Bioscience, Biotechnology, and Biochemistry最新文献_第3页

Structural and functional analysis of RIC8B variants regulating olfactory receptor responses. 调节嗅觉受体反应的RIC8B变异的结构和功能分析。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-22 DOI: 10.1093/bbb/zbag024

Rina Shirai, Shuji Hinuma, Shun'ichi Kuroda

引用次数: 0

Sensory and physicochemical factors characterizing the optimum eating ripeness of melting flesh peach (Prunus persica L.). 溶化果肉桃最佳食用成熟度的感官及理化因素研究。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-22 DOI: 10.1093/bbb/zbag028

Rei Osuga, Miho Tatsuki, Fukuyo Tanaka, Yuko Nakano, Hiroko Mochizuki-Kawai, Fumiyo Hayakawa

{"title":"Sensory and physicochemical factors characterizing the optimum eating ripeness of melting flesh peach (Prunus persica L.).","authors":"Rei Osuga, Miho Tatsuki, Fukuyo Tanaka, Yuko Nakano, Hiroko Mochizuki-Kawai, Fumiyo Hayakawa","doi":"10.1093/bbb/zbag028","DOIUrl":"10.1093/bbb/zbag028","url":null,"abstract":"Optimum eating ripeness is critical when selecting peaches for consumption; however, the underlying sensory drivers remain unclear. This study identified the sensory factors characterizing the perceived optimum eating ripeness of the melting flesh peach. Seven sample conditions were established from postharvest peaches based on the ripening days, where perceived ripeness shifted from unripe to optimum and then to overripe. The early phase was dominated by sensory textural changes (e.g. \"crispiness\") and the development of \"peach-identity (ID)\" flavor, while the late phase was predominated by an increase in \"overripe\" flavor. Instrumental firmness and ethyl acetate levels changed, accompanied by sensory textures and \"overripe\" flavor, respectively. These physicochemical indicators distinguished samples in different ripening phases. These findings highlight key sensory and physicochemical indicators for evaluating the optimum eating ripeness in peaches, reflecting the relationship between human perception and fruit biochemical changes and providing a foundation for improved postharvest quality management and consumer satisfaction.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"679-691"},"PeriodicalIF":1.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of pirfenidone on the regulation of lymph angiogenesis by PLK1 signaling to inhibit metastasis of lung cancer in vivo. 吡非尼酮在体内通过PLK1信号调控淋巴血管生成抑制肺癌转移的作用

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-21 DOI: 10.1093/bbb/zbag054

Zehai Xia, Quan Wang, Lei Zheng, Qun Lv

引用次数: 0

Concise synthesis of Inonophenol A and B, phenolic metabolites from the cultivated edible mushroom Inonotus hispidus. 栽培食用菌野菇酚类代谢产物野酚A、B的简明合成。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-20 DOI: 10.1093/bbb/zbag055

Yoshitaka Matsushima, Aika Oyokawa

引用次数: 0

Inhibition of hepatic lipogenesis and adipogenesis by cordyanhydride A isolated from Cordyceps Militaris cultivated on germinated soybeans. 蛹虫草虫草苷A对大豆发芽培养的肝脏脂肪生成和脂肪生成的抑制作用。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-20 DOI: 10.1093/bbb/zbag058

Kartic, Amitesh Sharma, Nattan Stalin, Sanggyun Yi, Amna Parveen, Sunyeou Kim, Tae-Sik Park

{"title":"Inhibition of hepatic lipogenesis and adipogenesis by cordyanhydride A isolated from Cordyceps Militaris cultivated on germinated soybeans.","authors":"Kartic, Amitesh Sharma, Nattan Stalin, Sanggyun Yi, Amna Parveen, Sunyeou Kim, Tae-Sik Park","doi":"10.1093/bbb/zbag058","DOIUrl":"https://doi.org/10.1093/bbb/zbag058","url":null,"abstract":"Regulation of lipid homeostasis requires coordinated control of fatty acid (FA) oxidation, lipogenesis, and adipocyte differentiation. Cordyanhydride A (CA) was isolated from Cordyceps militaris (CM) extract cultivated on germinated soybean through bioactivity-guided fractionation and structurally characterized using nuclear magnetic resonance (NMR) spectroscopy. The effect of CA was examined in mouse hepatocytes and adipocytes using gene expression analysis, immunoblotting, and lipid accumulation assays. In AML12 hepatocytes, CA upregulated the expression of enzymes and transcriptional regulators involved in FA oxidation and suppressed the lipogenic enzymes. In 3T3-L1 adipocytes, it markedly reduced lipid accumulation and downregulated the expression of transcription factors required for adipocyte differentiation. Molecular docking and dynamics simulations supported stable interactions between CA and key proteins involved in lipid metabolism. These results demonstrate that CA modulates lipid metabolism at the cellular level and underscore the value of integrated experimental and computational approaches in characterizing functional metabolites derived from fermented microorganisms.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to furaneol odor affects spontaneous locomotor activity in mice. 暴露于呋喃醇气味影响小鼠的自发运动活动。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-17 DOI: 10.1093/bbb/zbag056

