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Extraction and antioxidant capacity of mycosporine-like amino acids from red algae in Japan. 从日本红藻中提取霉菌素类氨基酸及其抗氧化能力
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-06-21 DOI: 10.1093/bbb/zbae051
Ryuya Yamamoto, Shigeru Toriumi, Chikara Kawagoe, Wataru Saburi, Hideki Kishimura, Yuya Kumagai
{"title":"Extraction and antioxidant capacity of mycosporine-like amino acids from red algae in Japan.","authors":"Ryuya Yamamoto, Shigeru Toriumi, Chikara Kawagoe, Wataru Saburi, Hideki Kishimura, Yuya Kumagai","doi":"10.1093/bbb/zbae051","DOIUrl":"10.1093/bbb/zbae051","url":null,"abstract":"<p><p>Mycosporine-like amino acids (MAAs) are the natural UV-absorbing compounds with antioxidant activity found in microalgae and macroalgae. We collected red algae Asparagopsis taxiformis, Meristotheca japonica, and Polysiphonia senticulosa from Nagasaki, where UV radiation is more intense than in Hokkaido, and investigated the effect of UV radiation on MAA content. It was suggested that A. taxiformis and M. japonica contained shinorine and palythine, while UV-absorbing compound in P. senticulosa could not be identified. The amounts of these MAAs were lower compared to those from Hokkaido. Despite an increase in UV radiation in both regions from February to April, MAA contents of red algae from Nagasaki slightly decreased while those from Hokkaido significantly decreased. This difference was suggested the amount of inorganic nitrogen in the ocean. Antioxidant activity of MAAs increased under alkaline conditions. The extract containing MAAs from P. senticulosa showed the highest antioxidant activity among 4 red algae.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PEG modification increases thermostability and inhibitor resistance of Bst DNA polymerase. PEG 修饰提高了 Bst DNA 聚合酶的热稳定性和抗抑制剂性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-06-21 DOI: 10.1093/bbb/zbae059
Mengxia Yang, Zhixing Li, Hongjie Ren, Chen Lu, Xinyu Gao, Henghao Xu
{"title":"PEG modification increases thermostability and inhibitor resistance of Bst DNA polymerase.","authors":"Mengxia Yang, Zhixing Li, Hongjie Ren, Chen Lu, Xinyu Gao, Henghao Xu","doi":"10.1093/bbb/zbae059","DOIUrl":"10.1093/bbb/zbae059","url":null,"abstract":"<p><p>Polyethylene glycol modification (PEGylation) is a widely used strategy to improve the physicochemical properties of various macromolecules, especially protein drugs. However, its application in enhancing the performance of enzymes for molecular biology remains underexplored. This study explored the PEGylation of Bst DNA polymerase, determining optimal modification reaction conditions. In comparison to the unmodified wild-type counterpart, the modified Bst DNA polymerase exhibited significantly improved activity, thermal stability, and inhibitor tolerance during loop-mediated isothermal amplification. When applied for the detection of Salmonella in crude samples, the modified enzyme demonstrated a notably accelerated reaction rate. Therefore, PEGylation emerges as a viable strategy for refining DNA polymerases, helping in the development of novel molecular diagnostic reagents.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140907675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing an amidase and its operon from actinomycete bacteria responsible for paraben catabolism 放线菌中一种负责对羟基苯甲酸酯分解的酰胺酶及其操作子的特征
IF 1.6 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-06-17 DOI: 10.1093/bbb/zbae083
M. Takenoya, Yoshiaki Hiratsuka, K. Shimamura, Shinsaku Ito, Yasuyuki Sasaki, Shunsuke Yajima
