发布求助
文献互助 智能选刊 最新文献

Bioscience, Biotechnology, and Biochemistry最新文献

筛选
英文 中文
PDRN-like marker DNA shows skin beneficial properties through its single-stranded form. pdrn样标记DNA通过其单链形式显示出对皮肤有益的特性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf067
Hye-Won Lim, Yu-Hua Huang, Hye-Seung Baek, Hong-Gyum Kim, Kyu Earn Kim, Chang-Jin Lim
{"title":"PDRN-like marker DNA shows skin beneficial properties through its single-stranded form.","authors":"Hye-Won Lim, Yu-Hua Huang, Hye-Seung Baek, Hong-Gyum Kim, Kyu Earn Kim, Chang-Jin Lim","doi":"10.1093/bbb/zbaf067","DOIUrl":"10.1093/bbb/zbaf067","url":null,"abstract":"<p><p>Using marker DNA, this work aimed to clarify which of the 2 conformational states of PDRNs (polydeoxyribonucleotides) as a DNA-based remedy, ssDNA random coil or dsDNA helical form, acts as an active player. The marker DNA solution (BN) was subjected to high temperature, which yielded the thermal-denatured BN solution (BN-H) with the enhanced ssDNA. BN-H exhibited significantly higher beneficial properties. The ssDNA state is responsible for its pharmacological properties.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1168-1172"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of homocarnosine for applications in bioactive peptide and functional food studies. 正肌肽的合成及其在生物活性肽和功能性食品研究中的应用。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf075
Tomoka Nagao, Kanako Sato, Takeshi Arima, Takumi Komaru, Sudathip Sae-Tan, Masubon Thongngam, Hisato Kuniyoshi, Makoto Hirayama, Yoshiaki Nakamura, Akiko Koi, Jun-Ichi Kakimura, Hitoshi Fujitaka, Ruge Cao, Noriyuki Yanaka, Thanutchaporn Kumrungsee
{"title":"Synthesis of homocarnosine for applications in bioactive peptide and functional food studies.","authors":"Tomoka Nagao, Kanako Sato, Takeshi Arima, Takumi Komaru, Sudathip Sae-Tan, Masubon Thongngam, Hisato Kuniyoshi, Makoto Hirayama, Yoshiaki Nakamura, Akiko Koi, Jun-Ichi Kakimura, Hitoshi Fujitaka, Ruge Cao, Noriyuki Yanaka, Thanutchaporn Kumrungsee","doi":"10.1093/bbb/zbaf075","DOIUrl":"10.1093/bbb/zbaf075","url":null,"abstract":"<p><p>Homocarnosine is a brain-specific dipeptide composed of γ-aminobutyric acid and L-histidine. In contrast to its well-known analog carnosine, homocarnosine is under-explored and noncommercially available. Here, we report an in-house and practical procedure for solid-phase synthesis of homocarnosine, yielding a purity of >95%. Applications of the synthesized homocarnosine in in vitro assays exhibited antioxidant and muscle-fiber-cell viability activities.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1212-1216"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light- and ascorbate-dependent regulation of VITAMIN C DEFECTIVE 2 protein expression in Arabidopsis. 光和抗坏血酸依赖调节拟南芥中维生素C缺陷2蛋白的表达。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf080
Yasuhiro Tanaka, Takanori Maruta, Takahiro Ishikawa
{"title":"Light- and ascorbate-dependent regulation of VITAMIN C DEFECTIVE 2 protein expression in Arabidopsis.","authors":"Yasuhiro Tanaka, Takanori Maruta, Takahiro Ishikawa","doi":"10.1093/bbb/zbaf080","DOIUrl":"10.1093/bbb/zbaf080","url":null,"abstract":"<p><p>Ascorbate accumulation under light conditions is regulated by GDP-L-galactose phosphorylase (GGP), which catalyzes the rate-limiting step in the ascorbate biosynthesis pathway and is encoded by the Vitamin C Defective 2 (VTC2). While the VTC2 gene expression and the GGP activity in response to light have been extensively studied, the behavior of the VTC2 protein remains unclear. To explore the role of VTC2 protein accumulation in modulating ascorbate biosynthesis, we generated transgenic plants expressing VTC2 fused with a Myc tag, driven by the native VTC2 promoter, within vtc2-4 lacking VTC2. Under normal light conditions, VTC2 transcripts, VTC2 protein levels, and GGP activity exhibited an increase during the early light period. These data highlight the importance of VTC2 protein accumulation during the early light phase in determining ascorbate biosynthesis capacity in response to light. Furthermore, our analysis demonstrated that high-ascorbate concentrations suppress VTC2 expression.