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Plant growth regulators from the liquid culture of Lepista sordida.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-08 DOI: 10.1093/bbb/zbaf048
Arbin Sunuwar, Jae-Hoon Choi, Masaaki Sumida, Kokoro Kume, Jing Wu, Akinobu Ito, Kimiko Yamashita, Hirofumi Hirai, Hirokazu Kawagishi
{"title":"Plant growth regulators from the liquid culture of Lepista sordida.","authors":"Arbin Sunuwar, Jae-Hoon Choi, Masaaki Sumida, Kokoro Kume, Jing Wu, Akinobu Ito, Kimiko Yamashita, Hirofumi Hirai, Hirokazu Kawagishi","doi":"10.1093/bbb/zbaf048","DOIUrl":"https://doi.org/10.1093/bbb/zbaf048","url":null,"abstract":"<p><p>\"Fairy rings\" are zones that stimulate or inhibit grass growth, caused by interactions between a fungus and a grass. Lepista sordida is one of the fairy ring-forming fungi. (1S,2S)-1-(4-Chloro-3-methoxyphenyl)propane-1,2-diol (1) along with ten compounds (2-11) were isolated from the culture broth and mycelia of L. sordida. The structures were identified by spectroscopic data analyses, and this was the first reported isolation of 1 from a natural source. The plant growth regulatory activity of 3-6 was investigated using bentgrass seedlings. Compound 3 promoted root growth at 0.1 μmol/paper, while inhibited it at 1 μmol/paper. Compound 4 inhibited root growth at 0.1 and 1 μmol/paper. Compound 6 significantly promoted shoot growth at 1 μmol/paper.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RASL10A, a member of the RAS subfamily of small GTPases, suppresses the EMT and invasion of human lung adenocarcinoma A549 cells.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-08 DOI: 10.1093/bbb/zbaf052
Makoto Nishizuka, Kanae Nakajima, Chie Odagiri, Nanaka Wada, Satoshi Sakai
{"title":"RASL10A, a member of the RAS subfamily of small GTPases, suppresses the EMT and invasion of human lung adenocarcinoma A549 cells.","authors":"Makoto Nishizuka, Kanae Nakajima, Chie Odagiri, Nanaka Wada, Satoshi Sakai","doi":"10.1093/bbb/zbaf052","DOIUrl":"https://doi.org/10.1093/bbb/zbaf052","url":null,"abstract":"<p><p>Lung adenocarcinoma (LUAD) is the most frequently diagnosed form of non-small cell lung cancer and is known to develop distant metastases, such as brain and bone metastases, which can considerably affect the prognosis of patients. Therefore, there is a need to elucidate the metastatic mechanisms of LUAD and establish treatments to control metastasis. In this study, Kaplan-Meier plotter analysis demonstrated that patients with LUAD and low RASL10A expression have a poor prognosis. Furthermore, loss or gain of function experiments revealed that RASL10A suppresses transforming growth factor-beta (TGF-β)-induced epithelial-mesenchymal transition (EMT) and the subsequent invasion of LUAD A549 cells. In addition, we found that RASL10A suppresses Smad3 phosphorylation and Snail expression during the early stages of EMT. These results indicate that RASL10A is a novel factor that inhibits TGF-β signaling-mediated EMT and invasion in A549 cells. RASL10A has the potential to become a new therapeutic target for patients with LUAD.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional and functional profiles of aquaponic leaf lettuce across seasons.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-07 DOI: 10.1093/bbb/zbaf051
Yasuaki Enoki, Satomi Tsutsuura, Keigo Mikame, Norikuni Ohtake, Tomoko Yamaguchi
{"title":"Nutritional and functional profiles of aquaponic leaf lettuce across seasons.","authors":"Yasuaki Enoki, Satomi Tsutsuura, Keigo Mikame, Norikuni Ohtake, Tomoko Yamaguchi","doi":"10.1093/bbb/zbaf051","DOIUrl":"https://doi.org/10.1093/bbb/zbaf051","url":null,"abstract":"<p><p>Aquaponics is a sustainable food production system that combines aquaculture and hydroponics. However, limited studies focused on the nutritional and functional properties of aquaponic produce. Thus, this study aimed to explore the nutritional and functional components of four leaf lettuce lines with different colors cultivated in a commercial aquaponic farm in four seasons from summer 2022 to spring 2023. The leaf lettuce lines grown in aquaponics had high levels of micronutrients such as vitamin C, vitamin K, and folic acid, with the levels of vitamin K and folic acid meeting Japan's health claim criteria. The lettuce lines, especially red leaf lettuce, were also rich in bioactive compounds such as nitrate ions, which are linked to blood pressure regulation, and antioxidants such as anthocyanins and chlorogenic acid. These findings suggest that leaf lettuce grown in aquaponics has potential use as a high-value functional food.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of the microalga Pavlova sp. OPMS 30543 with diclofenac attenuates hyperalgesia in adjuvant-induced arthritis mice.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-04 DOI: 10.1093/bbb/zbaf047
