Bioscience, Biotechnology, and Biochemistry最新文献_第2页

Effect of microemulsion system on water dispersibility and bioavailability of γ-oryzanol. 微乳液体系对γ-谷维醇水分散性和生物利用度的影响。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf002

Junya Ito, Naoko Kumagai, Ayaka Suzuki, Naoki Shoji, Isabella Supardi Parida, Mamoru Takahashi, Kiyotaka Nakagawa

引用次数: 0

FRPR-1, a G protein-coupled receptor in the FMRFamide-related peptide receptor family, modulates larval development as a receptor candidate of the FMRFamide-like peptide FLP-1 in Caenorhabditis elegans. FRPR-1是fmrfamily相关肽受体家族中的G蛋白偶联受体（GPCR），在秀丽隐杆线虫中作为fmrfamily样肽FLP-1的候选受体调节幼虫的发育。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf004

Risako Une, Riko Uegaki, Sho Maega, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Akira Shiraishi, Honoo Satake, Tsuyoshi Kawano

{"title":"FRPR-1, a G protein-coupled receptor in the FMRFamide-related peptide receptor family, modulates larval development as a receptor candidate of the FMRFamide-like peptide FLP-1 in Caenorhabditis elegans.","authors":"Risako Une, Riko Uegaki, Sho Maega, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Akira Shiraishi, Honoo Satake, Tsuyoshi Kawano","doi":"10.1093/bbb/zbaf004","DOIUrl":"10.1093/bbb/zbaf004","url":null,"abstract":"FMRFamide-like peptides (FLPs) and their receptors, FMRFamide-related peptide receptors (FRPRs) are widely conserved in free-living and parasitic nematodes. Herein, we identified FRPR-1 as an FLP-1 receptor candidate involved in larval development and diapause in the model nematode Caenorhabditis elegans. Our molecular genetic study, supported by in silico research, revealed the following: (1) frpr-1 loss-of-function completely suppresses the promotion of larval diapause caused by flp-1 overexpression; (2) AlphaFold2 analysis revealed the binding of FLP-1 to FRPR-1; (3) FRPR-1 as well as FLP-1 modulates the production and secretion of the predominant insulin-like peptide DAF-28, which is produced in ASI neurons; and (4) the suppression of larval diapause by frpr-1 loss-of-function is completely suppressed by a daf-28 defect. Thus, FRPR-1 regulates larval development and diapause by modulating DAF-28 production and secretion. This study may provide new insights into the development of novel nematicides targeting parasitic nematodes using FRPR-1 inhibitors.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"586-593"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmodium falciparum histidine-rich protein 2 exhibits cell penetration and cytotoxicity with autophagy dysfunction. 恶性疟原虫富组氨酸蛋白2表现出细胞渗透和细胞毒性，并伴有自噬功能障碍。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae209

Takashi Iwasaki, Mayu Shimoda, Haru Kanayama, Tsuyoshi Kawano

引用次数: 0

Manipulation and analysis of large DNA molecules by controlling their dynamics using micro and nanogaps. 操纵和分析大的DNA分子，通过控制他们的动态使用微和纳米间隙。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae179

Naoki Azuma

引用次数: 0

Genetic mechanisms underlying diverse panicle architecture in rice. 水稻穗型结构多样性的遗传机制。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae189

Ayumi Agata

引用次数: 0

Toward nanoscale structural and chemical analysis of microbial surfaces. 实现微生物表面的纳米级结构和化学分析。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae176

Ryo Kato, Keisuke Miyazawa, Takumi Imura, Takeo Minamikawa

引用次数: 0

Tetragonia tetragonioides extract prevented high-fat-diet-induced obesity and changed hepatic and adipose transcriptomic signatures in C57BL/6J male mice. 四角草提取物可预防高脂肪饮食引起的肥胖，并改变C57BL/6J雄性小鼠的肝脏和脂肪转录组特征。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf001

Hea Ry Oh, Yong Hyun Park, Hye Ryeong Hong, Hyun Jin Kim, Jinbong Park, Yohan Han, Seong-Gyu Ko, Eui Cheol Shin, Tae Gyun Kim, Hyung Taek Cho, Jeong Hoon Pan, Hyo Ri Shin, Youn Young Shim, Martin J T Reaney, Tae Jin Cho, Ji Youn Hong, Young Jun Kim, Bok Kyung Han, Geung-Joo Lee, Kangwook Lee, Seon Gil Do, Jae Kyeom Kim