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1136-1143"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,6-Digalloyl glucose in Emblica officinalis increases the proliferation of human keratinocytes and fibroblasts with upregulated expression of periostin. officinalis中的1,6-二烯丙基葡萄糖增加人角质形成细胞和成纤维细胞的增殖，并上调骨膜蛋白的表达。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf068
Yoshimi Yamakami, Kyoko Morino, Robert A Kanaly, Raku Irie, Masato Oikawa, Yuki Takauji, Kensuke Miki, Mohammad Nazir Hossain, Dai Ayusawa, Michihiko Fujii
{"title":"1,6-Digalloyl glucose in Emblica officinalis increases the proliferation of human keratinocytes and fibroblasts with upregulated expression of periostin.","authors":"Yoshimi Yamakami, Kyoko Morino, Robert A Kanaly, Raku Irie, Masato Oikawa, Yuki Takauji, Kensuke Miki, Mohammad Nazir Hossain, Dai Ayusawa, Michihiko Fujii","doi":"10.1093/bbb/zbaf068","DOIUrl":"10.1093/bbb/zbaf068","url":null,"abstract":"<p><p>Keratinocytes and fibroblasts are the major cell types in the epidermis and the dermis, respectively. Since both cells play important roles in wound healing, compounds that regulate their proliferation are expected to be beneficial to epidermal health. We have previously shown that the extract of Emblica officinalis, which is a well-known herb in Ayurvedic traditional medicine, increases the proliferation of keratinocytes. Here, we purified a compound that increased cell proliferation from E. officinalis extract. Through liquid chromatography electrospray ionization tandem mass spectrometry and nuclear magnetic resonance (NMR) techniques, the compound was determined to be 1,6-digalloyl glucose. Consistent with this, tannic acid, a type of polygalloyl glucose, also increased cell proliferation. We further found that E. officinalis extract increased the proliferation of fibroblasts as well and showed that it increased cell proliferation at least partly through upregulating the expression of periostin. These findings revealed the mechanism by which E. officinalis extract regulates cell proliferation.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1092-1105"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspergillus terreus AtfB (bZIP) differently regulates lovastatin production in submerged fermentation and in solid-state fermentation. 土曲霉AtfB （bZIP）在深层发酵和固态发酵中对洛伐他汀生产的调控不同。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf066
Montserratt Herrera-Martell, Armando Mejía, Luis Enrique Gómez-Quiroz, Javier Barrios-González
{"title":"Aspergillus terreus AtfB (bZIP) differently regulates lovastatin production in submerged fermentation and in solid-state fermentation.","authors":"Montserratt Herrera-Martell, Armando Mejía, Luis Enrique Gómez-Quiroz, Javier Barrios-González","doi":"10.1093/bbb/zbaf066","DOIUrl":"10.1093/bbb/zbaf066","url":null,"abstract":"<p><p>Lovastatin is industrially produced with Aspergillus terreus, generally by liquid submerged fermentation (SmF), but also by solid-state fermentation (SSF) since it shows higher yields. Its biosynthetic genes are positively regulated by reactive oxygen species (ROS). AtfB (AtatfB) knocked-down mutants displayed increased sensitivity to oxidative and osmotic stress in conidia. Transformants showed decreased lovastatin production in SSF, while increased production in SmF (also lower ROS levels in both systems). After ROS normalization, the differences in lovastatin production originally found were conserved. Moreover, biosynthetic gene expression (lovE and lovF) was higher in SmF, but lower in SSF. It is concluded that AtAtfB regulates lovastatin biosynthesis in A. terreus at transcriptional level, but has different functions in SmF and SSF, acting as a negative regulator in SmF, and as a positive regulator in SSF. This is the first report of a transcription factor regulating secondary metabolism with opposite functions in SSF and in SmF.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1227-1235"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the presence of jasmonoyl-l-isoleucine in 3 species of moss belonging to Bryophytes. 揭示了三种苔藓植物中茉莉异亮氨酸的存在。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf072