{"title":"Characterizing an amidase and its operon from actinomycete bacteria responsible for paraben catabolism","authors":"M. Takenoya, Yoshiaki Hiratsuka, K. Shimamura, Shinsaku Ito, Yasuyuki Sasaki, Shunsuke Yajima","doi":"10.1093/bbb/zbae083","DOIUrl":"https://doi.org/10.1093/bbb/zbae083","url":null,"abstract":"\u0000 Hydrazidase from Microbacterium hydrocarbonoxydans was revealed to catalyze synthetic hydrazide compounds, enabling the bacteria to grow with them as sole carbon source, but natural substrates have remained unknown.\u0000 In this study, kinetic analyses of hydrazidase with parabens showed that the compounds can be substrates. Then, methylparaben induced gene expressions of the operon containing hydrazidase and ABC transporter, and the compound as sole carbon source was able to grow the bacteria. Furthermore, homology search was carried out revealing that several actinomycetes possess hydrazidase-homolog in the operon. Among those bacteria, an amidase from Pseudonocardia acaciae was subjected to a kinetic analysis and a structure determination revealing similar but not identical to those of hydrazidase.\u0000 Since parabens are reported to exist in plants and soil, and several actinomycetes codes the homologous operon, the enzymes with those operons may play a physiologically important role for bacterial survival with use of parabens.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts 沙棘（Hippophae rhamnoides, L.）果肉油可防止紫外线诱导的人体成纤维细胞损伤
IF 1.6 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-25 DOI: 10.1093/bbb/zbae071
Takuya Okamoto, Fumie Nakashima, Takahiro Shibata, Daisuke Mori
{"title":"Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts","authors":"Takuya Okamoto, Fumie Nakashima, Takahiro Shibata, Daisuke Mori","doi":"10.1093/bbb/zbae071","DOIUrl":"https://doi.org/10.1093/bbb/zbae071","url":null,"abstract":"\u0000 Seabuckthorn pulp oil (SBO) is used in beauty products because of its rich lipophilic substances with high nutraceutical and cosmeceutical potential. However, the mechanism through which SBO enhances skin elasticity remains unclear. Therefore, in this study, we examined the anti-photoaging activity of SBO in normal human dermal fibroblasts (NHDF) under ultraviolet (UV) irradiation. Pretreatment with SBO significantly suppressed UV-B-induced cell toxicity and collagen degradation, suggesting that SBO contains anti-photoaging substances. Further, palmitoleic acid (POA), the main component of SBO, maintained cell viability and collagen levels in UV-B-irradiated NHDF by suppressing the expression of matrix metalloproteinase 1 (MMP-1) and acted on the inhibition of p38 and JNK phosphorylation and nuclear translocation of nuclear factor-kappa B (NF-κB). These findings suggest the utility of SBO as an anti-photoaging agent.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141098507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convenient pre-separation method depends on negative charges suitable for glycan sequencing analysis. 方便的预分离方法取决于负电荷，适用于糖测序分析。
IF 1.6 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae030
Shigemitsu Segawa, Shunji Natsuka
{"title":"Convenient pre-separation method depends on negative charges suitable for glycan sequencing analysis.","authors":"Shigemitsu Segawa, Shunji Natsuka","doi":"10.1093/bbb/zbae030","DOIUrl":"10.1093/bbb/zbae030","url":null,"abstract":"<p><p>For precise structural analysis of complex glycans, it is necessary to fractionate glycans based on acidity prior to liquid chromatography-mass spectrometry analysis. Conventional fractionation using high-performance liquid chromatography is time consuming and not high throughput. Therefore, we developed a rapid method for the fractionation using a small cartridge column. This enables rapid multi-sample processing for glycan sequencing.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140064896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of graphite carbon black assisted-laser desorption ionization-mass spectrometry for soy sauce product discrimination. 石墨炭黑辅助激光解吸电离质谱法在酱油产品鉴别中的应用。
IF 1.6 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae034
Mitsuru Tanaka, Keishiro Arima, Haruna Ide, Mariko Koshi, Naoto Ohno, Miho Imamura, Toshiro Matsui
