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1,6-Digalloyl glucose in Emblica officinalis increases the proliferation of human keratinocytes and fibroblasts with upregulated expression of periostin. officinalis中的1,6-二烯丙基葡萄糖增加人角质形成细胞和成纤维细胞的增殖，并上调骨膜蛋白的表达。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-09 DOI: 10.1093/bbb/zbaf068
Yoshimi Yamakami, Kyoko Morino, Robert A Kanaly, Raku Irie, Masato Oikawa, Yuki Takauji, Kensuke Miki, Mohammad Nazir Hossain, Dai Ayusawa, Michihiko Fujii
{"title":"1,6-Digalloyl glucose in Emblica officinalis increases the proliferation of human keratinocytes and fibroblasts with upregulated expression of periostin.","authors":"Yoshimi Yamakami, Kyoko Morino, Robert A Kanaly, Raku Irie, Masato Oikawa, Yuki Takauji, Kensuke Miki, Mohammad Nazir Hossain, Dai Ayusawa, Michihiko Fujii","doi":"10.1093/bbb/zbaf068","DOIUrl":"https://doi.org/10.1093/bbb/zbaf068","url":null,"abstract":"<p><p>Keratinocytes and fibroblasts are the major cell types in the epidermis and the dermis, respectively. Since both cells play important roles in wound healing, compounds that regulate their proliferation are expected to be beneficial to epidermal health. We have previously shown that the extract of Emblica officinalis, which is a well-known herb in Ayurvedic traditional medicine, increases the proliferation of keratinocytes. Here we purified a compound that increased cell proliferation from E. officinalis extract. Through liquid chromatography electrospray ionization tandem mass spectrometry and NMR techniques, the compound was determined to be 1,6-digalloyl glucose. Consistent with this, tannic acid, a type of polygalloyl glucose, also increased cell proliferation. We further found that E. officinalis extract increased the proliferation of fibroblasts as well and showed that it increased cell proliferation at least partly through upregulating the expression of periostin. These findings revealed the mechanism by which E. officinalis extract regulates cell proliferation.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved emulsifying property and reduced immunogenicity of β-lactoglobulin by conjugation with carboxymethyl cellulose of different molecular weight. 通过与不同分子量的羧甲基纤维素偶联，改善了β-乳球蛋白的乳化性能，降低了免疫原性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-09 DOI: 10.1093/bbb/zbaf069
Moeko Ono, Tadashi Yoshida, Makoto Hattori
{"title":"Improved emulsifying property and reduced immunogenicity of β-lactoglobulin by conjugation with carboxymethyl cellulose of different molecular weight.","authors":"Moeko Ono, Tadashi Yoshida, Makoto Hattori","doi":"10.1093/bbb/zbaf069","DOIUrl":"https://doi.org/10.1093/bbb/zbaf069","url":null,"abstract":"<p><p>β-Lactoglobulin (BLG) was conjugated with carboxymethyl cellulose (CMC) by using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide to improve its function. Three CMCs differing in molecular weight (1, 90 and 700 kDa) were used to investigate the effect of molecular weight of conjugated saccharide on the degree of functional changes. Reaction ratio was amino groups of BLG:carboxy groups of CMC:EDC = 1:3.5:20 (molar ratio). Conjugation was confirmed by SDS-PAGE. Composition of the BLG-low molecular weight (LMW) CMC, BLG-middle molecular weight (MMW) CMC and BLG-high molecular weight (HMW) CMC was BLG:CMC = 1:1.26, 1:1.30, and 1:1.26 (weight ratio) respectively. Emulsifying property of BLG in the acidic pH range and in the presence of NaCl was much improved by conjugation with CMC and the conjugation with HMW CMC was particularly effective. Immunogenicity of BLG was reduced by conjugation with CMC. In particular, conjugation with MMW CMC was effective and brought about not only quantitative but also qualitative improvements.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactiplantibacillus brownii strain MH-1 prolongs healthspan and improves stress resistance in Caenorhabditis elegans. 布朗氏乳杆菌MH-1菌株延长秀丽隐杆线虫的健康期并提高其抗逆性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-08 DOI: 10.1093/bbb/zbaf065
Mina Hashimoto, Yoshihiko Tanimoto, Eriko Kage-Nakadai
