Bioscience, Biotechnology, and Biochemistry最新文献_第10页

Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov. 一种红霉素生产者的重新分类以及 Actinacidiphila reveromycinica sp.

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae032

Hisayuki Komaki, Hiroshi Takagi, Shunji Takahashi, Hiroyuki Osada

{"title":"Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov.","authors":"Hisayuki Komaki, Hiroshi Takagi, Shunji Takahashi, Hiroyuki Osada","doi":"10.1093/bbb/zbae032","DOIUrl":"10.1093/bbb/zbae032","url":null,"abstract":"Streptomyces sp. SN-593, a reveromycin producer, was previously thought to belong to the genus Streptomyces based on its morphological and chemotaxonomic characteristics. In this paper, we re-considered its taxonomic position according to the current criteria. Phylogenetic analysis using 16S rRNA gene sequences showed that the strain belongs to the genus Actinacidiphila. In multilocus sequence and phylogenomic analyses, the strain SN-593 represented a distinct evolutionary lineage within this genus, and its closest neighbor was A. yanglinensis. Digital DNA-DNA hybridization indicated that the strain shares less than 32% DNA-DNA relatedness with the type strains of closely related species, confirming this strain is a novel genomospecies. According to its phenotypic distinctiveness from the closest neighbor, we propose Actinacidiphila reveromycinica sp. nov. for the strain SN-593T. Additionally, as Streptomyces acidipaludis belonged to the genus Actinacidiphila in these analyses, it should be transferred to the genus, for which Actinacidiphila acidipaludis comb. nov. is proposed.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical modification of Arthrobacter sarcosine oxidase by N-methylisothiazolinone reduces reactivity toward oxygen. 用 N-甲基异噻唑啉酮对节杆菌肌氨酸氧化酶进行化学修饰可降低其对氧气的反应性。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae039

Fuka Toyama, Hironori Kimura, Yuqi Zhang, Yoshiaki Nishiya

引用次数: 0

Production of docosahexaenoic acid by a novel isolated Aurantiochytrium sp. 6-2 using fermented defatted soybean as a nitrogen source for sustainable fish feed development. 利用发酵脱脂大豆作为可持续鱼饲料开发的氮源，通过新分离的 Aurantiochytrium sp.

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae035

Chi-Hei Ip, Hibiki Higuchi, Chang-Yu Wu, Tomoyo Okuda, Shohei Katsuya, Jun Ogawa, Akinori Ando

引用次数: 0

Multifunctional enzymes related to amino acid metabolism in bacteria. 与细菌氨基酸代谢有关的多功能酶。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae027

Tetsuya Miyamoto

引用次数: 0

Human milk-specific fat components enhance the secretion of ghrelin by MGN3-1 cells. 人乳特异性脂肪成分会增强 MGN3-1 细胞分泌胃泌素的能力。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae028

Kentaro Kaneko, Eriko Taniguchi, Yui Funatsu, Yoshitaka Nakamura, Hiroshi Iwakura, Kousaku Ohinata

引用次数: 0

A modified system using macrophage-conditioned medium revealed that the indirect effects of anti-inflammatory food-derived compounds improve inflammation-induced suppression of UCP-1 mRNA expression in 10T1/2 adipocytes. 一个使用巨噬细胞条件培养基的改良系统显示，抗炎食物衍生化合物的间接作用改善了炎症引起的对 10T1/2 脂肪细胞中 UCP-1 mRNA 表达的抑制。

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae033

Hisako Takahashi, Miori Morikawa, Emi Ozaki, Minami Numasaki, Hiromu Morimoto, Miori Tanaka, Hirofumi Inoue, Tsuyoshi Goto, Teruo Kawada, Fumio Eguchi, Mariko Uehara, Nobuyuki Takahashi

{"title":"A modified system using macrophage-conditioned medium revealed that the indirect effects of anti-inflammatory food-derived compounds improve inflammation-induced suppression of UCP-1 mRNA expression in 10T1/2 adipocytes.","authors":"Hisako Takahashi, Miori Morikawa, Emi Ozaki, Minami Numasaki, Hiromu Morimoto, Miori Tanaka, Hirofumi Inoue, Tsuyoshi Goto, Teruo Kawada, Fumio Eguchi, Mariko Uehara, Nobuyuki Takahashi","doi":"10.1093/bbb/zbae033","DOIUrl":"10.1093/bbb/zbae033","url":null,"abstract":"Recently, it has been suggested that brown and beige adipocytes may ameliorate obesity because these adipocytes express uncoupling protein-1 (UCP-1), which generates heat by consuming lipid. However, obesity-induced inflammation suppresses the expression of UCP-1. To improve such conditions, food components with anti-inflammatory properties are attracting attention. In this study, we developed a modified system to evaluate only the indirect effects of anti-inflammatory food-derived compounds by optimizing the conventional experimental system using conditioned medium. We validated this new system using 6-shogaol and 6-gingerol, which have been reported to show the anti-inflammatory effects and to increase the basal expression of UCP-1 mRNA. In addition, we found that the acetone extract of Sarcodon aspratus, an edible mushroom, showed anti-inflammatory effects and rescued the inflammation-induced suppression of UCP-1 mRNA expression. These findings indicate that the system with conditioned medium is valuable for evaluation of food-derived compounds with anti-inflammatory effects on the inflammation-induced thermogenic adipocyte dysfunction.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-activity relationship of anti-inflammatory meroterpenoids isolated from Dictyopteris polypodioides in RAW264 cells. 在 RAW264 细胞中分离自多翅蝶形花的抗炎经络萜类化合物的结构-活性关系。