{"title":"Application of graphite carbon black assisted-laser desorption ionization-mass spectrometry for soy sauce product discrimination.","authors":"Mitsuru Tanaka, Keishiro Arima, Haruna Ide, Mariko Koshi, Naoto Ohno, Miho Imamura, Toshiro Matsui","doi":"10.1093/bbb/zbae034","DOIUrl":"10.1093/bbb/zbae034","url":null,"abstract":"<p><p>In a previous study, we developed a novel analytical method to directly and simultaneously detect taste- and odor-active compounds using graphite carbon black (GCB)-assisted laser desorption ionization mass spectrometry (LDI-MS). In this study, we aimed to evaluate food quality using a variety of soy sauces using the method to discriminate each product. Graphite carbon black-laser desorption ionization-mass spectrometry allowed the provision of hundreds of MS peaks derived from soy sauces in both positive and negative modes without any tedious sample pretreatments. Principal component analysis using the obtained MS peaks clearly distinguished three soy sauce products based on the manufacturing countries (Japan, China, and India). Moreover, this method identified distinct MS peaks for discrimination, which significantly correlated with their quantitative amounts in the products. Thus, GCB-LDI-MS analysis was established as a simple and rapid technique for food analysis, illustrating the chemical patterns of food products.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substrate profiling of human transglutaminase 1 using cDNA display and next-generation sequencing. 利用 cDNA 展示和新一代测序分析人类 Transglutaminase 1 的底物图谱。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae029
T I K Munaweera, Jasmina Damnjanović, Maurizio Camagna, Moeri Nezu, Beixi Jia, Kiyotaka Hitomi, Naoto Nemoto, Hideo Nakano
{"title":"Substrate profiling of human transglutaminase 1 using cDNA display and next-generation sequencing.","authors":"T I K Munaweera, Jasmina Damnjanović, Maurizio Camagna, Moeri Nezu, Beixi Jia, Kiyotaka Hitomi, Naoto Nemoto, Hideo Nakano","doi":"10.1093/bbb/zbae029","DOIUrl":"10.1093/bbb/zbae029","url":null,"abstract":"<p><p>Human transglutaminase 1 (TG1) modulates skin development, while its involvement in diseases remains poorly understood, necessitating comprehensive exploration of its substrate interactions. To study the substrate profile of TG1, an in vitro selection system based on cDNA display technology was used to screen two peptide libraries with mutations at varying distance from the reactive glutamine. Next-generation sequencing and bioinformatics analysis of the selected DNA pools revealed a detailed TG1 substrate profile, indicating preferred and non-preferred amino acid sequences. The peptide sequence, AEQHKLPSKWPF, was identified showing high reactivity and specificity to TG1. The position weight matrix calculated from the per amino acid enrichment factors was employed to search human proteins using an in-house algorithm, revealing six known TG1 substrate proteins with high scores, alongside a list of candidate substrates currently under investigation. Our findings are expected to assist in future medical diagnoses and development of treatments for skin disorders.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catechol-O-methyltransferase and monoamine oxidase B inhibitory activities of Australian bee pollen. 澳大利亚蜂花粉的儿茶酚-O-甲基转移酶和单胺氧化酶 B 抑制活性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae041
Chie Watanabe, Aoi Yanagihara, Ryo Miyata, Taichi Mitsui, Chihiro Honda, Daisuke Fujinami, Shigenori Kumazawa
{"title":"Catechol-O-methyltransferase and monoamine oxidase B inhibitory activities of Australian bee pollen.","authors":"Chie Watanabe, Aoi Yanagihara, Ryo Miyata, Taichi Mitsui, Chihiro Honda, Daisuke Fujinami, Shigenori Kumazawa","doi":"10.1093/bbb/zbae041","DOIUrl":"10.1093/bbb/zbae041","url":null,"abstract":"<p><p>Bee pollen is an apicultural product collected by honeybees from flower stamens and used as a functional food worldwide. In the present study, we aim to elucidate the functions of Australian bee pollen. Australian bee pollen extracts and their main components were tested for catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) inhibitory activities. These