{"title":"Lactiplantibacillus brownii strain MH-1 prolongs healthspan and improves stress resistance in Caenorhabditis elegans.","authors":"Mina Hashimoto, Yoshihiko Tanimoto, Eriko Kage-Nakadai","doi":"10.1093/bbb/zbaf065","DOIUrl":"https://doi.org/10.1093/bbb/zbaf065","url":null,"abstract":"<p><p>Lactiplantibacillus brownii was first discovered in 2023. We previously isolated L. brownii strain MH-1 from homemade pickled Chinese cabbage in Hiroshima Prefecture, Japan, and performed whole-genome sequencing. In this study, we examined the beneficial effects of L. brownii strain MH-1 on a host using C. elegans. MH-1 and heat-killed MH-1 extended the lifespan and also alleviated motility decline during aging in worms. Feeding MH-1 to nematodes indicated its presence in the intestinal tract with no change in body or brood sizes, suggesting that dietary restrictions did not occur. There were no significant differences in intestinal barrier enhancement or fat accumulation in MH-1-fed C. elegans. The stress response of C. elegans was enhanced by MH-1 for oxidative stress tolerance. MH-1 increased the expression of genes involved in defense response and lipid catabolism. These results demonstrate the beneficial effects of MH-1 on nematodes and its potential use as a probiotic.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspergillus terreus AtfB (bZIP) differently regulates lovastatin production in submerged fermentation and in solid-state fermentation. 土曲霉AtfB （bZIP）在深层发酵和固态发酵中对洛伐他汀生产的调控不同。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-06 DOI: 10.1093/bbb/zbaf066
Montserratt Herrera-Martell, Armando Mejía, Luis Enrique Gómez-Quiroz, Javier Barrios-González
{"title":"Aspergillus terreus AtfB (bZIP) differently regulates lovastatin production in submerged fermentation and in solid-state fermentation.","authors":"Montserratt Herrera-Martell, Armando Mejía, Luis Enrique Gómez-Quiroz, Javier Barrios-González","doi":"10.1093/bbb/zbaf066","DOIUrl":"https://doi.org/10.1093/bbb/zbaf066","url":null,"abstract":"<p><p>Lovastatin is industrially produced with Aspergillus terreus, generally by liquid submerged fermentation (SmF), but also by solid-state fermentation (SSF) since it shows higher yields. Its biosynthetic genes are positively regulated by reactive oxygen species. AtfB (AtatfB) knocked-down mutants displayed increased sensitivity to oxidative and osmotic stress in conidia. Transformants showed decreased lovastatin production in SSF, while increased production in SmF (also lower ROS levels in both systems). After ROS normalization, the differences in lovastatin production originally found were conserved. Moreover, biosynthetic genes expression (lovE and lovF) was higher in SmF, but lower in SSF. It is concluded that AtAtfB regulates lovastatin biosynthesis in A. terreus at transcriptional level, but has different functions in SmF and SSF, acting as a negative regulator in SmF, and as a positive regulator in SSF. This is the first report of a transcription factor regulating secondary metabolism with opposite functions in SSF and in SmF.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDRN-like marker DNA shows skin beneficial properties through its single-stranded form. pdrn样标记DNA通过其单链形式显示出对皮肤有益的特性。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-05 DOI: 10.1093/bbb/zbaf067
Hye-Won Lim, Yu-Hua Huang, Hye-Seung Baek, Hong-Gyum Kim, Kyu Earn Kim, Chang-Jin Lim
{"title":"PDRN-like marker DNA shows skin beneficial properties through its single-stranded form.","authors":"Hye-Won Lim, Yu-Hua Huang, Hye-Seung Baek, Hong-Gyum Kim, Kyu Earn Kim, Chang-Jin Lim","doi":"10.1093/bbb/zbaf067","DOIUrl":"https://doi.org/10.1093/bbb/zbaf067","url":null,"abstract":"<p><p>Using marker DNA, this work aimed to clarify which of the two conformational states of PDRNs (Polydeoxyribonucleotides) as a DNA-based remedy, ssDNA random coil or dsDNA helical form, acts as an active player. The marker DNA solution (BN) was subjected to high temperature, which yielded the thermal-denatured BN solution (BN-H) with the enhanced ssDNA. BN-H exhibited significantly higher beneficial properties. The ssDNA state is responsible for its pharmacological properties.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of combination of krill oil with curcumin and/or silymarin on mouse non-alcoholic fatty liver disease. 磷虾油与姜黄素和/或水飞蓟素联合使用对小鼠非酒精性脂肪肝的影响。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-05 DOI: 10.1093/bbb/zbaf064
Sidan Lu, Yangyang Jiang, Yong Ling, Xuguang Zhai, Yajun Zhou