{"title":"Tetragonia tetragonioides extract prevented high-fat-diet-induced obesity and changed hepatic and adipose transcriptomic signatures in C57BL/6J male mice.","authors":"Hea Ry Oh, Yong Hyun Park, Hye Ryeong Hong, Hyun Jin Kim, Jinbong Park, Yohan Han, Seong-Gyu Ko, Eui Cheol Shin, Tae Gyun Kim, Hyung Taek Cho, Jeong Hoon Pan, Hyo Ri Shin, Youn Young Shim, Martin J T Reaney, Tae Jin Cho, Ji Youn Hong, Young Jun Kim, Bok Kyung Han, Geung-Joo Lee, Kangwook Lee, Seon Gil Do, Jae Kyeom Kim","doi":"10.1093/bbb/zbaf001","DOIUrl":"10.1093/bbb/zbaf001","url":null,"abstract":"Obesity, often driven by high-fat diets (HFDs), is a major global health issue, necessitating effective preventive measures. Tetragonia tetragonoides, a plant with known medicinal properties, has not been extensively studied for its effects on HFD-induced obesity and related genetic changes in mice. This study explores the impact of T. tetragonoides extract (TTE; 300 mg/kg) on obesity-related traits in C57BL/6J male mice, with a focus on transcriptomic changes in the liver and white adipose tissue (WAT). Over 8 weeks, TTE supplementation led to significant reductions in obesity-related phenotypes and modulated gene expression altered by HFD. Key genes like Cd180 and MUPs, linked to immune responses and lipid metabolism, were notably influenced by TTE. The study highlighted TTE's effects on lipid metabolism pathways in the liver and immune processes in WAT, underscoring its potential as an anti-obesity agent, while advocating for further research into its bioactive components.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"599-611"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prokaryotic ATP-binding cassette type F proteins in overcoming ribosomal stalling: mechanisms, evolution, and perspective for applications in bio-manufacturing. 原核ABCF蛋白克服核糖体失速：机制、进化和在生物制造中的应用前景。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae201

Hiraku Takada, Ryota Sugimoto, Taku Oshima

{"title":"Prokaryotic ATP-binding cassette type F proteins in overcoming ribosomal stalling: mechanisms, evolution, and perspective for applications in bio-manufacturing.","authors":"Hiraku Takada, Ryota Sugimoto, Taku Oshima","doi":"10.1093/bbb/zbae201","DOIUrl":"10.1093/bbb/zbae201","url":null,"abstract":"ATP-binding cassette type F (ABCF) proteins are key components of prokaryotic translation systems, resolving ribosomal stalling. These adenosine triphosphatases (ATPases) contain 2 ATPase domains and an interdomain linker, the length and composition of which are key determinants of their function. Antibiotic resistance ABCF proteins counteract ribosome-targeting antibiotics by binding to the E site of the 70S ribosome, promoting drug dissociation. In contrast, housekeeping ABCF proteins, such as YfmR and YkpA in Bacillus subtilis, resolve intrinsic translation challenges without conferring antibiotic resistance. YfmR addresses stalling at proline-rich motifs, while YkpA resolves stalling caused by charged motifs. This review draws on the work of Chadani, Boël, Fega, and our own studies to compare the structural and functional diversity of ABCF proteins across bacterial species. It highlights the key roles of antibiotic resistance/P site tRNA interaction motif domains in defining their specific functions and explores future research directions to further our understanding of ABCF proteins in translation control.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"481-488"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunostimulatory effects of Heyndrickxia coagulans SANK70258. 海因德里克夏凝血剂SANK70258的免疫刺激作用。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae203

Yuki Ikeda, Niya Yamashita, Naoto Ito, Natsuki Minamikawa, Hotaka Okamura, Takuya Yashiro, Masakazu Hachisu, Masanori Aida, Ryouichi Yamada, Kazuki Nagata, Chiharu Nishiyama

{"title":"Immunostimulatory effects of Heyndrickxia coagulans SANK70258.","authors":"Yuki Ikeda, Niya Yamashita, Naoto Ito, Natsuki Minamikawa, Hotaka Okamura, Takuya Yashiro, Masakazu Hachisu, Masanori Aida, Ryouichi Yamada, Kazuki Nagata, Chiharu Nishiyama","doi":"10.1093/bbb/zbae203","DOIUrl":"10.1093/bbb/zbae203","url":null,"abstract":"Here, we examined the immunomodulating effects of Heyndrickxia coagulans SANK70258 (SANK70258). Mouse splenocytes treated with γ-ray-irradiated SANK70258 produced higher levels of interferon (IFN)-γ than those with 7 types of lactic acid bacteria. IFN-γ was mainly produced by natural killer (NK) cells, involving IL-12/IL-23, dendritic cells (DCs), and NF-κB signaling. SANK70258 induced the release of IL-6, IL-10, and IL-12p40 from mouse DCs and the expression of cytokine genes in the human monocyte. Cytokine release from SANK70258-treated DCs was partially reduced by the knockdown of Tlr2 or Nod2, and was abolished by Myd88 knockout. DC-stimulating components of SANK70258 were enriched in ether- and butanol-insoluble peptidoglycan-related fractions. The SANK70258 component induced high levels of immunoglobulin (Ig) A production in Peyer's patch cells, and its oral intake significantly increased intestinal IgA and IgA-expressing B cells in Peyer's patches in mice. We conclude that the SANK70258 component exhibits high activity as an immunostimulant that induces the production of IFN-γ and IgA.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"622-632"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique substrate specificity of PonAAS2, an aromatic aldehyde synthase, involved in phytohormone auxin biosynthesis in a gall-inducing sawfly Euura sp. "Pontania". PonAAS2是一种芳香醛合成酶，参与植物激素生长素的生物合成，具有独特的底物特异性。“Pontania”。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf005

Yoshihito Suzuki, Hikaru Ichikawa, Yuri Kunioka, Umi Miyata, Shugo Nakamura, Zui Fujimoto

引用次数: 0