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Characterization of the nucleoside monophosphate kinase from Thermus thermophilus phage p23-45 and its application in the biosynthesis of deoxynucleoside triphosphates. 嗜热热菌噬菌体p23-45核苷单磷酸激酶的鉴定及其在三磷酸脱氧核苷生物合成中的应用。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf018
Nai-Wei Cheng, Li-Ching Kok, Hui-Chun Cheng, Hwan-You Chang
{"title":"Characterization of the nucleoside monophosphate kinase from Thermus thermophilus phage p23-45 and its application in the biosynthesis of deoxynucleoside triphosphates.","authors":"Nai-Wei Cheng, Li-Ching Kok, Hui-Chun Cheng, Hwan-You Chang","doi":"10.1093/bbb/zbaf018","DOIUrl":"10.1093/bbb/zbaf018","url":null,"abstract":"<p><p>Nucleoside monophosphate kinases (NMKs) are essential enzymes in nucleotide biosynthesis. In this study, an NMK from Thermus thermophilus phage p23-45 (ϕNMK) was overexpressed and characterized, which exhibited relatively low sequence similarity (∼20%) to cellular NMKs. The enzyme demonstrated broad specificity for all 4 deoxynucleoside monophosphates (dNMPs) (KM: 0.27-0.45 m m), optimal activity at 70 °C, and retained 95% activity after 8 h at 37 °C. Structural modeling and site-directed mutagenesis identified key catalytic roles for K39 and R66. A one-pot deoxyribonucleoside triphosphate (dNTP) synthesis workflow using ϕNMK and T. thermophilus pyruvate kinase enhanced ATP regeneration efficiency compared to acetate kinases, achieving >85% conversion of all dNMPs to dNTPs. These findings highlight ϕNMK's thermostability and efficiency, establishing it as a promising candidate for industrial dNTP production.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"712-719"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of d-β-hydroxybutyrate on sleep quality in healthy participants: a randomized, double-blind, placebo-controlled study. D-β-羟基丁酸酯对健康受试者睡眠质量的影响：一项随机、双盲、安慰剂对照研究
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf017
Shohei Katsuya, Yoshikazu Kawata, Yosuke Kawamura, Jun Kawamura, Jun Tsubota
{"title":"Effect of d-β-hydroxybutyrate on sleep quality in healthy participants: a randomized, double-blind, placebo-controlled study.","authors":"Shohei Katsuya, Yoshikazu Kawata, Yosuke Kawamura, Jun Kawamura, Jun Tsubota","doi":"10.1093/bbb/zbaf017","DOIUrl":"10.1093/bbb/zbaf017","url":null,"abstract":"<p><p>We investigated the effects of d-β-hydroxybutyric acid (D-BHB) on sleep quality in healthy Japanese adults. In this randomized, placebo-controlled, double-blind, parallel-group study, each group comprised 30 healthy Japanese adults. Participants received 1.5 g of D-BHB (low D-BHB group), 2.9 g of D-BHB (high D-BHB group), or a placebo beverage (placebo group) for 14 days. Before and after the intervention, the Oguri-Shirakawa-Azumi sleep inventory, middle-aged and aged version (OSA-MA), and sleep state test were conducted. After 14 days, compared to the placebo group, the OSA-MA scores for \"Sleepiness on rising\" and \"Frequent dreaming\" were significantly higher in both the low and high D-BHB groups. Additionally, the score for \"Initiation and maintenance of sleep\" was significantly higher in the low D-BHB group, and the score for \"Refreshing on rising\" was significantly higher in the high D-BHB group. We found that D-BHB can improve sleep quality in healthy Japanese adults.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"769-775"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The DNA binding of plant-specific GROWTH-REGULATING FACTOR transcription factors is stabilized by GRF-INTERACTING FACTOR coactivators. 植物特异性生长调节因子转录因子的 DNA 结合受到 GRF-INTERACTING FACTOR 辅激活因子的稳定。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf016
Shohei Nosaki, Masae Ohtsuka
