{"title":"酵母受体Can1中抑制脯氨酸利用的关键调控区域。","authors":"Ryoya Tanahashi, Hiroshi Takagi, Akira Nishimura","doi":"10.1093/bbb/zbaf110","DOIUrl":null,"url":null,"abstract":"<p><p>The transceptor Can1 negatively regulates proline utilization in the yeast Saccharomyces cerevisiae. Here, we demonstrated that Can1 physically interacts with the catalytic subunits of protein kinase A (Tpk1, Tpk2, and Tpk3). Furthermore, we identified a specific site in Can1 that is essential for inhibiting proline utilization. These findings provide a mechanistic basis for Can1-mediated metabolic regulation.</p>","PeriodicalId":9175,"journal":{"name":"Bioscience, Biotechnology, and Biochemistry","volume":" ","pages":"1521-1524"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A key regulatory region required for the inhibition of proline utilization in the yeast transceptor Can1.\",\"authors\":\"Ryoya Tanahashi, Hiroshi Takagi, Akira Nishimura\",\"doi\":\"10.1093/bbb/zbaf110\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The transceptor Can1 negatively regulates proline utilization in the yeast Saccharomyces cerevisiae. Here, we demonstrated that Can1 physically interacts with the catalytic subunits of protein kinase A (Tpk1, Tpk2, and Tpk3). Furthermore, we identified a specific site in Can1 that is essential for inhibiting proline utilization. These findings provide a mechanistic basis for Can1-mediated metabolic regulation.</p>\",\"PeriodicalId\":9175,\"journal\":{\"name\":\"Bioscience, Biotechnology, and Biochemistry\",\"volume\":\" \",\"pages\":\"1521-1524\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioscience, Biotechnology, and Biochemistry\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1093/bbb/zbaf110\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience, Biotechnology, and Biochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1093/bbb/zbaf110","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
A key regulatory region required for the inhibition of proline utilization in the yeast transceptor Can1.
The transceptor Can1 negatively regulates proline utilization in the yeast Saccharomyces cerevisiae. Here, we demonstrated that Can1 physically interacts with the catalytic subunits of protein kinase A (Tpk1, Tpk2, and Tpk3). Furthermore, we identified a specific site in Can1 that is essential for inhibiting proline utilization. These findings provide a mechanistic basis for Can1-mediated metabolic regulation.
期刊介绍:
Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).