Bioscience, Biotechnology, and Biochemistry最新文献_第9页

Total synthesis and stability analysis of natural diacyl-type tuliposides and their non-natural isomers. 天然二酰基型郁金香脂苷及其非天然异构体的全合成及稳定性分析。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI: 10.1093/bbb/zbag085

Yasuo Kato, Kaito Sano, Taiji Nomura

引用次数: 0

Long-term antibiotic treatment attenuates the development of food allergy in a murine model. 在小鼠模型中，长期抗生素治疗可减轻食物过敏的发展。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag069

Yingnan Guo, Junjie Li, Shunsuke Nishio, Hiroyuki Hattori, Tomonori Nochi, Tsukasa Matsuda, Masako Toda

{"title":"Long-term antibiotic treatment attenuates the development of food allergy in a murine model.","authors":"Yingnan Guo, Junjie Li, Shunsuke Nishio, Hiroyuki Hattori, Tomonori Nochi, Tsukasa Matsuda, Masako Toda","doi":"10.1093/bbb/zbag069","DOIUrl":"10.1093/bbb/zbag069","url":null,"abstract":"While short-term antibiotic exposure has been reported to exacerbate the development of allergies, the effects of long-term administration remain less understood. This study addressed the influences of prolonged antibiotic administration in a murine model of food allergy. Mice received a broad-spectrum antibiotic cocktail (ABX) for six weeks from presensitization through allergen challenge. ABX reduced allergic reactions, serum IgE levels, and intestinal mast cell counts. Production of Th2 cytokine, but not of Th1 and Th17 cytokines, was lowered in allergen-stimulated splenocytes of ABX-treated allergic mice, whereas the levels of these cytokines in their intestines decreased. ABX did not significantly alter the levels of regulatory cytokine IL-10 in intestines and regulatory T cells in spleens. ABX reduced gut bacterial amount, though Lactobacillus, Lactococcus, and Streptococcus remained detectable. Collectively, long-term ABX suppresses allergic reaction by modulating Th2-mediated events dominantly, providing insights into the complex role of antibiotics in allergy models.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1083-1094"},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and identification of a novel Maillard pigment, beer-furpipate, from dark beer. 从黑啤酒中分离鉴定一种新型美拉德色素——啤酒糠酸。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag064

Yodai Katano, Yuta Azuma, Kyoko Noda, Masatsune Murata

引用次数: 0

Ana o 2, an 11S globulin (legumin), and Ana o 3, a 2S albumin, in cashew nut induce epicutaneous sensitization in mice. 腰果中的11S球蛋白（豆类蛋白）Ana o 2和2S白蛋白Ana o 3诱导小鼠表皮致敏。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag077

Shoki Yamamoto, Saya Abe, Kokoro Hino, Rio Enoki, Nobuhiro Zaima, Tatsuya Moriyama

引用次数: 0

Proanthocyanidin-rich fractions prepared from blueberry leaf hot-water extracts inhibits interleukin-1β production in RAW264 cells and induces autophagy. 蓝莓叶热水提取物制备的富含原花青素的组分可抑制RAW264细胞产生白细胞介素-1β，诱导细胞自噬。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag063

Naoya Takehara, Naoki Kodama, Natsuko Tanaka, Chu-Shin Kyoku, Shaikh Mizanoor Rahman, Yumi Yamasaki, Yosuke Suzuki, Kazuhiro Sugamoto, Kenjirou Ogawa, Kazuo Nishiyama, Masao Yamasaki

