Bioscience, Biotechnology, and Biochemistry最新文献_第3页

Toward nanoscale structural and chemical analysis of microbial surfaces. 实现微生物表面的纳米级结构和化学分析。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae176

Ryo Kato, Keisuke Miyazawa, Takumi Imura, Takeo Minamikawa

引用次数: 0

Tetragonia tetragonioides extract prevented high-fat-diet-induced obesity and changed hepatic and adipose transcriptomic signatures in C57BL/6J male mice. 四角草提取物可预防高脂肪饮食引起的肥胖，并改变C57BL/6J雄性小鼠的肝脏和脂肪转录组特征。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf001

Hea Ry Oh, Yong Hyun Park, Hye Ryeong Hong, Hyun Jin Kim, Jinbong Park, Yohan Han, Seong-Gyu Ko, Eui Cheol Shin, Tae Gyun Kim, Hyung Taek Cho, Jeong Hoon Pan, Hyo Ri Shin, Youn Young Shim, Martin J T Reaney, Tae Jin Cho, Ji Youn Hong, Young Jun Kim, Bok Kyung Han, Geung-Joo Lee, Kangwook Lee, Seon Gil Do, Jae Kyeom Kim

{"title":"Tetragonia tetragonioides extract prevented high-fat-diet-induced obesity and changed hepatic and adipose transcriptomic signatures in C57BL/6J male mice.","authors":"Hea Ry Oh, Yong Hyun Park, Hye Ryeong Hong, Hyun Jin Kim, Jinbong Park, Yohan Han, Seong-Gyu Ko, Eui Cheol Shin, Tae Gyun Kim, Hyung Taek Cho, Jeong Hoon Pan, Hyo Ri Shin, Youn Young Shim, Martin J T Reaney, Tae Jin Cho, Ji Youn Hong, Young Jun Kim, Bok Kyung Han, Geung-Joo Lee, Kangwook Lee, Seon Gil Do, Jae Kyeom Kim","doi":"10.1093/bbb/zbaf001","DOIUrl":"10.1093/bbb/zbaf001","url":null,"abstract":"Obesity, often driven by high-fat diets (HFDs), is a major global health issue, necessitating effective preventive measures. Tetragonia tetragonoides, a plant with known medicinal properties, has not been extensively studied for its effects on HFD-induced obesity and related genetic changes in mice. This study explores the impact of T. tetragonoides extract (TTE; 300 mg/kg) on obesity-related traits in C57BL/6J male mice, with a focus on transcriptomic changes in the liver and white adipose tissue (WAT). Over 8 weeks, TTE supplementation led to significant reductions in obesity-related phenotypes and modulated gene expression altered by HFD. Key genes like Cd180 and MUPs, linked to immune responses and lipid metabolism, were notably influenced by TTE. The study highlighted TTE's effects on lipid metabolism pathways in the liver and immune processes in WAT, underscoring its potential as an anti-obesity agent, while advocating for further research into its bioactive components.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"599-611"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prokaryotic ATP-binding cassette type F proteins in overcoming ribosomal stalling: mechanisms, evolution, and perspective for applications in bio-manufacturing. 原核ABCF蛋白克服核糖体失速：机制、进化和在生物制造中的应用前景。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae201

Hiraku Takada, Ryota Sugimoto, Taku Oshima

{"title":"Prokaryotic ATP-binding cassette type F proteins in overcoming ribosomal stalling: mechanisms, evolution, and perspective for applications in bio-manufacturing.","authors":"Hiraku Takada, Ryota Sugimoto, Taku Oshima","doi":"10.1093/bbb/zbae201","DOIUrl":"10.1093/bbb/zbae201","url":null,"abstract":"ATP-binding cassette type F (ABCF) proteins are key components of prokaryotic translation systems, resolving ribosomal stalling. These adenosine triphosphatases (ATPases) contain 2 ATPase domains and an interdomain linker, the length and composition of which are key determinants of their function. Antibiotic resistance ABCF proteins counteract ribosome-targeting antibiotics by binding to the E site of the 70S ribosome, promoting drug dissociation. In contrast, housekeeping ABCF proteins, such as YfmR and YkpA in Bacillus subtilis, resolve intrinsic translation challenges without conferring antibiotic resistance. YfmR addresses stalling at proline-rich motifs, while YkpA resolves stalling caused by charged motifs. This review draws on the work of Chadani, Boël, Fega, and our own studies to compare the structural and functional diversity of ABCF proteins across bacterial species. It highlights the key roles of antibiotic resistance/P site tRNA interaction motif domains in defining their specific functions and explores future research directions to further our understanding of ABCF proteins in translation control.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"481-488"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunostimulatory effects of Heyndrickxia coagulans SANK70258. 海因德里克夏凝血剂SANK70258的免疫刺激作用。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae203

Yuki Ikeda, Niya Yamashita, Naoto Ito, Natsuki Minamikawa, Hotaka Okamura, Takuya Yashiro, Masakazu Hachisu, Masanori Aida, Ryouichi Yamada, Kazuki Nagata, Chiharu Nishiyama