{"title":"Effects of combination of krill oil with curcumin and/or silymarin on mouse non-alcoholic fatty liver disease.","authors":"Sidan Lu, Yangyang Jiang, Yong Ling, Xuguang Zhai, Yajun Zhou","doi":"10.1093/bbb/zbaf064","DOIUrl":"https://doi.org/10.1093/bbb/zbaf064","url":null,"abstract":"<p><p>No effective pharmacological therapy is available for non-alcoholic fatty liver disease. The use of natural products is an alternative therapeutic. The natural antioxidants such as curcumin and silymarin are used in clinical trials against non-alcoholic fatty liver disease, which are hampered by their membrane permeability and consequent low absorption. The amphipathic phospholipid is beneficial to their absorption and antarctic krill oil contains rich phospholipids. We demonstrated that the mixture (antarctic krill oil, curcumin and silymarin) exhibited remarkable roles in inhibiting high-fat diet-induced mouse non-alcoholic fatty liver disease. The effect of the mixture on high-fat diet-induced mouse non-alcoholic fatty liver disease were associated with their regulating the transcriptions of genes related to triglyceride synthesis and fatty acid metabolism, inflammation-related factors, and with the endogenous antioxidant capacity, which might suggest a new choice for inhibiting human non-alcoholic fatty liver disease.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of reactive carbonyl species in inhibition of germination and seedling growth by salt stress in rice. 活性羰基物种在盐胁迫下抑制水稻萌发和幼苗生长中的作用。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-01 DOI: 10.1093/bbb/zbaf062
Faruk Hossain Khan, Yoshitaka Nakashima, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshihiko Hirai, Md Anamul Hoque, Mohammad Saidur Rhaman, Shintaro Munemasa, Jun'ichi Mano, Yoshiyuki Murata
{"title":"Involvement of reactive carbonyl species in inhibition of germination and seedling growth by salt stress in rice.","authors":"Faruk Hossain Khan, Yoshitaka Nakashima, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshihiko Hirai, Md Anamul Hoque, Mohammad Saidur Rhaman, Shintaro Munemasa, Jun'ichi Mano, Yoshiyuki Murata","doi":"10.1093/bbb/zbaf062","DOIUrl":"https://doi.org/10.1093/bbb/zbaf062","url":null,"abstract":"<p><p>Salt stress increases levels of reactive oxygen species (ROS), leading to a variety of damages in plants. Production of reactive carbonyl species (RCS) following ROS accumulation has been reported to be closely related to damage by salt stress. We investigated effects of RCS scavengers, carnosine and pyridoxamine, on inhibition of germination and seedling growth of Nipponbare (Oryza sativa L.) by salt stress. The inhibition of germination and the seedling growth by 50 mM NaCl was alleviated by the scavengers. The scavengers suppressed the malondialdehyde accumulation and protein carbonylation but not the ROS accumulation in the salt-stressed shoots. These results indicate that suppression of RCS accumulation improves salt tolerance without affecting ROS production in rice and suggest that RCS accumulation is responsible for the inhibitory effects on seeds and seedlings in rice.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purification and characterization of CcdB and CcdA toxin-antitoxin system from Acetobacter malorum. 甘露醋杆菌CcdB和CcdA毒素-抗毒素系统的纯化及特性研究。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-26 DOI: 10.1093/bbb/zbaf063
Chenguang Yang, Zhenhua Fan, Lvming Wu, Bo Fu, Hongbin Sun
{"title":"Purification and characterization of CcdB and CcdA toxin-antitoxin system from Acetobacter malorum.","authors":"Chenguang Yang, Zhenhua Fan, Lvming Wu, Bo Fu, Hongbin Sun","doi":"10.1093/bbb/zbaf063","DOIUrl":"https://doi.org/10.1093/bbb/zbaf063","url":null,"abstract":"<p><p>The Toxin-Antitoxin (TA) system, a genetic element in microorganisms, consists of a stable toxin and an unstable antitoxin. The CcdAB system, a typical TA system, encodes the CcdB toxin and CcdA antitoxin and was identified in Acetobacter, though its biological role remains unclear. In this study, CcdA and CcdB proteins were successfully expressed, and purification conditions were optimized to obtain high-purity proteins. Their interaction was studied using a pull-down assay and confirmed through bioinformatics tools, revealing stable secondary structures. Induced expression of CcdB inhibited E. coli growth, demonstrating its toxic effect. Additionally, the structures of CcdA and CcdB were predicted, with structural alignment showing CcdB's evolution is highly conserved. These findings enhance understanding of the CcdA-CcdB interaction mechanism, providing a foundation for further research on TA systems in acetic acid bacteria and their potential roles in microbial survival and stress responses.