{"title":"A key regulatory region required for the inhibition of proline utilization in the yeast transceptor Can1.","authors":"Ryoya Tanahashi, Hiroshi Takagi, Akira Nishimura","doi":"10.1093/bbb/zbaf110","DOIUrl":null,"url":null,"abstract":"<p><p>The transceptor Can1 negatively regulates proline utilization in the yeast Saccharomyces cerevisiae. Here, we demonstrated that Can1 physically interacts with the catalytic subunits of protein kinase A (Tpk1, Tpk2, and Tpk3). Furthermore, we identified a specific site in Can1 that is essential for inhibiting proline utilization. These findings provide a mechanistic basis for Can1-mediated metabolic regulation.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1521-1524"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience, Biotechnology, and Biochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1093/bbb/zbaf110","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The transceptor Can1 negatively regulates proline utilization in the yeast Saccharomyces cerevisiae. Here, we demonstrated that Can1 physically interacts with the catalytic subunits of protein kinase A (Tpk1, Tpk2, and Tpk3). Furthermore, we identified a specific site in Can1 that is essential for inhibiting proline utilization. These findings provide a mechanistic basis for Can1-mediated metabolic regulation.
期刊介绍:
Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).