{"title":"The DNA binding of plant-specific GROWTH-REGULATING FACTOR transcription factors is stabilized by GRF-INTERACTING FACTOR coactivators.","authors":"Shohei Nosaki, Masae Ohtsuka","doi":"10.1093/bbb/zbaf016","DOIUrl":"10.1093/bbb/zbaf016","url":null,"abstract":"<p><p>The plant-specific GROWTH-REGULATING FACTOR (GRF) transcription factor family proteins play crucial role in regulating diverse aspects of plant life. The transcriptional activity of GRFs is known to be enhanced through direct interaction with the GRF-INTERACTING FACTOR (GIF) coactivators. However, it remains unclear how the binding to GIF affects the biochemical ability of GRFs. Herein, we present evidence that GIFs also stabilize the DNA binding of GRFs. A combination of biochemical experiments and AlphaFold-predicted structural models suggests that the GIF-binding domain in GRFs may partially restrict their own DNA binding through direct interaction with the DNA-binding domain in the absence of GIFs. These findings deepen our understanding of the GRF:GIF module in plant regulation and provide a basis for strategies to manipulate this module for agricultural and biotechnological applications.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"761-768"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NPD7426 suppresses sterol regulatory element-binding proteins by promoting the degradation of mature SREBP forms. NPD7426 通过促进成熟 SREBP 形式的降解来抑制固醇调节元件结合蛋白。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf012
Manami Kodaka, Yuki Matsunaga, Seiya Terada, Minami Kamei, Tsukasa Suzuki, Yuji Yamamoto, Jun Inoue
{"title":"NPD7426 suppresses sterol regulatory element-binding proteins by promoting the degradation of mature SREBP forms.","authors":"Manami Kodaka, Yuki Matsunaga, Seiya Terada, Minami Kamei, Tsukasa Suzuki, Yuji Yamamoto, Jun Inoue","doi":"10.1093/bbb/zbaf012","DOIUrl":"10.1093/bbb/zbaf012","url":null,"abstract":"<p><p>Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate various genes involved in cholesterol and fatty acid synthesis, playing a central role in lipid metabolism regulation in vivo. SREBP-1c activity is significantly elevated in the liver under conditions of obesity, fatty liver disease, and type II diabetes, while suppression of SREBP-1c activity has been shown to alleviate these symptoms. Consequently, targeting SREBP-1c activity is considered a potential therapeutic approach for these conditions. In this study, we identified NPD7426 as a compound with inhibitory effects on SREBP activity. Furthermore, we demonstrated that NPD7426 promotes the proteasome-mediated degradation of mature SREBP protein forms. These findings provide new insights into the mechanism of SREBP activity suppression by small-molecule compounds containing NPD7426, suggesting that NPD7426 may be a promising candidate for the development of therapeutic drugs targeting SREBPs.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"704-711"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of trans-to-cis isomerization of cinnamic acid in Arabidopsis using stable-isotope-labeled cinnamic acid. 利用稳定同位素标记肉桂酸研究拟南芥中肉桂酸的反式-顺式异构化。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf019
Kei Tsuzuki, Taiki Suzuki, Kotaro Nishiyama, Yoshiya Seto
{"title":"Investigation of trans-to-cis isomerization of cinnamic acid in Arabidopsis using stable-isotope-labeled cinnamic acid.","authors":"Kei Tsuzuki, Taiki Suzuki, Kotaro Nishiyama, Yoshiya Seto","doi":"10.1093/bbb/zbaf019","DOIUrl":"10.1093/bbb/zbaf019","url":null,"abstract":"<p><p>Cinnamic acid (CA) is a widely distributed metabolite in plant species and is a precursor of many important plant molecules such as lignin and flavonoids. CA exists as both trans and cis isomers; the trans isomer is more common in nature. Previous reports have revealed that the cis isomer of CA (cis-CA) has auxin-like activity when exogenously applied. Moreover, cis-CA was found as an endogenous compound in planta. Here, we report the chemical synthesis of stable-isotope-labeled trans- and cis-CA. Using these labeled compounds as internal standards, we developed a quantification method of CA using liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry (LC-MS/MS). We identified cis-CA in diverse plant species, including liverwort, moss, and lycophyte, implying an important role of cis-CA in the terrestrial plant kingdom.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"743-749"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of machine learning-assisted screening of PKC ligands: PKC binding affinity and activation. 机器学习辅助筛选PKC配体的验证：PKC结合亲和力和激活。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf008