{"title":"Immunostimulatory effects of Heyndrickxia coagulans SANK70258.","authors":"Yuki Ikeda, Niya Yamashita, Naoto Ito, Natsuki Minamikawa, Hotaka Okamura, Takuya Yashiro, Masakazu Hachisu, Masanori Aida, Ryouichi Yamada, Kazuki Nagata, Chiharu Nishiyama","doi":"10.1093/bbb/zbae203","DOIUrl":"10.1093/bbb/zbae203","url":null,"abstract":"Here, we examined the immunomodulating effects of Heyndrickxia coagulans SANK70258 (SANK70258). Mouse splenocytes treated with γ-ray-irradiated SANK70258 produced higher levels of interferon (IFN)-γ than those with 7 types of lactic acid bacteria. IFN-γ was mainly produced by natural killer (NK) cells, involving IL-12/IL-23, dendritic cells (DCs), and NF-κB signaling. SANK70258 induced the release of IL-6, IL-10, and IL-12p40 from mouse DCs and the expression of cytokine genes in the human monocyte. Cytokine release from SANK70258-treated DCs was partially reduced by the knockdown of Tlr2 or Nod2, and was abolished by Myd88 knockout. DC-stimulating components of SANK70258 were enriched in ether- and butanol-insoluble peptidoglycan-related fractions. The SANK70258 component induced high levels of immunoglobulin (Ig) A production in Peyer's patch cells, and its oral intake significantly increased intestinal IgA and IgA-expressing B cells in Peyer's patches in mice. We conclude that the SANK70258 component exhibits high activity as an immunostimulant that induces the production of IFN-γ and IgA.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"622-632"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique substrate specificity of PonAAS2, an aromatic aldehyde synthase, involved in phytohormone auxin biosynthesis in a gall-inducing sawfly Euura sp. "Pontania". PonAAS2是一种芳香醛合成酶，参与植物激素生长素的生物合成，具有独特的底物特异性。“Pontania”。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf005

Yoshihito Suzuki, Hikaru Ichikawa, Yuri Kunioka, Umi Miyata, Shugo Nakamura, Zui Fujimoto

引用次数: 0

Fatty acids from cheese stimulate cholesterol efflux by ATP-binding cassette transporters. 奶酪中的脂肪酸通过ABC转运蛋白刺激胆固醇外排。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae207

Michinori Matsuo, Shiho Takaoka, Kai Nakayama, Akika Nagira, Hirofumi Goto, Akihiro Nakajima

{"title":"Fatty acids from cheese stimulate cholesterol efflux by ATP-binding cassette transporters.","authors":"Michinori Matsuo, Shiho Takaoka, Kai Nakayama, Akika Nagira, Hirofumi Goto, Akihiro Nakajima","doi":"10.1093/bbb/zbae207","DOIUrl":"10.1093/bbb/zbae207","url":null,"abstract":"It is essential to remove cholesterol from the body to suppress atherosclerosis progression. ABCA1 and ABCG1 transport cholesterol in peripheral cells, including macrophages, and function in the formation of high-density lipoprotein. ABCG5/ABCG8 functions in the efflux of cholesterol from the body. In this study, we investigated the effects of Camembert cheese extracts and ingredients on cholesterol transport via ABC transporters. Camembert cheese extracts were added to baby hamster kidney (BHK) cells expressing ABCA1, ABCG1, or ABCG5/ABCG8, and THP-1 cells expressing ABCA1 and ABCG1. Organic solvent extracts of Camembert cheese increased cholesterol efflux in THP-1 and BHK cells expressing ABCA1 or ABCG5/ABCG8. After fractionation of the extracts, palmitoleic acid was found to increase cholesterol efflux by ABCA1 and ABCG5/ABCG8, whereas 10-hydroxypalmitic acid increased it by ABCA1 and ABCG1. It is suggested that palmitoleic acid and 10-hydroxypalmitic acid in Camembert cheese may prevent the accumulation of excess cholesterol in cells by stimulating ABC transporters.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"573-585"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial induction of the UPR by Tet-off system-dependent expression of Hac1 and its application in Saccharomyces cerevisiae cells.

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf006

Yuki Ishiwata-Kimata, Masaki Monguchi, Ralph Allen Capistrano Geronimo, Maya Sugimoto, Yukio Kimata

{"title":"Artificial induction of the UPR by Tet-off system-dependent expression of Hac1 and its application in Saccharomyces cerevisiae cells.","authors":"Yuki Ishiwata-Kimata, Masaki Monguchi, Ralph Allen Capistrano Geronimo, Maya Sugimoto, Yukio Kimata","doi":"10.1093/bbb/zbaf006","DOIUrl":"10.1093/bbb/zbaf006","url":null,"abstract":"In response to endoplasmic reticulum (ER) stress, yeast Saccharomyces cerevisiae cells produce Hac1, which is a transcription factor responsible for the unfolded protein response (UPR). When Hac1 is unregulatedly expressed from a constitutive promoter, the ER is artificially enforced and enlarged, even without ER stress stimuli. However, such cells are unsuitable for applicative bioproduction because they grow quite slowly and quickly lose their high-UPR phenotype upon their long-term storage. To avoid this problem, we constructed S. cerevisiae plasmids for Hac1 expression under the control of the inducible Tet-off promoter. Yeast cells carrying these plasmids did not exhibit a considerable UPR and grew rapidly when the Tet-off promoter was repressed by doxycycline. In contrast, under the Tet-off inducing condition, these plasmids caused UPR induction, growth retardation, and ER expansion, depending on the copy number of the plasmid. Moreover, as expected, lipidic molecule production was increased under these conditions.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"562-572"},"PeriodicalIF":1.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional expression mechanisms of food-derived components based on target proteins. 基于靶蛋白的食源性成分功能表达机制。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf003

Takakazu Mitani

引用次数: 0

Development of biocatalysts for high-value-added compounds. 开发高附加值化合物的生物催化剂。

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbae139

Atsushi Usami

引用次数: 0

Piceatannol promotes the osteogenic differentiation of human periodontal ligament cells through MAPKs activation.

IF 1.4 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-03-24 DOI: 10.1093/bbb/zbaf040

Hiromu Morimoto, Hirofumi Inoue, Kotone Date, Shinpei Kawakami, Sadao Mori, Hiroko Maruki-Uchida, Nobuyuki Takahashi, Mariko Uehara

引用次数: 0