Bioscience, Biotechnology, and Biochemistry最新文献_第3页

Human intestinal organoids as a valuable tool to investigate human intestinal biology. 人类肠道类器官是研究人类肠道生物学的重要工具。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-23 DOI: 10.1093/bbb/zbaf099

Yu Takahashi

引用次数: 0

Comparative analysis of quorum-sensing systems that control pathogenicity in three phylogenetic groups of Pseudomonas isolated from tomato pith necrosis in Japan. 控制日本番茄髓坏死假单胞菌3个系统发育群致病性的群体感应系统比较分析。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-23 DOI: 10.1093/bbb/zbaf100

Tomohiro Morohoshi, Xiaonan Xie, Tomohiro Suzuki, Nobutaka Someya

{"title":"Comparative analysis of quorum-sensing systems that control pathogenicity in three phylogenetic groups of Pseudomonas isolated from tomato pith necrosis in Japan.","authors":"Tomohiro Morohoshi, Xiaonan Xie, Tomohiro Suzuki, Nobutaka Someya","doi":"10.1093/bbb/zbaf100","DOIUrl":"10.1093/bbb/zbaf100","url":null,"abstract":"Tomato pith necrosis (TPN) is a common disease worldwide. In this study, we investigated the relationship between acylhomoserine lactone (AHL)-mediated quorum sensing and pathogenicity in 21 TPN isolates, which were classified into three groups: group 1 (Pseudomonas corrugata), group 2 (Pseudomonas mediterranea), and group 3 (novel taxonomic group). All strains produced N-hexanoyl-l-homoserine lactone as the dominant AHL molecule. Phylogenetic analyses revealed high conservation of quorum-sensing genes among the three groups, with nearly identical sequences and arrangements. Whole-genome sequencing of the group 3 strain MAFF 730105 revealed the presence of a type III secretion system gene cluster, similar to well-known plant pathogens. Although quorum sensing influences virulence, its impact is limited, and some virulence factors may be constitutive or regulated independently. These results suggest that quorum sensing contributes to TPN symptoms; however, additional factors and regulatory mechanisms are involved in the pathogenicity of TPN isolates.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1509-1516"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an electroporation-based transformation system for Moniliella megachiliensis. 基于电穿孔的巨芽孢杆菌转化系统的研制。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-23 DOI: 10.1093/bbb/zbaf107

Taisuke Watanabe, Shinkuro Kimura, Takafumi Kasumi, Jun Ogihara

引用次数: 0

Correction to: Liraglutide enhances myotube differentiation and muscle contractile activity upon electric pulse stimulation in mouse skeletal muscle cells. 更正：利拉鲁肽在电脉冲刺激小鼠骨骼肌细胞时增强肌管分化和肌肉收缩活动。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-23 DOI: 10.1093/bbb/zbaf116

引用次数: 0

Apple Sourness and Sweetness Intensities Standardized Using a General-purpose Standard Solution and a Taste Sensor System. 使用通用标准溶液和味觉传感器系统标准化苹果酸甜强度。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-17 DOI: 10.1093/bbb/zbaf136

Tomomi Ujihara, Nobuyuki Hayashi, Hidekazu Ikezaki

引用次数: 0

Amino acid profile affecting the lactic acid bacterial community in kimoto seed mash at various brewing years. 不同酿造年份kimoto种子醪中氨基酸分布对乳酸菌群落的影响。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-17 DOI: 10.1093/bbb/zbaf134

Hayato Takeuchi, Kazunari Ito, Yuji Miyake, Yuka Tanino, Shuzo Watanabe, Kouzo Watanabe, Tsuyoshi Miyake

引用次数: 0

Co-administration of histidine and soy isoflavones induces beige adipogenesis in male rats: depot-specific responses in white adipose tissue. 组氨酸和大豆异黄酮共同给药诱导雄性大鼠米色脂肪生成：白色脂肪组织中的仓库特异性反应。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-12 DOI: 10.1093/bbb/zbaf135

Riku Asahi, Haruhide Udagawa, Remiko Oshiro, Shigeru Nakajima, Nobuyuki Kanzawa, Yukiko Shimizu, Tadashi Okamura, Takahiko J Fujimi