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae038

Momochika Kumagai, Akana Matsuda, Nozomi Shiiba, Tomoki Tsuruta, Hikaru Endo, Keisuke Nishikawa, Yoshiki Morimoto

{"title":"Structure-activity relationship of anti-inflammatory meroterpenoids isolated from Dictyopteris polypodioides in RAW264 cells.","authors":"Momochika Kumagai, Akana Matsuda, Nozomi Shiiba, Tomoki Tsuruta, Hikaru Endo, Keisuke Nishikawa, Yoshiki Morimoto","doi":"10.1093/bbb/zbae038","DOIUrl":"10.1093/bbb/zbae038","url":null,"abstract":"In this study, we explored anti-inflammatory compounds from the brown alga Dictyopteris polypodioides and isolated 7 meroterpenoids. Their anti-inflammatory activities were evaluated using the lipopolysaccharide-stimulated mouse macrophage cell line, RAW264. Yahazunol (1) exhibited similar nitric oxide (NO) production inhibitory activity as zonarol (2), which has previously been shown to be an anti-inflammatory compound. Yahazunol (1), zonarol (2), and isozonarol (3) inhibited not only NO production but also inducible nitric oxide synthase, interleukin-6, and C-C motif chemokine ligand 2 mRNA expression in RAW264 cells. The structure-activity relationships of the 11 compounds, including their synthetic analogs, revealed the significance of the hydroquinone moiety in the anti-inflammatory activity of these sesquiterpenoids in RAW264 cells. Diacetylated zonarol (9) exhibited an activity comparable to that of zonarol as a result of intracellular deacetylation. These results provide new insights into the anti-inflammatory activity of hydroquinone-containing natural products.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene. 通过使用多药敏感酿酒酵母筛选系统和引入全球次级代谢调节因子 laeA 基因的新药物发现平台，重新发现 MS-347a 作为候选杀真菌剂。

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-04-25 DOI: 10.1093/bbb/zbae050

Sota Honma, Aoi Kimishima, Atsushi Kimishima, Masako Honsho, Hiroki Kojima, T. Tokiwa, Atsuka Nishitomi, Satoshi Kato, N. Kondo, Yasuko Araki, Tadashi Takahashi, Takumi Chinen, Takeo Usui, Shin-Ichi Fuji, Kotaro Ito, Yukihiro Asami

{"title":"Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.","authors":"Sota Honma, Aoi Kimishima, Atsushi Kimishima, Masako Honsho, Hiroki Kojima, T. Tokiwa, Atsuka Nishitomi, Satoshi Kato, N. Kondo, Yasuko Araki, Tadashi Takahashi, Takumi Chinen, Takeo Usui, Shin-Ichi Fuji, Kotaro Ito, Yukihiro Asami","doi":"10.1093/bbb/zbae050","DOIUrl":"https://doi.org/10.1093/bbb/zbae050","url":null,"abstract":"We found that the culture broth of fungi showed anti-fungal activity against multidrug-sensitive budding yeast. However, we could not identify the anti-fungal compound due to the small quantity. Therefore, we attempted to increase the productivity of the target compound by the introduction of a global secondary metabolism regulator, laeA to the strain, which led to the successful isolation of ten-folds greater amount of MS-347a (1) than Aspergillus sp. FKI-5362. Compound 1 was not effective against Candida albicans and the detailed anti-fungal activity of 1 remains unverified. After our anti-fungal activity screening, 1 was found to inhibit the growth of broad plant pathogenic fungal species belonging to the Ascomycota. It is noteworthy that 1 showed little insecticidal activity against silkworms, suggesting its selective biological activity against plant pathogenic fungi. Our study implies that the combination strategy of multidrug-sensitive yeast and the introduction of laeA is useful for new anti-fungal drug discovery.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of the A/D/E-ring Core Compounds of Maoecrystal V. 合成毛晶 V 的 A/D/E 环核心化合物。

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-04-23 DOI: 10.1093/bbb/zbae049

Hiroki Asao, Yasuharu Shimasaki, Ayaka Sasaki, Shunki Katayama, K. Ida, Masaaki Kotake, Eriko Sato, Yuki Sato, Taiki Ishimoto, Minoru Izumi, C. Vavricka, Kuwahara Shigefumi, Hiromasa Kiyota

引用次数: 0

Identification of the female sex pheromone of Bastilla arctotaenia (Lepidoptera: Erebidae). Bastilla arctotaenia（鳞翅目：Erebidae）雌性信息素的鉴定。

IF 1.6 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-04-22 DOI: 10.1093/bbb/zbae020

Tareq A S Abubaker, Yuki Matsui, Hideshi Naka

引用次数: 0