在胰岛素作用下，补充胆酸的饮食可抑制大鼠体内极低密度脂蛋白的分泌。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-20 DOI:10.1093/bbb/zbaf041

Fumika Yokoyama, Satoshi Tsuyama, Satoshi Ishizuka

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引用次数: 0

摘要

我们研究了膳食中补充胆酸（CA）是否会抑制大鼠肝脏极低密度脂蛋白（VLDL）的分泌。在体内胰岛素存在的情况下，膳食补充胆酸可抑制 VLDL 的分泌。这些结果表明，肠肝12-羟基化胆汁酸进一步增强了胰岛素对肝脏VLDL分泌的抑制，从而导致肝脏脂质积累。

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A cholic acid-supplemented diet suppresses very-low-density lipoprotein secretion in rats in the presence of insulin.

We investigated whether dietary supplementation with cholic acid (CA) suppressed hepatic very-low-density lipoprotein (VLDL) secretion in rats. Dietary CA supplementation suppressed VLDL secretion in vivo in the presence of insulin. These results suggest that enterohepatic 12-hydroxylated bile acids further enhance insulin-induced suppression of hepatic VLDL secretion, which contributes to hepatic lipid accumulation.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).