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of various CaCl2 concentrations on the physiological and growth responses of Asarin Scandens Rose under salt stress. 不同浓度CaCl2对盐胁迫下细辛玫瑰生理和生长响应的影响。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-25 DOI: 10.1093/bbb/zbaf061
Nana Wu, Ruyu Fu, Mingxu Dong, Xinyue Zhang, Jinzhu Zhang, Tao Yang, Jie Dong, Jinping Fan
{"title":"The effects of various CaCl2 concentrations on the physiological and growth responses of Asarin Scandens Rose under salt stress.","authors":"Nana Wu, Ruyu Fu, Mingxu Dong, Xinyue Zhang, Jinzhu Zhang, Tao Yang, Jie Dong, Jinping Fan","doi":"10.1093/bbb/zbaf061","DOIUrl":"https://doi.org/10.1093/bbb/zbaf061","url":null,"abstract":"<p><p>Asarin Scandens Rose ('F499') is a perennial vine that is visually appealing, yet the salinization of the soil due to urban activity may reduce its potential as a landscaping plant. Our research utilized exogenous calcium to diminish the negative effects of salt stress on the growth of F499. Under salt stress, the application of 5 and 10 mM CaCl2 resulted in a considerable expansion of the leaf area, in addition to a heightened deposition of chlorophyll, thus improving the color of the leaves. Additionally, it was shown that F499's net photosynthetic rate (Pn), stomatal conductance (Gs), intercellular CO2 concentration (Ci), transpiration rate (Tr), proline and soluble protein levels all increased under the beneficial effects of CaCl2. Consequently, supplementation with appropriate amounts of exogenous calcium in urban saline soils is an effective way for plants to adapt to salt stress and maintain their ornamental value.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosae multiflorae fructus extracts regulate the differentiation and vascular endothelial cell-mediated proliferation of keratinocytes. 多花玫瑰提取物调节角质形成细胞的分化和血管内皮细胞介导的增殖。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf007
Sae Asayama, Tami Igarashi, Yosihimi Abe, Ayaka Iwasaki, Mizuki Kubo, Ayaka Ikeda, Kouki Akiyama, Tadashi Okamoto, Masayuki Yagi, Yoko Niki, Hideya Ando, Masamitsu Ichihashi, Ken-Ichi Mizutani
{"title":"Rosae multiflorae fructus extracts regulate the differentiation and vascular endothelial cell-mediated proliferation of keratinocytes.","authors":"Sae Asayama, Tami Igarashi, Yosihimi Abe, Ayaka Iwasaki, Mizuki Kubo, Ayaka Ikeda, Kouki Akiyama, Tadashi Okamoto, Masayuki Yagi, Yoko Niki, Hideya Ando, Masamitsu Ichihashi, Ken-Ichi Mizutani","doi":"10.1093/bbb/zbaf007","DOIUrl":"10.1093/bbb/zbaf007","url":null,"abstract":"<p><p>Keratinocytes are the primary component of the epidermis, so maintaining the precise balance between proliferation and differentiation is essential for conserving epidermal structure and function. Rosae multiflorae fructus extract (RMFE) has wide application in the cosmetic industry, but the molecular mechanisms underlying beneficial effects on keratinocytes are still not fully understood. In this study, we found that RMFE promoted epidermal differentiation and enhanced the barrier function of normal human epidermal keratinocytes (NHEKs) and three-dimensional epidermis model in culture. In addition, RMFE promoted human umbilical vein endothelial cell (HUVEC) proliferation and angiogenesis, whereas the conditioned medium from RMFE-treated HUVECs further promoted NHEK proliferation and increased wound healing ability. Analysis of constituent bioactivities identified a quercetin derivative as a potential mediator of NHEK and HUVEC responses to RMFE. Taken together, these results suggest that RMFE enhances epidermal functions through both direct effects on keratinocytes and indirect effects mediated by endothelial cells.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"750-760"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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