引用次数: 0

Augmented glucagon-induced gluconeogenesis in primary hepatocytes from Otsuka Long-Evans Tokushima Fatty rats. 胰高血糖素诱导的大鼠原代肝细胞糖异生增强。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-10 DOI: 10.1093/bbb/zbaf133

Miwako Deguchi, Akemi Hosoda, Tomoe Fukumura, Shigeru Saeki, DongHo Kim

{"title":"Augmented glucagon-induced gluconeogenesis in primary hepatocytes from Otsuka Long-Evans Tokushima Fatty rats.","authors":"Miwako Deguchi, Akemi Hosoda, Tomoe Fukumura, Shigeru Saeki, DongHo Kim","doi":"10.1093/bbb/zbaf133","DOIUrl":"https://doi.org/10.1093/bbb/zbaf133","url":null,"abstract":"Glucagon dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), yet its early hepatic effects remain unclear. Here, we demonstrate that glucagon-induced gluconeogenesis is markedly enhanced in primary hepatocytes from prediabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a well-established model of human T2DM. Compared to control LETO rats, OLETF hepatocytes showed significantly higher glucagon-stimulated expression of gluconeogenic genes (Pepck, G6pase, Fbp1) at both mRNA and protein levels, along with elevated glucose production. Notably, mRNA decay analysis revealed prolonged half-lives of gluconeogenic transcripts in OLETF hepatocytes, indicating enhanced mRNA stability as a novel mechanism contributing to increased hepatic glucose output. These findings highlight aberrant glucagon responsiveness and post-transcriptional regulation as potential predisposing factors in genetically susceptible models prior to the onset of overt metabolic abnormality, suggesting may be of interest for preventive or therapeutic strategies for controlling fasting hyperglycemia.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-1β restrains its own apoptosis-promoting activity via NF-κB (RelA) Ser276/p62-mediated elimination of damaged mitochondria in Chondrocytes. IL-1β通过NF-κB (RelA) Ser276/p62介导的软骨细胞中受损线粒体的消除抑制其自身的促凋亡活性。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-09 DOI: 10.1093/bbb/zbaf119

Junzheng Hu, Weituo Zhang, Zhe Zhao

{"title":"IL-1β restrains its own apoptosis-promoting activity via NF-κB (RelA) Ser276/p62-mediated elimination of damaged mitochondria in Chondrocytes.","authors":"Junzheng Hu, Weituo Zhang, Zhe Zhao","doi":"10.1093/bbb/zbaf119","DOIUrl":"https://doi.org/10.1093/bbb/zbaf119","url":null,"abstract":"Interleukin-1β (IL-1β) is a central proinflammatory cytokine implicated in osteoarthritis (OA), but its precise role in chondrocyte apoptosis remains to be fully elucidated. In this study, we demonstrate that IL-1β triggers mitophagy in chondrocytes by promoting Parkin translocation and p62 recruitment to damaged mitochondria, thereby reducing mitochondrial dysfunction and apoptosis. Loss of p62 resulted in impaired mitophagy, excessive mitochondrial superoxide accumulation, and increased cell death. Mechanistically, IL-1β enhanced NF-κB (RelA) phosphorylation at Ser276 and Ser536, accompanied by elevated MSK1 expression. Inhibition of MSK1 selectively suppressed Ser276 phosphorylation without affecting Ser536, leading to reduced p62 expression and disrupted mitophagy. These findings reveal a previously unrecognized intrinsic regulatory mechanism by which IL-1β limits its own apoptosis-promoting effect through activation of the NF-κB (RelA) Ser276-p62-mitophagy axis. This pathway facilitates the clearance of damaged mitochondria and preserves chondrocyte viability, offering potential therapeutic insight into inflammation-associated cartilage degeneration in OA.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic analysis of lignocellulosic biomass saccharification by the filamentous fungus Talaromyces cellulolyticus. 丝状真菌Talaromyces cellulose olyticus对木质纤维素生物质糖化的机理分析。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-09 DOI: 10.1093/bbb/zbaf132

Tatsuya Fujii

引用次数: 0