{"title":"Proanthocyanidin-rich fractions prepared from blueberry leaf hot-water extracts inhibits interleukin-1β production in RAW264 cells and induces autophagy.","authors":"Naoya Takehara, Naoki Kodama, Natsuko Tanaka, Chu-Shin Kyoku, Shaikh Mizanoor Rahman, Yumi Yamasaki, Yosuke Suzuki, Kazuhiro Sugamoto, Kenjirou Ogawa, Kazuo Nishiyama, Masao Yamasaki","doi":"10.1093/bbb/zbag063","DOIUrl":"10.1093/bbb/zbag063","url":null,"abstract":"Blueberry leaves (Vaccinium virgatum Aiton), cultivated in Miyazaki Prefecture, Japan, represent a promising natural health-promoting resource. This study investigated the anti-inflammatory effects of blueberry leaf extract (BLEx) using lipopolysaccharide-stimulated RAW264 macrophage cells. BLEx (up to 100 μg/mL) significantly suppressed nitric oxide production and reduced both the secretion and mRNA expression of interleukin (IL)-1β and IL-6, while showing no significant effect on tumor necrosis factor-α, indicating selective anti-inflammatory activity. Highly polymerized proanthocyanidins, one of the major components of BLEx, contributed to the suppression of IL-1β production. BLEx treatment also induced morphological changes, including intracellular vacuole formation, suggesting the involvement of autophagy. Consistently, the expression of autophagy-related factors increased in a concentration-dependent manner, and inhibition of autophagy attenuated the suppressive effect of BLEx on IL-1β. Overall, BLEx exerts anti-inflammatory effects partly via autophagy activation and may be useful for preventing IL-1β-related inflammatory disorders.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1095-1104"},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and characterization of a salt- and oxygen-tolerant Bifidobacterium from Kishu-Narezushi. 一株Kishu-Narezushi耐盐耐氧双歧杆菌的分离与鉴定。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag062

Takato Hirata, Koki Obai, Miki Kubo, Yuichiro Ikagawa, Hitoshi Iwahashi

{"title":"Isolation and characterization of a salt- and oxygen-tolerant Bifidobacterium from Kishu-Narezushi.","authors":"Takato Hirata, Koki Obai, Miki Kubo, Yuichiro Ikagawa, Hitoshi Iwahashi","doi":"10.1093/bbb/zbag062","DOIUrl":"10.1093/bbb/zbag062","url":null,"abstract":"Bifidobacterium psychraerophilum was isolated from Kishu-Narezushi, marking the first discovery of the Bifidobacterium species originating from a spontaneously fermented traditional Japanese food. Kishu-Narezushi is a traditional Japanese spontaneously fermented food composed of fish, rice, and salt. Typically, Bifidobacterium species are isolated from milk-related fermented foods or human intestines. The isolated strain was identified as B. psychraerophilum and named the Yasuke strain. Bifidobacterium psychraerophilum is closely related to Bifidobacterium aquikeferi and Bifidobacterium crudilactis. The Yasuke strain and Bifidobacterium psychraerophilum DSM 22366 exhibited greater resistance to salt and oxygen compared to other Bifidobacterium species. Draft genome analysis of the Yasuke strain and four other B. psychraerophilum strains indicates the presence of stress-tolerance-related genes. Superoxide dismutase [Mn] and glutathione peroxidase genes are observed in this species. Genes involved in phage interactions, proline metabolism, and sugar and amino acid transport were uniquely identified in the Yasuke strain.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1114-1121"},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PPARγ-dependent transcriptional regulation of Vaspin expression in adipocytes. 脂肪细胞中Vaspin表达的ppar γ依赖性转录调控。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag073

Daisuke Aibara, Kimihiko Matsusue

引用次数: 0

Targeting Porphyromonas gingivalis virulence and viability with epimedokoreanin B prevents alveolar bone destruction in vivo. 针对牙龈卟啉单胞菌的毒力和活力与epimedokoreanin B防止牙槽骨破坏在体内。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag075

Toru Kariu, Keisuke Nakashima, Tsuyoshi Ikeda

{"title":"Targeting Porphyromonas gingivalis virulence and viability with epimedokoreanin B prevents alveolar bone destruction in vivo.","authors":"Toru Kariu, Keisuke Nakashima, Tsuyoshi Ikeda","doi":"10.1093/bbb/zbag075","DOIUrl":"10.1093/bbb/zbag075","url":null,"abstract":"Periodontal disease is a major oral infectious condition that leads to the degradation of alveolar bone and subsequent tooth loss. Porphyromonas gingivalis, a keystone pathogen in periodontitis, plays a critical role in disease initiation and progression. In a previous study, we demonstrated the anti-P. gingivalis activity of epimedokoreanin B, a prenylated flavonoid derived from Epimedium species. However, its in vivo efficacy against periodontitis remains unclear. Oral administration of epimedokoreanin B attenuated P. gingivalis-induced alveolar bone resorption in murine periodontitis models and suppressed infection-induced antibody production. Furthermore, epimedokoreanin B compromised bacterial membrane integrity and virulent gene expressions. In this preclinical study, in vitro and in vivo analyses indicate that epimedokoreanin B suppressed both bacterial viability and virulence, thereby attenuating alveolar bone loss caused by periodontitis. These findings suggest that epimedokoreanin B is a promising candidate for the development of novel therapeutics targeting periodontal pathogens.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1064-1071"},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis of the lipid composition in Saccharomyces cerevisiae, Saccharomyces eubayanus, and Saccharomyces pastorianus grown at different temperatures by untargeted lipidomics. 利用非靶向脂质组学对不同温度下培养的酿酒酵母、真巴酵母和pastorianus酵母的脂质组成进行综合分析。