Vera Fitriya Ersalena, Naoki Kitaoka, Hideyuki Matsuura
{"title":"Unveiling the presence of jasmonoyl-l-isoleucine in 3 species of moss belonging to Bryophytes.","authors":"Vera Fitriya Ersalena, Naoki Kitaoka, Hideyuki Matsuura","doi":"10.1093/bbb/zbaf072","DOIUrl":"10.1093/bbb/zbaf072","url":null,"abstract":"<p><p>There is no existing evidence of the existence of jasmonates and (+)-7-iso-Jasmonoyl-ʟ-isoleucine (JA-l-Ile) in Bryophytes. Mosses belong to Bryophytes, and it was found that 3 kinds of mosses, Calohypnum plumiforme, Lencobryum bowringii, and Pyrrhobryum dozyanum, accumulated detectable levels of endogenous JA-l-Ile in the aerial parts, but not in Bartramia pomiformis belonging to the same plant group.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1177-1181"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering rhamnose-inducible T7 expression systems in Bacillus subtilis utilizing the rhaEW promoter and identifying critical residues in RhaR regulating this promoter. 利用rhaEW启动子在枯草芽孢杆菌中构建鼠李糖诱导的T7表达系统，并鉴定调节该启动子的RhaR中的关键残基。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf077
Yuna Kuwahara, Kazutake Hirooka
{"title":"Engineering rhamnose-inducible T7 expression systems in Bacillus subtilis utilizing the rhaEW promoter and identifying critical residues in RhaR regulating this promoter.","authors":"Yuna Kuwahara, Kazutake Hirooka","doi":"10.1093/bbb/zbaf077","DOIUrl":"10.1093/bbb/zbaf077","url":null,"abstract":"<p><p>We constructed T7 expression systems in Bacillus subtilis, in which the rhamnose-inducible rhaEW promoter and its derivative were used to control the T7 RNA polymerase gene. This promoter is regulated by the RhaR repressor, which is derepressed by rhamnulose-1-phosphate derived from rhamnose. To prolong the induction, we deleted the chromosomal rhaEW gene, thereby accumulating the effector. A mutated green fluorescent protein (EGFP) was expressed using these systems. However, high basal activity of the rhaEW promoter caused loss of regulation and growth inhibition of the expression strains upon rhamnose addition. Two spontaneous mutant strains carrying single-point mutations in the rhaR gene (T103A and Q188L) alleviated rhamnose-dependent growth inhibition and enabled rhamnose-induced EGFP expression. The lacZ reporter analysis showed that both mutations reduced RhaR's sensitivity to the effector. Incorporation of each mutant rhaR allele into the T7 expression system, distinct from the spontaneous mutants, improved the induction ratio.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1154-1167"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactiplantibacillus brownii strain MH-1 prolongs healthspan and improves stress resistance in Caenorhabditis elegans. 布朗氏乳杆菌MH-1菌株延长秀丽隐杆线虫的健康期并提高其抗逆性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf065
Mina Hashimoto, Yoshihiko Tanimoto, Eriko Kage-Nakadai