Motoko Ohata, Momoka Kinowaki, Kenta Sato, Issei Yokoyama, Eri Kakimoto, Kazumi Osada

引用次数: 0

Integrating Seed-Based Design with Ribosome Display for the Development of Nanobody-like Protein Scaffolds. 基于种子设计与核糖体展示相结合的纳米体样蛋白支架的开发。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-17 DOI: 10.1093/bbb/zbag057

Zhujun Ye, Jie Zhang, Xiangrong Shu, Hao Qi

{"title":"Integrating Seed-Based Design with Ribosome Display for the Development of Nanobody-like Protein Scaffolds.","authors":"Zhujun Ye, Jie Zhang, Xiangrong Shu, Hao Qi","doi":"10.1093/bbb/zbag057","DOIUrl":"https://doi.org/10.1093/bbb/zbag057","url":null,"abstract":"Protein scaffolds are indispensable in biology and bioengineering, providing stable, engineerable frameworks for diverse molecular applications. However, existing methods are limited in structural diversity and require extensive experimental or computational resources. Here, we present an integrated strategy that combines seed-based framework design with ribosome display to generate novel nanobody-like protein scaffolds. Sequence alignment of nanobody frameworks defined four conserved 10-residue seed frameworks, which were embedded in random sequences to generate a synthetic library exceeding 10¹³ variants. Iterative ribosome display selection coupled with next-generation sequencing, and subsequent structural prediction using AlphaFold 3 indicated that top candidates adopt canonical nanobody-like folds. Two candidates were stably expressed and exhibited good thermal stability, with Tm around 63.2°C, validating the functional feasibility of the scaffolds generated by this pipeline. This work establishes a proof-of-concept scaffold-generation paradigm that bypasses reliance on natural templates or purely computational design, offering a streamlined and efficient route.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Principles of Lipid Oxidation: From Hydroperoxide Formation to Secondary Oxidation Reactions. 脂质氧化的机理：从过氧化氢形成到二次氧化反应。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-14 DOI: 10.1093/bbb/zbag053

Shunji Kato

{"title":"Mechanistic Principles of Lipid Oxidation: From Hydroperoxide Formation to Secondary Oxidation Reactions.","authors":"Shunji Kato","doi":"10.1093/bbb/zbag053","DOIUrl":"https://doi.org/10.1093/bbb/zbag053","url":null,"abstract":"Lipid oxidation plays crucial roles in both food deterioration and biological processes. Despite extensive studies, the mechanistic principles governing the formation of oxidized lipids remain incompletely understood, largely due to the remarkable structural diversity of oxidation products. In this review, we discuss lipid oxidation from the perspective of chemical reactivity, focusing on the formation and decomposition of lipid hydroperoxides (LOOH) as primary oxidation products. We summarize the major oxidation mechanisms determining the positional distribution of hydroperoxyl groups, including radical, enzymatic, and singlet oxygen-mediated pathways. Recent advances in liquid chromatography-tandem mass spectrometry for structural analysis of LOOH isomers are also reviewed. Particular attention is given to mechanistic principles governing secondary oxidation reactions, where decomposition pathways are largely dictated by radical intermediate stability and surrounding double-bond topology. Integrating structural analysis with stability-based mechanistic principles provides a framework for understanding lipid oxidation and predicting diverse oxidized lipid species.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled structures of class I hydrophobin RolA from the fungus Aspergillus oryzae on PTFE surfaces in the absence of an air-water interface. 米曲霉在没有空气-水界面的PTFE表面上的I类疏水性蛋白RolA的自组装结构。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-06 DOI: 10.1093/bbb/zbag051

Shuma Iio, Nao Takahashi, Yuki Terauchi, Takumi Tanaka, Akira Yoshimi, Hiroshi Yabu, Keietsu Abe

引用次数: 0

Fabrication of β-Glucan Nanocarriers for Enhanced Encapsulation and Delivery of Doxorubicin for Triple Negative Breast Cancer Treatment. β-葡聚糖纳米载体的制备用于阿霉素三阴性乳腺癌治疗的增强包封和递送。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-04-05 DOI: 10.1093/bbb/zbag066

Morteza Servatan, Fatma Zeynep Bozkurt, Zeynep Yilmazer Hitit, Birgütay Şahin, Damla Nur Parıltı, Suna Ertunç, Pelin Mutlu

引用次数: 0