enzymes are key neurotransmitters involved in Parkinson's disease and depression. Myricetin (5), tricetin (6), and luteolin (7) exhibited high COMT inhibitory activities (half maximal inhibitory concentration [IC50] = 23.3, 13.8, and 47.4 µM, respectively). In contrast, 5, 7, and annulatin (8) exhibited MAOB inhibitory activities (IC50 = 89.7, 32.8, and 153 µM, respectively). Quantitative analysis via high-performance liquid chromatography revealed that 5 was abundant in Australian bee pollen extracts. Our findings suggest that 5 contributes to the COMT and MAOB inhibitory activities of Australian bee pollen.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of soy-derived lysophosphatidylcholine compared with that of glycerophosphocholine: a randomized controlled trial. 大豆提取的溶血磷脂酰胆碱与甘油磷脂酰胆碱的药代动力学比较：随机对照试验。
IF 1.6 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae031
Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada
{"title":"Pharmacokinetics of soy-derived lysophosphatidylcholine compared with that of glycerophosphocholine: a randomized controlled trial.","authors":"Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada","doi":"10.1093/bbb/zbae031","DOIUrl":"10.1093/bbb/zbae031","url":null,"abstract":"<p><p>Lysophosphatidylcholine (LPC) is present in various foods and contains a choline moiety such as in glycerophosphocholine (GPC). However, the potential of LPC as a choline source remains unclear. This study investigated the single-dose pharmacokinetics of 480 mg soy-derived LPC in 12 healthy men compared with that of either soy oil with the same lipid amount (placebo) or GPC with the same choline amount. Both LPC and GPC supplementation increased plasma choline, serum phospholipid, and serum triglyceride concentrations, but neither of them significantly elevated plasma trimethylamine N-oxide concentration. In addition, although the intake of LPC slightly increased plasma LPC16:0, LPC18:2, and total LPC concentrations, their concentrations remained within physiological ranges. No adverse events were attributed to the LPC supplementation. To the best of our knowledge, this study is the first to compare LPC and GPC pharmacokinetics in humans and shows that LPC can be a source of choline.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzymatic extraction of anthocyanins from the pomace of aronia (Aronia melanocarpa). 用酶提取海棠果渣中的花青素。
IF 1.6 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-22 DOI: 10.1093/bbb/zbae037
Jinman Kim, Yejin Lee, Hee-Jae Suh, Hee-Seok Lee, Chan Lee
{"title":"Enzymatic extraction of anthocyanins from the pomace of aronia (Aronia melanocarpa).","authors":"Jinman Kim, Yejin Lee, Hee-Jae Suh, Hee-Seok Lee, Chan Lee","doi":"10.1093/bbb/zbae037","DOIUrl":"10.1093/bbb/zbae037","url":null,"abstract":"<p><p>Efficient extraction of natural pigments is a key focus in enhancing the utilization of by-products for applications in the food industry. In this study, an enzymatic extraction method using Pectinex Ultra SP-L, Pectinex XXL, Novoshape, and Celluclast was used to investigate natural pigment production from the pomace of aronia, a commercially important plant. The method's performance was monitored using high-performance liquid chromatography with diode-array detection by measuring total and individual anthocyanin levels. Pectinex XXL (0.5%) yielded the highest total anthocyanin extraction (2082.41 ± 85.69 mg/100 g) in the single enzyme treatment, followed by Pectinex Ultra SP-L (0.05%), Celluclast (0.01%), and Novoshape (0.1%). Combining Pectinex XXL (0.25%) with Celluclast (0.01%) increased the extraction ratio of total anthocyanins (2 323.04 ± 61.32 mg/100 g) by ∼50.7% compared with that obtained using the solvent extraction method. This study demonstrated an effective enzymatic extraction method for application in the food industry.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140304873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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