Wataru Nemoto, Kotaro Yamada, Ruka Kobayashi, Tomohiro Hoshi, Ken Nakahara, Akihiko Kanamoto, Osamu Nakagawasai, Koichi Tan-No
{"title":"Combination of the microalga Pavlova sp. OPMS 30543 with diclofenac attenuates hyperalgesia in adjuvant-induced arthritis mice.","authors":"Wataru Nemoto, Kotaro Yamada, Ruka Kobayashi, Tomohiro Hoshi, Ken Nakahara, Akihiko Kanamoto, Osamu Nakagawasai, Koichi Tan-No","doi":"10.1093/bbb/zbaf047","DOIUrl":"https://doi.org/10.1093/bbb/zbaf047","url":null,"abstract":"<p><p>Marine microalgae, such as Pavlova spp., are known to produce bioactive compounds and have been extensively studied as natural resources with anti-inflammatory properties. Among several Pavlova spp., OPMS 30543 (Pav) has recently been found to contain a high fucoxanthin content. In this study, we aimed to evaluate the effects of Pav treatment on hyperalgesia using a mouse model of adjuvant-induced arthritis (AIA), which was established by injecting complete Freund's adjuvant (CFA). Pav alone did not suppress the hyperalgesia observed in AIA mice. However, combined with low-dose diclofenac (DFC; 0.1 mg/kg) resulted in marked analgesia. In AIA mice, the activation of excitatory neurons was observed in the spinal cord; however, this activation was suppressed by the combination of Pav and DFC. These findings suggest that Pav enhances the analgesic effect of DFC in a mouse arthritis-associated hyperalgesia, and may aid in the development of improved strategies for inflammatory pain management.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycolaldehyde affects the growth of and metabolic flux distribution in Synechocystis sp. PCC 6803. 乙二醛影响 Synechocystis sp. PCC 6803 的生长和代谢通量分布。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-04 DOI: 10.1093/bbb/zbaf046
Tatsumi Imada, Yoshihiro Toya, Hiroshi Shimizu
{"title":"Glycolaldehyde affects the growth of and metabolic flux distribution in Synechocystis sp. PCC 6803.","authors":"Tatsumi Imada, Yoshihiro Toya, Hiroshi Shimizu","doi":"10.1093/bbb/zbaf046","DOIUrl":"https://doi.org/10.1093/bbb/zbaf046","url":null,"abstract":"<p><p>Glycolaldehyde (GA) is widely used as a photosynthetic inhibitor to suppress metabolic reactions. We aimed to evaluate the effects of GA on the growth of and metabolic flux distribution in Synechocystis sp. PCC 6803. GA significantly inhibited the growth (IC50 = 244 μM) and metabolic flux through the Calvin-Benson-Bassham cycle without decreasing in flux of pentose phosphate pathway.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Functional analysis of a S-adenosylmethionine-insensitive methylenetetrahydrofolate reductase identified in methionine-accumulating yeast mutants.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-03 DOI: 10.1093/bbb/zbaf036
{"title":"Correction to: Functional analysis of a S-adenosylmethionine-insensitive methylenetetrahydrofolate reductase identified in methionine-accumulating yeast mutants.","authors":"","doi":"10.1093/bbb/zbaf036","DOIUrl":"https://doi.org/10.1093/bbb/zbaf036","url":null,"abstract":"","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regio-specific synthesis of flavonoid glucuronides using plant UDP-glucuronosyltransferase expressed in yeast.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-02 DOI: 10.1093/bbb/zbaf049
Mst Julia Sultana, Takuto Kurakawa, Miyu Nishikawa, Shinichi Ikushiro
{"title":"Regio-specific synthesis of flavonoid glucuronides using plant UDP-glucuronosyltransferase expressed in yeast.","authors":"Mst Julia Sultana, Takuto Kurakawa, Miyu Nishikawa, Shinichi Ikushiro","doi":"10.1093/bbb/zbaf049","DOIUrl":"https://doi.org/10.1093/bbb/zbaf049","url":null,"abstract":"<p><p>Glucuronidation is a well-established biotransformation process that modifies the physiological and pharmacological properties of small molecules, making it a valuable tool for enhancing the chemical diversity of natural compounds in drug development. However, the chemical synthesis of glucuronides is often complex, time-consuming, and environmentally unsustainable. To overcome these challenges, plant uridine diphosphate (UDP)-glucuronosyltransferase (UGT)-mediated glucuronidation, using transformed yeast, offers a selective and efficient alternative for producing flavonoid glucuronides. This study aimed to conjugate quercetin with glucuronic acid by stably co-transforming Saccharomyces cerevisiae with plant UGTs (UGT78A11 and UGT88D7) and rat UDP-glucose-6-dehydrogenease. The UGT78A11 and UGT88D7 selectively conjugated quercetin at specific positions, producing quercetin-3-O-glucuronide and quercetin-7-O-glucuronide, respectively. The whole-cell biotransformation platform effectively leverages the regio-selectivity of UGT78A11 and UGT88D7 to convert polyhydroxy secondary metabolites into monoglucuronides with promising yields, thereby enhancing the availability and physiological potential of these glucuronides.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Peptaibols as Specific Inhibitors of the Futalosine Pathway.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-02 DOI: 10.1093/bbb/zbaf050
