Bioscience, Biotechnology, and Biochemistry最新文献_第5页

Study on authentication of ingredients and geographical origin of Japanese sake based on hydrogen stable isotope analysis by deuterium NMR. 基于氘核磁共振氢稳定同位素分析的日本清酒成分及产地鉴别研究。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf098

Kenji Ogura, Ren Mizutani

引用次数: 0

Characterization of N-malonylurea hydrolase in the pyrimidine oxidative degradation pathway of Rhodococcus erythropolis JCM 3132. 红红红球菌JCM 3132嘧啶氧化降解途径中n -丙二酰脲水解酶的表征

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf083

Kengo Deguchi, Nobuyuki Horinouchi, Michiki Takeuchi, Chee-Leong Soong, Sakayu Shimizu, Jun Ogawa

引用次数: 0

Discovery of a monomeric flavin-containing opine dehydrogenase from bacteria. 从细菌中发现单体含黄素的阿片脱氢酶。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf096

Seiya Watanabe, Kentaroh Yoshiwara, Mizue Date, Yasunori Watanabe

引用次数: 0

Therapeutic impact of polysaccharide from Chinese yam (Dioscorea opposita Thunb) on DSS-induced ulcerative colitis in mice. 山药多糖对dss致小鼠溃疡性结肠炎的治疗作用。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf086

Jianing Tan, Ziliang Zhuo, Ling Zhang, Xuemin Jin, Xiuyu Wang, Yanshuang Zhang, Yajun Zhou

{"title":"Therapeutic impact of polysaccharide from Chinese yam (Dioscorea opposita Thunb) on DSS-induced ulcerative colitis in mice.","authors":"Jianing Tan, Ziliang Zhuo, Ling Zhang, Xuemin Jin, Xiuyu Wang, Yanshuang Zhang, Yajun Zhou","doi":"10.1093/bbb/zbaf086","DOIUrl":"10.1093/bbb/zbaf086","url":null,"abstract":"While yam polysaccharide (YP) demonstrates diverse biological activities, its anti-inflammatory mechanisms remain insufficiently characterized. This study systematically investigates the therapeutic efficacy of YP in ulcerative colitis (UC) through integrated in vitro and in vivo approaches. YP was purified from Dioscorea opposita Thunb. via ethanol precipitation, followed by cytotoxicity profiling. In Lipopolysaccharide (LPS)-stimulated intestinal epithelial cells (IEC-6), YP significantly attenuated proinflammatory responses. For in vivo validation, a murine colitis model was established through dextran sulfate sodium administration in drinking water. Systematic macroscopic and histopathological assessments revealed that YP treatment reduced colon shortening and mitigated crypt architectural distortion. Further analyses combining H&E staining, immunofluorescence, and western blotting demonstrated that YP exerts anti-inflammatory effects through upregulating interleukin-10 expression. These findings position YP as a multifaceted modulator of intestinal inflammation, suggesting its potential as a novel therapeutic agent for UC management.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1362-1372"},"PeriodicalIF":1.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel fatty acid-derived biopolymer with tunable polarity. 一种新型极性可调脂肪酸衍生生物聚合物的研制。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf095

Takeshi Imai, Hiroto Achira, Akihiko Tanitame, Hisaaki Mihara

引用次数: 0

Seawater biodegradation of a microbial lactate-based polyester (LAHB) as an advanced version of non-degradable polylactide. 海水生物降解的微生物乳酸基聚酯（LAHB）作为不可降解聚乳酸的高级版本。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf097

Sangho Koh, Miwa Suzuki, Ken-Ichi Kasuya, Seiichi Taguchi

引用次数: 0

A unique tetrasaccharide-containing anchor glycolipid of lipoteichoic acid is commonly found in Lactobacillus gasseri and Lactobacillus paragasseri. 一种独特的含有脂磷胆酸的四糖锚定糖脂常见于干酪乳杆菌和副干酪乳杆菌中。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf081

Tsukasa Shiraishi, Ryosuke Kutomi, Yamaha Sato, Akihito Endo, Satoru Fukiya, Satoshi Takahashi, Atsushi Yokota, Shin-Ichi Yokota

{"title":"A unique tetrasaccharide-containing anchor glycolipid of lipoteichoic acid is commonly found in Lactobacillus gasseri and Lactobacillus paragasseri.","authors":"Tsukasa Shiraishi, Ryosuke Kutomi, Yamaha Sato, Akihito Endo, Satoru Fukiya, Satoshi Takahashi, Atsushi Yokota, Shin-Ichi Yokota","doi":"10.1093/bbb/zbaf081","DOIUrl":"10.1093/bbb/zbaf081","url":null,"abstract":"Lipoteichoic acid (LTA) is a cell surface molecule with physiologically important roles in Gram-positive bacteria. Previously, we identified a novel tetrasaccharide-containing anchor glycolipid in the Lactobacillus gasseri JCM 1131T LTA. However, it is unclear whether this tetrasaccharide-containing anchor glycolipid structure is characteristic of JCM 1131T alone or is commonly found in other L. gasseri-related isolates. Lactobacillus paragasseri has been proposed as a new species, separated from the L. gasseri. In the present study, we characterized the chemical structures of LTA from 2 strains of L. gasseri and 4 strains of L. paragasseri. All 6 strains shared a polymer comprising repeating units of glycerophosphate with partial D-alanine substitutions, as well as L. gasseri JCM 1131T. Anchor glycolipid structure suggested that all strains shared a tetrasaccharide-containing glyceroglycolipid with 2 and 3 acyl groups. Focusing on LTA from L. gasseri and L. paragasseri species, a tetrasaccharide-containing anchor glycolipid is a specific feature.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1382-1390"},"PeriodicalIF":1.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of various CaCl2 concentrations on the physiological and growth responses of Asarin Scandens Rose under salt stress. 不同浓度CaCl2对盐胁迫下细辛玫瑰生理和生长响应的影响。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf061

