癸二酸促进成骨细胞分化。

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-09-05 DOI:10.1093/bbb/zbaf128

Thira Rojasawasthien, Takumi Ito, Hideto Okamoto, Nobuaki Okumura, Sachiko Yamashita Takeuchi, Tomohiko Shirakawa, Takuma Matsubara, Shoichiro Kokabu

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引用次数: 0

摘要

蜂王浆（RJ）由蜜蜂分泌，含有10-羟基-2-癸烯酸（10H2DA）和10-羟基癸酸（10HDAA）等主要脂肪酸，被认为有助于骨骼代谢。然而，这些脂肪酸在摄入后在肝脏中迅速代谢，分别产生2-癸烯酸（2DA）和癸二酸（SA）。因此，阐明这些代谢物在骨代谢中的作用具有相当重要的意义。在本研究中，我们重点研究了2DA和SA对成骨细胞分化的影响。SA处理显著上调成骨细胞标记基因的表达，而2DA处理无明显影响。此外，SA可增强碱性磷酸酶活性，碱性磷酸酶是成骨细胞分化和矿化的典型标志。

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Sebacic acid promotes osteoblast differentiation.

Royal jelly (RJ), secreted by honeybees, contains major fatty acids such as 10-hydroxy-2-decenoic acid (10H2DA) and 10-hydroxydecanoic acid (10HDAA), which are considered to contribute to bone metabolism. However, these fatty acids are rapidly metabolized in the liver following ingestion, resulting in 2-decenoic acid (2DA) and sebacic acid (SA), respectively. Therefore, elucidating the roles of these metabolites in bone metabolism is of considerable importance. In this study, we focused and investigated the effects of 2DA and SA on osteoblast differentiation using osteoblast-lineage cells. SA treatment significantly upregulated the expression of osteoblast marker genes whereas 2DA had no apparent effect. In addition, SA enhanced alkaline phosphatase activity, a typical marker of osteoblast differentiation and mineralization.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).