Marie Kikuchi, Haruka Kiyanagi, Takeshi Tsunoda, Yuki Inahashi, Kenichi Nonaka, Tohru Dairi, Yasushi Ogasawara
{"title":"Identification of Peptaibols as Specific Inhibitors of the Futalosine Pathway.","authors":"Marie Kikuchi, Haruka Kiyanagi, Takeshi Tsunoda, Yuki Inahashi, Kenichi Nonaka, Tohru Dairi, Yasushi Ogasawara","doi":"10.1093/bbb/zbaf050","DOIUrl":"https://doi.org/10.1093/bbb/zbaf050","url":null,"abstract":"<p><p>Menaquinone is an indispensable cofactor in the electron-transfer pathway for most Gram-positive bacteria. While most bacteria biosynthesize menaquinone by the well-known canonical pathway, some bacteria including Helicobacter pylori, which is a pathogen causing stomach cancer, use the futalosine pathway. Because beneficial intestinal bacteria such as lactobacilli use the canonical pathway, the futalosine pathway will be a great target to develop antibiotics specific to H. pylori. In this study, we searched for such metabolites from actinomycetes and fungi and identified four new peptaibols from culture broth of Verruciconidia sp. FKI-8918 as specific inhibitors of the futalosine pathway.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of the bread containing resistant starch from wheat (Triticum aestivum) on the improvement in bowel movements: A randomized, double-blind, placebo-controlled, crossover study.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-28 DOI: 10.1093/bbb/zbaf044
Yosuke Kikuchi, Yuto Otomo, Kazuki Toyota, Satoshi Noma, Shukuko Ebihara
{"title":"Effects of the bread containing resistant starch from wheat (Triticum aestivum) on the improvement in bowel movements: A randomized, double-blind, placebo-controlled, crossover study.","authors":"Yosuke Kikuchi, Yuto Otomo, Kazuki Toyota, Satoshi Noma, Shukuko Ebihara","doi":"10.1093/bbb/zbaf044","DOIUrl":"https://doi.org/10.1093/bbb/zbaf044","url":null,"abstract":"<p><p>This study aimed to evaluate the gut-regulating effects of wheat-derived resistant starch. A randomized, double-blind, placebo-controlled crossover study was conducted with 46 healthy Japanese adults. They were divided into two groups, consuming 3.26 g/day of wheat-derived resistant starch and a control food for 4 weeks each, separated by a 4-week washout period. There were no significant differences observed in the primary endpoint of defecation frequency. However, subgroup analysis showed significant improvements in bowel movements for participants who felt a strong sensation of incomplete evacuation. No gut-regulating effects were noted in other subgroups and secondary endpoints. The intake of 3.26 g/day of resistant starch was safe with no overall efficacy observed. Increased stool frequency was observed in participants with less frequent bowel movements and a strong feeling of incomplete evacuation, but no effects were confirmed in other subgroup analyses. No significant changes were observed in secondary endpoints. (UMIN ID: UMIN000052543).</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-allergic properties of Australian bee pollen.
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-27 DOI: 10.1093/bbb/zbaf045
Chie Watanabe, Taichi Mitsui, Satoshi Uchiyama, Tomomi Morimoto, Masashi Kato, Yoko Saito, Aoi Yanagihara, Ryo Miyata, Chihiro Honda, Shigenori Kumazawa
{"title":"Anti-allergic properties of Australian bee pollen.","authors":"Chie Watanabe, Taichi Mitsui, Satoshi Uchiyama, Tomomi Morimoto, Masashi Kato, Yoko Saito, Aoi Yanagihara, Ryo Miyata, Chihiro Honda, Shigenori Kumazawa","doi":"10.1093/bbb/zbaf045","DOIUrl":"https://doi.org/10.1093/bbb/zbaf045","url":null,"abstract":"<p><p>Bee pollen, an apicultural product collected by honeybees from flower stamens, is attracting attention as a functional food material. Our previous studies have shown that the major components of Australian bee pollen are hydroxycinnamoyl acid amides (HCAAs) (1-4) and flavonoids (5-8). In this study, we aimed to elucidate the effectiveness of Australian bee pollen. Australian bee pollen extracts and their main compounds were tested for their inhibitory on hyaluronidase activity and leukotriene B4 (LTB4) release. HCAAs strongly inhibited hyaluronidase activity and LTB4 release. Subsequently the anti-allergy effects of Australian bee pollen extracts were studied using a guinea pig rhinitis model. Administration of Australian bee pollen inhibited nasal secretion in the guinea pig rhinitis model. Australian bee pollen, which likely exhibits anti-allergic properties, is anticipated to be highly valuable for use.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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