Nana Wu, Ruyu Fu, Mingxu Dong, Xinyue Zhang, Jinzhu Zhang, Tao Yang, Jie Dong, Jinping Fan

引用次数: 0

Presence of isomaltose transporters in Aspergilli demonstrated through nuclear translocation assays of the transcription factor AmyR. 通过转录因子AmyR的核易位测定，证实了曲霉中存在异麦芽糖转运体。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf085

Shoki Fujita, Da Min Jeong, Takanori Ichikawa, Takahiro Shintani, Katsuya Gomi

{"title":"Presence of isomaltose transporters in Aspergilli demonstrated through nuclear translocation assays of the transcription factor AmyR.","authors":"Shoki Fujita, Da Min Jeong, Takanori Ichikawa, Takahiro Shintani, Katsuya Gomi","doi":"10.1093/bbb/zbaf085","DOIUrl":"10.1093/bbb/zbaf085","url":null,"abstract":"Maltose is readily incorporated into Aspergillus oryzae cells. In contrast, isomaltose is unlikely to be incorporated into both A. oryzae and Aspergillus nidulans, even though extremely low concentrations of isomaltose can induce the nuclear translocation of AmyR. This suggests the presence of sensor-like proteins or isomaltose transporters in both Aspergilli. In this study, we showed that isomaltose can be incorporated via sugar/H+ symporters using AmyR nuclear translocation assays. Assuming that sugar transporters are proton-coupled symporters, we examined the effect of the protonophore carbonyl cyanide m-chlorophenyl hydrazone on isomaltose-induced AmyR nuclear translocation. Consequently, AmyR nuclear translocation was impaired by the addition of the protonophore in A. oryzae. This was confirmed under high pH conditions where AmyR nuclear translocation was abrogated in both Aspergilli. These results suggest that instead of sensors, isomaltose is most likely incorporated by sugar/H+ symporters with low isomaltose transport activity, triggering isomaltose-induced AmyR nuclear translocation.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1391-1399"},"PeriodicalIF":1.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of noncanonical fumagillin derivatives with a twisted cyclohexane conformation through engineered biosynthesis. 通过工程生物合成产生具有扭曲环己烷构象的非规范富马青霉素衍生物。

IF 1.3 4区生物学

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-23 DOI: 10.1093/bbb/zbaf091

Yuta Tsunematsu, Yuji Ogata, Kanji Niwa, Namiko Ogata, Seiki Kobayashi, Michio Sato, Takuma Matsushita, Ryota Shizu, Kouichi Yoshinari, Mihoko Mori, Yumiko Saito-Nakano, Tomoyoshi Nozaki, Kenji Watanabe

{"title":"Generation of noncanonical fumagillin derivatives with a twisted cyclohexane conformation through engineered biosynthesis.","authors":"Yuta Tsunematsu, Yuji Ogata, Kanji Niwa, Namiko Ogata, Seiki Kobayashi, Michio Sato, Takuma Matsushita, Ryota Shizu, Kouichi Yoshinari, Mihoko Mori, Yumiko Saito-Nakano, Tomoyoshi Nozaki, Kenji Watanabe","doi":"10.1093/bbb/zbaf091","DOIUrl":"10.1093/bbb/zbaf091","url":null,"abstract":"Fumagillin-class natural products, known as methionine aminopeptidase 2 inhibitors, have been explored as drug candidates for cancer, obesity, and infectious diseases such as amoebiasis. However, clinical development has been hindered by adverse effects. Here, we identified 2 fumagillin analogues via engineered biosynthesis in Saccharomyces cerevisiae, coupled with metabolomics and activity-guided isolation. Spectroscopic analysis revealed unique 6-oxabicyclo[3.2.1]octane scaffolds that are unprecedented among naturally occurring fumagillins. The compounds exhibited selective antiamoebic activity without cytotoxicity to human lung cells. Stereochemical and computational studies suggested that the unique bicyclic system arises from a twist-boat conformer that enables intramolecular ether formation. These findings demonstrate that biosynthetic pathway engineering can expand the chemical diversity of fumagillin-related molecules and provide new leads for antiparasitic drug discovery.","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1264-1270"},"PeriodicalIF":1.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0