Breeding of the sake yeast K1801 with normal checkpoint integrity by isolating spontaneous cdc55 revertants.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-06-23 DOI:10.1093/bbb/zbaf089

Tetsuya Goshima, Ikuhisa Nishida, Hitoshi Shimoi, Takeshi Akao, Dai Hirata

引用次数: 0

Abstract

Sake yeast strain K1801 with high productivity of ethyl caproate is widely used for high-quality sake brewing, however K1801 has a defect in spindle assembly checkpoint (SAC), whose responsible mutation is R48P of the PP2A regulatory subunit Cdc55. Here, we successfully isolated spontaneous revertants of the cdc55 mutation with the excellent brewing property similar to K1801 and normal checkpoint integrity.

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通过分离cdc55自然复归物选育具有正常检查点完整性的清酒酵母K1801。

清酒酵母菌K1801具有较高的己酸乙基产量，被广泛用于高品质清酒酿造，但K1801存在纺锤体组装检查点（SAC）缺陷，其主要突变为PP2A调控亚基Cdc55的R48P。在这里，我们成功地分离了cdc55突变的自发复合体，具有与K1801相似的良好酿造特性和正常的检查点完整性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).