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag067

Tomoko Takahashi, Ryo Iwama, Nobuyuki Okahashi, Fumio Matsuda, Ryouichi Fukuda, Ryo Nakasato, Yoichi Noda

{"title":"Comprehensive analysis of the lipid composition in Saccharomyces cerevisiae, Saccharomyces eubayanus, and Saccharomyces pastorianus grown at different temperatures by untargeted lipidomics.","authors":"Tomoko Takahashi, Ryo Iwama, Nobuyuki Okahashi, Fumio Matsuda, Ryouichi Fukuda, Ryo Nakasato, Yoichi Noda","doi":"10.1093/bbb/zbag067","DOIUrl":"10.1093/bbb/zbag067","url":null,"abstract":"The brewer's yeast Saccharomyces pastorianus originated as a hybrid between the mesophilic yeast Saccharomyces cerevisiae and the cryotolerant yeast Saccharomyces eubayanus. In this study, we investigated temperature-dependent changes in lipid composition in three yeast species using untargeted lipidomics. We found that both S. cerevisiae and S. pastorianus accumulated storage lipids, particularly triacylglycerols (TG), as the temperature decreased, whereas TG levels in S. eubayanus showed slight temperature-dependent changes. Mitochondria-associated lipids, such as cardiolipin (CL) and its precursor phosphatidylglycerol, also exhibited species-specific patterns. In particular, S. cerevisiae and S. eubayanus differed in their regulatory modes of fatty acid desaturation in CL. The acyl chain composition of CL in S. pastorianus was biased toward the characteristics of S. eubayanus. Our findings show that S. pastorianus integrates parental lipid regulatory systems in a lipid class-specific manner, combining S. cerevisiae-like regulation of storage lipids with S. eubayanus-like control of mitochondrial membrane lipids.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1122-1134"},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-faceted regulation by butyrophilin 1A1 to produce MUC5AC and IL-8 from human colonic cell line HT29-MTX-E12. 嗜丁酸蛋白1A1对人结肠细胞系HT29-MTX-E12产生MUC5AC和IL-8的双重调控

IF 1.5 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-07-23 DOI: 10.1093/bbb/zbag072

Minori Ishida, Yuki Kuwana, Mizuki Tsujimoto, Hyejin Namgung, Ayami Furue, Fumito Tani

{"title":"Dual-faceted regulation by butyrophilin 1A1 to produce MUC5AC and IL-8 from human colonic cell line HT29-MTX-E12.","authors":"Minori Ishida, Yuki Kuwana, Mizuki Tsujimoto, Hyejin Namgung, Ayami Furue, Fumito Tani","doi":"10.1093/bbb/zbag072","DOIUrl":"10.1093/bbb/zbag072","url":null,"abstract":"Butyrophilin subfamily 1 member A1 (BTN1A1) is a major protein of the milk fat globule membrane, but its immunoregulatory function remains largely unresolved, despite its structural similarity to the B7 co-stimulatory molecules. In this study, we investigated the immunological significance of BTN1A1 in gastrointestinal epithelial cells. The human ectodomain of BTN1A1 expressed as a soluble Fc fusion protein (ectoBTN-Fc) was added to HT29-MTX-E12 cells as a model for gastrointestinal epithelial cells. In the absence of tumor necrosis factor (TNF)-α, it significantly promoted MUC5AC production via a weak activation of NF-κB signal transduction pathway. In contrast, prior incubation with ectoBTN-Fc inhibited TNF-α-provoked-IL-8 secretion by suppressing the phosphorylation of NF-κB p65. Binding analyses demonstrated that ectoBTN-Fc likely binds to HT29-MTX-E12 cells, followed by its endocytosis. These results suggest a dual-faceted regulatory function of BTN1A1. It reinforces intestinal mucosal barrier function under basal conditions, while it may endow a prophylactic effect alleviating strong inflammatory stimulation.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1007-1018"},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0