Jumpei Maki, Asami Oshimura, Yudai Shiotani, Maki Yamanaka, Sogen Okuda, Ryo C Yanagita, Shigeru Kitani, Yasuhiro Igarashi, Yutaka Saito, Yasubumi Sakakibara, Chihiro Tsukano, Kazuhiro Irie
{"title":"Validation of machine learning-assisted screening of PKC ligands: PKC binding affinity and activation.","authors":"Jumpei Maki, Asami Oshimura, Yudai Shiotani, Maki Yamanaka, Sogen Okuda, Ryo C Yanagita, Shigeru Kitani, Yasuhiro Igarashi, Yutaka Saito, Yasubumi Sakakibara, Chihiro Tsukano, Kazuhiro Irie","doi":"10.1093/bbb/zbaf008","DOIUrl":"10.1093/bbb/zbaf008","url":null,"abstract":"<p><p>Protein kinase C (PKC) is a family of serine/threonine kinases, and PKC ligands have the potential to be therapeutic seeds for cancer, Alzheimer's disease, and human immunodeficiency virus infection. However, in addition to desired therapeutic effects, most PKC ligands also exhibit undesirable pro-inflammatory effects. The discovery of new scaffolds for PKC ligands is important for developing less inflammatory PKC ligands, such as bryostatins. We previously reported that machine learning combined with our knowledge of the pharmacophore yielded 15 PKC ligand candidates, but we did not evaluate their PKC binding affinities fully. In this paper, PKC binding affinities of four candidates were examined to assess their potential as PKC ligands and to validate machine learning-assisted screening. Although compound 3' did not bind to PKC C1 domains, 1a, 2', and 4a exhibited moderate PKC binding affinities, suggesting that machine learning-assisted screening is advantageous in identifying new PKC ligand scaffolds.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"668-679"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crystal structure of l-2-keto-3-deoxyrhamnonate 4-dehydrogenase involved in the non-phosphorylating pathway of l-rhamnose metabolism by bacteria. 参与细菌 L-鼠李糖代谢非磷酸化途径的 L-2-keto-3-deoxyrhamnonate 4-dehydrogenase 晶体结构。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf015
Miyu Akagashi, Seiya Watanabe
{"title":"Crystal structure of l-2-keto-3-deoxyrhamnonate 4-dehydrogenase involved in the non-phosphorylating pathway of l-rhamnose metabolism by bacteria.","authors":"Miyu Akagashi, Seiya Watanabe","doi":"10.1093/bbb/zbaf015","DOIUrl":"10.1093/bbb/zbaf015","url":null,"abstract":"<p><p>In the non-phosphorylative l-rhamnose and l-fucose pathways in bacteria, the C4-OH groups of the l-2-keto-3-deoxyrhamnonate (l-KDR) and l-2-keto-3-deoxyfuconate (l-KDF) intermediates are oxidized by different NAD+-dependent dehydrogenases, which belong to the same superfamily: l-KDRDH and l-KDFDH, respectively. To further elucidate their opposite stereospecificities, we herein investigated the crystal structures of l-KDRDH (from Herbaspirillum huttiense) in ligand-free and NAD+-bound forms. The interactions between the side chains of Asp39 and Gln18, and the 2'- and/or 3'-hydroxyl group(s) of NAD+ were consistent with strict specificity for NAD+. In a binding model for the substrate, Asn151 and Arg247 interacted with the C1 carboxyl and/or C5 hydroxyl group(s) of l-KDR with the acrylic α-keto form, which differed from l-KDFDH, which recognizes l-KDF with the cyclic hemiketal. A comparison of gene clusters on the bacterial genome and biochemical characterization suggested that l-KDRDH functions as a novel 4-hydroxy-2-oxopentanoate dehydrogenase in the degradation of aromatic compounds.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"733-742"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oregano leaf odor regulates sodium chloride consumption in mice. 牛至叶气味调节小鼠氯化钠摄入量。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf014
