Inhibitory activity of amyloid-β aggregation by flavonoids and rosmarinic acid related compounds isolated from Zostera marina.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-06-23 DOI:10.1093/bbb/zbaf058

Mitsuhiro Sekiguchi, Mafumi Horiuchi, Ayuko Tanaka, Yuki Yamada, Yuta Tozawa, Yasuki Higashimura, Hideyuki Shigemori

引用次数: 0

Abstract

The amyloid β (Aβ) aggregation inhibitory activity of compounds isolated from eelgrass (Zostera marina) was evaluated, and it was found that in the flavonoid compounds, when the hydroxy substituent was replaced by methoxy or sulfate, the activity weakened in that order. The efficacy of rosmarinic acid treatment against mutant nematodes was also evaluated.

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黄酮类化合物和迷迭香酸相关化合物抑制淀粉样蛋白-β聚集活性的研究

对从大叶藻（Zostera marina）中分离的化合物进行了淀粉样蛋白β (Aβ)聚集抑制活性的测定，结果表明，当羟基取代基被甲氧基或硫酸盐取代时，类黄酮化合物的活性依次减弱。对迷迭香酸处理对突变线虫的防治效果也进行了评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).