠杆菌 O157 中的 II 型毒素-抗毒素系统 ECs3274-Ecs3275。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-18 DOI: 10.1093/bbb/zbae146

Yuka Sasaki, Yuna Mogi, Mizuki Yoshioka, Ke Liu, Yuichi Otsuka

引用次数: 0

Identification of Linalool Disaccharide Glycoside (Linalyl β-Vicianoside) in Soybean Leaves and Its Implication for Herbivore Resistance. 鉴定大豆叶中的芳樟醇二糖苷 (Linalyl β-Vicianoside) 及其对草食动物抗性的影响。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-10-18 DOI: 10.1093/bbb/zbae144

Juliano Mwenda Ntoruru, Tsukiho Osawa, Toshiyuki Ohnishi, Kenji Matsui

{"title":"Identification of Linalool Disaccharide Glycoside (Linalyl β-Vicianoside) in Soybean Leaves and Its Implication for Herbivore Resistance.","authors":"Juliano Mwenda Ntoruru, Tsukiho Osawa, Toshiyuki Ohnishi, Kenji Matsui","doi":"10.1093/bbb/zbae144","DOIUrl":"https://doi.org/10.1093/bbb/zbae144","url":null,"abstract":"Linalool is anticipated to have significant ecological roles. In this study, linalyl 6-O-α-arabinopyranosyl-β-D-glucopyranoside (linalyl β-vicianoside: LinVic) was synthesized, and a linalool diglycoside purified from soybean leaves was identified as LinVic by using liquid chromatography-mass spectrometry. High levels of LinVic were detected in leaves and sepals during soybean plant growth. The LinVic content did not significantly increase following methyl jasmonate treatment of the leaves, indicating that its synthesis is independent of the jasmonic acid signaling pathway. In addition to LinVic, soybean also contains 1-octen-3-yl primeveroside. We treated soybean leaves with vaporized linalool and 1-octen-3-ol to determine whether the glycosylation system discriminates between these two volatile alcohols. Linalool treatment resulted in the accumulation of LinVic, while 1-octen-3-ol treatment caused little change in the amount of 1-octen-3-yl primeveroside, suggesting discrimination between these compounds. Linalool-treated soybean leaves exhibited increased resistance against common cutworms, indicating that LinVic may contribute to herbivore resistance.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0