Kazumi Osada, Nanako Akiyama, Akira Hosono, Motoko Ohata, Issei Yokoyama, Sadaharu Miyazono, Michio Komai
{"title":"Oregano leaf odor regulates sodium chloride consumption in mice.","authors":"Kazumi Osada, Nanako Akiyama, Akira Hosono, Motoko Ohata, Issei Yokoyama, Sadaharu Miyazono, Michio Komai","doi":"10.1093/bbb/zbaf014","DOIUrl":"10.1093/bbb/zbaf014","url":null,"abstract":"<p><p>This study explores how the odor of oregano and its active component, carvacrol, influence salt preference in mice. Using a 2-bottle choice test (distilled water vs 0.15 m NaCl), 66 C57BL/6J mice were exposed to oregano odor. Female mice showed a significant reduction in saline intake with oregano or carvacrol exposure, while the effect was lower in males. Carvacrol was identified in dried oregano using gas chromatography-mass spectrometry (GC-MS) with headspace-solid-phase microextraction (HS-SPME). Neurologically, oregano odor increased c-Fos immunoreactivity in the ventral bed nucleus of the stria terminalis, a region regulating salt appetite. These results suggest that oregano odor decreases salt preference, partly due to carvacrol, which stimulates brain areas controlling salt appetite. This study highlights the role of olfactory cues in modulating dietary behavior and suggests potential applications for managing salt consumption in health contexts.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"776-786"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of thermally stable and water-soluble pantetheine trisulfide and its composites. 热稳定水溶性三硫化泛硫氨酸及其复合材料的合成与表征。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf010
Shoichiro Tomonaga, Hiroaki Ishimaru, Shizuki Misada, Takahiro Isobe, Etsuo Ohshima, Shinji Kitagaki
{"title":"Synthesis and characterization of thermally stable and water-soluble pantetheine trisulfide and its composites.","authors":"Shoichiro Tomonaga, Hiroaki Ishimaru, Shizuki Misada, Takahiro Isobe, Etsuo Ohshima, Shinji Kitagaki","doi":"10.1093/bbb/zbaf010","DOIUrl":"10.1093/bbb/zbaf010","url":null,"abstract":"<p><p>We clarified for the first time the synthesis procedure and characterization of pantetheine trisulfide, a potential new drug. Pantetheine trisulfide is the first supersulfur compound with both thermal stability and water solubility. Its hygroscopicity and deliquescence promote the hydrolysis of trisulfide, but these limitations are overcome by powdered composites of pantetheine trisulfide with silica gel or lactose.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"687-692"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of (S)-4-methylgeranyl esters, the pheromone components of the ponerine ant, Holcoponera striatula, and their (R)-isomers. (S)-4-甲基香叶醚酯及其(R)-异构体的合成。
IF 1.4 4区 生物学
Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI: 10.1093/bbb/zbaf021
Takuya Tashiro, Hiroyuki Watanabe
{"title":"Synthesis of (S)-4-methylgeranyl esters, the pheromone components of the ponerine ant, Holcoponera striatula, and their (R)-isomers.","authors":"Takuya Tashiro, Hiroyuki Watanabe","doi":"10.1093/bbb/zbaf021","DOIUrl":"10.1093/bbb/zbaf021","url":null,"abstract":"<p><p>(2E,4S)-3,4,7-Trimethylocta-2,6-dien-1-yl octanoate [(S)-1], decanoate [(S)-2], and dodecanoate [(S)-3] are the main trail pheromone components of the Dufour's gland secretion of the ponerine ant, Holcoponera striatula. We synthesized these pheromone components from an optically active alcohol, (R)-5, by using Johnson-Claisen rearrangement reaction as the key step for constructing a methyl-branched alkyl chain. The alcohol (R)-5 was prepared by using the enzymatic resolution of its racemate. To investigate the biological activity of the enantiomers of these pheromone components, we synthesized the antipodes (R)-1, (R)-2, and (R)-3.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"680-686"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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