{"title":"Lactiplantibacillus brownii strain MH-1 prolongs healthspan and improves stress resistance in Caenorhabditis elegans.","authors":"Mina Hashimoto, Yoshihiko Tanimoto, Eriko Kage-Nakadai","doi":"10.1093/bbb/zbaf065","DOIUrl":"10.1093/bbb/zbaf065","url":null,"abstract":"<p><p>Lactiplantibacillus brownii was first discovered in 2023. We previously isolated L. brownii strain MH-1 from homemade pickled Chinese cabbage in Hiroshima Prefecture, Japan, and performed whole-genome sequencing. In this study, we examined the beneficial effects of L. brownii strain MH-1 on a host using C. elegans. MH-1 and heat-killed MH-1 extended the lifespan and also alleviated motility decline during aging in worms. Feeding MH-1 to nematodes indicated its presence in the intestinal tract with no change in body or brood sizes, suggesting that dietary restrictions did not occur. There were no significant differences in intestinal barrier enhancement or fat accumulation in MH-1-fed C. elegans. The stress response of C. elegans was enhanced by MH-1 for oxidative stress tolerance. MH-1 increased the expression of genes involved in defense response and lipid catabolism. These results demonstrate the beneficial effects of MH-1 on nematodes and its potential use as a probiotic.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1236-1247"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of reactive carbonyl species in inhibition of germination and seedling growth by salt stress in rice. 活性羰基物种在盐胁迫下抑制水稻萌发和幼苗生长中的作用。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf062
Faruk Hossain Khan, Yoshitaka Nakashima, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshihiko Hirai, Md Anamul Hoque, Mohammad Saidur Rhaman, Shintaro Munemasa, Jun'ichi Mano, Yoshiyuki Murata
{"title":"Involvement of reactive carbonyl species in inhibition of germination and seedling growth by salt stress in rice.","authors":"Faruk Hossain Khan, Yoshitaka Nakashima, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshihiko Hirai, Md Anamul Hoque, Mohammad Saidur Rhaman, Shintaro Munemasa, Jun'ichi Mano, Yoshiyuki Murata","doi":"10.1093/bbb/zbaf062","DOIUrl":"10.1093/bbb/zbaf062","url":null,"abstract":"<p><p>Salt stress increases levels of reactive oxygen species (ROS), leading to a variety of damages in plants. Production of reactive carbonyl species (RCS) following ROS accumulation has been reported to be closely related to damage by salt stress. We investigated the effects of RCS scavengers, carnosine and pyridoxamine, on the inhibition of germination and seedling growth of Nipponbare (Oryza sativa L.) by salt stress. The inhibition of germination and the seedling growth by 50 mm NaCl was alleviated by the scavengers. The scavengers suppressed the malondialdehyde accumulation and protein carbonylation but not the ROS accumulation in the salt-stressed shoots. These results indicate that suppression of RCS accumulation improves salt tolerance without affecting ROS production in rice and suggest that RCS accumulation is responsible for the inhibitory effects on seeds and seedlings in rice.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1106-1113"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total synthesis and structure determination of ephedroidin. 麻黄素的全合成及结构测定。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-07-23 DOI: 10.1093/bbb/zbaf059
Ami Sakurai, Atsushi Kawamura, Yasunao Hattori, Hidefumi Makabe
{"title":"Total synthesis and structure determination of ephedroidin.","authors":"Ami Sakurai, Atsushi Kawamura, Yasunao Hattori, Hidefumi Makabe","doi":"10.1093/bbb/zbaf059","DOIUrl":"10.1093/bbb/zbaf059","url":null,"abstract":"<p><p>The total synthesis and structure determination of enantiomerically pure (+)- and (-)-ephedroidin from the leguminous plant is described. (+)- and (-)-Ephedroidin were a flavonoid with a chiral secondary alcohol on a side chain derived from a prenyl group. These compounds were obtained by optical resolution of (±)-ephedroidin through α-methoxyphenylacetic acid (MPA) esterification. The racemic secondary hydroxy group of (±)-ephedroidin was generated by photooxidation of prenylated flavonoid. Based on the total synthesis and Trost's method using α-MPA ester derivatives, the absolute configurations of (+)- and (-)-ephedroidin were revealed.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1075-1080"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信